Agitation effects on submerged growth and product formation of Aspergillus niger

Bioprocess and Biosystems Engineering

Volumn 26, Issue 5, 2004, Pages 315-323

  Kelly, Sven ^a   Grimm, Luis H ^a   Hengstler, Jan ^a   Schultheis, Ellen ^a   Krull, Rainer ^a   Hempel, Dietmar C ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Aspergillus niger; Glucoamylase production; Morphology; Pellet formation; Shear stress

Indexed keywords

BIOMASS; BIOREACTORS; DATA REDUCTION; ENERGY DISSIPATION; ENZYMES; HYDRODYNAMICS; MORPHOLOGY;

AGITATION EFFECTS; BIOMASS GROWTH; PELLET MORPHOLOGY; SUBMERGED GROWTH;

MICROORGANISMS;

GLUCAN 1,4 ALPHA GLUCOSIDASE;

ARTICLE; ASPERGILLUS NIGER; BIOMASS; BIOREACTOR; CORRELATION ANALYSIS; ENZYME ACTIVITY; FUNGUS GROWTH; HYDRODYNAMICS; MORPHOLOGY; MYCELIAL GROWTH; NONHUMAN; PRIORITY JOURNAL;

ASPERGILLUS NIGER; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; COMPUTER SIMULATION; FUNGAL PROTEINS; GLUCOSE; MECHANOTRANSDUCTION, CELLULAR; MICROFLUIDICS; MODELS, BIOLOGICAL; MOTION; PHYSICAL STIMULATION;

ASPERGILLUS; ASPERGILLUS NIGER;

EID: 8744287349     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-004-0368-y     Document Type: Article

References (34)

1. Amanullah A, Jüsten P, Davies A, Paul GC, Nienow AW, Thomas CR (2000) Agitation induced mycelial fragmentation of Aspergillus oryzae and Penicillium chrysogenum. Biochem Eng J 5:109-114
2. Amanullah A, Leonildi E, Nienow AW, Thomas CR (2001) Dynamics of mycelia aggregation in cultures of Aspergillus oryzae. Bioproc Biosyst Eng 24:101-107
3. Bhargava S, Wenger K, Marten M (2003) Pulsed addition of limiting-carbon during Aspergillus oryzae fermentation leads to improved productivity of a recombinant enzyme. Biotechnol Bioeng 85(1):111-117
4. Braun S, Vecht-Lifshitz SE (1991) Mycelial morphology and metabolite production. Trends Biotechnol 9:63-68
5. Cox PW, Thomas CR (1992) Classification and measurement of fungal pellets by automated image analysis. Biotechnol Bioeng 39:945-952
6. Cui YQ, van der Lans RGJM, Luyben KCAM (1997) Effect of agitation intensities on fungal morphology of submerged fermentation. Biotechnol Bioeng 55(5):715-726
7. Cui YQ, van der Lans RGJM, Giuseppin MLF, Luyben KCAM (1998) Influence of fermentation conditions and scale on the submerged fermentation of Aspergillus awamori. Enz Micro Tech 23:157-167
8. Cui YQ, van der Lans RGJM, Luyben KCAM (1998) Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation. Biotechnol Bioeng 57(4):409-419
9. Cui YQ, Okkerse WJ, van der Lans RGJM, Luyben KCAM (1998) Modeling and measurements of fungal growth and morphology in submerged fermentations. Biotechnol Bioeng 60(2):216-229
10. Davies JL, Baganz F, Ison AP, Lye GJ (2000) Studies on the interaction of fermentation and microfiltration operations: erythromycin recovery from Saccharopolyspora erythraea fermentation broths. Bioproc Eng 69(4):429-439
11. Dynesen J, Nielsen J (2003) Surface hydrophobicity of Aspergillus nidulans conidiospores and its role in pellet formation. Biotechnol Prog 19(3):1049-1052
12. El-Enshasy HA (1998) Optimization of glucose oxidase production and excretion by recombinant Aspergillus niger. Technische Universität Carolo-Wilhelmina, Braunschweig
13. El-Enshasy HA, Hellmuth K, Rinas U (1999) Fungal morphology in submerged cultures and its relation to glucose oxidase excretion by recombinant Aspergillus niger. Appl Biochem Biotechnol 81(1):1-11
14. Fujita M, Iwahori KST, Yamakawa K (1994) Analysis of pellet formation of Aspergillus niger based on shear-stress. J Ferment Bioeng 78(5):368-373
15. Ganzlin M (2000) Untersuchungen der induzierten Proteinproduktion unter Kontrolle des Glucoamylasepromotors in Aspergillus niger. Technische Universität Carolo-Wilhelmina, Braunschweig
16. Grimm LH, Kelly S, Hengstler J, Göbel A, Krull R, Hempel DC (2003) Kinetic studies on the aggregation of Aspergillus niger conidia. Biotechnol Bioeng 87(2):213-218
17. Hellendoorn L, Mulder H, van den Heuvel JC, Ottengraf SPP (1998) Intrinsic kinetic parameters of the pellet forming fungus Aspergillus awamori. Biotechnol Bioeng 58(5):478-485
18. Johansen CL, Coolen L, Hunik JH (1998) Influence of morphology on product formation in Aspergillus awamori during submerged fermentations. Biotechnol Prog 14:233-240
19. Koutinas AA, Wang R, Webb C (2003) Estimation of fungal growth in complex, heterogeneous culture. Biochem Eng J 14:93-100
20. Li ZJ, Shukla V, Fordyce AP, Pedersen AG, Wenger KS, Marten MR (2000) Fungal morphology and fragmentation behavior in a fed-batch Aspergillus oryzae fermentation at the production scale. Biotechnol Bioeng 70(3):300-312
21. Liu F, Li W, Ridgway D, Gu T, Moo-Young M (1998) Inhibition of extracellular protease secretion by Aspergillus niger using cell immobilization. Biotechnol Lett 20(6):539-542
22. Liu J-Z, Weng L-P, Zhang Q-L, Xu H, Ji L-N (2003) A mathematical model for gluconic acid fermentation by Aspergillus niger. Biochem Eng J 14:137-141
23. Mahnke EU (2001) Fluiddynamisch induzierte Partikelbeanspruchung in pneumatisch gerührten Mehrphasenreaktoren. In: Hempel DC (ed) ibvt-Schriftenreihe, vol 12. FIT-Verlag: Paderborn as well as PhD thesis, Technische Universität Carolo-Wilhelmina zu Braunschweig
24. Mattern IE, van Noort JM, van den Berg P, Archer DB, Roberts IN, van den Hondel CAMJJ (1992) Isolation and characterization of mutants of Aspergillus niger deficient in extracellular proteases. Mol Gen Genomics 234:332-336
25. Metz B, Kossen NWF (1977) The growth of molds in the form of pellets - a literature review. Biotechnol Bioeng 14:781-799
26. Mitard A, Riba JP (1988) Morphology and growth of Aspergillus niger ATCC 26036 cultivated at several shear rates. Biotechnol Bioeng 32:835-840
27. Nielsen J, Johansen CL, Jacobsen M, Krabben P, Villadsen J (1995) Pellet formation and fragmentation in submerged cultures of Penicillium chrysogenum and its relation to penicillin production. Biotechnol Prog 11(1):93-98
28. Papagianni M, Mattey M, Kristiansen B (1998) Citric acid production and morphology of Aspergillus niger as functions of the mixing intensity in a stirred tank and a tubular loop bioreactor. Biochem Eng J 2:197-205
29. Paul GC, Priede MA, Thomas CR (1999) Relationship between morphology and citric acid production in submerged Aspergillus niger fermentations. Biochem Eng J 3:121-129
30. Punt PJ, van Biezen N, Conesa A, Albers AJM, van den Hondel CAMJJ (2002) Filamentous fungi as cell factories for heterologous protein production. Trends Biotechnol 20(5):200-206
31. Sauer T (1986) Einfluß inerter Partikel auf die Hydrodynamik und den volumetrischen Stoffübergangskoeffizienten in einer Suspensions-Blasensäule, Uni-GH Paderborn
32. Withers JM, Swift RJ, Wiebe MG, Robson GD, Punt PJ, van den Hondel CAMJJ, Trinci APJ (1998) Optimization and stability of glucoamylase production by recombinant strains of Aspergillus niger in chemostat culture. Biotechnol Bioeng 59(4):407-418
33. Wongwicharn A, Harvey LM, McNeil B (1999) Secretion of heterologous and native proteins, growth and morphology in batch cultures of Aspergillus niger B1-D at varying agitation rates. J Chem Technol Biotechnol 74:821-828
34. Zetelaki K, Vas K (1968) The role of aeration and agitation in the production of glucose oxidase in submerged culture. Biotechnol Bioeng 10:45-59