-
1
-
-
0033604596
-
The epidemic of allergy and asthma
-
Holgate ST. The epidemic of allergy and asthma. Nature 1999; 402 (suppl):B2-B4.
-
(1999)
Nature
, vol.402
, pp. B2-B4
-
-
Holgate, S.T.1
-
2
-
-
0026566147
-
An economic evaluation of asthma in the United States
-
Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med 1992; 326:862-866.
-
(1992)
N Engl J Med
, vol.326
, pp. 862-866
-
-
Weiss, K.B.1
Gergen, P.J.2
Hodgson, T.A.3
-
4
-
-
0033604599
-
Therapeutic strategies for allergic diseases
-
Barnes PJ. Therapeutic strategies for allergic diseases. Nature 1999; 402 (suppl):B31-B38.
-
(1999)
Nature
, vol.402
, pp. B31-B38
-
-
Barnes, P.J.1
-
5
-
-
0018886940
-
Cortoic acids: Explorations at the frontier of corticosteroid metabolism
-
Monder C, Bradlow HL. Cortoic acids: explorations at the frontier of corticosteroid metabolism. Recent Progr Horm Res 1980; 36:345-400.
-
(1980)
Recent Progr Horm Res
, vol.36
, pp. 345-400
-
-
Monder, C.1
Bradlow, H.L.2
-
6
-
-
0021294113
-
The soft drug approach
-
Bodor N. The soft drug approach. Chemtech 1984; 14(1): 28-38.
-
(1984)
Chemtech
, vol.14
, Issue.1
, pp. 28-38
-
-
Bodor, N.1
-
7
-
-
0033966357
-
Soft drug design: General principles and recent applications
-
Bodor N, Buchwald P. Soft drug design: general principles and recent applications. Med Res Rev 2000; 20:58-101.
-
(2000)
Med Res Rev
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
8
-
-
0004215574
-
Novel approaches for the design of membrane transport properties of drugs
-
Roche EB, ed, Washington, DC: Academy of Pharmaceutical Sciences
-
Bodor N. Novel approaches for the design of membrane transport properties of drugs. In: Roche EB, ed. Design of Biopharmaceutical Properties through Prodrugs and Analogs. Washington, DC: Academy of Pharmaceutical Sciences, 1977:98-135.
-
(1977)
Design of Biopharmaceutical Properties through Prodrugs and Analogs
, pp. 98-135
-
-
Bodor, N.1
-
11
-
-
0019014701
-
Soft drugs
-
Bodor N, Woods R, Raper C, Kearney P, Kaminski J. Soft drugs. 3. A new class of anticholinergic agents. J Med Chem 1980; 23:474-480.
-
(1980)
3. A new class of anticholinergic agents. J Med Chem
, vol.23
, pp. 474-480
-
-
Bodor, N.1
Woods, R.2
Raper, C.3
Kearney, P.4
Kaminski, J.5
-
14
-
-
0010615439
-
Soft drugs: Strategies for design of safer drugs
-
Briot M, Cautreels W, Roncucci R, eds, Montpellier: CLIN MIDY
-
Bodor N. Soft drugs: strategies for design of safer drugs. In: Briot M, Cautreels W, Roncucci R, eds. Metabolisme et Conception Medicaments: Quo Vadis? Proceedings of Symposium at Montpellier, France, November 26-27, 1981. Montpellier: CLIN MIDY, 1983:217-251.
-
(1983)
Metabolisme et Conception Medicaments: Quo Vadis? Proceedings of Symposium at Montpellier, France, November 26-27, 1981
, pp. 217-251
-
-
Bodor, N.1
-
15
-
-
0018615111
-
Effects of induction of cytochrome P-450 enzymes on the concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds
-
Gillette JR. Effects of induction of cytochrome P-450 enzymes on the concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds. Drug Metab Rev 1979; 10:59-87.
-
(1979)
Drug Metab Rev
, vol.10
, pp. 59-87
-
-
Gillette, J.R.1
-
16
-
-
0006689060
-
Hepatic cytochrome P-450-linked drug-metabolizing systems
-
Testa B, Jenner P, eds, New York: Marcel Dekker, Inc
-
Mannering GJ. Hepatic cytochrome P-450-linked drug-metabolizing systems. In:Testa B, Jenner P, eds. Concepts in Drug Metabolism Part B. New York: Marcel Dekker, Inc, 1981:53-166.
-
(1981)
Concepts in Drug Metabolism Part B
, pp. 53-166
-
-
Mannering, G.J.1
-
17
-
-
84981851435
-
Multiple forms of esterase in vertebrate blood plasma
-
Augustinsson K-B. Multiple forms of esterase in vertebrate blood plasma. Ann NY Acad Sci 1961; 94:844-860.
-
(1961)
Ann NY Acad Sci
, vol.94
, pp. 844-860
-
-
Augustinsson, K.-B.1
-
18
-
-
77956922959
-
Carboxylic ester hydrolases
-
Boyer PD, ed, New York: Academic Press
-
Krisch K. Carboxylic ester hydrolases. In: Boyer PD, ed. The Enzymes. Vol. 5. New York: Academic Press, 1971:43-69.
-
(1971)
The Enzymes
, vol.5
, pp. 43-69
-
-
Krisch, K.1
-
19
-
-
0038608625
-
Hydrolysis of carboxylic esters and amides
-
Jakoby WB, Bend JR, Caldwell J, eds, New York: Academic Press
-
Heymann E. Hydrolysis of carboxylic esters and amides. In: Jakoby WB, Bend JR, Caldwell J, eds. Metabolic Basis of Detoxication. New York: Academic Press, 1982:229-245.
-
(1982)
Metabolic Basis of Detoxication
, pp. 229-245
-
-
Heymann, E.1
-
20
-
-
0021070489
-
Esterases: Problems of identification and classification
-
Walker CH, Mackness MI. Esterases: problems of identification and classification. Biochem Pharmacol 1983; 32:3265-3569.
-
(1983)
Biochem Pharmacol
, vol.32
, pp. 3265-3569
-
-
Walker, C.H.1
Mackness, M.I.2
-
21
-
-
0021996062
-
Clinical significance of esterases in man
-
Williams FW. Clinical significance of esterases in man. Clin Pharmacokin 1985; 10:392-403.
-
(1985)
Clin Pharmacokin
, vol.10
, pp. 392-403
-
-
Williams, F.W.1
-
22
-
-
0023614883
-
Possible physiological roles of carboxylic ester hydrolases
-
Leinweber F-J. Possible physiological roles of carboxylic ester hydrolases. Drug Metab Rev 1987; 18:379-439.
-
(1987)
Drug Metab Rev
, vol.18
, pp. 379-439
-
-
Leinweber, F.-J.1
-
23
-
-
0031800635
-
The mammalian carboxylesterases: From molecules to functions
-
Satoh T, Hosokawa M. The mammalian carboxylesterases: from molecules to functions. Annu Rev Pharmacol Toxicol 1998; 38:257-288.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 257-288
-
-
Satoh, T.1
Hosokawa, M.2
-
24
-
-
0023901668
-
Species differences in the stereoselective hydrolysis of esmolol by blood esterases
-
Quon CY, Mai K, Patil G, Stampfli HF. Species differences in the stereoselective hydrolysis of esmolol by blood esterases. Drug Metab Dispos 1988; 16:425-428.
-
(1988)
Drug Metab Dispos
, vol.16
, pp. 425-428
-
-
Quon, C.Y.1
Mai, K.2
Patil, G.3
Stampfli, H.F.4
-
25
-
-
0029024175
-
Species differences in hydrolysis of isocarbacyclin methyl ester (TEI-9090) by blood esterases
-
Minagawa T, Kohno Y, Suwa T, Tsuji A. Species differences in hydrolysis of isocarbacyclin methyl ester (TEI-9090) by blood esterases. Biochem Pharmacol 1995; 49:1361-1365.
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 1361-1365
-
-
Minagawa, T.1
Kohno, Y.2
Suwa, T.3
Tsuji, A.4
-
26
-
-
0033576649
-
Quantitative structure-metabolism relationships: Steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters
-
Buchwald P, Bodor N. Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters. J Med Chem 1999; 42:5160-5168.
-
(1999)
J Med Chem
, vol.42
, pp. 5160-5168
-
-
Buchwald, P.1
Bodor, N.2
-
27
-
-
0034127364
-
Structure-based estimation of enzymatic hydrolysis rates and its application in computer-aided retrometabolic drug design
-
Buchwald P, Bodor N. Structure-based estimation of enzymatic hydrolysis rates and its application in computer-aided retrometabolic drug design. Pharmazie 2000; 55:210-217.
-
(2000)
Pharmazie
, vol.55
, pp. 210-217
-
-
Buchwald, P.1
Bodor, N.2
-
29
-
-
0001189322
-
Soft drugs
-
Dulbecco R, ed, San Diego: Academic Press
-
Bodor N. Soft drugs. In: Dulbecco R, ed. Encyclopedia of Human Biology. Vol. 7. San Diego: Academic Press, 1991:101-117.
-
(1991)
Encyclopedia of Human Biology
, vol.7
, pp. 101-117
-
-
Bodor, N.1
-
30
-
-
0031278026
-
Drug targeting via retrometabolic approaches
-
Bodor N, Buchwald P. Drug targeting via retrometabolic approaches. Pharmacol Ther 1997; 76:1-27.
-
(1997)
Pharmacol Ther
, vol.76
, pp. 1-27
-
-
Bodor, N.1
Buchwald, P.2
-
32
-
-
0017735004
-
Unterschungen zur Pharmakologie von 6a-Fluor-11b-hydroxy-16a-methyl-3, 20-dioxo-1, 4-pregnadiene-21-säure-butylester (Fluocortin-butylester)
-
Kapp JF, Koch H, Töpert M, Kessler H-J, Gerhards E. Unterschungen zur Pharmakologie von 6a-Fluor-11b-hydroxy-16a-methyl-3, 20-dioxo-1, 4-pregnadiene-21-säure-butylester (Fluocortin-butylester). Arzneim Forsch 1977; 27:2191-2202.
-
(1977)
Arzneim Forsch
, vol.27
, pp. 2191-2202
-
-
Kapp, J.F.1
Koch, H.2
Töpert, M.3
Kessler, H.-J.4
Gerhards, E.5
-
33
-
-
0020037486
-
Anti-inflammatory steroids without pituitary-adrenal suppresion
-
Lee HJ, Soliman MRI. Anti-inflammatory steroids without pituitary-adrenal suppresion. Science 1982; 215:989-991.
-
(1982)
Science
, vol.215
, pp. 989-991
-
-
Lee, H.J.1
Soliman, M.R.I.2
-
34
-
-
0031009643
-
New steroidal anti-inflammatory antedrugs:Methyl 3, 20-dioxo-9a-fluoro-11b, 17a, 21-trihydroxy-1, 4-pregnadiene-16a-carboxylate and methyl 21-acetyloxy-3, 20-dioxo-11b, 17a-dihydroxy-9a-fluoro-1, 4-pregnadiene-16a-carboxylate
-
Heiman AS, Ko D-H, Chen M, Lee HJ. New steroidal anti-inflammatory antedrugs:methyl 3, 20-dioxo-9a-fluoro-11b, 17a, 21-trihydroxy-1, 4-pregnadiene-16a-carboxylate and methyl 21-acetyloxy-3, 20-dioxo-11b, 17a-dihydroxy-9a-fluoro-1, 4-pregnadiene-16a-carboxylate. Steroids 1997; 62:491-499.
-
(1997)
Steroids
, vol.62
, pp. 491-499
-
-
Heiman, A.S.1
Ko, D.-H.2
Chen, M.3
Lee, H.J.4
-
35
-
-
0026002038
-
Synthesis and evaluation of antiinflammatory activities of a series of corticosteroids 17a-esters containing a functional group
-
Ueno H, Maruyama A, Miyake M, Nakao E, Nakao K, Umezu K, Nitta I. Synthesis and evaluation of antiinflammatory activities of a series of corticosteroids 17a-esters containing a functional group. J Med Chem 1991; 34:2468-2473.
-
(1991)
J Med Chem
, vol.34
, pp. 2468-2473
-
-
Ueno, H.1
Maruyama, A.2
Miyake, M.3
Nakao, E.4
Nakao, K.5
Umezu, K.6
Nitta, I.7
-
36
-
-
0032835577
-
Examination of local anti-inflammatory activties of new steroids, hemisuccinyl methyl glycolates
-
Suzuki T, Sato E, Tada H, Tojima Y. Examination of local anti-inflammatory activties of new steroids, hemisuccinyl methyl glycolates. Biol Pharm Bull 1999; 22:816-821.
-
(1999)
Biol Pharm Bull
, vol.22
, pp. 816-821
-
-
Suzuki, T.1
Sato, E.2
Tada, H.3
Tojima, Y.4
-
37
-
-
0034642502
-
Selective plasma hydrolysis of glucocorticoid g-lactones and cyclic carbonates by the enzyme paraoxonase: An ideal plasma inactivation mechanism
-
Biggadike K, Angell RM, Burgess CM, Farrell RM, Hancock AP, Harker AJ, Irving WR, Loannou C, Procopiou PA, Shaw RE, Solanke YE, Singh OMP, Snowden MA, Stubbs RJ, Walton S, Weston HE. Selective plasma hydrolysis of glucocorticoid g-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism. J Med Chem 2000; 43:19-21.
-
(2000)
J Med Chem
, vol.43
, pp. 19-21
-
-
Biggadike, K.1
Angell, R.M.2
Burgess, C.M.3
Farrell, R.M.4
Hancock, A.P.5
Harker, A.J.6
Irving, W.R.7
Loannou, C.8
Procopiou, P.A.9
Shaw, R.E.10
Solanke, Y.E.11
Singh, O.M.P.12
Snowden, M.A.13
Stubbs, R.J.14
Walton, S.15
Weston, H.E.16
-
38
-
-
2642655272
-
Synthesis and enzymatic hydrolysis of esters, constituting simple models of soft drugs
-
Graffner-Nordberg M, Sjödin K, Tunek A, Hallberg A. Synthesis and enzymatic hydrolysis of esters, constituting simple models of soft drugs. Chem Pharm Bull 1998; 46:591-601.
-
(1998)
Chem Pharm Bull
, vol.46
, pp. 591-601
-
-
Graffner-Nordberg, M.1
Sjödin, K.2
Tunek, A.3
Hallberg, A.4
-
39
-
-
84943667325
-
Intrinsic potencies of novel thiol ester corticosteroids RS-85095 and RS-21314 as compared with clobetasol 17-propionate and fluocinonide
-
Ong JTH, Poulsen BJ, Akers WA, Scholtz JR, Genter FC, Kertesz DJ. Intrinsic potencies of novel thiol ester corticosteroids RS-85095 and RS-21314 as compared with clobetasol 17-propionate and fluocinonide. Arch Dermatol 1989; 125:1662-1665.
-
(1989)
Arch Dermatol
, vol.125
, pp. 1662-1665
-
-
Ong, J.T.H.1
Poulsen, B.J.2
Akers, W.A.3
Scholtz, J.R.4
Genter, F.C.5
Kertesz, D.J.6
-
40
-
-
0029849213
-
Dynamic modeling of cortisol reduction after inhaled administration of fluticasone propionate
-
Rohatagi S, Bye A, Falcoz C, Mackie AE, Meibohm B, Möllmann H, Derendorf H. Dynamic modeling of cortisol reduction after inhaled administration of fluticasone propionate. J Clin Pharmacol 1996; 36:938-941.
-
(1996)
J Clin Pharmacol
, vol.36
, pp. 938-941
-
-
Rohatagi, S.1
Bye, A.2
Falcoz, C.3
Mackie, A.E.4
Meibohm, B.5
Möllmann, H.6
Derendorf, H.7
-
41
-
-
0031044945
-
Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects
-
Thorsson L, Dahlström K, Edsbäcker S, Källén A, Paulson J, Wirén J-E. Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects. Br J Clin Pharmacol 1997; 43:155-161.
-
(1997)
Br J Clin Pharmacol
, vol.43
, pp. 155-161
-
-
Thorsson, L.1
Dahlström, K.2
Edsbäcker, S.3
Källén, A.4
Paulson, J.5
Wirén, J.-E.6
-
43
-
-
0002050603
-
The application of soft drug approaches to the design of safer corticosteroids
-
Christophers E, Kligman AM, Schöpf E, Stoughton RB, eds, New York: Raven Press Ltd
-
Bodor N. The application of soft drug approaches to the design of safer corticosteroids. In: Christophers E, Kligman AM, Schöpf E, Stoughton RB, eds. Topical Corticosteroid Therapy: A Novel Approach to Safer Drugs. New York: Raven Press Ltd, 1988:13-25.
-
(1988)
Topical Corticosteroid Therapy: A Novel Approach to Safer Drugs
, pp. 13-25
-
-
Bodor, N.1
-
44
-
-
0025014561
-
Effect of a novel soft steroid on the wound healing of rabbit cornea
-
Bodor N, Varga M. Effect of a novel soft steroid on the wound healing of rabbit cornea. Exp Eye Res 1990; 50:183-187.
-
(1990)
Exp Eye Res
, vol.50
, pp. 183-187
-
-
Bodor, N.1
Varga, M.2
-
46
-
-
0025991941
-
Ocular absorption and distribution of loteprednol etabonate, a soft steroid, in rabbit eyes
-
Druzgala P, Wu W-M, Bodor N. Ocular absorption and distribution of loteprednol etabonate, a soft steroid, in rabbit eyes. Curr Eye Res 1991; 10:933-937.
-
(1991)
Curr Eye Res
, vol.10
, pp. 933-937
-
-
Druzgala, P.1
Wu, W.-M.2
Bodor, N.3
-
47
-
-
0000112026
-
Lipophilicity, solubility and permeability of loteprednol etabonate: A novel, soft anti-inflammatory corticosteroid
-
Alberth M, Wu W-M, Winwood D, Bodor N. Lipophilicity, solubility and permeability of loteprednol etabonate: a novel, soft anti-inflammatory corticosteroid. J Biopharm Sci 1991; 2:115-125.
-
(1991)
J Biopharm Sci
, vol.2
, pp. 115-125
-
-
Alberth, M.1
Wu, W.-M.2
Winwood, D.3
Bodor, N.4
-
48
-
-
0026046245
-
Novel soft steroids: Effects on cell growth in vitro and on wound healing in the mouse
-
Bodor NS, Kiss-Buris ST, Buris L. Novel soft steroids: effects on cell growth in vitro and on wound healing in the mouse. Steroids 1991; 56:434-439.
-
(1991)
Steroids
, vol.56
, pp. 434-439
-
-
Bodor, N.S.1
Kiss-Buris, S.T.2
Buris, L.3
-
49
-
-
0026638362
-
A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits
-
Bodor N, Bodor N, Wu W-M. A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits. Curr Eye Res 1992; 11:525-530.
-
(1992)
Curr Eye Res
, vol.11
, pp. 525-530
-
-
Bodor, N.1
Bodor, N.2
Wu, W.-M.3
-
50
-
-
0026788230
-
Metabolism, distribution, and transdermal permeability of a soft corticosteroid, loteprednol etabonate
-
Bodor N, Loftsson T, Wu W-M. Metabolism, distribution, and transdermal permeability of a soft corticosteroid, loteprednol etabonate. Pharm Res 1992; 9:1275-1278.
-
(1992)
Pharm Res
, vol.9
, pp. 1275-1278
-
-
Bodor, N.1
Loftsson, T.2
Wu, W.-M.3
-
51
-
-
0027053957
-
Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs
-
Hochhaus G, Chen L-S, Ratka A, Druzgala P, Howes J, Bodor N, Derendorf H. Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs. J Pharm Sci 1992; 81:1210-1215.
-
(1992)
J Pharm Sci
, vol.81
, pp. 1210-1215
-
-
Hochhaus, G.1
Chen, L.-S.2
Ratka, A.3
Druzgala, P.4
Howes, J.5
Bodor, N.6
Derendorf, H.7
-
52
-
-
0028455013
-
The pharmacokinetics and transdermal delivery of loteprednol etabonate and related soft steroids
-
Loftsson T, Bodor N. The pharmacokinetics and transdermal delivery of loteprednol etabonate and related soft steroids. Adv Drug Deliv Rev 1994; 14:293-299.
-
(1994)
Adv Drug Deliv Rev
, vol.14
, pp. 293-299
-
-
Loftsson, T.1
Bodor, N.2
-
53
-
-
0029076419
-
Soft drugs
-
Bodor N, Murakami T, Wu W-M. Soft drugs. 18. Oral and rectal delivery of loteprednol etabonate, a novel soft corticosteroid, in rats-for safer treatment of gastrointestinal inflammation. Pharm Res 1995; 12:869-874.
-
(1995)
18. Oral and rectal delivery of loteprednol etabonate, a novel soft corticosteroid, in rats-for safer treatment of gastrointestinal inflammation. Pharm Res
, vol.12
, pp. 869-874
-
-
Bodor, N.1
Murakami, T.2
Wu, W.-M.3
-
54
-
-
0028998734
-
Soft drugs
-
Bodor N, Wu W-M, Murakami T, Engel S. Soft drugs. 19. Pharmacokinetics, metabolism and excretion of a novel soft corticosteroid, loteprednol etabonate, in rats. Pharm Res 1995; 12:875-879.
-
(1995)
19. Pharmacokinetics, metabolism and excretion of a novel soft corticosteroid, loteprednol etabonate, in rats. Pharm Res
, vol.12
, pp. 875-879
-
-
Bodor, N.1
Wu, W.-M.2
Murakami, T.3
Engel, S.4
-
55
-
-
0029885907
-
Permeability of a soft steroid, loteprednol etabonate, through an excised rabbit cornea
-
Reddy IK, Khan MA, Wu WM, Bodor NS. Permeability of a soft steroid, loteprednol etabonate, through an excised rabbit cornea. J Ocul Pharmacol Ther 1996; 12:159-167.
-
(1996)
J Ocul Pharmacol Ther
, vol.12
, pp. 159-167
-
-
Reddy, I.K.1
Khan, M.A.2
Wu, W.M.3
Bodor, N.S.4
-
56
-
-
0032920189
-
Loteprednol etabonate, a new soft steroid is effective in a rabbit acute experimental model for arthritis
-
Buris LF, Bodor N, Buris L. Loteprednol etabonate, a new soft steroid is effective in a rabbit acute experimental model for arthritis. Pharmazie 1999; 54:58-61.
-
(1999)
Pharmazie
, vol.54
, pp. 58-61
-
-
Buris, L.F.1
Bodor, N.2
Buris, L.3
-
57
-
-
0032982918
-
Soft drugs based on hydrocortisone: The inactive metabolite approach and its application to steroidal antiinflammatory agents
-
Little RJ, Bodor N, Loftsson T. Soft drugs based on hydrocortisone: the inactive metabolite approach and its application to steroidal antiinflammatory agents. Pharm Res 1999; 16:961-967.
-
(1999)
Pharm Res
, vol.16
, pp. 961-967
-
-
Little, R.J.1
Bodor, N.2
Loftsson, T.3
-
58
-
-
0029739497
-
Corticosteroid therapy of eye disease: Fifty years later
-
Raizman M. Corticosteroid therapy of eye disease: fifty years later. Arch Ophthalmol 1996; 114:1000-1001.
-
(1996)
Arch Ophthalmol
, vol.114
, pp. 1000-1001
-
-
Raizman, M.1
-
59
-
-
0030608873
-
Steroid-induced cataract: New perspectives from in vitro and lens culture studies
-
Dickerson JE, Jr., Dotzel E, Clark AF. Steroid-induced cataract: New perspectives from in vitro and lens culture studies. Exp Eye Res 1997; 65:507-516.
-
(1997)
Exp Eye Res
, vol.65
, pp. 507-516
-
-
Dickerson, J.E.1
Dotzel, E.2
Clark, A.F.3
-
60
-
-
0001287213
-
Über die Bildung eines Aminozuckers aus d-Fruktose und Ammoniak
-
Heyns K, Koch W. Über die Bildung eines Aminozuckers aus d-Fruktose und Ammoniak. Z Naturforsch B 1952; 7B:486-488.
-
(1952)
Z Naturforsch B
, vol.7 B
, pp. 486-488
-
-
Heyns, K.1
Koch, W.2
-
61
-
-
0019921782
-
Formation of covalent adducts between cortisol and 16a-hydroxyestrone and protein: Possible role in the pathogenesis of cortisol toxicity and systemic lupus erythematosus
-
Bucala R, Fishman J, Cerami A. Formation of covalent adducts between cortisol and 16a-hydroxyestrone and protein: possible role in the pathogenesis of cortisol toxicity and systemic lupus erythematosus. Proc Natl Acad Sci USA 1982; 79:3320-3324.
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 3320-3324
-
-
Bucala, R.1
Fishman, J.2
Cerami, A.3
-
62
-
-
0021690560
-
Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts
-
Manabe S, Bucala R, Cerami A. Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts. J Clin Invest 1984; 74:1803-1810.
-
(1984)
J Clin Invest
, vol.74
, pp. 1803-1810
-
-
Manabe, S.1
Bucala, R.2
Cerami, A.3
-
63
-
-
0022312929
-
Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts
-
Bucala R, Gallati M, Manabe S, Cotlier E, Cerami A. Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts. Exp Eye Res 1985; 40:853-863.
-
(1985)
Exp Eye Res
, vol.40
, pp. 853-863
-
-
Bucala, R.1
Gallati, M.2
Manabe, S.3
Cotlier, E.4
Cerami, A.5
-
64
-
-
0022994025
-
Corticosteroid-induced cataracts
-
Urban RC, Jr., Cotlier E. Corticosteroid-induced cataracts. Surv Ophthalmol 1986; 31:102-110.
-
(1986)
Surv Ophthalmol
, vol.31
, pp. 102-110
-
-
Urban, R.C.1
Cotlier, E.2
-
65
-
-
0027745484
-
Design of novel soft corticosteroids
-
Korting HC, Maibach HI, eds, Basel: Karger
-
Bodor N. Design of novel soft corticosteroids. In: Korting HC, Maibach HI, eds. Topical Glucocorticoids with Increased Benefit /Risk Ratio. Basel: Karger, 1993:11-19.
-
(1993)
Topical Glucocorticoids with Increased Benefit /Risk Ratio
, pp. 11-19
-
-
Bodor, N.1
-
66
-
-
0002622795
-
Designing safer drugs based on the soft drug approach
-
Bodor N. Designing safer drugs based on the soft drug approach. Trends Pharmacol Sci 1982; 3:53-56.
-
(1982)
Trends Pharmacol Sci
, vol.3
, pp. 53-56
-
-
Bodor, N.1
-
67
-
-
0026052024
-
Regioselective O-alkylation of cortienic acid and synthesis of a new class of glucocorticoids containing a 17a-alkoxy, a 17a-(1-alkoxyethyloxy), a 17a-alkoxymethyloxy, or a 17a-methylthiomethyloxy function
-
Druzgala P, Bodor N. Regioselective O-alkylation of cortienic acid and synthesis of a new class of glucocorticoids containing a 17a-alkoxy, a 17a-(1-alkoxyethyloxy), a 17a-alkoxymethyloxy, or a 17a-methylthiomethyloxy function. Steroids 1991; 56:490-494.
-
(1991)
Steroids
, vol.56
, pp. 490-494
-
-
Druzgala, P.1
Bodor, N.2
-
68
-
-
0021210779
-
Soft drugs: Principles and methods for the design of safe drugs
-
Bodor N. Soft drugs: principles and methods for the design of safe drugs. Med Res Rev 1984; 3:449-469.
-
(1984)
Med Res Rev
, vol.3
, pp. 449-469
-
-
Bodor, N.1
-
69
-
-
0006645882
-
Prodrugs versus soft drugs
-
Bundgaard H, ed, Amsterdam:Elsevier
-
Bodor N. Prodrugs versus soft drugs. In: Bundgaard H, ed. Design of Prodrugs. Amsterdam:Elsevier, 1985:333-354.
-
(1985)
Design of Prodrugs
, pp. 333-354
-
-
Bodor, N.1
-
70
-
-
0002450382
-
Designing safer ophthalmic drugs
-
van der Goot H, Domany G, Pallos L, Timmerman H, eds, Proceeding of the Xth International Symposium on Medicinal Chemistry. Amsterdam: Elsevier
-
Bodor N. Designing safer ophthalmic drugs. In: van der Goot H, Domany G, Pallos L, Timmerman H, eds. Trends in Medicinal Chemistry 88. Proceeding of the Xth International Symposium on Medicinal Chemistry. Amsterdam: Elsevier, 1989:145-164.
-
(1989)
Trends in Medicinal Chemistry 88
, pp. 145-164
-
-
Bodor, N.1
-
71
-
-
0027159211
-
Intraocular pressure response to loteprednol etabonate in known steroid responders
-
Bartlett JD, Horwitz B, Laibovitz R, Howes JF. Intraocular pressure response to loteprednol etabonate in known steroid responders. J Ocul Pharmacol 1993; 9:157-165.
-
(1993)
J Ocul Pharmacol
, vol.9
, pp. 157-165
-
-
Bartlett, J.D.1
Horwitz, B.2
Laibovitz, R.3
Howes, J.F.4
-
72
-
-
0032467764
-
Change in intraocular pressure during long-term use of loteprednol etabonate
-
Novack GD, Howes J, Crockett RS, Sherwood MB. Change in intraocular pressure during long-term use of loteprednol etabonate. J Glaucoma 1998; 7:266-269.
-
(1998)
J Glaucoma
, vol.7
, pp. 266-269
-
-
Novack, G.D.1
Howes, J.2
Crockett, R.S.3
Sherwood, M.B.4
-
73
-
-
0031966882
-
Failure to detect systemic levels and effects of loteprednol etabonate and its metabolite, PJ-91, following chronic ocular administration
-
Howes J, Novack GD. Failure to detect systemic levels and effects of loteprednol etabonate and its metabolite, PJ-91, following chronic ocular administration. J Ocul Pharmacol Ther 1998; 14:153-158.
-
(1998)
J Ocul Pharmacol Ther
, vol.14
, pp. 153-158
-
-
Howes, J.1
Novack, G.D.2
-
74
-
-
0027311235
-
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis
-
Bartlett JD, Howes JF, Ghormley NR, Amos JF, Laibovitz R, Horwitz B. Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. Curr Eye Res 1993; 12:313-321.
-
(1993)
Curr Eye Res
, vol.12
, pp. 313-321
-
-
Bartlett, J.D.1
Howes, J.F.2
Ghormley, N.R.3
Amos, J.F.4
Laibovitz, R.5
Horwitz, B.6
-
75
-
-
0031021022
-
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis
-
Asbell P, Howes J. A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. CLAO J 1997; 23:31-36.
-
(1997)
CLAO J
, vol.23
, pp. 31-36
-
-
Asbell, P.1
Howes, J.2
-
76
-
-
0030999849
-
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis
-
Friedlaender MH, Howes J. A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. Am J Ophthalmol 1997; 123:455-464.
-
(1997)
Am J Ophthalmol
, vol.123
, pp. 455-464
-
-
Friedlaender, M.H.1
Howes, J.2
-
77
-
-
0030963092
-
A controlled evaluation of the efficacy and safety of loteprednol etabonate in the prophylactic treatment of seasonal allergic conjunctivitis
-
Dell SJ, Shulman DG, Lowry GM, Howes J. A controlled evaluation of the efficacy and safety of loteprednol etabonate in the prophylactic treatment of seasonal allergic conjunctivitis. Am J Ophthalmol 1997; 123:791-797.
-
(1997)
Am J Ophthalmol
, vol.123
, pp. 791-797
-
-
Dell, S.J.1
Shulman, D.G.2
Lowry, G.M.3
Howes, J.4
-
78
-
-
0031722635
-
A randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in patients with seasonal allergic conjunctivitis
-
Dell SJ, Lowry GM, Northcutt JA, Howes J, Novack GD, Hart K. A randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in patients with seasonal allergic conjunctivitis. J Allergy Clin Immunol 1998; 102:251-255.
-
(1998)
J Allergy Clin Immunol
, vol.102
, pp. 251-255
-
-
Dell, S.J.1
Lowry, G.M.2
Northcutt, J.A.3
Howes, J.4
Novack, G.D.5
Hart, K.6
-
79
-
-
0033511435
-
A randomized, double-masked, placebocontrolled parallel study of loteprednol etabonate 0.2% in patients with seasonal allergic conjunctivitis
-
Shulman DG, Lothringer HL, Rubin JM. A randomized, double-masked, placebocontrolled parallel study of loteprednol etabonate 0.2% in patients with seasonal allergic conjunctivitis. Ophthalmology 1999; 106:362-369.
-
(1999)
Ophthalmology
, vol.106
, pp. 362-369
-
-
Shulman, D.G.1
Lothringer, H.L.2
Rubin, J.M.3
-
80
-
-
0343640813
-
A double-masked, placebo-controlled evaluation of 0.5% loteprednol etabonate in the treatment of postoperative inflammation
-
Beehler C, Bodner B, Bowman B, Cooke D, Crabb JL, DeBarge LR, Donnenfeld E, Estopinal M, Fox K, Kastl P, Olander K, Sharpe E, Shofner R, Stahl J, Stevenson D, Stewart W, Walters T, Gill S, Howes J, Lawson C, Smerick M, Zaccardelli D, Fazio R, Novack GD, Crockett RS, Hart K. A double-masked, placebo-controlled evaluation of 0.5% loteprednol etabonate in the treatment of postoperative inflammation. Ophthalmology 1998; 105:1780-1786.
-
(1998)
Ophthalmology
, vol.105
, pp. 1780-1786
-
-
Beehler, C.1
Bodner, B.2
Bowman, B.3
Cooke, D.4
Crabb, J.L.5
DeBarge, L.R.6
Donnenfeld, E.7
Estopinal, M.8
Fox, K.9
Kastl, P.10
Olander, K.11
Sharpe, E.12
Shofner, R.13
Stahl, J.14
Stevenson, D.15
Stewart, W.16
Walters, T.17
Gill, S.18
Howes, J.19
Lawson, C.20
Smerick, M.21
Zaccardelli, D.22
Fazio, R.23
Novack, G.D.24
Crockett, R.S.25
Hart, K.26
more..
-
81
-
-
0031791136
-
A double-masked, placebo controlled evaluation of 0.5% loteprednol etabonate in the treatment of post-operative inflammation
-
Stewart R, Horwitz B, Howes J. A double-masked, placebo controlled evaluation of 0.5% loteprednol etabonate in the treatment of post-operative inflammation. J Cataract Refr Surg 1998; 24:1480-1489.
-
(1998)
J Cataract Refr Surg
, vol.24
, pp. 1480-1489
-
-
Stewart, R.1
Horwitz, B.2
Howes, J.3
-
82
-
-
0032914924
-
Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis
-
Caldwell D, Cohen GR, Davis J, DeBarge LR, Foley J, Foster CS, Fox K, Friedlaender M, John G, Kaufman A, Nozik R, Olander K, Ostrov C, Raizman M, Rosenbaum J, Sall K, Sheppard J, Stewart D, Stewart W, Tauber J, Trocme S, Zimmerman P, Howes J, Coultas S, Crockett RS, Novack GD, Strahlman ER, Neumann R. Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. Am J Ophthalmol 1999; 127:537-544.
-
(1999)
Am J Ophthalmol
, vol.127
, pp. 537-544
-
-
Caldwell, D.1
Cohen, G.R.2
Davis, J.3
DeBarge, L.R.4
Foley, J.5
Foster, C.S.6
Fox, K.7
Friedlaender, M.8
John, G.9
Kaufman, A.10
Nozik, R.11
Olander, K.12
Ostrov, C.13
Raizman, M.14
Rosenbaum, J.15
Sall, K.16
Sheppard, J.17
Stewart, D.18
Stewart, W.19
Tauber, J.20
Trocme, S.21
Zimmerman, P.22
Howes, J.23
Coultas, S.24
Crockett, R.S.25
Novack, G.D.26
Strahlman, E.R.27
Neumann, R.28
more..
-
84
-
-
0034031333
-
Loteprednol etabonate: A review of ophthalmic clinical studies
-
Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie 2000; 55:178-183.
-
(2000)
Pharmazie
, vol.55
, pp. 178-183
-
-
Howes, J.F.1
-
85
-
-
0001550248
-
Effects of topically administered loteprednol etabonate on allergic rhinitis in Brown-Norway rats and on late phase allergic eosinophilia in guinea pigs
-
Poppe H, Szelenyi I. Effects of topically administered loteprednol etabonate on allergic rhinitis in Brown-Norway rats and on late phase allergic eosinophilia in guinea pigs. N-S Arch Pharmacol 1998; 358 (suppl 1):R327.
-
(1998)
N-S Arch Pharmacol
, vol.358
, pp. R327
-
-
Poppe, H.1
Szelenyi, I.2
-
86
-
-
0001018659
-
Effects of loteprednol etabonate on TNFa and GM-CSF release in vitro and on late phase allergic eosinophilia in guinea pigs administered intratracheally as a dry powder
-
Poppe H, Marx D, Heer S, Szelenyi I. Effects of loteprednol etabonate on TNFa and GM-CSF release in vitro and on late phase allergic eosinophilia in guinea pigs administered intratracheally as a dry powder. Am J Respir Crit Care Med 1998; 157(suppl. 3):A522.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. A522
-
-
Poppe, H.1
Marx, D.2
Heer, S.3
Szelenyi, I.4
-
87
-
-
0003374220
-
Effect of AWD 12-281, a new selective PDE4-inhibitor, loteprednol, and beclomethasone in models of allergic rhinitis and airway inflammation in Brown-Norway rats
-
Poppe H, Küsters S, Szelenyi I. Effect of AWD 12-281, a new selective PDE4-inhibitor, loteprednol, and beclomethasone in models of allergic rhinitis and airway inflammation in Brown-Norway rats. Am J Respir Crit Care Med 1999; 159(suppl 3): A95.
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. A95
-
-
Poppe, H.1
Küsters, S.2
Szelenyi, I.3
-
88
-
-
4243284488
-
Comparison of the therapeutic effects of loteprednol, beclomethasone and fluticasone in preclinical models of allergic rhinitis and airway inflammation and on thymus weight in rats
-
Poppe H, Marx D, Szelenyi I. Comparison of the therapeutic effects of loteprednol, beclomethasone and fluticasone in preclinical models of allergic rhinitis and airway inflammation and on thymus weight in rats. Eur Respir J 1999; 14(suppl 30):158s.
-
(1999)
Eur Respir J
, vol.14
, pp. 158
-
-
Poppe, H.1
Marx, D.2
Szelenyi, I.3
-
89
-
-
0034079575
-
Loteprednol etabonate: A soft steroid for the treatment of allergic diseases of the airways
-
Szelenyi I, Hochhaus G, Heer S, Küsters S, Marx D, Poppe H, Engel J. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today 2000; 36:313-320.
-
(2000)
Drugs Today
, vol.36
, pp. 313-320
-
-
Szelenyi, I.1
Hochhaus, G.2
Heer, S.3
Küsters, S.4
Marx, D.5
Poppe, H.6
Engel, J.7
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