The effect of food and nutrients on iron overload: what do we know so far?

European Journal of Clinical Nutrition

Volumn 75, Issue 12, 2021, Pages 1771-1780

  Omena, Juliana ^a   Curioni, Cíntia ^a   Cople Rodrigues, Cláudia dos Santos ^a   Citelli, Marta ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEPCIDIN; POLYPHENOL DERIVATIVE; PROCYANIDIN DERIVATIVE; SHOGAOL; IRON;

AEROBIC METABOLISM; ALCOHOL CONSUMPTION; ASCORBIC ACID DEFICIENCY; DIETARY INTAKE; FERRITIN BLOOD LEVEL; FOOD DRUG INTERACTION; HEMOCHROMATOSIS; HUMAN; IRON ABSORPTION; IRON OVERLOAD; IRON RESTRICTION; NUTRIENT; PATHOPHYSIOLOGY; PREFERRED REPORTING ITEMS FOR SYSTEMATIC REVIEWS AND META-ANALYSES; PRESCRIPTION; PROTEIN BLOOD LEVEL; REVIEW; VITAMIN SUPPLEMENTATION; ADVERSE EVENT; COMPLICATION; INTESTINE ABSORPTION; IRON INTAKE; METABOLISM;

FERRITINS; HEMOCHROMATOSIS; HEPCIDINS; HUMANS; INTESTINAL ABSORPTION; IRON; IRON OVERLOAD; IRON, DIETARY; NUTRIENTS;

EID: 85102595969     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/s41430-021-00887-5     Document Type: Review

References (54)

1. McDermid JM, Lönnerdal B. Iron. Adv Nutr. 2012;3:532–3. 10.3945/an.112.002261 DOI: 10.3945/an.112.002261
2. Green R, Charlton R, Seftel H, Bothwell T, Mayet F, Adams B, et al. Body iron excretion in man: a collaborative study. Am J Med. 1968;45:336–53. 10.1016/0002-9343(68)90069-7 DOI: 10.1016/0002-9343(68)90069-7
3. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823:1434–43. 10.1016/j.bbamcr.2012.01.014 DOI: 10.1016/j.bbamcr.2012.01.014
4. Ward R. An update on disordered iron metabolism and iron overload. Hematology. 2010;15:311–7. 10.1179/102453310X12647083621164 DOI: 10.1179/102453310X12647083621164
5. Darbari DS, Kple-Faget P, Kwagyan J, Rana S, Gordeuk VR, Castro O. Circumstances of death in adult sickle cell disease patients. Am J Hematol. 2006;81:858–63. 10.1002/ajh.20685 DOI: 10.1002/ajh.20685
6. Piperno A, Pelucchi S, Mariani R. Inherited iron overload disorders. Transl Gastroenterol Hepatol. 2020;5:25 10.21037/tgh.2019.11.15 DOI: 10.21037/tgh.2019.11.15
7. Piperno A. Classification and diagnosis of iron overload. Haematolgica. 1998;83:447–55.
8. Fowler C. Hereditary hemochromatosis: pathophysiology, diagnosis, and management. Crit Care Nurs Clin North Am. 2008;20:191–201. 10.1016/j.ccell.2008.01.003 DOI: 10.1016/j.ccell.2008.01.003
9. Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American association for the study of liver diseases. Hepatology. 2011;54:328–43. 10.1002/hep.24330. DOI: 10.1002/hep.24330
10. Tavill AS. American association for the study of liver diseases, American college of gastroenterology; American gastroenterological association. diagnosis and management of hemochromatosis. Hepatology. 2001;33:1321–8. 10.1053/jhep.2001.24783 DOI: 10.1053/jhep.2001.24783
11. Powell LW, Seckington RC, Deugnier Y. Haemochromatosis. Lancet. 2016;388:706–16. 10.1016/S0140-6736(15)01315-X DOI: 10.1016/S0140-6736(15)01315-X
12. Rachmilewtiz EA, Giardina PJ. How I treat thalassemia. Blood. 2011;118:3479–88. 10.1182/blood-2010-08-300335 DOI: 10.1182/blood-2010-08-300335
13. Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. Lancet. 2010;376:2018–31. 10.1016/S0140-6736(10)61029-X DOI: 10.1016/S0140-6736(10)61029-X
14. Giardina PJ, Grady RW. Chelation therapy in beta-thalassemia: the benefits and limitations of desferroxamine. Semin Hematol. 1995;32:304–12.
15. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290:G199–203. 10.1152/ajpgi.00412.2005 DOI: 10.1152/ajpgi.00412.2005
16. Ohemeng A, Boadu I. The role of nutrition in the pathophysiology and management of sickle cell disease among children: a review of literature. Crit Rev Food Sci Nutr. 2018;58:2299–305. 10.1080/10408398.2017.1319794 DOI: 10.1080/10408398.2017.1319794
17. Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematol Am Soc Hematol Educ Program. 2006;507:29–35. 10.1182/asheducation-2006.1.29 DOI: 10.1182/asheducation-2006.1.29
18. Kaitha S, Bashir M, Ali T. Iron deficiency anemia in inflammatory bowel disease. World J Gastrointest Pathophysiol. 2015;6:62–72. 10.4291/wjgp.v6.i3.62 DOI: 10.4291/wjgp.v6.i3.62
19. Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil H. Chapter 11: scoping reviews (2020 version). In: Aromatari ES, Munn Z, editors. JBI manual for evidence synthesis. JBI, 2020. https://synthesismanual.jbi.global Accessed 7 June 2020.
20. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097 10.1371/journal.pmed.1000097 DOI: 10.1371/journal.pmed.1000097
21. Bezwoda WR, Disler PB, Lynch SR, Charlton RW, Torrance JD, Derman D, et al. Patterns of food iron absorption in iron-deficient white and indian subjects and in venesected haemochromatotic patients. Br J Haematol. 1976;33:425–36. 10.1111/j.1365-2141.1976.tb03560.x DOI: 10.1111/j.1365-2141.1976.tb03560.x
22. Lynch SR, Skikne BS, Cook JD. Food iron absorption in idiopathic hemochromatosis. Blood. 1989;74:2187–93. DOI: 10.1182/blood.V74.6.2187.bloodjournal7462187
23. Milder MS, Cook JD, Finch CA. Influence of food iron absorption on the plasma iron level in idiopathic hemochromatosis. Acta Haematol. 1978;60:65–75. 10.1159/000207699 DOI: 10.1159/000207699
24. Kaltwasser JP, Werner E, Schalk K, Hansen C, Gottschalk R, Seidl C. Clinical trial on the effect of regular tea drinking on iron accumulation in genetic haemochromatosis. Gut. 1998;43:699–704. 10.1136/gut.43.5.699 DOI: 10.1136/gut.43.5.699
25. Lobbes H, Gladine C, Mazur A, Pereira B, Dualé C, Cardot JM. Effect of procyanidin on dietary iron absorption in hereditary hemochromatosis and in dysmetabolic iron overload syndrome: a crossover double-blind randomized controlled trial. Clin Nutr. 2020;39:97–103. 10.1016/j.clnu.2019.02.012 DOI: 10.1016/j.clnu.2019.02.012
26. Golombick T, Diamond TH, Manoharan A, Ramakrishna R, Badmaev V. Effect of the ginger derivative, 6-shogaol, on ferritin levels in patients with low to intermediate-1-risk myelodysplastic syndrome—a small, investigative study. Clin Med Insights Blood Disord. 2017;10:1179545X17738755 10.1177/1179545X17738755 DOI: 10.1177/1179545X17738755
27. Elalfy MS, Saber MM, Adly AAM, Ismail EA, Tarif M, Ibrahim F, et al. Role of vitamin C as an adjuvante therapy to different iron chelators in young β-thalassemia major patients: efficacy and safety in relation to tissue iron overload. Eur J Haematol. 2015;96:318–26. 10.1111/ejh.12594 DOI: 10.1111/ejh.12594
28. Chapman RW, Hussain MA, Gorman A, Laulicht M, Politis D, Flynn DM, et al. Effect of ascorbic acid deficiency on serum ferritin concentration in patients with β-thalassemia major and iron overload. J Clin Pathol. 1982;35:487–91. 10.1136/jcp.35.5.487 DOI: 10.1136/jcp.35.5.487
29. Walters GO, Jacobs A, Worwood M, Trevett D, Thomson W. Iron absorption in normal subjects and patients with idiopathic haemochromatosis: relationship with serum ferritin concentration. Gut. 1975;16:188–92. 10.1136/gut.16.3.188 DOI: 10.1136/gut.16.3.188
30. International Atomic Energy Agency (IAEA). Assessment of iron bioavailability in humans using stable iron isotope techniques. IAEA Human Health Series no. 21. International Atomic Energy Agency, Austria, 2012.
31. De Alarcon PA, Donovan ME, Forbes GB, Landaw AS, Stockman JA 3rd. Iron absorption in the thalassemia syndromes and its inhibition by tea. N Engl J Med. 1979;300:5–8. 10.1056/NEJM197901043000102 DOI: 10.1056/NEJM197901043000102
32. Alqasoumi S, Yusufoglu H, Farraj A, Alam A. Effect of 6-shogaol and 6-gingerol on diclofenac sodium induced liver injury. Int J Pharm. 2011;7:868–73. 10.3923/ijp.2011.868.873 DOI: 10.3923/ijp.2011.868.873
33. Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, et al. Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015;4:1–18. 10.3402/jev.v4.28713 DOI: 10.3402/jev.v4.28713
34. Bell H, Skinningsrud A, Raknerud N, Try K. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. J Intern Med. 1994;236:315–22. 10.1111/j.1365-2796.1994.tb00802.x DOI: 10.1111/j.1365-2796.1994.tb00802.x
35. Rouault TA. Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis? Alcohol. 2003;30:103–6. 10.1016/s0741-8329(03)00102-2 DOI: 10.1016/s0741-8329(03)00102-2
36. Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006;281:22974–82. 10.1074/jbc.M602098200 DOI: 10.1074/jbc.M602098200
37. Milman N, Kirchhoff M. Relationship between serum ferritin, alcohol intake, and social status in 2235 Danish men and women. Ann Hematol. 1996;72:145–51. 10.1007/s002770050153 DOI: 10.1007/s002770050153
38. Whitfield JB, Zhu G, Heath AC, Powell LW, Martin NG. Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res. 2001;25:1037–45. DOI: 10.1111/j.1530-0277.2001.tb02314.x
39. Ioannou GN, Dominitz JA, Weiss NS, Heagerty PJ, Kowdley KV. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology. 2004;126:1293–301. 10.1053/j.gastro.2004.01.020 DOI: 10.1053/j.gastro.2004.01.020
40. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Pathophysiological classification of iron overloa Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology. 2002;122:281–9. 10.1053/gast.2002.30992 DOI: 10.1053/gast.2002.30992
41. Scotet V, Mérour MC, Mercier AY, Chanu B, Le Faou T, Raguénes O, et al. Hereditary hemochromatosis: Effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation. Am J Epidemiol. 2003;158:129–34. 10.1093/aje/kwg123 DOI: 10.1093/aje/kwg123
42. Lane DJR, Bae DH, Merlot AM, Sahni S, Richardson DR. Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. Nutrients. 2015;7:2274–96. 10.3390/nu7042274 DOI: 10.3390/nu7042274
43. Chiu PF, Ko SY, Chang CC. Vitamin C affects the expression of hepcidin and erythropoietin receptor in HepG2 cells. J Ren Nutr. 2012;22:373–6. 10.1053/j.jrn.2011.09.007 DOI: 10.1053/j.jrn.2011.09.007
44. O´Brien RT. Ascorbic acid enhancement of desferrioxamine-induced urinary iron excretion in thalassemia major. Ann N Y Acad Sci. 1974;232:221–5. 10.1111/j.1749-6632.1974.tb20588.x DOI: 10.1111/j.1749-6632.1974.tb20588.x
45. Modell CB, Beck J. Long-term desferrioxamine therapy in thalassemia. Ann N Y Acad Sci. 1974;232:201–10. 10.1111/j.1749-6632.1974.tb20586.x DOI: 10.1111/j.1749-6632.1974.tb20586.x
46. Brissot P, Deugnier Y, Le Treut A, Regnouard F, Simon M, Bourel M. Ascorbic acid status in idiopathic hemochromatosis. Digestion. 1978;17:479–87. 10.1159/000198154 DOI: 10.1159/000198154
47. Sarantos K, Evans P, Garbowski M, Davis B, Porter JB. Vitamin C in patients on long-term deferasirox without supplementation. Blood. 2008;112:1858 10.1182/blood.V112.11.1858.1858 DOI: 10.1182/blood.V112.11.1858.1858
48. Schulz EJ, Swanepoel H. Scorbutic pseudoscleroderma: an aspect of Bantu siderosis. S Afr Med J. 1962;36:367–72.
49. Lynch SR, Seftel HC, Torrance JD, Charlton RW, Bothwell TH. Accelerated oxidative catabolism of ascorbic acid in siderotic Bantu. Am J Clin Nutr. 1967;20:641–7. 10.1093/ajcn/20.6.641 DOI: 10.1093/ajcn/20.6.641
50. Imam MU, Zhang S, Ma J, Wang H, Wang F. Antioxidants mediate both iron homeostasis and oxidative stress. Nutrients. 2017;9:3–19. 10.3390/nu9070671 DOI: 10.3390/nu9070671
51. Erlandson ME, Walden B, Stern G, Hilgartner MW, Wehman J, Smith CH. Studies on congenital hemolytic syndromes, IV. Gastrointestinal absorption of iron. Blood. 1962;19:359–78. DOI: 10.1182/blood.V19.3.359.359
52. Ringelhann B, Konotey-Ahulu F, Dodu SR. Studies on iron metabolism in sickle cell anaemia, sickle cell haemoglobin C disease, and haemoglobin C disease using a large volume liquid scintillation counter. J Clin Pathol. 1970;23:127–34. 10.1136/jcp.23.2.127 DOI: 10.1136/jcp.23.2.127
53. Omena J, Cople-Rodrigues CS, Cardoso JDA, Soares AR, Fleury MK, Brito FSB, et al. Serum hepcidin concentration in individuals with sickle cell anemia: Basis for the dietary recommendation of iron. Nutrients. 2018;10:498 10.3390/nu10040498 DOI: 10.3390/nu10040498
54. Mangaonkar AA, Thawer F, Son J, Ajebo G, Xu H, Barrett NJ, et al. Regulation of iron homeostasis through the erythroferrone-hepcidin axis in sickle cell disease. Br J Haematol. 2020;189:1204–9. 10.1111/bjh.16498 DOI: 10.1111/bjh.16498