The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c

Journal of Biological Chemistry

Volumn 279, Issue 44, 2004, Pages 45462-45469

  Jakel, Heidelinde ^a   Nowak, Maxime ^a   Moitrot, Emanuelle ^a   Dehondt, Hélène ^a   Hum, Dean W ^b   Pennacchio, Len A ^c   Fruchart Najib, Jamila ^a   Fruchart, Jean Charles ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b Genfit SA   (France)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOLOGICAL ORGANS; GENES; LIPIDS; METABOLISM; MUTAGENESIS; PROTEINS; TISSUE;

GENE EXPRESSIONS; LIGANDS; MUTATION ANALYSIS;

GENETIC ENGINEERING;

APOLIPOPROTEIN A; APOLIPOPROTEIN A5; LIGAND; LIVER X RECEPTOR; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; E BOX ELEMENT; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID METABOLISM; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEINS; APOLIPOPROTEINS A; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDES; TRANSCRIPTION FACTORS; TRANSFECTION; TRIGLYCERIDES;

MUS MUSCULUS;

EID: 8544267260     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404744200     Document Type: Article

References (54)

1. Austin, M. A., Hokanson, J. E., and Edwards, K. L. (1998) Am. J. Cardiol. 81, 7B-12B
2. Haim, M., Benderly, M., Brunner, D., Behar, S., Graff, E., Reicher-Reiss, H., and Goldbourt, U. (1999) Circulation 100, 475-482
3. Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J. C., Krauss, R. M., and Rubin, E. M. (2001) Science 294, 169-173
4. Baum, L., Tomlinson, B., and Thomas, G. N. (2003) Clin. Genet. 63, 377-379
5. Eichenbaum-Voline, S., Olivier, M., Jones, E. L., Naoumova, R. P., Jones, B., Gau, B., Patel, H. N., Seed, M., Betteridge, D. J., Galton, D. J., Rubin, E. M., Scott, J., Shoulders, C. C., and Pennacchio, L. A. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 167-174
6. Endo, K., Yanagi, H., Araki, J., Hirano, C., Yamakawa-Kobayashi, K., and Tomura, S. (2002) Hum. Genet. 111, 570-572
7. Pennacchio, L. A., Olivier, M., Hubacek, J. A., Krauss, R. M., Rubin, E. M., and Cohen, J. C. (2002) Hum. Mol. Genet. 11, 3031-3038
8. Talmud, P. J., Hawe, E., Martin, S., Olivier, M., Miller, G. J., Rubin, E. M., Pennacchio, L. A., and Humphries, S. E. (2002) Hum. Mol. Genet. 11, 3039-3046
9. Prieur, X., Coste, H., and Rodriguez, J. C. (2003) J. Biol. Chem. 278, 25468-25480
10. Vu-Dac, N., Gervois, P., Jakel, H., Nowak, M., Bauge, E., Dehondt, H., Staels, B., Pennacchio, L. A., Rubin, E. M., Fruchart-Najib, J., and Fruchart, J. C. (2003) J. Biol. Chem. 278, 17982-17985
11. Schultz, J. R., Tu, H., Luk, A., Repa, J. J., Medina, J. C., Li, L., Schwendner, S., Wang, S., Thoolen, M., Mangelsdorf, D. J., Lustig, K. D., and Shan, B. (2000) Genes Dev. 14, 2831-2838
12. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
13. Tobin, K. A., Ulven, S. M., Schuster, G. U., Steineger, H. H., Andresen, S. M., Gustafsson, J. A., and Nebb, H. I. (2002) J. Biol. Chem. 277, 10691-10697
14. Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G., Goodman, J., Hagger, G. N., Tran, J., Tippin, T. K., Wang, X., Lusis, A. J., Hsueh, W. A., Law, R. E., Collins, J. L., Willson, T. M., and Tontonoz, P. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 7604-7609
15. Terasaka, N., Hiroshima, A., Koieyama, T., Ubukata, N., Morikawa, Y., Nakai, D., and Inaba, T. (2003) FEBS Lett. 536, 6-11
16. Grefhorst, A., Elzinga, B. M., Voshol, P. J., Plosch, T., Kok, T., Bloks, V. W., van der Sluijs, F. H., Havekes, L. M., Romijn, J. A., Verkade, H. J., and Kuipers, F. (2002) J. Biol. Chem. 277, 34182-34190
17. Yoshikawa, T., Shimano, H., Amemiya-Kudo, M., Yahagi, N., Hasty, A. H., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Kimura, S., Ishibashi, S., and Yamada, N. (2001) Mol. Cell. Biol. 21, 2991-3000
18. Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., and Hobbs, H. H. (1995) Genomics 25, 667-673
19. Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Le Liepvre, X., Berthelier-Lubrano, C., Spiegelman, B., Kim, J. B., Ferre, P., and Foufelle, F. (1999) Mol. Cell. Biol. 19, 3760-3768
20. Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., and Goldstein, J. L. (1997) J. Clin. Investig. 99, 846-854
21. Shimomura, I., Shimano, H., Horton, J. D., Goldstein, J. L., and Brown, M. S. (1997) J. Clin. Investig. 99, 838-845
22. Latasa, M. J., Moon, Y. S., Kim, K. H., and Sul, H. S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10619-10624
23. Lopez, J. M., Bennett, M. K., Sanchez, H. B., Rosenfeld, J. M., and Osborne, T. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1049-1053
24. Ericsson, J., Jackson, S. M., Kim, J. B., Spiegelman, B. M., and Edwards, P. A. (1997) J. Biol. Chem. 272, 7298-7305
25. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
26. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S., and Goldstein, J. L. (1996) Cell 85, 1037-1046
27. Kim, J. B., Spotts, G. D., Halvorsen, Y. D., Shih, H. M., Ellenberger, T., Towle, H. C., and Spiegelman, B. M. (1995) Mol. Cell. Biol. 15, 2582-2588
28. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J. C., Staels, B., and Auwerx, J. (1995) J. Clin. Investig. 96, 741-750
29. Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S., and Yamada, N. (2000) J. Biol. Chem. 275, 31078-31085
30. Blanquart, C., Barbier, O., Fruchart, J. C., Staels, B., and Glineur, C. (2002) J. Biol. Chem. 277, 37254-37259
31. Fruchart-Najib, J., Bauge, E., Niculescu, L. S., Pham, T., Thomas, B., Rommens, C., Majd, Z., Brewer, B., Pennacchio, L. A., and Fruchart, J. C. (2004) Biochem. Biophys. Res. Commun. 319, 397-404
32. van der Vliet, H. N., Sammels, M. G., Leegwater, A. C., Levels, J. H., Reitsma, P. H., Boers, W., and Chamuleau, R. A. (2001) J. Biol. Chem. 276, 44512-44520
33. Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S., and Yamada, N. (2002) J. Lipid Res. 43, 1220-1235
34. van der Vliet, H. N., Schaap, F. G., Levels, J. H., Ottenhoff, R., Looije, N., Wesseling, J. G., Groen, A. K., and Chamuleau, R. A. (2002) Biochem. Biophys. Res. Commun. 295, 1156-1159
35. Pai, J. T., Guryev, O., Brown, M. S., and Goldstein, J. L. (1998) J. Biol. Chem. 273, 26138-26148
36. Mater, M. K., Thelen, A. P., Pan, D. A., and Jump, D. B. (1999) J. Biol. Chem. 274, 32725-32732
37. Shih, H. M., Liu, Z., and Towle, H. C. (1995) J. Biol. Chem. 270, 21991-21997
38. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
39. Sato, R., Miyamoto, W., Inoue, J., Terada, T., Imanaka, T., and Maeda, M. (1999) J. Biol. Chem. 274, 24714-24720
40. Chakravarty, K., Leahy, P., Becard, D., Hakimi, P., Foretz, M., Ferre, P., Foufelle, F., and Hanson, R. W. (2001) J. Biol. Chem. 276, 34816-34823
41. Norlin, M., and Chiang, J. Y. (2004) Biochem. Biophys. Res. Commun. 316, 158-164
42. del Castillo-Olivares, A., and Gil, G. (2002) J. Biol. Chem. 277, 6750-6757
43. Yamamoto, T., Shimano, H., Nakagawa, Y., Ide, T., Yahagi, N., Matsuzaka, T., Nakakuki, M., Takahashi, A., Suzuki, H., Sone, H., Toyoshima, H., Sato, R., and Yamada, N. (2004) J. Biol. Chem.
44. Chakravarty, K., Wu, S. Y., Chiang, C. M., Samols, D., and Hanson, R. W. (2004) J. Biol. Chem. 279, 15385-15395
45. Nara, T. Y., He, W. S., Tang, C., Clarke, S. D., and Nakamura, M. T. (2002) Biochem. Biophys. Res. Commun. 296, 111-117
46. Barber, M. C., Vallance, A. J., Kennedy, H. T., and Travers, M. T. (2003) Biochem. J. 375, 489-501
47. Kan, H. Y., Pissios, P., Chambaz, J., and Zannis, V. I. (1999) Nucleic Acids Res. 27, 1104-1117
48. Kardassis, D., Zannis, V. I., and Cladaras, C. (1992) J. Biol. Chem. 267, 7956
49. Ogami, K., Hadzopoulou-Cladaras, M., Cladaras, C., and Zannis, V. I. (1990) J. Biol. Chem. 265, 9808-9815
50. Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S., and Yamada, N. (1999) J. Biol. Chem. 274, 35832-35839
51. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., and Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528
52. Inaba, T., Matsuda, M., Shimamura, M., Takei, N., Terasaka, N., Ando, Y., Yasumo, H., Koishi, R., Makishima, M., and Shimomura, I. (2003) J. Biol. Chem. 278, 21344-21351
53. Joseph, S. B., Laffitte, B. A., Patel, P. H., Watson, M. A., Matsukuma, K. E., Walczak, R., Collins, J. L., Osborne, T. F., and Tontonoz, P. (2002) J. Biol. Chem. 277, 11019-11025
54. Tontonoz, P., and Mangelsdorf, D. J. (2003) Mol. Endocrinol. 17, 985-993