Artificial neural network prediction of the patterns of deposition of polydisperse aerosols within human lungs

Journal of Pharmaceutical Sciences

Volumn 94, Issue 9, 2005, Pages 1986-1997

  Nazir, Javed ^a   Barlow, David J ^a   Lawrence, M Jayne ^a   Shrubb, Ian ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Artificial neural networks; Human lungs; Polydisperse aerosol deposition

Indexed keywords

RESPIRATORY TRACT AGENT;

AEROSOL; ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER PREDICTION; COST EFFECTIVENESS ANALYSIS; DISPERSION; DOSE RESPONSE; DRY POWDER; FILTERING OPERATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHALATION; INHALATION SPACER; LUNG DEPOSIT; METERED DOSE INHALER; NEBULIZATION; NEBULIZER; NONHUMAN; PARTICLE RESUSPENSION; RELIABILITY;

EID: 27644583244     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20413     Document Type: Article

References (20)

1. Rudolf G, Gebhart J, Heyder J, Schiller CF, Stahlhofen W. 1986. An empirical formula describing aerosol deposition in man for any particle size. J Aerosol Sci 17:350-355.
2. International Commission on Radiological Protection. 1994. Human respiratory tract model for radiological protection: a report of a task group of the International Commission on Radiological Protection. Oxford, United Kingdom: Elsevier Science Ltd. ICRP publication 66: Annals of the ICRP: Vol. 24, nos. 1-3.
3. Martonen TB, Zhang Z, Yue G, Musante CJ. 2002. 3-D Particle transport within the human upper respiratory tract. J Aerosol Sci 33:1095-1110.
4. Lee DY, Lee JW. 2002. Dispersion of aerosol bolus during one respiration cycle in a model of lung airways. J Aerosol Sci 33:1219-1234.
5. Richardson CJ, Barlow DJ. 1996. Neural network computer simulation of medical aerosols. J Pharm Pharmacol 48:581-591.
6. Nazir J, Barlow DJ, Lawrence MJ, Richardson CJ, Shrubb I. 2002. Artificial neural network prediction of aerosol deposition in human lungs. Pharm Res 19:1130-1136.
7. Heyder J, Gebhart J, Ruddolf G, Schiller CF, Stahlhofen W. 1986. Deposition of particles in the human respiratory tract in the size range 0.005-15 μm. J Aerosol Sci 17:811-825.
8. Finlay WH, Stapleton KW, Zuberbuhler P. 1998. Variations in predicted regional lung deposition of salbutamol sulphate between 19 nebulizer types. J Aerosol Med 11:65-80.
9. Silkstone VL, Dennis JH, Pieron CA, Chrystyn H. 2002. An investigation of in vitro/in vivo correlations for salbutamol nebulized by eight systems. J Aerosol Med 15:251-259.
10. Raabe OG. 1971. Particle size analysis utilizing grouped data and the log-normal distribution. J Aerosol Sci 2:289-303.
11. Thiel CG. 2002. Cascade impactor data and the log-normal distribution: Non-linear regression for a better fit. J Aerosol Sci 15:369-378.
12. Hiller C, Mazumder M, Wilson D, Bone R. 1978. Aerodynamic size distribution of metered-dose bronchodilator aerosols. Am Rev Resp Dis 118: 311-317.
13. Clay MM, Pavia D, Newman SP, Clarke SW. 1983. Factors influencing the size distribution from jet nebulisers. Thorax 38:755-759.
14. Persson G, Wiren JE. 1989. The bronchodilator response from inhaled terbutaline is influenced by the mass of small particles: A study on a dry powder inhaler (TurbuhalerR). Eur Resp J 2:253-256.
15. Finlay WH, Stapleton KW. 1995. The effect on deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase. J Aerosol Sci 26:655-670.
16. Newman SP, Pitcairn GR, Hooper G, Knoch M. 1994. Efficient drug delivery to the lungs from a continuously operated open-vent nebulizer and low pressure compressor system. Eur Resp J 7:1177-1181.
17. Martonen TB, Katz I. 1993. Deposition patterns of polydisperse aerosols within human lungs. J Aerosol Med 6:251-274.
18. Newman SP, Clarke SW. 1983. Therapeutic aerosols. I. Physical and practical considerations. Thorax 38:881-886.
19. Gonda I. 1990. Aerosols for delivery of therapeutic and diagnostic agents to the respiratory tract. Crit Rev Ther Drug Carrier Syst 6:273.
20. Timsina MP, Martin GP, Marriott C, Ganderton D, Yianneskis M. 1994. Drug delivery to the respiratory tract using dry powder inhalers. Int J Pharm 101:1-13.