Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients

Inhalation Toxicology

Volumn 14, Issue 7, 2002, Pages 705-720

  Segal, R A ^a,b   Martonen, T B ^a   Kim, C S ^c   Shearer, M ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEROSOL; AIRWAY RESISTANCE; ALGORITHM; ARTICLE; CALCULATION; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER MODEL; COMPUTER SIMULATION; DISEASE SEVERITY; HUMAN; IN VIVO STUDY; LUNG DEPOSIT; LUNG EMPHYSEMA; MORTALITY; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; TIDAL VOLUME;

AEROSOLS; AIR POLLUTANTS; AIRWAY RESISTANCE; BRONCHITIS, CHRONIC; COMPUTER SIMULATION; EMPHYSEMA; HUMANS; LUNG; MODELS, BIOLOGICAL; PARTICLE SIZE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 0036068083     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370290084593     Document Type: Article

References (29)

1. Effects of cystic fibrosis on inhaled aerosol boluses
2. Enhanced deposition of fine particles in COPD patients spontaneous breathing at rest
3. Effect of lung inflation on bronchial length and diameter in excised lungs
4. Extrathoracic airway resistance in man
5. Aerosol deposition in the lung with obstructed airways
6. Aerosol deposition in the airway model with excessive mucus secretions
7. Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease
8. Deposition of aerosol particles and flow resistance in mathematical and experimental airway models
9. Measurement of total lung aerosol deposition as an index of lung abnormality
10. Enhanced aerosol deposition in the lung with mild airways obstruction
11. Methodological issues of using observational human data in lung dosimetry models for particulates
12. The effect of bronchial obstruction on central airway deposition of a saline aerosol in patients with asthma
13. Integrated exposure and dose modeling and analysis system: Deposition of inhaled particles in the human respiratory tract
14. Analytical model of hydroscopic particle behavior in human airways
15. Mathematical model for the selective deposition of inhaled pharmaceuticals
16. Deposition patterns of aerosolized drugs within human lungs: Effects of ventilatory parameters
17. Deposition patterns of polydisperse aerosols within human lungs
18. Inter-related effects of morphology and ventilation on drug deposition patterns
19. Interspecies modeling of inhaled gases
20. Strategies in preserving lung health and preventing COPD and associated diseases
21. The prediction of pressure drop and variation of resistance in the human bronchial airways
22. COPD: Overview of definition, epidemiology and factors influencing its development
23. Air pollution and hospital admissions for respiratory disease
24. Particulate air pollution and acute health effects
25. Comparison of computer simulations of total lung deposition to human subject data in healthy subjects
26. Deposition of ultrafine particles in the human tracheo-bronchial airways of adults and children
27. Regional deposition of 3.5 μm particles in subjects with mild to moderately severe asthma
28. Short term variation in hospital admissions and mortality and particulate air pollution