Cobatoxin 1 from Centruroides noxius scorpion venom: Chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K + channels

Biochemical Journal

Volumn 377, Issue 1, 2004, Pages 37-49

  Jouirou, Besma ^a,b   Mosbah, Amor ^a   Visan, Violeta ^c   Grissmer, Stephan ^c   M'Barek, Sarrah ^a   Fajloun, Ziad ^a   Van Rietschoten, Jurphaas ^a   Devaux, Christiane ^a   Rochat, Hervé ^a   Lippens, Guy ^d   El Ayeb, Mohamed ^a,b   De Waard, Michel ^e   Mabrouk, Kamel ^a   Sabatier, Jean Marc ^a  

^a CNRS   (France)

^b PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^c UNIVERSITY OF ULM   (Germany)

^d INSTITUT PASTEUR DE LILLE   (France)

^e CEA GRENOBLE   (France)

Author keywords

Chemical synthesis; Cobatoxin 1; Docking simulation; K+ channel; Scorpion toxin; Three dimensional structure

Indexed keywords

CALCIUM; CELLS; CHEMICAL BONDS; CONFORMATIONS; DRUG PRODUCTS; ELECTRIC CURRENTS; ENZYME KINETICS; OXIDATION; POTASSIUM; SYNTHESIS (CHEMICAL); TOXIC MATERIALS;

VENOMS;

BIOCHEMISTRY;

COBATOXIN 1; POTASSIUM CHANNEL; SCORPION VENOM; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCORPION; SIMULATION; SYNAPTOSOME; SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CIRCULAR DICHROISM; COMPUTER SIMULATION; DISULFIDES; HUMANS; KV1.2 POTASSIUM CHANNEL; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID;

ARACHNIDA; CENTRUROIDES; CENTRUROIDES NOXIUS; HEXAPODA; SCORPIONES; VERTEBRATA;

EID: 9144245516     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030977     Document Type: Article

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