Dynamic modeling of cortisol reduction after inhaled administration of fluticasone propionate

Journal of Clinical Pharmacology

Volumn 36, Issue 10, 1996, Pages 938-941

  Rohatagi, Shashank ^a   Bye, Alan ^b   Falcoz, Christine ^b   Mackie, Alison E ^b   Meibohm, Bernd ^a   Möllmann, Helmut ^a   Derendorf, Hartmut ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; FLUTICASONE PROPIONATE; HYDROCORTISONE;

ADULT; ARTICLE; ASTHMA; BIOAVAILABILITY; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HYDROCORTISONE RELEASE; INHALATIONAL DRUG ADMINISTRATION; MALE; MOLECULAR MODEL; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; RECEPTOR AFFINITY;

EID: 0029849213     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1996.tb04761.x     Document Type: Article

References (10)

1. Würthwein G, Rehder S, Rohdewald P: Lipophilicity and receptor affinity of glucocorticoids. Pharm Ztg Wissenschaft 1992;137:161-167.
2. Falcoz C, Mackie AE, McDowall J, McRae J, Yogendran L, Ventresca GP, Bye A: Oral bioavailability of fluticasone propionate in healthy subjects. Br J Clin Pharmacol 1996;41:459P-460P.
3. Fuller R, Johnson M, Bye A: Fluticasone propionate: an update on preclinical and clinical experience. Respir Med 1995;89(Suppl A):3-18.
4. Spilker B: Guide to Clinical Trials. New York: Raven Press, 1991.
5. Bain BM, Harrison G, Jenkins KD, Pateman AJ, Shenoy EVB: A sensitive radioimmunoassay, incorparating solid-phase extraction, for fluticasone 17-propionate in plasma. J Pharm Biomed Anal 1993;11:557-561.
6. Derendorf H, Möllmann H, Barth J, Möllmann C, Tunn S, Krieg M: Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol 1991;31:473-476.
7. Rohatagi S, Bye A, Mackie A, Derendorf H: Mathematical modeling of cortisol baseline and Cortisol suppression. Eur J Pharm Sci (in press).
8. MicroMath: Scientist User Handbook. Salt Lake City, UT: MicroMath Inc., 1993.
9. Rohatagi S, Hochhaus G, Möllmann H, Barth J, Galia E, Erdmann M, et al: Pharmacokinetic/pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral and inhaled administration. J Clin Pharmacol 1995;35:1187-1193.
10. Rohatagi S, Täuber U, Richter K, Derendorf H: Pharmacokinetic/pharmacodynamic modeling of cortisol suppression after oral administration of fluocortolone. J Clin Pharmacol 1996;36: 311-314.