Khat (Catha edulis) consumption causes genotoxic effects in humans

International Journal of Cancer

Volumn 92, Issue 3, 2001, Pages 329-332

  Kassie, Fekadu ^a   Darroudi, Firouz ^a   Kundi, Michael ^b   Schulte Hermann, Rolf ^b   Knasmüller, Siegfried ^a,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Institute of Environmental Health   (Austria)

Author keywords

Aneugen; Buccal mucosa; Khat; Micronuclei

Indexed keywords

CATHA EDULIS EXTRACT;

ADULT; ALCOHOL CONSUMPTION; ANEUPLOIDY; ARTICLE; BLADDER MUCOSA; CENTROMERE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC DAMAGE; GENOTOXICITY; HUMAN; KINETICS; MICRONUCLEUS TEST; MOUTH CANCER; MOUTH MUCOSA; PRIORITY JOURNAL; TOBACCO;

ADULT; CATHA; CENTRAL NERVOUS SYSTEM STIMULANTS; HUMANS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MOUTH MUCOSA; MUTAGENICITY TESTS; PLANT EXTRACTS;

EID: 0035342561     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1195     Document Type: Article

References (39)

1. The use of khat: A stimulant with regional distribution
2. The use of khat (Catha edulis) in Yemen: Social and medical observations
3. Review on the pharmacology of khat
4. The oral and dental effects of q'at chewing
5. Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice
6. Cytological effects of khat (Catha edulis) in somatic and male germ cells of mice
7. The molecular genetic of cancer
8. Tumours and malformations in the adult offspring of cyclophosphamide-treated and control male rats. Preliminary communications
9. In vivo cytogenetic assays
10. The DNA content of micronuclei induced in bone marrow by gamma-radiation: Evidence that micronuclei arise from acentric chromosome fragments
11. Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells
12. Validation of smoking history with micronucleus test
13. Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: Betel quid chewers
14. Evaluation of chromosomal aberrations in lymphocytes and micronuclei in lymphocytes, oral mucosa and hair root cells of patients under antiblastic therapy
15. Localized induction of micronuclei in the oral mucosa of xeroderma pigmentosum patients
16. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada
17. Chromosomal damage in urothelial cells from Egyptians with chronic Schistosoma hematobium infections
18. Detection of aneugenic and clastogenic potential of X-rays and directly acting chemicals in human hepatoma (HepG2) cells and peripheral blood lymphocytes, using the micronucleus assays and fluorescence in situ hybridisation with a DNA centromeric probe
19. Measurement and characterization of micronuclei in exfoliated human cells by fluorescence in situ hybridization with a centromeric probe
20. Adaptation of the DNA-repair and micronucleus tests to human cell suspensions and exfoliated cells
21. Reduction in chromosomal damage in schistosomiasis patients after treatment with praziquatel
22. Micronuclei in exfoliated urothelial cells and urine mutagenicity in smokers
23. Etiological and preventive implications in alcohol carcinogenesis
24. Histidine reversion in Ames Salmonella strains induced by extracts of khat - A substance of abuse
25. The carcinogenic activity of tannic acid. Liver tumors induced in rats by prolonged subcutaneous administration of tannic acid solution
26. Induction of tumours by tannin extracts
27. Investigations on the toxicity of small chronic doses of tannic acid with special reference to possible carcinogenicity
28. Khat chewing in the Near East
29. Lymphoma development in mice and humans: Diversity of initiation is followed by convergent cytogenetic evaluation
30. Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer
31. A genetic model for colorectal tumorigenesis
32. Molecular genetics of human cancer predisposition and progression
33. Oesophageal and gastric carcinoma in the republic of Yemen
34. Khat and oral cancer
35. Chemoprevention of oral leukoplakia with vitamin A, and β-carotene: An assessment
36. Aneuploidy data review committee: Summary compilation of chemical data base and evaluation of test methodology