In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 1, 2003, Pages 138-145

  Rothman, Richard B ^a   Vu, Nga ^a   Partilla, John S ^a   Roth, Bryan L ^b   Hufeisen, Sandra J ^b   Compton Toth, Beth A ^b   Birkes, Jon ^b   Young, Richard ^c   Glennon, Richard A ^c  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; BIOGENIC AMINE; CATHINONE; DECONGESTIVE AGENT; DOPAMINE TRANSPORTER; EPHEDRINE; METHAMPHETAMINE; METHCATHINONE; NORADRENALIN; NORADRENALIN TRANSPORTER; NOREPHEDRINE; NORPSEUDOEPHEDRINE; PHENYLPROPANOLAMINE; PSEUDOEPHEDRINE; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN HEMORRHAGE; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOMERISM; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; STEREOISOMERISM; STROKE;

ADRENERGIC AGENTS; ALKALOIDS; ANIMALS; BIOGENIC AMINES; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EPHEDRINE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0141742515     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053975     Document Type: Article

References (25)

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