Novel tacrine analogues for potential use against Alzheimer's disease: Potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3516-3523

  McKenna, Maureen T ^a   Proctor, George R ^a   Young, Louise C ^a   Harvey, Alan L ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

13 AMINO 6,7 DIHYDRO 5H BENZO[3,4]CYCLOHEPTA[1,2 B]QUINOLINE; 6 AMINO 4,5 BENZO 5H CYCLOPENTA[1,2 B]QUINOLINE; ACETYLCHOLINESTERASE; SEROTONIN UPTAKE INHIBITOR; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT; RECEPTOR AFFINITY; SEROTONIN UPTAKE; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SEROTONIN UPTAKE INHIBITORS; TACRINE;

EID: 0030725741     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970150t     Document Type: Article

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