Glutamate in enteral nutrition: Can glutamate replace glutamine in supplementation to enteral nutrition in burned rats?

Journal of Parenteral and Enteral Nutrition

Volumn 23, Issue 5_suppl, 1999, Pages S78-S82

  Hasebe, Masaharu ^a   Suzuki, Hiromasa ^a   Mori, Eigo ^a   Furukawa, Junko ^a   Kobayashi, Kunio ^a   Ueda, Yoshitsugu ^b  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TERUMO CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; GLUTATHIONE; AMINO ACID;

ABNORMAL BEHAVIOR; ABSENCE OF SIDE EFFECTS; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BODY WEIGHT; BURN; CATABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENTERIC FEEDING; ENZYME ACTIVITY; INTESTINE MUCOSA; JEJUNUM MUCOSA; MALE; NEUROTOXICITY; NITROGEN BALANCE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; JEJUNUM; METABOLISM; SPRAGUE DAWLEY RAT;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; BURNS; ENTERAL NUTRITION; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; INTESTINAL MUCOSA; JEJUNUM; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033192540     PISSN: 01486071     EISSN: 19412444     Source Type: Journal    
DOI: 10.1177/014860719902300520     Document Type: Conference Paper

References (32)

1. Souba WW, Klimberg, Plumley DA, et al. The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection. J Surg Res 48: 383-391, 1990
2. Rouse K., Nwokedi E., Woodliff JE, et al. Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg 221: 420-426, 1990
3. Klimberg VS: Glutamine, cancer, and its therapy. Am J Surg 172: 418-424, 1996
4. Klimberg VS, Souba WW, Kasper M., et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg 125: 1040-1045, 1990
5. Newsholme EA, Carrie AL: Quantitative aspects of glucose and glutamine metabolism by intestinal cells. Gut 35 (1 Suppl): S13-S17, 1994
6. Wu G.: Intestinal mucosal amino acid catabolism. J Nutr 128: 1249-1252, 1998
7. Windmueller HG, Spaeth AE: Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch Biochem Biophys 171: 662-672, 1975
8. Reeds PJ, Burrin DG, Stoll B., et al. Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets. Am J Physiol 273: E408-415, 1997
9. Mori E., Suzuki H., Hasebe M., et al. Alterations in levels of plasma phenylalanine and its catabolism in the liver of stressed rats. Metabolism 41: 807-813, 1992
10. Mori E., Hasebe M., Kobayashi K.: Metabolic effect of short-term total parenteral nutrition (TPN) highly enriched with leucine or valine in rats recovering from severe trauma. JPEN 16: 236-240, 1992
11. Gella FJ, Pascual MA: Assay of glutaminase activity by colorimetric determination of glutamate. Anal Biochem 127: 322-325, 1982
12. Rowe WB, Ronzio RA, Wellner VP, et al. Glutamine synthetase (sheep brain). Method Enzymol XV IIA: 900-910, 1970
13. Griffith OW: Glutathione and glutathione disulphide. IN Methods of Enzymatic Analysis, Vol VIII, Bergmeyer HU (ed). VCH Press, Weinheim, 1985, pp 521-529
14. Garlick PJ, McNurlan MA, Preedy VR: Rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of 3H-phenylalanine. Biochem J 192: 719-723, 1980
15. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurements with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951
16. Windmueller HG, Spaeth AE: Vascular perfusion of rat small intestine: metabolic studies with isolated and in situ preparations. Fed Proc 36: 177-181, 1977
17. Reeds PJ, Burrin DG, Davis TA, et al. Amino acid metabolism and the energetics of growth. Arch Tierernahr 51: 187-197. 1998
18. Ardawi MS, Newsholme EA: Maximal activities of glutaminase and some enzymes of glycolysis and ketone body utilization and rates of utilization of glutamine, glucose and ketone bodies by intestinal mucosa after burn injury. Burns Include Therm Inj 13: 438-444, 1987
19. Bark S., Kihlberg R.: Amino acid concentration in plasma after gastro-intestinal, intraportal and intravenous administration of glutamic acid. Acta Chir Scand 146: 529-534, 1980
20. Ardawi MS, Majzoub MF, Kateilah SM, et al. Maximal activity of phosphate-dependent glutaminase and glutamine metabolism in septic rats. J Lab Clin Med 118: 26-32, 1991
21. Jones ME: Conversion of glutamate to ornithine and proline: Pyrroline-5-carboxylate, a possible modulator of arginine requirements. J Nutr 115: 509-515, 1985
22. Wakabayashi Y., Jones ME: Pyrroline-5-carboxylate synthesis from glutamate by rat intestinal mucosa. J Biol Chem 258: 3865-3872, 1983
23. Takasaki Y., Matsuzawa Y., Iwata S., et al. Toxicological studies of monosodium L-glutamate in rodents: Relationship between routes of administration and neurotoxicity. IN Glutamic Acid: Advances in Biochemistry and Physiolosy, Filer LJ Jr, Garantini S, Morley RK, et al (eds). Raven Press, New York, 1979, pp 255-275
24. Owen G., Cherry CP, Prentice DE, et al. The feeding of diets containing up to 4% monosodium glutamate to rats for 2 years. Toxicol Lett 1: 221-226, 1978
25. Garlick PJ, Millward DJ, James WP: The diurnal response of muscle and liver protein synthesis in vivo in meal fed rats. Biochem J 136: 935-945
26. Wakabayashi Y., Iwashima A., Yamada E., et al. Enzymological evidence for the indispensability of small intestine in the synthesis of arginine from glutamate. I. Pyrroline-5-carboxylate synthase. Arch Biochem Biophys 297: 1-8, 1991
27. Wakabayashi Y., Yamada E., Hasegawa T., et al. Enzymological evidence for the indispensability of small intestine in the synthesis of arginine from glutamate. II. N-Acetylglutamate synthase. Arch Biochem Biophys 297: 9-14, 1991
28. Mordrell A., Huneau JF, Tome D.: Sodium-independent transport of L-glutamate in the rat intestinal crypt-like cell line IEC-17. Biochem Biophys Res Commun 233: 244-247, 1997
29. Gardiner KR, Ahrendt GM, Garginer RE, et al. Failure of intestinal amino acid absorptive mechanisms in sepsis. J Am Coll Surg 181: 431-436, 1995
30. Austgen TR, Chen MK, Flynn TC, et al. The effects of endotoxin on the splanchnic metabolism of glutamine and related substrates. J Trauma 31: 742-752, 1991
31. Burrin DG, Shulman RJ, Storm MC, et al. Glutamine or glutamic acid effects on intestinal growth and disaccharidase activity in infant piglets receiving TPN. JPEN 15: 262-266, 1991
32. Ziegler TR, Benfell K., Wilmore DW, et al. Safety and metabolic effects of L-glutamine administration in human. JPEN 14: 137S-146S, 1990