Errors in regional lung deposition predictions of nebulized salbutamol sulphate due to neglect or partial inclusion of hydroscopic effects

International Journal of Pharmaceutics

Volumn 149, Issue 1, 1997, Pages 63-72

  Finlay, W H ^a   Stapleton, K W ^a   Zuberbuhler, P ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

Hygroscopic; Model; Nebulizer; Regional deposition

Indexed keywords

SALBUTAMOL; SALBUTAMOL SULFATE;

AEROSOL; ARTICLE; DRUG DISPOSITION; ERROR; HUMIDITY; MODEL; NEBULIZER; PREDICTION; PRIORITY JOURNAL; TEMPERATURE;

EID: 0030969361     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04860-0     Document Type: Article

References (20)

1. Bachalo, W.D., Experimental methods in multiphase flows. Int. J. Multiphase Flow, 20 (1994) 261-295.
2. Cinkotai, F.F., The behaviour of sodium chloride particles in moist air. J. Aerosol Sci., 2 (1971) 325.
3. Clark, A.R., The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int. J. Pharm., 115 (1995) 69-78.
4. Daviskas, E., Gonda, I. and Anderson, S.D., Mathematical modeling of heat and water transport in the human respiratory tract. J. Appl. Physiol., 69 (1990) 362.
5. Ferron, G.A., Kreyling, W.O. and Haider, B., Inhalation of salt aerosol particles. II. Growth and deposition in the human respiratory tract. J. Aerosol Sci., 19 (1988) 611.
6. Ferron, G.A. and Soderholm, S.C., Estimation of the times for evaporation of pure water droplets and for stabilisation of salt solution particles. J. Aerosol Sci., 21 (1990) 415.
7. Finlay, W. H. and Stapleton, K. W., The effect on deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase. J. Aerosol Sci., 26 (1995) 655-670.
8. Finlay, W.H., Stapleton, K.W., Chan, H.-K., Zuberbuhler, P. and Gonda, I., Regional deposition of inhaled hygroscopic aerosols: in vivo SPECT compared with mathematical deposition modeling. J. Appl. Phyiol., 81 (1996) 374-383.
9. Gormley, P.G. and Kennedy, K., Diffusion from a stream flowing through a cylindrical tube. Proc. R. Irish Acad., 52A (1949) 163.
10. Johnston, J.R., Isles, K.D. and Muir, D.C F., Inertial deposition of particles in human branching airways. Inhaled Particles IV, 1 (1977) 61-73.
11. Martonen, T.B., Bell, K.A., Phalen, R.F., Wilson, A.F. and Ho, A., Growth rate measurements and deposition modelling of hygroscopic aerosols in human tracheobronchial models. Ann. Occup. Hyg., 26 (1982) 93-108.
12. Persons, D.D., Hess, G.D., Muller, W.J. and Scherer, P.W., Airway deposition of hygroscopic heterodispersed aerosols: results of a computer calculation. J. Appl. Physiol., 63 (1987) 1195.
13. Prokop, R.M., Finlay, W.H., Stapleton, K.W. and Zuberbuhler, P., The effect of ambient relative humidity on regional dosages delivered by a jet nebulizer. J. Aerosol Med., 8 (1995a) 363-372.
14. Prokop, R.M., Finlay, W.H. and Stapleton, K.W., An in vitro technique for calculating the regional dosages of drugs delivered by an ultrasonic nebulizer. J. Aerosol Sci., 26 (1995b) 847-860.
15. Rudolf, G., Köbrich, R., and Stahlhofen, W., Modelling and algebraic formulation of regional aerosol deposition in man. J. Aerosol Sci., 21 (1990) 5403-5406.
16. Stapleton, K.W. and Finlay, W.H., Determining solution concentration within aerosol droplets output by jet nebulizers. J. Aerosol Sci. 26, (1995) 137-145.
17. Stapleton, K.W., Finlay, W.H. and Zuberbuhler, P., An in vitro method for determining regional dosages delivered by jet nebulizers. J. Aerosol Med., 7 (1994) 325-344.
18. Taulbee, D.B., Yu, C.P. and Heyder, J., Aerosol transport in the human lung from analysis of single breaths. J. Appl. Physiol., 44 (1978) 803-812.
19. Wang, C.-S., Gravitational deposition of particles from laminar flows in inclined channels. J. Aerosol Sci., 6 (1975) 191-204.
20. Waldrep, J.C., Keyhani, K., Black, M. and Knight, V., Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol. Chest, 105 (1994) 106-110.