Allosteric activation of antithrombin critically depends upon hinge region extension

Journal of Biological Chemistry

Volumn 279, Issue 45, 2004, Pages 47288-47297

  Langdown, Jonathan ^a   Johnson, Daniel J D ^a   Baglin, Trevor P ^a   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BLOOD; CHEMICAL BONDS; COAGULATION; CONFORMATIONS; SULFUR COMPOUNDS;

ALLOSTERIC ACTIVATION; ANTITHROMBIN (AT); BLOOD COAGULATION; DISULFIDE BONDS; PENTASACCHARIDE SEQUENCE;

PROTEINS;

AMINO ACID; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; HEPARIN COFACTOR II; PENTASACCHARIDE; PROTEINASE; THROMBIN;

ALLOSTERISM; ARTICLE; CHEMICAL ENGINEERING; CONFORMATION; DISULFIDE BOND; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEINASE INHIBITION; STOICHIOMETRY;

ALLOSTERIC SITE; ANIMALS; ANTITHROMBINS; CELL LINE; CRICETINAE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR IXA; FACTOR XA; HEPARIN; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; POLYSACCHARIDES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; THROMBIN;

STAPHYLOCOCCUS PHAGE 3A;

EID: 8744274071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408961200     Document Type: Article

References (38)

1. Kojima, T. (2002) Int. J. Hematol. 76, Suppl. 2, 36-39
2. Lindahl, U., Thunberg, L., Backstrom, G., and Riesenfeld, J. (1981) Biochem. Soc. Trans. 9, 499-551
3. Casu, B., Oreste, P., Torri, G., Zoppetti, G., Choay, J., Lormeau, J. C., Petitou, M., and Sinay, P. (1981) Biochem. J. 197, 599-609
4. Olson, S. T., Bjork, I., Sheffer, R., Craig, P. A., Shore, J. D., and Choay, J. (1992) J. Biol. Chem. 267, 12528-12538
5. Bedsted, T., Swanson, R., Chuang, Y. J., Bock, P. E., Bjork, I., and Olson, S. T. (2003) Biochemistry 42, 8143-8152
6. Olson, S. T., and Bjork, I. (1991) J. Biol. Chem. 266, 6353-6364
7. Sie, P., Petitou, M., Lormeau, J. C., Dupouy, D., Boneu, B., and Choay, J. (1988) Biochim. Biophys. Acta 966, 188-195
8. Schreuder, H. A., de Boer, B., Dijkema, R., Mulders, J., Theunissen, H. J., Grootenhuis, P. D., and Hol, W. G. (1994) Nat. Struct. Biol. 1, 48-54
9. Whisstock, J. C., Pike, R. N., Jin, L., Skinner, R., Pei, X. Y., Carrell, R. W., and Lesk, A. M. (2000) J. Mol. Biol. 301, 1287-1305
10. Carrell, R. W., Stein, P. E., Fermi, G., and Wardell, M. R. (1994) Structure 2, 257-270
11. Jin, L., Abrahams, J. P., Skinner, R., Petitou, M., Pike, R. N., and Carrell, R. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14683-14688
12. Olson, S. T., and Chuang, Y. J. (2002) Trends Cardiovasc. Med. 12, 331-338
13. Manithody, C., Yang, L., and Rezaie, A. R. (2002) Biochemistry 41, 6780-6788
14. Yang, L., Manithody, C., and Rezaie, A. R. (2002) Biochemistry 41, 6149-6157
15. Chuang, Y. J., Swanson, R., Raja, S. M., Bock, S. C., and Olson, S. T. (2001) Biochemistry 40, 6670-6679
16. Izaguirre, G., Zhang, W., Swanson, R., Bedsted, T., and Olson, S. T. (2003) J. Biol. Chem. 278, 51433-51440
17. Baglin, T. P., Carrell, R. W., Church, F. C., Esmon, C. T., and Huntington, J. A. (2002) Proc. Natl. Acad. Sci. U. S.A. 99, 11079-11084
18. Huntington, J. A. (2003) J. Thromb. Haemost. 1, 1535-1549
19. Huntington, J. A., McCoy, A., Belzar, K. J., Pei, X. Y., Gettins, P. G., and Carrell, R. W. (2000) J. Biol. Chem. 275, 15377-15383
20. Desai, U. R., Petitou, M., Bjork, I., and Olson, S. T. (1998) J. Biol. Chem. 273, 7478-7487
21. Mushunje, A., Zhou, A., Carrell, R. W., and Huntington, J. A. (2003) Blood 102, 4028-4034
22. Zettlmeissl, G., Wirth, M., Hauser, H., and Kupper, H. A. (1988) Behring Inst. Mitt. 82, 26-34
23. Garone, L., Edmunds, T., Hanson, E., Bernasconi, R., Huntington, J. A., Meagher, J. L., Fan, B., and Gettins, P. G. (1996) Biochemistry 35, 8881-8889
24. Riener, C. K., Kada, G., and Gruber, H. J. (2002) Anal. Bioanal. Chem. 373, 266-276
25. Olson, S. T., Bjork, I., and Shore, J. D. (1993) Methods Enzymol. 222, 525-559
26. Johnson, D. J., and Huntington, J. A. (2004) J. Biol. Chem. 279, 4913-4921
27. Olson, S. T., and Shore, J. D. (1981) J. Biol. Chem. 256, 11065-11072
28. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Bes. Commun. 27, 157-162
29. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
30. Olson, S. T., Srinivasan, K. R., Bjork, I., and Shore, J. D. (1981) J. Biol. Chem. 256, 11073-11079
31. Meagher, J. L., Beechem, J. M., Olson, S. T., and Gettins, P. G. (1998) J. Biol. Chem. 273, 23283-23289
32. Johnson, D. J., and Huntington, J. A. (2003) Biochemistry 42, 8712-8719
33. Li, W., Johnson, D. J., Esmon, C., and Huntington, J. A. (2004) Nat. Struct. Mol. Biol. 11, 857-862
34. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926
35. Gettins, P. G. W., Patston, P. A., and Olson, S. T. (1996) Serpins: Structure, Function and Biology, R. G. Landes Co., Austin, TX
36. van Boeckel, C. A., Grootenhuis, P. D., and Visser, A. (1994) Nat. Struct. Biol. 1, 423-425
37. Chuang, Y. J., Swanson, R., Raja, S. M., and Olson, S. T. (2001) J. Biol. Chem. 276, 14961-14971
38. Olson, S. T. (1985) J. Biol. Chem. 260, 10153-10160