Deposition mechanics of pharmaceutical particles in human airways

Inhalation Aerosols: Physical and Biological Basis for Therapy

Volumn , Issue , 2006, Pages 1-30

  Sbirlea Apiou, Gabriela ^a   Caillibotte, Georges ^a   Yang, Yadong ^b   Katz, Ira ^a,c   Martonen, Ted ^d,e  

^a AIR LIQUIDE   (France)

^b USACrawford Communications Inc ^*  (United States)

^c LAFAYETTE COLLEGE   (United States)

^d CyberMedicine   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85123026813     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (190)

1. Martonen TB. The behavior of cigarette smoke in human airways. Am Ind Hyg Assoc J 1992; 53:6-15.
2. Martonen TB. Aerosol therapy implications of particle deposition patterns in simulated human airways. J Aerosol Med 1991; 4:25-40.
3. Martonen TB. Deposition of inhaled particulate matter in the upper respiratory tract, larynx, and bronchial airways: a mathematical description. J Toxicol Environ Health 1983; 12:787-795.
4. Stahlhofen W, Rudolf G, James AC. Intercomparison of experimental regional aerosol deposition data. J Aerosol Med 1989; 2:285-308.
5. Bell JH, Brown K, Glasby J. Variation in delivery of isoprenaline from various pressurized inhalers. J Pharm Pharmacol 1973; 25:32-36.
6. Davis DS. Pharmacokinetics of inhaled substances. Postgrad Med 1975; 51:69-75.
7. Dolovich M, Ruffin RE, Roberts R, Newhouse MT. Optimal delivery of aerosols from metered dose inhalers. Chest 1981; 80:911-915.
8. Kim CS, Eldridge MA, Sackner MA. Oropharyngeal deposition and delivery aspects of metered-dose inhaler aerosols. Am Rev Respir Dis 1987; 135:157-164.
9. Newman SP, Pavia D, Moren F, Sheahan NF, Clarke SW. Deposition of pressurized aerosols in the human respiratory tract. Thorax 1981; 36:52-55.
10. Swift DL. Apparatus and method for measuring regional distribution of therapeutic aerosols and comparing delivery systems. J Aerosol Sci 1992; 23:495-498.
11. Ashworth HL, Wilson CG, Sims EE, Wotton PK, Hardy JG. Delivery of propellant soluble drug from a metered dose inhaler. Thorax 1991; 46:245247.
12. Idris AH, McDermott MF, Raucci JC, Morrabel A, McGorray S, Hendeles L. Emergency department treatment of severe asthma. Chest 1993; 103:665-672.
13. Meeker DP, Stelmach K. Modification of the spacer device. Chest 1992; 102:1243-1244.
14. Rodrigo G, Rodrigo C. Comparison of salbutamol delivered by nebulizer or metered-dose inhaler with a pear-shaped spacer in acute asthma. Curr Ther Res 1993; 54:797-808.
15. Newman SP, Clarke SW. Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler. Chest 1993; 103:1442-1446.
16. Nieminen MM, Vidgren M, Laurikainen K, et al. Easyhaler, a novel multiple dose powder inhaler: clinically equivalent to salbutamol metered dose inhaler and easier to use. Respiration 1993; 61:37-41.
17. Hanania NA, Wittman R, Kesten S, Chapman KR. Medical personnel's knowledge of and ability to use inhaling devices. Chest 1994; 105:111-116.
18. Weibel ER. Design of airways and blood vessels as branching trees. In: Crystal RG, West JB, Barnes PJ, Cherniack NS, Weibel ER, eds. The Lung: Scientific Foundations, Vol. 1. New York: Raven Press, 1991:711-720.
19. Weibel ER. Morphometry of the Human Lung. New York: Academic Press, 1963.
20. Soong TT, Nicolaides P, Yu CP, Soong SC. A statistical description of the human tracheo-bronchial tree geometry. Respir Physiol 1979; 37:161-172.
21. Horsfield K, Cumming G. Morphology of the bronchial tree in man. J Appl Physol 1968; 24:373-383.
22. Horsfield K. Pulmonary airways and blood vessels considered as confluent trees. In: Crystal RG, West JB, Barnes PJ, Cherniack NS, Weibel ER, eds. The Lung: Scientific Foundations, Vol. 1. New York: Raven Press, 1991:721-727.
23. Martonen TB. On the fate of inhaled particles in the human: a comparison of experimental data with theoretical computations based on a symmetric and asymmetric lung. Bull Math Biol 1983; 45:409-424.
24. Martonen TB. Mathematical model for the selective deposition of inhaled pharmaceuticals. J Pharm Sci 1993; 82:1191-1199.
25. Martonen TB, Katz I. Deposition patterns of polydisperse aerosols within human lungs. J Aerosol Med 1993; 6:251-274.
26. Martonen TB, Katz I. Deposition patterns of aerosolized drugs within human lungs: effect of ventilatory parameters. Pharm Res 1993; 10:871-878.
27. Martonen TB, Katz I. Inter-related effects of morphology and ventilation on drug deposition patterns. STP Pharm Sci 1994; 4:11-18.
28. Martonen TB, Graham RC, Hofmann W. Human subject age and activity level: factors addressed in a biomathernatical deposition program for extrapolation modeling. Health Phys 1989; 57(suppl 1):49-59.
29. Martonen TB. Measurement of particle dose distribution in a model of a human larynx and tracheobronchial tree. J Aerosol Sci 1983; 14:11-22.
30. Martonen TB, Hofmann W. Factors to be considered in a dosimetry model for risk assessment of inhaled particles. Rad Prot Dosim 1986; 15:225-232.
31. Martonen TB, Bell KA, Phalen RF, Wilson AF, Ho A. Growth rate measurements and deposition modeling of hygroscopic aerosols in human tracheobronchial models. Ann Occup Hyg 1982; 26:93-108.
32. Martonen TB. Development of surrogate lung systems with controlled thermodynamic environments to study hygroscopic particles: air pollutants and pharmacologic drugs. Part Sci Technol 1990; 8:1-20.
33. Martonen TB, Yang Y, Xue Z. Effects of carinal ridge shapes on lung air streams. Aerosol Sci Tech 1994; 21:119-136.
34. Martonen TB, Yang Y, Xue Z. Influences of cartilaginous rings on tracheobronchial fluid dynamics. Inhal Toxicol 1994; 6:185-203.
35. McBride JT. Architecture of the tracheobronchial tree. In: Parent RA, ed. Comparative Biology of the Normal Lung, Vol. 1. Boca Raton, FL: CRC Press, 1992:49-61.
36. Martonen TB, Zhang Z, Yang Y. Extrapolation modeling of aerosol deposition in human and laboratory rat lungs. Inhal Tox 1992; 4:303-324.
37. Martonen TB, Zhang Z, Yang Y. Interspecies modeling of inhaled particle deposition patterns. J. Aerosol Sci 1992; 23:389-406.
38. Martonen TB, Yang Y. A mathematical model for aerosol deposition in the respiratory tract of the guinea pig. Inhal Tox 1994; 6:1-19.
39. Horsfield K, Cumming G. Angles of branching and diameters of branches in the human bronchial tree. Bull Math Biophys 1967; 29:207-217.
40. Heyder, J. Gravitational deposition of aerosol particles within a system of randomly oriented tubes. J Aerosol Sci 1977; 8:289-295.
41. Hofmann W, Martonen TB, Graham RC. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. J Aerosol Med 1989; 2:49-68.
42. Schlesinger RB, Lippmann M. Particle deposition in the trachea: in vivo and in hollow casts. Thorax 1976; 31:678-684.
43. Martonen TB, Lowe J. Assessment of aerosol deposition patterns in human respiratory tract casts. In: Marple VA, Liu BYH, eds. Aerosols in the Mining and Industrial Work Environments. Ann Arbor, MI: Ann Arbor Science, 1983:151-164.
44. West, JB, Hugh-Jones P. Patterns of gas flow in the upper bronchial tree. J Appl Physiol 1959; 14:753-759.
45. Dekker E. Transition between laminar and turbulent flow in human trachea. J Appl Physiol 1961; 16:1060-1064.
46. Pedley TJ, Schroter RC, Sudlow MF. Gas flow and mixing in the airways. In: West JB, ed. Bioengineering Aspects of the Lung. New York: Marcel Dekker, 1979:163-265.
47. Sudlow MF, Olson DE, Schroter RC. Fluid mechanics of bronchial air-flow. In: Walton WH, ed. Inhaled Particles III England: Unwin Bros Ltd. Old Woking, Surrey, U.K.: Gresham Press, 1970:19-31.
48. Chang HK, El Masry OA. A model study of flow dynamics in human central airways. Part 1: Axial velocity profiles. Respir Physiol 1982; 49:75-95.
49. Sekihara T, Olson DE, Filley GF. Airflow regimes and geometrical factors in the human airway. In Proceedings of the 11th Aspen Emphysema Conference, U.S. Dept. HEW, Arlington, VA, 1968:103-114.
50. Olson, DE, Sudlow MF, Horsfield K, Filley GF. Convective patterns of flow during inspiration. Arch Intern Med 1973; 131:51-57.
51. Schroter RL, Sudlow MIT. Flow patterns in models of the human bronchial airways. Respir Physiol 1969; 7:341-355.
52. Isabey D, Chang HK. A model study of flow dynamics in human central airways. Part II: Secondary flow profiles. Respir Physiol 1982; 49:97-11.
53. Martonen TB. Analytical model of hygroscopic particle behavior in human airways. Bull Math Biol 1982; 44:425-442.
54. Martonen TB, Zhang Z, Lessmann R. Fluid dynamics of the human larynx and upper tracheo-bronchial airways. Aerosol Sci Technol 1993; 19:133-156.
55. Chan TL, Lippinann M, Cohen VR, Schlesinger RB. Effect of electrostatic charges on particle deposition in a hollow cast of the human larynx tracheobronchial tree. J Aerosol Sci 1978; 9:463-475.
56. Smoluchowski MS. On the practical applicability of Stokes' law of resistance and modifications of it required in certain cases. Fifth International Conference of Mathematics, Vol. 2, Cambridge, 1912:192.
57. Timbrell V. The inhalation of fibrous dusts. Ann NY Acad Sci 1965; 132:255-262.
58. Harris RL, Fraser DA. A model for deposition of fibers in the human respiratory system. Am Ind Hyg Assoc J 1976; 37:73-80.
59. Asgharian B, Yu P. Deposition of inhaled fibrous particles in the human lung. J Aerosol Med 1988; 1:3745.
60. Balashazy 1, Martonen TB, Hofmann W. Fiber deposition in airway bifurcations. J Aerosol Med 1990; 4:243-250.
61. Balashazy 1, Martonen TB, Hofmann W. Inertial impaction and gravitational deposition of aerosols in curved tubes and airway bifurcations. Aerosol Sci Technol 1990; 13:308-320.
62. Martonen TB. Aerodynamic size measurement of airborne fibers and health effects implications. Adv Powder Technol 1992; 3:311-317.
63. Myojo T. Deposition of fibrous aerosols in model bifurcations. J Aerosol Med 1987; 18:337-345.
64. Sussman RG, Cohen BS, Lippmann M. Asbestos fiber deposition in a human tracheobronchial cast. 1. Experimental. Inhal Toxicol 1991; 3:145-160.
65. Sussman RG, Cohen BS, Lippmann M. Asbestos fiber deposition in a human tracheobronchial cast. 1. Empirical model. Inhal Toxicol 1991; 3:161-179.
66. Gonda 1, Khalik AFA. On the calculation of aerodynamic diameters of fibers. Aerosol Sci Technol 1985; 4:233-243.
67. Hickey AJ, Gonda 1, Irwin WJ, Fildes FJT. Effect of hydrophobic coating on the behavior of a hygroscopic aerosol powder in an environment of controlled temperature and relative humidity. J Pharm Sci 1990; 79:1009-1018.
68. Johnson DL, Martonen TB. Behavior of inhaled fibers: potential applications to medicinal aerosols. Part Sci Tech 1994; 12:161-173.
69. Melandri C, Prodi V, Tarroni G, et al. On the deposition of unipolarly charged particles in the human respiratory tract. In: Walton WH, ed. Inhaled Particles IV. Oxford: Pergamon Press, 1977:193-205.
70. Melandri C, Tarroni G, Prodi V, De Zaiacomo T, Formignani M, Lombardi CC. Deposition of charged particles in the human airways. J Aerosol Sci 1983; 14(3):184-186.
71. Tarroni G, Melandri C, Prodi V, De Zaiacomo T, Fromignani M, Bassi P. An indication on the biological variability of aerosol total deposition in humans. Am Ind Hyg Assoc J 1980; 41:826-841.
72. Pich J. Comments on the paper: C.P. Yu: Precipitation of unipolarly charged particles in cylindrical and spherical vessels. J Aerosol Sci 1978; 9:275-280.
73. Chen RY. Deposition of aerosol particles in a channel due to diffusion and electric charge. J Aerosol Sci 1978; 9:254-274.
74. Chen RY. Deposition of charged particles in tubes. J Aerosol Sci 1978; 9:449-463.
75. Muir DCF, Sweetland K, Love RG. Inhaled aerosol boluses in man. In: Walton WH, ed. Inhaled Particles 111. Sheffield, U.K.: Gresham Press, 1971:81-90.
76. Scheuch G, Stahlhofen W. Particle deposition of inhaled aerosol boluses in the upper human airways. J Aerosol Med 1988; 1:29-36.
77. Landahl HD. On the removal of air-borne droplets by the human respiratory tract: 1. The lung. Bull Math Biophys 1950; 12:43-51.
78. Heyder J, Gebhart J, Scheuch G. Interaction of diffusional and gravitational particle transport in aerosols. Aerosol Sci Technol 1985; 4:315-324.
79. Chen YK, Yu CP. Particle deposition from duct flows by combined mechanisms. Aerosol Sci Technol 1993; 19:389-399.
80. Martonen TB, Yang Y, Dolovich M. Definition of airway composition within gamma camera images. J Thorac Imaging 1994; 9:188-197.
81. Martonen TB, Katz I, Cress W. Aerosol deposition as a function of airway disease: cystic fibrosis. Pharin Res 1995; 12:96-102.
82. Martonen TB, Zhang Z, Yang Y, Bottei G. Airway surface irregularities promote particle diffusion in the human lung. Rad Prot Dosim 1995; 59:5-14.
83. Hickey AJ, Martonen TB, Yang, Y. Theoretical relationship of lung deposition to the fine article fraction of inhalation aerosols. Pharma Acta Helv 1996; 71:185-190.
84. Zhang Z, Martonen TB. Comparison of theoretical and experimental particle diffusion data within human airway casts. Cell Biochem Biophys 1996; 27:97-108.
85. Musante CJ, Martonen TB. Computer simulations of particle deposition in the developing human lung. J Air Waste Manag Assoc 2000; 50:1426-1432.
86. Martonen TB, Musante CJ, Segal RA, et al. Lung models: strengths and limitations. Respir Care 2000; 45:712-736.
87. Martonen TB, Guan X. Effects of tumors on inhaled pharmacologic drugs: II Particle motion. Cell Biochem Biophys 2001; 35:245-253.
88. Schroeter JD, Musante CJ, Hwang D, Burton R, Guilmette R, Martonen TB. Hygroscopic growth and deposition of inhaled secondary cigarette smoke in human nasal pathways. Aerosol Sci Technol 2001; 34:137-143.
89. Martonen T, Fleming J, Schroeter J, Conway J, Hwang D. In silico modeling of asthma. Adv Drug Del Rev 2003; 55:829-849.
90. Hofmann W. Modeling techniques for inhaled particle deposition: the state of the art. J Aerosol Med 1996; 9:369-388.
91. Bergmann R, Hofmann W, Koblinger L. Particle deposition modeling in the human lung: comparison between Monte Carlo and ICRP model predictions. J Aerosol Sci Suppl 1 1997; 28:S433-S434.
92. Hofmann W, Morawska L, Bergmann R. Environmental tobacco smoke deposition in the human respiratory tract: differences between experimental and theoretical approaches. J Aerosol Med 2001; 14:317-326.
93. Salma I, Balásházy I, Winkler-Heil R, Hofmann W, Záray G. Effect of particle mass size distribution on the deposition of aerosols in the human respiratory system. J Aerosol Sci 2002; 33:119-132.
94. Salma I, Balásházy I, Hofmann W, Záray G. Effect of physical exertion on the deposition of urban aerosols in the human respiratory system. J Aerosol Sci 2002; 33:983-997.
95. Alföldy B, Török SZ, Balásházy I, Hofmann W, Winkler-Heil R. EPMA and XRF characterization of therapeutic cave aerosol particles and their deposition in the respiratory system. X-Ray Spectrom 2002; 31:363-367.
96. Hofmann W, Sturm R, Fleming JS, Conway JH, Bolt L. Simulation of the three-dimensional particle deposition patterns in human lungs and comparison with experimental SPECT data. Aerosol Sci Technol 2005; 39:771-781.
97. Finlay WH and Stapelton KW. The effect of regional lung deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase. J Aerosol Sci 1995; 26:655-670.
98. Finlay WH, Stapleton KW, Chan HK, Zuberbuhler P, Gonda I. Regional deposition of inhaled hygroscopic aerosols: in vivo SPECT compared with mathematical modeling. J Appl Physiol 1996; 81:374-383.
99. Finlay WH, Stapelton KW, Zuberbuhler P. Predicting regional dosages of a nebulized suspension: pulmicort(budesonide). Part Sci Tech 1997; 15:185-193.
100. Finlay WH, Stapelton KW, Zuberbuhler P. Fine particle fraction as a measure of mass depositing in the lung during inhalation of nearly isotonic nebulized aerosols. J Aerosol Sci 1997; 28:1301-1309.
101. Finlay WH, Stapelton KW, Zuberbuhler P. Errors in regional lung deposition predictions of nebulized salbutamol sulphate due to neglect or partial inclusion of hygroscopic effects. Int J Pharm 1997; 149:63-72.
102. Finlay WH. Estimating the type of hygroscopic behaviour exhibited by aqueous droplets. J Aerosol Med 1998; 11:221-229.
103. Finlay WH, Wong JP. Regional lung deposition of nebulized liposome-encapsulated ciprofloxacin. Int J Pharm 1998; 167:121-127.
104. DeHaan WH, Finlay WH. In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices. J Aerosol Med 2001; 14:361-367.
105. Johnstone A, Uddin M, Pollard A, Heenan A, Finlay WH. The flow inside an idealised form of the human extra-thoracic airway. Exp Fluids 2004; 37:673-689.
106. DeHaan WH, Finlay WH. Predicting extrathoracic deposition from dry powder inhalers. J Aerosol Sci 2004; 35:309-331.
107. Grgic B, Finlay WH, Burnell PKP, Heenan AF. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J Aerosol Sci 2004; 35:1025-1040.
108. Kutkov VA. Influence of stochastics in lung deposition of airborne particles on human body contamination. Rad Prot Dosim 2000; 89:263-266.
109. Harvey RP, Hamby DM. Age-specific uncertainty in particule deposition for 1 μm AMAD particles using the ICRP 66 lung model. Health Physics 2002; 82:807-816.
110. 222Rn progeny. J Environ Rad 2002; 61:305-318.
111. Voutilainen A, Kaipio JP, Pekkanen J, Timonen KL, Ruuskanen J. Theoretical analysis of the influence of aerosol size distribution and physical activity on particle deposition pattern in human lungs. Scand J Work Environ Health 2004; 30(suppl. 2):73-79.
112. Fritsch P. Uncertainties in aerosol deposition within the respiratory tract using the ICRP 66 model: a study in workers. Health Phys 2006; 90:114-126.
113. Bailey AG, Hashish AH, Williams TJ. Drug delivery by inhalation of charged particles. J Electro-stat 1998; 44:3-10.
114. Jeffers DE. Relative magnitudes of the effects of electrostatic image and thermophoretic forces on particles in the respiratory tract. Rad Prot Dosim 2005; 113:189-194.
115. Zhou Y, Podgorski A, Marijnissen JCM, Lemkowtz SM, Bibo HB. Deposition model for fibers in the deep parts of the lung. J Aerosol Sci 1996 27(suppl. 1):S491-S492.
116. Ding JY, Yu CP, Zhang L, Chen YK. Deposition modeling of fibrous particles in rats: comparisons with available experimental data. Aerosol Sci Technol 1997; 26:403-414.
117. Kartal S, Rodgers GJ. Statistical mechanics of a deposition-diffusion process. Phys Lets A 1997; 225:239-244.
118. Meyer T, Brand P, Ehlich H, et al. Deposition of Foradil P in human lungs: comparison of in vitro and in vivo data. J Aerosol Med 2004; 17:43-49.
119. Carpenter RL. Aerosol deposition modeling using ACSL. Drug Chem Toxic 1999; 22:73-90.
120. Gradon L, Orlicki D, Prodgórski A. Deposition and retention of ultrafine aerosol particles in the human respiratory system. Normal and pathological cases. Int J Occup Safety Ergon 2000; 6:189-207.
121. Smith S, Cheng Y-S, Yeh HC. Deposition of ultrafine particles in human tracheobronchial airways of adults and children. Aerosol Sci Technol 2001; 35:697-709.
122. Asgharian B, Ménache MG, Miller FJ. Modeling age-related particle deposition in humans. J Aerosol Med 2004; 17:213-224.
123. Cooney D, Kazantseva, M, Hickey AJ. Development of a size-dependent aerosol deposition model utilising human airway epithelial cells for evaluating aerosol drug delivery. ATLA 2004; 32:581-590.
124. Mitsakou C, Helmis C, Housiadas C. Eulerian modelling of lung deposition with sectional representation of aerosol dynamics. J Aerosol Sci 2005; 36:75-94.
125. Nazir J, Barlow, DJ, Lawrence MJ, Shrubb I. Artificial neural network prediction of the patterns of deposition of polydisperse aerosols within human lungs. J Pharm Sci 2005; 94:1986-1997.
126. Ehtezazi T, Southern KW, Allanson D, Jenkinson I, O'Callaghan C. Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers. Pharm Res 2005; 22:166-170.
127. Martonen TB, Zhang Z, Yu G, Musante CJ. Three-dimensional computer modeling of the human upper respiratory tract. Cell Biochem Biophys 2001; 35:255-261.
128. Martonen TB, Zhang Z, Yu G, Musante CJ. 3-D particle transport within the human upper respiratory tract. J Aerosol Sci 2002; 33:1095-1110.
129. Martonen TB, Quan L, Zhang Z, Musante CJ. Flow simulation in the human upper respiratory tract. Cell Biochem Biophys 2002; 37:27-36.
130. Balásházy I, Farkas Á, Szöke I, Hofmann W, Sturm R. Simulation of deposition and clearance of inhaled particles in central human airways. Rad Prot Dosim 2003; 105:129-132.
131. Balásházy I, Moustafa M, Hofmann W, Szöke R, El-Hussein A, Abdel-Rahman A. Simulation of fiber deposition in bronchial airways. Inhal Tox 2005; 17:717-727.
132. Stapleton KW, Guentsch E, Hoskinson MK, Finlay WH. On the suitability of k-e turbulence modelling for aerosol deposition in the mouth and throat: a comparison with experiment. J Aerosol Sci 2000; 31:739-749.
133. Matida EA, Finlay WH, Lange CF, Grgic B. Improved numerical simulation of aerosol deposition in an idealized mouth-throat. J Aerosol Sci 2004; 35:1-19.
134. Heenan AF, Matida E, Pollard A, Finlay WH. Experimental measurements and computational modeling of the flow field in an idealized human oropharynx. Exp Fluids 2004; 35:70-84.
135. Zhang Y, Finlay WH, Matida EA. Particle Deposition measurements and numerical simulation in a highly idealized mouth-throat. J Aerosol Sci 2004; 35:789-803.
136. Ferron GA, Edwards DA. Numerical simulation of air and particle transport in the conducting airways. J Aerosol Med 1996; 9:303-316.
137. Zhang L, Asgharian B, Anjilvel S. Inertial deposition of particles in the human upper airway bifurcations. Aerosol Sci Technol 1997; 26:97-110.
138. Li W-I, Perzi M, Ferron GA, Batycky R, Heyder J, Edwards DA. The macrotransport properties of aerosol particles in the human oral-pharyngeal region. J Aerosol Sci 1998; 29:995-1010.
139. Coates AL, MacNeish CF, Allen PD, Ho SL, Lands LC. Do sinusoidal models of respiration accurately reflect the respiratory events of patients breathing on nebulizers. J Aerosol Med 1999; 12:265-273.
140. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields. J Fluid Mech 2001; 435:25-54.
141. Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys Fluids 2002; 14:862-880.
142. Moskal A, Gradon L. Temporary and spatial deposition of aerosol particles in the upper human airways during breathing cycle. J Aerosol Sci 2002; 33:1525-1539.
143. Koolpiruck D, Prakoonwit S, Balachandran W. Deposition of charged inhaled aerosols with transient airflow in sequential lung airway model. IEEE Ind Appl Conf 39th IAS Ann Mtg 2004; 2:941-947.
144. Coates MS, Fletcher DF, Chan H-K, Raper JA. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1. Grid structure and mouthpiece length. J Pharm Sci 2004; 93:2863-2876.
145. Vial L. Ecoulements dans des modèles des voies aériennes proximales provenant de l'imagerie médicale. Thèse de Doctorat Université Pierre et Marie Curie, France, 2005.
146. Fodil R, de Rochefort L, Vial L, et al. Coupling experimental measurements and computational modelling of airflow using physical and numerical 3D-reconstructions of realistic human airway geometry. Experimental and Computational Biofluid Mechanics, Euromech Colloquium 456, 2004.
147. Vial L, Perchet D, Fodil R, et al. Airflow modelling of steady inspiration in two realistic proximal airway trees reconstructed from human thoracic tomodensitometric images. Comput Meth Biomech Biomed Eng 2005; 8(4):267-277.
148. Fodil R, Croce C, Louis B, et al. Morpho functional simulator of upper and central airways. ITBM-RBM 2005; 26:72-77.
149. de Rochefort L, Maître X, Fodil R, et al. Phase contrast velocimetry with hyperpolarized helium-3 for in vitro and in vivo characterization of airflow. Magn Reson Med 2006; 55(6):1318-1325.
150. Martonen TB, Smyth H, Isaacs K, Burton R. Issues in drug delivery: concepts and practice. Respir Care 2005; 50:1228-1252.
151. Isaacs KK, Rosati JA, Martonen TB. Mechanisms of particle deposition. In: Aerosols Handbook: Measurement, Dosimetry, and Health Effects. Boca Raton, FL: CRC Press, 2005:75-99.
152. Martonen TB, Rosati JA, Isaacs KK. Modeling deposition of inhaled particles. In: Aerosols Handbook: Measurement, Dosimetry, and Health Effects. Chapter 8. Boca Raton, FL: CRC Press, 2005:113-155.
153. Martonen TB, Hofmann W. Dosimetry of localized accumulations of cigarette smoke and radon progeny at bifurcations. Rad Prot Dosim 1991; 38:81-89.
154. Martonen TB, Yang Y, Hwang D, Fleming JS. Computer simulations of human lung structures for medical applications. Comput Biol Med 1995; 25:431.
155. Martonen TB, Yang Y, Hwang D, Fleming JS. Computer model of human lung morphology to complement SPECT analyses. Int J Bio-Med Comp 1995; 40:5.
156. Martonen TB, Zhang Z, Yang Y. Particle diffusion with entrance effects in a smooth-walled cylinder. J Aerosol Sci 1996; 27:139.
157. Martonen TB, Zhang Z, Yang Y. Particle diffusion from developing flows in rough-walled tubes. Aerosol Sci Technol 1997; 26:1.
158. Martonen TB, Yang Y, Dolovich M, Guan X. Computer simulations of lung morphologies within planar gamma camera images. Nucl Med Comm 1997; 18:86.
159. Martonen TB, Hwang D, Guan X, Yang Y, Fleming JS. Supercomputer-generated human lung morphologies for use in imaging analysis. In: Power H, Brebbia CA, Kenney J, eds. Simulations in Biomedicine IV. Southampton, U.K.: Comp Mech Publ, 1997:281-290.
160. Martonen TB, Hwang D, Guan X, Fleming JS. Supercomputer description of human lung morphology for imaging analysis. J Nucl Med 1998; 39:745.
161. Martonen TB, Schroeter JD, Hwang D, Fleming JS, Conway JH. Human lung morphology models for particle deposition studies. Inhal Toxicol 2000; 12:109-121.
162. Spencer RM, Schroeter JD, Martonen TB. Computer simulations of lung airway structures using data-driven surface modeling techniques. Comp Biol Med 2001; 31:499-511.
163. Schroeter JD, Fleming JS, Hwang D, Martonen TB. A computer model of lung morphology to analyze SPECT images. Comp Med Imag Graph 2002; 26:237-246.
164. Burton RT, Isaacs KK, Fleming JS, Martonen TB. Computer reconstruction of a human lung boundary model from magnetic resonance images. Respir Care 2004; 49:180-185.
165. Schroeter JD, Pritchard JN, Hwang D, Martonen TB. Airway identification within planar gamma camera images using computer models of lung morphology. Pharm Res 2005; 22:1692-1699.
166. Yang Y, Martonen TB. Flow dynamics in human respiratory and circulatory systems. Inhal Toxicol 1996; 8:877.
167. Martonen TB, Hwang D, Guan X, Fleming J. Computational fluid dynamics simulations of the human lung: an overview. In: Cerrolaza M, Jugo D, Brebbia CA, eds. Simulation Modelling in Bioengineering. Southampton, U.K.: Comp Mech Publ, 1996:69.
168. Katz IM, Martonen TB. Flow patterns in three dimensional laryngeal models. J Aerosol Med 1997; 9:501.
169. Katz IM, Martonen TB. Three-dimensional fluid particle trajectories in the human larynx and trachea. J Aerosol Med 1997; 9:513.
170. Guan X, Martonen TB. Simulations of flow in curved tubes. Aerosol Sci Technol 1997; 26:485.
171. Katz IM, Martonen TB, Flaa W. Three-dimensional computational study of inspiratory aerosol flow through the larynx: the effect of glottal aperture modulation. J Aerosol Sci 1997; 28:1073.
172. Katz IM, Davis BM, Martonen TB. A numerical study of particle motion within the human larynx and trachea. J Aerosol Sci 1999; 30:173.
173. Guan X, Martonen TB. Flow transition in bends and applications to airways. J Aerosol Sci 2000; 31:833-847.
174. Musante CJ, Martonen TB. Computational fluid dynamics in human lungs: I. Effects of natural airway features. In: Martonen TB, ed. Medical Modelling: The Respiratory System. Southampton, U.K.: WIT Press, 2001:131-145.
175. Musante CJ, Martonen TB. Computational fluid dynamics in human lungs: II. Effects of airway disease. In: TB Martonen, ed. Medical Modelling: The Respiratory System. Southampton, U.K.: WIT Press, 2001:147-164.
176. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations: I. Primary flows. Inhal Toxicol 2001; 13:261-279.
177. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations: II. Secondary currents. Inhal Toxicol 2001; 13:281-289.
178. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations: III. Localized flow conditions. Inhal Toxicol 2001; 13:291-305.
179. Martonen TB, Hwang D, Katz I, Yang Y. Cystic fibrosis: treatment with a supercomputer drug delivery model. Adv Eng Software 1997; 28:359.
180. Segal RA, Martonen TB, Kim CS, Shearer M. Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients. Inhal Toxicol 2002; 14:705-720.
181. Guan X, Martonen TB. Effects of tumor-induced flow patterns on aerosol drug delivery. In: Power H, Brebbia CA, Kenney J, eds. Simulations in Biomedicine IV. Southampton, U.K.: Comp Mech Publ, 1997:135-144.
182. Martonen TB, Guan X. Effects of tumors on inhaled pharmacologic drugs: I. Flow patterns, Cell Biochem Biophys 2001; 35:233-243.
183. Sbirlea-Apiou G, Lemaire M, Katz I, Conway J, Fleming J, Martonen T. Simulation of the regional manifestation of asthma. J Pharm Sci 2004; 93:1205-1216.
184. Katz IM, Schroeter JD, Martonen TB. Factors affecting the deposition of aerosolized insulin. Diabet Technol Therapeut 2001; 3:387-397.
185. Martonen TB, Schroeter JD, Zhang Z, Hwang D, Fleming JS. Targeted delivery of inhaled proteins. In: Respiratory Drug Delivery VIII. Godalming, Surrey, U.K.: DHI Publ Ltd 2002:723-725.
186. Musante CJ, Martonen TB. Predicted deposition patterns of ambient particulate air pollutants in children's lungs under resting conditions. In: Proceedings of the Third Colloquium on Particulate Air Pollution and Human Health, APHEL Report No. 99-01, University of California, Irvine 1999:7-15 to 7-20.
187. Segal RA, Guan X, Shearer M, Martonen TB. Mathematical model of airflow in the lungs of children. I. Effects of tumor sizes and locations. J Theoret Med 2000; 2:199-213.
188. Guan X, Segal RA, Shearer M, Martonen TB. Mathematical model of airflow in the lungs of children. II. Effects of ventilatory parameters. J Theoret Med 2000; 3:51-62.
189. Isaacs KK, Martonen TB. Particle deposition in children's lungs: theory and experiment. J Aerosol Med 2005; 18:337-353.
190. Martonen TB, Isaacs KK, Hwang D. Three-dimensional simulations of airways within human lungs. Cell Biochem Biophys 2005; 42:223-249.