Transferrin receptor 2 protein is not expressed in normal erythroid cells

Biochemical Journal

Volumn 381, Issue 3, 2004, Pages 629-634

  Calzolari, Alessia ^a   Deaglio, Silvia ^b   Sposi, Nadia Maria ^a   Petrucci, Eleonora ^a   Morsilli, Ornella ^a   Gabbianelli, Marco ^a   Malavasi, Fabio ^a   Peschle, Cesare ^a   Testa, Ugo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Erythropoiesis; Haemochromatosis; Iron; Liver; Transferrin; Transferrin receptor

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; BIOLOGICAL ORGANS; CELLS; RNA;

ERYTHROID PRECURSORS; HEPATIC CELLS;

PROTEINS;

CD34 ANTIGEN; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY G 14C2; MONOCLONAL ANTIBODY G 14E8; RECEPTOR PROTEIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; LIVER CELL; MORPHOLOGICAL TRAIT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBODIES; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; ERYTHROID CELLS; ERYTHROID PROGENITOR CELLS; HUMANS; K562 CELLS; LIVER NEOPLASMS; MOLECULAR WEIGHT; PROTEIN ISOFORMS; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; SUBCELLULAR FRACTIONS;

EID: 4344576977     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040230     Document Type: Article

References (22)

1. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F. and Koeffler, H. P. (1999) Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J. Biol. Chem. 274, 20826-20832
2. Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W. and Koeffler, H. P. (2000) Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo. J. Biol. Chem. 275, 16618-16625
3. Kawabata, H., Germain, R. S., Ikezoe, T., Tong, X., Green, E. M., Gombart, A. F. and Koeffler, H. P. (2001) Regulation of expression of murine transferrin receptor 2. Blood 98, 1949-1954
4. Kawabata, H., Nakamaki, T., Ikonomi, P., Smith, R. D., Germain, R. S. and Koeffler, H. P. (2001) Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood 98, 2714-2719
5. Kollia, P., Samara, M., Stamatopoulos, K., Belessi, C., Stavroyanni, N., Tsompanakou, A., Athanasiadou, A., Vamvakopoulos, N., Laoutaris, N., Anagnostopoulos, A. and Fassas, A. (2003) Molecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemia. Leuk. Res. 27, 1101-1103
6. Griffiths, W. J. H. and Cox, T. M. (2003) Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J. Histochem. Cytochem. 51, 613-623
7. Levy, J. E., Jin, O., Fuiiwara, Y., Kuo, F. and Andrews, N. C. (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21, 396-399
8. Camaschella, C., Roetto, A., Calì, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A. and Gasparini, P. (2000) The gene TFR2 is mutated in a new type of hemochromatosis mapping to 7q22. Nat. Genet. 25, 14-15
9. Roetto, A., Totaro, A., Pieperno, A., Piga, A., Longo, F., Garozzo, G., Calì, A., De Gobbi, M., Gasparini, P. and Camaschella, C. (2001) New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood 97, 2555-2560
10. Girelli, D., Bozzini, C., Roetto, A., Alberti, F., Daraio, F., Colombari, R., Olivieri, O., Corrocher, R. and Camaschella, C. (2002) Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene. Gastroenterology 122, 1295-1302
11. Fleming, R. E., Ahmann, J. R., Migas, M. C., Waheed, A., Koeffler, H. P., Kawabata, H., Britton, R. S., Bacon, B. R. and Sly, W. S. (2002) Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc. Natl. Acad. Sci. U.S.A. 99, 10653-10658
12. Deaglio, S., Capobianco, A., Calì, A., Bellora, F., Alberti, F., Righi, L., Sapino, A., Camaschella, C. and Malavasi, F. (2002) Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood 100, 3782-3789
13. Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Bjorkman, P. J. and Enns, C. A. (2003) Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 101, 2008-2014
14. De Maria, R., Zeuner, A., Eramo, A., Domenichelli, C., Bonci, D., Grignani, F., Srinivasula, S. M., Alnemri, E. S., Testa, U. and Peschle, C. (1999) Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature (London) 401, 489-493
15. Zeuner, A., Eramo, A., Testa, U., Felli, N., Pelosi, E., Mariani, G., Srinivasula, S. M., Alnemri, E. S., Condorelli, G., Peschle, C. and De Maria, R. (2003) Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1. Cell Death Differ 10, 905-913
16. Casella, I., Feccia, T., Chelucci, C., Samoggia, P., Castelli, G., Guerriero, R., Parolini, I., Petrucci, E., Pelosi, E., Morsilli, O., Gabbianelli, M., Testa, U. and Peschle, C. (2003) Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Fit1 receptor. Blood 101, 1316-1323
17. Sposi, N. M., Cianetti, L., Tritarelli, E., Pelosi, E., Militi, S., Barberi, T., Gabbianelli, M., Saulle, E., Kuhn, L., Peschle, C. and Testa, U. (2000) Mechanisms of differential transferrin receptor expression in normal hematopoiesis. Eur. J. Biochem. 267, 6762-6774
18. Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, Jr, R., Ellis, M. C., Fullan, A. et al. (1996) A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat. Genet. 13, 399-408
19. Pietrangelo, A. (2004) Nor-HFE hemochromatosis. Hepatology 39, 21-29
20. Nakamaki, T., Kawabata, H., Saito, B., Matsunawa, M., Suzuki, J., Adachi, D., Tomoyasu, S. and Koeffler, H. P. (2004) Elevated levels of transferrin receptor 2 mRNA, not transferrin receptor 1 mRNA, are associated with increased survival in acute myeloid leukaemia. Br. J. Haematol. 125, 42-49
21. Zhang, A. S., Xiong, S., Tsukamoto, H. and Enns, C. A. (2004) Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 103, 1509-1514
22. Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M. P., Andres, L., MacFarlane, J., Sakellaropoulos, N. and Politou, M. (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36, 77-82