Mathematical model of airflow in the lungs of children I: Effects of tumor sizes and locations

Journal of Theoretical Medicine

Volumn 2, Issue 3, 2000, Pages 199-213

  Segal, R A ^a   Guan, X ^b   Shearer, M ^a   Martonen, T B ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aerosol therapy; Fluid dynamics; Mathematical model; Pediatric medicine; Tumors

Indexed keywords

ANTINEOPLASTIC AGENT;

AEROSOL; ARTICLE; BREATHING PATTERN; CASE REPORT; CLINICAL PROTOCOL; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLOW RATE; HUMAN; HYDRODYNAMICS; LUNG MODEL; LUNG TUMOR; LUNG VENTILATION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PRESCHOOL CHILD; RESPIRATORY AIRFLOW; SIMULATION; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 0034587294     PISSN: 10273662     EISSN: None     Source Type: Journal    
DOI: 10.1080/10273660008833046     Document Type: Article

References (34)

1. Andrassy, R. J., Feldtmann, R. W. and Stanford, W. (1977). Bronchial carcinoid tumors in children and adolescents. Journal of Pediatric Surgery, 12, 513-517.
2. Asgharian, B. and Anjilvel, S. (1994). Inertial and gravitational deposition of particles in a square cross section bifurcating airway. Aerosol Science and Technology, 20, 177-193.
3. Augustin, N., Hofmann-V. Kap-herr, S. and Wuring, P. (1987). Endotracheal and endobronchial tumors in childhood. Progress in Pediatric Surgery, 21, 136-444.
4. Bellah, R. D., Mahboubi, S. and Berdon, W. E. (1992). Malignant endobronchial lesions of adolescence. Pediatric Radiology, 22, 563-567.
5. Clements, R. and Gravelle, I. H. (1986). Laryngeal Papillomatosis. Clinical Radiology, 37, 547-550.
6. Cleveland, R. H. (1979). Symmetry of Bronchial Angles in Children. Pediatric Radiology, 133, 89-93.
7. Cohen, S. R., Seltzer, S., Geller, K. A. and Thompson, J. W. (1980). Papilloma of the larynx and tracheobronchial tree in children. Annals of Otology. Rhinology, and Laryngology, 89, 497-503.
8. dePareder, C. G., Pierce, W. S., Groff, D. B. and Waldhausen, J. A. (1970). Bronchogenic tumors in children. Archives of Surgery, 100, 574-576.
9. FIDAP. (1993). Fluid Dynamics International. Evanston, Illinois.
10. Fontenelle, L. J. (1976). Primary adenocarcinoma of lung in a child: a review of the literature. American Surgery, 42, 296.
11. Hancock, B. J., Di Lorenzo, M., Youssef, S., Yazbeck, S., Marcotte, J. E. and Collin, P. P. (1993). Childhood primary pulmonary neoplasms. Journal of Pediatric Surgery, 28, 1133-1136.
12. Heistracher, T. and Hofmann, W. (1995). Physiologically realistic models of bronchial airway bifurcations. Journal of Aerosol Science, 26, 497-509.
13. Hofmann, W., Martonen, T. B. and Graham, R. C. (1989). Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. Journal of Aerosol Medicine, 2, 49-68.
14. Kirchner, J. A. (1951). Papilloma of the larynx with extensive lung involvement. Laryngoscope, 61, 1022-1029.
15. Knight, V. and Gilbert, B. E. (1990). Aerosol treatment of respiratory viral disease. Lung, Suppl, 406-413.
16. Kramer, S. S., Wehunt, W. D., Stocker, J. T. and Kashima, H. (1985). Pulmonary Manifestations of Juvenile Laryngotracheal Papillomatosis. AJR, 144, 687-694.
17. Lack, E. E., Harris, G. B. C., Eraklis, A. J. and Vawter, G. F. (1983). Primary bronchial tumors in childhood: A clinicopathologic Study of six cases. Cancer, 51, 492-497.
18. Martonen, T. B., Graham, R. C. and Hoffman, W. (1989). Human subject age and activity level: Factors addressed in a biomathematical deposition program for extrapolation modeling. Health Physics, 57, 49-59.
19. Martonen, T. B., Zhang, Z. and Lessmann, R. (1993). Fluid dynamics of the human larynx and upper tracheobronchial airways. Aerosol Science and Technology, 19, 133-156.
20. Martonen, T. B., Yang, Y. and Xue, Z. Q. (1994a). Influences of cartilaginous rings of tracheobronchial fluid dynamics. Inhalation Toxicology, 6, 185-203.
21. Martonen, T. B., Yang, Y. and Xue, Z. Q. (1994b). Effects of carinal ridge shapes on lung airstreams. Aerosol Science and Technology, 21, 119-136.
22. Martonen, T. B., Hwang, D., Katz, I., Yang, Y. and Guan, X. (1997). Cystic fibrosis: treatment with a supercomputer drug delivery model. Advances in Engineering Software, 28, 359-364.
23. Meyer, J. S. and Nicotra, J. J. (1998). Tumors of the pediatric chest. Seminars in Roentgenology, 33, 187-198.
24. Morrison, G. A. J., Kotecha, B. and Evans, J. N. G. (1993). Ribavirin treatment for juvenile respiratory papillomatosis. The Journal of Laryngology and Otology, 107, 423-426.
25. Oho, K. and Amemiya, R. (1980). Practical Fiberoptic Bronchoscopy. IGAKU-SHOIN Ltd., Tokyo, Japan.
26. Oleszczuk-Raszke, K. and Cremin, B. J. (1988). Computed tomography in pulmonary papillomatosis. The British Journal of Radiology, 61, 160-161.
27. Olson, D. E., Dart, G. A. and Filley, G. F. (1970). Pressure drop and fluid flow regime of air inspired into the human lung. Journal of Applied Physiology, 28, 482-494.
28. Roberts, K. D. (1954). Bronchial adenoma on childhood. Archives of Diseases in Childhood, 29, 360-362.
29. Schroter, R. C. and Sudlow, M. F. (1969). Flow patterns in models of the bronchial airways. Respiration physiology, 7, 341-355.
30. Simons, F. E. R. (1997). A comparison of Beclomethasone, Salmeterol and placebo in children with asthma. The New England Journal of Medicine, 337, 1659-1665.
31. Tatsumura. T., Koyama, S., Tsujimoto, M., Kitagawa, M. and Kagamimori, S. (1993). Further study of nebulisation chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: fundamental and clinical. British Journal of Cancer, 68, 1146-1149.
32. Verska, J. J. and Connolly, J. E. (1986). Bronchial adenomas in children. Journal of Thoracic Cardiovascular Surgery, 55, 411-417.
33. Wilkins, E. W. Jr., Darting, R. C., Soutter, L. and Sniffen, R. C. (1963). A continuing clinical survey of adenomas of the trachea and bronchus in a general hospital. Journal of Thoracic Cardiovascular Surgery, 46, 279.
34. Weibel, E. R. (1963). Morphometry of the human lung. Academic Press, New York.