Absorption of enterally administered N-acetyl-l-glutamine versus glutamine in pigs

Clinical Nutrition

Volumn 23, Issue 6, 2004, Pages 1303-1312

  Arnaud, Alexandra ^a   Ramírez, Maria ^a   Baxter, Jeffrey H ^b   Angulo, Antonio J ^a  

^a ABBOTT LABORATORIES   (Spain)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Bioavailability; Glutamine; Intestinal absorption; N acetyl l glutamine; Pig

Indexed keywords

GLUTAMINE; N ACETYLGLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET SUPPLEMENTATION; DIGESTION; DRUG ABSORPTION; ENTERIC FEEDING; HYDROLYSIS; ILEUM; INTESTINE ABSORPTION; INTESTINE MUCOSA; JEJUNUM; LIQUID CULTURE; MOLECULAR STABILITY; NONHUMAN; PORTAL VEIN BLOOD; SWINE;

ANIMALS; BIOLOGICAL AVAILABILITY; DIGESTION; DISEASE MODELS, ANIMAL; ENTERAL NUTRITION; GLUCOSE; GLUTAMINE; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; SWINE;

EID: 8744222482     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2004.04.004     Document Type: Article

References (38)

1. Dudrick P.S. Souba W.W. The role of glutamine in nutrition Curr Opin Gastroenterol 7 1991 299-305
2. Mobrahan S. Glutamine: A conditionally essential nutrient or another nutritional puzzle Nutr Rev 50 1992 331-333
3. Reeds P.J. Burrin D.G. Glutamine and the bowel J Nutr 131 2001 2505S-2508S
4. Houdijk A.P.J. Rijnburger E.R. Jansen J. et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma Lancet 352 1998 772-776
5. Jones C. Palmer T.E.A. Griffiths D. Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition Nutrition 15 1999 108-115
6. Wilmore D.W. The effect of glutamine supplementation in patients following elective surgery and accidental injury J Nutr 131 2001 2543S-2549S
7. Neu J. Roig J.C. Meetze W.H. et al. Enteral glutamine supplementation for very low birth infants decreases morbidity J Pediatr 131 1997 691-699
8. Bergana M.M. Holton J.D. Reyser I.L. Snowden M.K. Baxter J.H. Pound V.L. NMR and MS analysis of decomposition compounds produced from N-acetyl-l-glutamine at lowpH J Agric Food Chem 48 2000 6003-6010
9. Boza J.J. Maire J.C. Bovetto L. Ballevre O. Plasma glutamine response to enteral administration of l-glutamine in human volunteers (free glutamine versus protein-bound glutamine) Nutrition 16 2000 1037-1042
10. Snowden M.K. Baxter J.H. Mamula Bergana M. Reyzer I. Pound V. Stability of N-acetylglutamine and glutamine in aqueous solution and in a liquid nutritional product by an improved HPLC method J Food Sci 67 2002 384-389
11. Neuhäuser-Berthold M. Wirth S. Hellmann U. Bässler K.H. Utilization of N-acetyl-l-glutamine during long-term parenteral nutrition in growing rats: Significance of glutamine for weight and nitrogen balance Clin Nutr 7 1988 145-150
12. Gouttebel M.C. Astre C. Briand D. Saint-Aubert B. Girardot P.M. Joyeux H.J. Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in dog J Parenter Enteral Nutr 16 1992 117-121
13. Magnusson I. Kihlber R. Alvestrand A. Wernerman J. Ekman L. Wahren J. Utilization of intravenously administered N-acetyl-l-glutamine in humans Metabolism 38 1989 82-88
14. Miller E.R. Ullrey D.E. The pig as a model for human nutrition Annu Rev Nutr 7 1987 361-382
15. Subcommittee on Swine Nutrition, Committee on Animal Nutrition, Board on Agriculture National Research Council. Nutrient Requirements of Swine, 10th revised edn. Washington, DC: National Academy Press, 1998
16. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248-254
17. Aguilera J.F. Prieto C. Molina E. Lachica M. Micro-method for routine analysis of chromic oxide in nutrition studies Analysis 16 1988 454-457
18. Sebastian S. Touchburn S.P. Chavez E.R. Lague P.C. Apparent digestibility of protein and amino acids in broiler chickens fed a corn-soybean diet supplemented with microbial phytase Poult Sci 76 1997 1760-1769
19. Fan M.Z. Sauer W.C. Determination of true ileal amino acid digestibility and the endogenous amino acid outputs associated with barley samples for growing-finishing pigs by the regression analysis technique J Anim Sci 80 2002 1593-1605
20. Souba W.W. Smith R.J. Wilmore D.W. Glutamine metabolism by the intestinal tract J Parenter Enteral Nutr. 9 1985 608-617
21. Yamauchi A. Ueda N. Hanafusa S. Yamashita E. Kihara M. Naito S. Tissue distribution of and species differences in deacetylation of N-acetyl-l-cysteine and immunohistochemical localization of acylase I in the primate kidney J Pharm Pharmacol 54 2002 205-212
22. Giardina T. Biagini A. Massey-Harroche D. Puigserver A. Distribution and subcellular localization of acylpeptide hydrolase and acylase I along the hog gastro-intestinal tract Biochimie 81 1999 1049-1055
23. Stegink L.D. Filer L.J. Jr Baker G.L. Plasma and urinary methionine levels in one-year-old infants after oral loading with l-methionine and N-acetyl-l-methionine J Nutr 112 1982 597-603
24. Baxter J. Kim Y. Snowden M. Hydrolysis of N-acetyl-l-glutamine by acylase I J Food Sci 66 2001 1428-1433
25. Islam S. Mahalanabis D. Chowdhury A.K. Wahed M.A. Rahman A.S. Glutamine is superior to glucose in stimulating water and electrolyte absorption across rabbit ileum Dig Dis Sci 42 1997 420-423
26. Fleming S.E. Zambell K.L. Fitch M.D. Glucose and glutamine provide similar proportions of energy to mucosal cells of rat small intestine Am J Physiol 273 1997 G968-G978
27. Palmerini C.A. De Medio G.E. Porcellati G. Uptake of doubly labelled N-acetyl-l-glutamine in rat brain and intestinal mucosa in vivo Farmaco 36 1981 347-355
28. Stegink L.D. Filer L.J. Baker G.L. Plasma methionine levels in normal adult subjects after oral loading with l-methionine and N-acetyl-l-methionine J Nutr 110 1980 42-49
29. Uttamsingh V. Baggs R.B. Krenitsky D.M. Anders M.W. Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-l-cysteine and haloalkene-derived mercapturates Drug Metab Dispos 28 2000 625-632
30. Giardina T. Biagini A. Dalle-Ore F. Ferre E. Reynier M. Puigserver A. The hog intestinal mucosa acylase I: Subcellular localization, isolation, kinetic studies and biological function Biochimie 79 1997 265-273
31. Reeds P.J. Burrin D.G. Jahoor F. Wykes L. Henry J. Frazer E.M. Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs Am J Physiol 270 1996 E413-E418
32. Hasebe M. Suzuki H. Mori E. Furukawa J. Kobayashi K. Ueda Y. Glutamate in enteral nutrition: Can glutamate replace glutamine in supplementation to enteral nutrition in burned rats? J Parenter Enteral Nutr 23 1999 S78-S82
33. James L.A. Lunn P.G. Elia M. Glutamine metabolism in the gastrointestinal tract of the rat assessed by the relative activities of glutaminase (EC 3.5.1.2) and glutamine synthetase (EC 6.3.1.2) Br J Nutr 79 1998 365-372
34. James L.A. Lunn P.G. Middleton S. Elia M. Distribution of glutaminase and glutamine synthetase activities in the human gastrointestinal tract Clin Sci 94 1998 313-319
35. McCauley R. Kong S.E. Heel K. Hall J.C. The role of glutaminase in the small intestine Int J Biochem Cell Biol 31 1999 405-413
36. Guoyao W. Intestinal mucosal amino acid catabolism J Nutr 128 1998 1249-1252
37. Hankard R.G. Darmaun D. Sager B.K. D'Amore D. Parsons W.R. Haymond M. Response of glutamine metabolism to exogenous glutamine in humans Am J Physiol 269 1995 E663-E670
38. Manzano M. Rueda R. Baxter J.H. Lopez-Pedrosa J.M. Preventive effect of N-acetyl-glutamine (NAQ) vs glutamine (Q) on intestinal dysfunction induced by protein-energy malnutrition (PEM) in pigs Clin Nutr 22 2003 S43