메뉴 건너뛰기




Volumn 91, Issue 9, 2004, Pages 1726-1734

Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells

Author keywords

Apoptosis; Caspases; Cathine; Cathinone; Khat; Leukaemia cells

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLTRYPTOPHYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLTYROSYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLASPARTYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLGLUTAMYLISOLEUCYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CATHA EDULIS EXTRACT; CATHINONE; CYCLOHEXIMIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; NORPSEUDOEPHEDRINE; UNCLASSIFIED DRUG;

EID: 9144263045     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602197     Document Type: Article
Times cited : (51)

References (36)
  • 1
    • 0023870225 scopus 로고
    • Cytoxicity of khat (Catha edulis) extract on cultured mammalian cells: Effects on macromolecule biosynthesis
    • Al-Ahdal MN, McGarry TJ, Hannan M (1988) Cytoxicity of khat (Catha edulis) extract on cultured mammalian cells: effects on macromolecule biosynthesis. Mutat Res 204: 317-322
    • (1988) Mutat Res , vol.204 , pp. 317-322
    • Al-Ahdal, M.N.1    McGarry, T.J.2    Hannan, M.3
  • 2
    • 0036218034 scopus 로고    scopus 로고
    • Investigation into the toxicological effects of Catha edulis leaves: A short term study in animals
    • Al-Mamary M, Al-Habori M, Al-Aghbari AM, Baker MM (2002) Investigation into the toxicological effects of Catha edulis leaves: a short term study in animals. Phytother Res 16: 127-132
    • (2002) Phytother Res , vol.16 , pp. 127-132
    • Al-Mamary, M.1    Al-Habori, M.2    Al-Aghbari, A.M.3    Baker, M.M.4
  • 4
    • 0036667465 scopus 로고    scopus 로고
    • Khat: Pharmacological and medical aspects and its social use in Yemen
    • Al-Motarreb A, Baker K, Broadley KJ (2002) Khat: pharmacological and medical aspects and its social use in Yemen. Phytother Res 16: 403-413
    • (2002) Phytother Res , vol.16 , pp. 403-413
    • Al-Motarreb, A.1    Baker, K.2    Broadley, K.J.3
  • 5
    • 0036889616 scopus 로고    scopus 로고
    • Effect of khat, its constituents and restraint stress on free radical metabolism of rats
    • Al-Qirim TM, Shahwan M, Zaidi KR, Uddin Q, Banu N (2002) Effect of khat, its constituents and restraint stress on free radical metabolism of rats. J Ethnopharmacol 83: 245-250
    • (2002) J Ethnopharmacol , vol.83 , pp. 245-250
    • Al-Qirim, T.M.1    Shahwan, M.2    Zaidi, K.R.3    Uddin, Q.4    Banu, N.5
  • 6
    • 0028808820 scopus 로고
    • R8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line
    • Bøe R, Gjertsen BT, Doskeland SO, Vintermyr OK (1995) R8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line. Br J Cancer 72: 1151-1159
    • (1995) Br J Cancer , vol.72 , pp. 1151-1159
    • Bøe, R.1    Gjertsen, B.T.2    Doskeland, S.O.3    Vintermyr, O.K.4
  • 7
    • 0038712179 scopus 로고    scopus 로고
    • Flt3-mediated signaling in human acute myelogenous leukemai (AML) blasts: A functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities
    • Bruserud O, Hovland R, Wergeland L, Huang T, Gjertsen B (2003) Flt3-mediated signaling in human acute myelogenous leukemai (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities. Haematologica 88: 416-428
    • (2003) Haematologica , vol.88 , pp. 416-428
    • Bruserud, O.1    Hovland, R.2    Wergeland, L.3    Huang, T.4    Gjertsen, B.5
  • 8
    • 0038689279 scopus 로고    scopus 로고
    • The toxilogical potential of khat
    • Carvalho F (2003) The toxilogical potential of khat. J Ethnopharmacol 87: 1-2
    • (2003) J Ethnopharmacol , vol.87 , pp. 1-2
    • Carvalho, F.1
  • 9
    • 0034705626 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation
    • Communal C, Colucci WS, Singh K (2000) p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation. J Biol Chem 275: 19395-19400
    • (2000) J Biol Chem , vol.275 , pp. 19395-19400
    • Communal, C.1    Colucci, W.S.2    Singh, K.3
  • 11
    • 0028581962 scopus 로고
    • Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line
    • Gjertsen BT, Cressey LI, Ruchaud S, Houge G, Lanotte M, Døskeland SO (1994) Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. J Cell Sci 107: 3363-3377
    • (1994) J Cell Sci , vol.107 , pp. 3363-3377
    • Gjertsen, B.T.1    Cressey, L.I.2    Ruchaud, S.3    Houge, G.4    Lanotte, M.5    Døskeland, S.O.6
  • 12
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Herngartner MO (2000) The biochemistry of apoptosis. Nature 407: 770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Herngartner, M.O.1
  • 14
    • 0033067526 scopus 로고    scopus 로고
    • Caspase-1-related protease inhibition retards the execution of okadaic acid- And camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells
    • Jensen PH, Fladmark KE, Gjertsen BT, Vintermyr OK (1999) Caspase-1-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells. Brit J Cancer 79: 1685-1691
    • (1999) Brit J Cancer , vol.79 , pp. 1685-1691
    • Jensen, P.H.1    Fladmark, K.E.2    Gjertsen, B.T.3    Vintermyr, O.K.4
  • 15
    • 0026601939 scopus 로고
    • Cathinone, a natural amphetamine
    • Kalix P (1992) Cathinone, a natural amphetamine. Pharmacol Toxicol 70: 77-86
    • (1992) Pharmacol Toxicol , vol.70 , pp. 77-86
    • Kalix, P.1
  • 17
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Brit J Cancer 26: 239-257
    • (1972) Brit J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 18
    • 0038269752 scopus 로고    scopus 로고
    • Use of doubly protonated molecules in the analyusis of cathedulins in crude extract of khat (Catha edulis) by liquid chromatography/serial mass spectrometry
    • Kite GC, Ismail M, Simmonds M, Houghton P (2003) Use of doubly protonated molecules in the analyusis of cathedulins in crude extract of khat (Catha edulis) by liquid chromatography/serial mass spectrometry. Rapid Communicat Mass Spectrom 17: 1553-1564
    • (2003) Rapid Communicat Mass Spectrom , vol.17 , pp. 1553-1564
    • Kite, G.C.1    Ismail, M.2    Simmonds, M.3    Houghton, P.4
  • 19
    • 0032919161 scopus 로고    scopus 로고
    • Differentiation and assessment of cell death
    • Koester SK, Bolton WE (1999) Differentiation and assessment of cell death. Clin Chem Lab Med 37: 311-317
    • (1999) Clin Chem Lab Med , vol.37 , pp. 311-317
    • Koester, S.K.1    Bolton, W.E.2
  • 20
    • 0013609392 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1 converting enzyme
    • Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MSS, Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 converting enzyme. Nature 267: 1998-2000
    • (1995) Nature , vol.267 , pp. 1998-2000
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Mss, S.6    Flavell, R.A.7
  • 21
    • 0026026561 scopus 로고
    • Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line
    • Lanotte M, Riviere JB, Hermouet S, Houge G, Vintermyr OK, Gjertsen BT, Døskeland SO (1991) Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. J Cell Physiol 146: 73-80
    • (1991) J Cell Physiol , vol.146 , pp. 73-80
    • Lanotte, M.1    Riviere, J.B.2    Hermouet, S.3    Houge, G.4    Vintermyr, O.K.5    Gjertsen, B.T.6    Døskeland, S.O.7
  • 22
    • 0029047037 scopus 로고
    • The identification of cathinone in khat (Catha edulis): A time study
    • Lee MM (1995) The identification of cathinone in khat (Catha edulis): a time study. J Forens Sci 40: 116-121
    • (1995) J Forens Sci , vol.40 , pp. 116-121
    • Lee, M.M.1
  • 23
    • 0026558346 scopus 로고
    • Adrenergic effects on the biology of the adult mammalian cardiocyte
    • Mann DL, Kent RL, Parsons B, Cooper Gt (1992) Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 85: 790-804
    • (1992) Circulation , vol.85 , pp. 790-804
    • Mann, D.L.1    Kent, R.L.2    Parsons, B.3    Cooper, Gt.4
  • 24
    • 0027449187 scopus 로고
    • Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homologue of the C.elegans cell death gene ced-3
    • Miura M, Zhu H, Rotello R, Hartweig ZA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homologue of the C.elegans cell death gene ced-3. Cell 75: 653-660
    • (1993) Cell , vol.75 , pp. 653-660
    • Miura, M.1    Zhu, H.2    Rotello, R.3    Hartweig, Z.A.4    Yuan, J.5
  • 25
    • 0030814675 scopus 로고    scopus 로고
    • Caspases: Killer proteases
    • Nicholson DW, Thornberry NA (1997) Caspases: killer proteases. TIBS 22: 299-306
    • (1997) TIBS , vol.22 , pp. 299-306
    • Nicholson, D.W.1    Thornberry, N.A.2
  • 27
    • 0141742515 scopus 로고    scopus 로고
    • In-vitro characterization of ephedrine-related stereoisomers at biogenic amine trasporters and the receptorome reveals selective actions and norepinephrine transporter substrates
    • Rothman RB, Nga V, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA (2003) In-vitro characterization of ephedrine-related stereoisomers at biogenic amine trasporters and the receptorome reveals selective actions and norepinephrine transporter substrates. J Pharmacol Exp Therapeut 307: 138-145
    • (2003) J Pharmacol Exp Therapeut , vol.307 , pp. 138-145
    • Rothman, R.B.1    Nga, V.2    Partilla, J.S.3    Roth, B.L.4    Hufeisen, S.J.5    Compton-Toth, B.A.6    Birkes, J.7    Young, R.8    Glennon, R.A.9
  • 28
    • 0031973493 scopus 로고    scopus 로고
    • Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells
    • Schumann RR, Belka C, Reuter D, Lamping N, Kirsching CJ, Weber JR, Pfeil D (1998) Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 15: 577-584
    • (1998) Blood , vol.15 , pp. 577-584
    • Schumann, R.R.1    Belka, C.2    Reuter, D.3    Lamping, N.4    Kirsching, C.J.5    Weber, J.R.6    Pfeil, D.7
  • 30
    • 0032968347 scopus 로고    scopus 로고
    • Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons
    • Stumm G, Schlegel J, Schafer T, Wurz C, Mennel HD, Krieg JC, Vedder H (1999) Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J 13: 1065-1072
    • (1999) FASEB J , vol.13 , pp. 1065-1072
    • Stumm, G.1    Schlegel, J.2    Schafer, T.3    Wurz, C.4    Mennel, H.D.5    Krieg, J.C.6    Vedder, H.7
  • 31
    • 0019254131 scopus 로고
    • The chemistry of khat
    • Szendrei K (1980) The chemistry of khat. Bull Narcotics 32: 5-35
    • (1980) Bull Narcotics , vol.32 , pp. 5-35
    • Szendrei, K.1
  • 32
    • 0037998726 scopus 로고    scopus 로고
    • Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves
    • Toennes SW, Harder S, Schramm M, Niess C, Kauert GF (2003) Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol 56: 125-130
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 125-130
    • Toennes, S.W.1    Harder, S.2    Schramm, M.3    Niess, C.4    Kauert, G.F.5
  • 33
    • 0037184809 scopus 로고    scopus 로고
    • Apoptosis and toxicology - What relevance?
    • Vaux DL (2002) Apoptosis and toxicology - what relevance? Toxicology 181: 3-7
    • (2002) Toxicology , vol.181 , pp. 3-7
    • Vaux, D.L.1
  • 34
    • 0346792725 scopus 로고    scopus 로고
    • TRAIL and apoptosis induction by TNF-family death receptors
    • Wang S, El-Deiry WS (2003) TRAIL and apoptosis induction by TNF-family death receptors. Oncogene 22: 8628-8633
    • (2003) Oncogene , vol.22 , pp. 8628-8633
    • Wang, S.1    El-Deiry, W.S.2
  • 36
    • 0034480328 scopus 로고    scopus 로고
    • Application of a new TLC chemical method for detection of cyclopeptides in plants
    • Zhou J, Ninghua T (2000) Application of a new TLC chemical method for detection of cyclopeptides in plants. Chin Sci Bull 45: 1825-1831
    • (2000) Chin Sci Bull , vol.45 , pp. 1825-1831
    • Zhou, J.1    Ninghua, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.