Biohydrogenation of linoleic acid by lactic acid bacteria for the production of functional cultured dairy products: A review

Foods

Volumn 5, Issue 1, 2016, Pages 1-11

  Kuhl, Gabriela Christina ^a   Lindner, Juliano De Dea ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Biohydrogenation; Conjugated linoleic acid; Dairy products; Functional food; Lactic acid bacteria

Indexed keywords

EID: 85101930253     PISSN: None     EISSN: 23048158     Source Type: Journal    
DOI: 10.3390/foods5010013     Document Type: Review

References (66)

1. Alhaj, O.A.; Kanekanian, A. Milk and Dairy Products as Functional Foods; John Wiley & Sons, Ltd: Chichester, UK, 2014; pp. 1–22.
2. De Dea Lindner, J.; Penna, A.L.B.; Demiate, I.M.; Yamaguishi, C.T.; Prado, M.R.M.; Parada, J.L. Fermented Foods and Human Health Benefits of Fermented Functional Foods. In Fermentation Processes Engineering in the Food Industry, 1st ed.; Soccol, C.R., Pandey, A., Larroche, C., Eds.; CRC Press: Bosa Roca, FL, USA, 2013; Volume 1, pp. 263–297.
3. Alhaj, O.A.; Kanekanian, A. Milk and Dairy Products as Functional Foods; John Wiley & Sons, Ltd: Chichester, UK, 2014; pp. 237–288.
4. Fernández, M.; Hudson, J.A.; Korpela, R.; de los Reyes-Gavilán, C.G. Impact on human health of microorganisms present in fermented dairy products: An overview. Bio. Med. Res. Int. 2015, 41, 1–13. [CrossRef] [PubMed]
5. Brazil. Resolução n. 18, de 30 de abril de 1999. Aprova o Regulamento Técnico que Estabelece as Diretrizes Básicas para Análise e Comprovação de Propriedades Funcionais e ou de Saúde Alegadas em Rotulagem de Alimentos. Diário Oficial da União, Poder Executivo: Brazil, 03 maio 1999. Available online: http://portal.anvisa.gov.br/wps/wcm/connect/815ada0047458a7293e3d73fbc4c6735/RESOLUCAO_18 _ 1999.pdf?MOD=AJPERES (accessed on 22 Februray 2016).
6. Brazil. Resolução n. 16, de 30 de abril de 1999. Aprova o Regulamento Técnico de Procedimentos para Registro de Alimentos e ou Novos Ingredientes. Diário Oficial da União, Poder Executivo: Brazil, 03 maio 1999. Available online: http://portal.anvisa.gov.br/wps/wcm/connect/96fa548047458ef597fdd 73fbc4c6735/RESOLUCAO_16_1999.pdf?MOD=AJPERES (accessed on 22 Februray 2016).
7. Brazil. Resolução n. 17, de 30 de abril de 1999. Aprova o Regulamento Técnico que Estabelece as Diretrizes Básicas para Avaliação de Risco e Segurança dos Alimentos. Diário Oficial da União, Poder Executivo: Brazil, 03 maio 1999. Available online: http://portal.anvisa.gov.br/wps/wcm/connect/ea58f88047457 ce3895cdd3fbc4c6735/RESOLUCAO_17_1999.pdf?MOD=AJPERES (accessed on 22 Februray 2016).
8. Brazil. Resolução n. 19, de 30 de abril de 1999. Aprova o Regulamento Técnico de Procedimentos para Registro de Alimento com Alegação de Propriedades Funcionais e ou de Saúde em sua Rotulagem. Diário Oficial da União, Poder Executivo: Brazil, 3 de maio de 1999. Available online: http://portal.anvisa.gov. br/wps/wcm/connect/727a7f004745792d8641d63fbc4c6735/RESOLUCAO_19_1999.pdf?MOD=AJPERES (accessed on 22 Februray 2016).
9. Brazil. Informe Técnico n. 23, de 17 de abril de 2007. Agência Nacional de Vigilância Sanitária. Gerência Geral de Alimentos Gerência de Produtos Especiais; Esclarecimentos sobre as avaliações de segurança do ácido linoleico conjugado (CLA). ANVISA: Brasília, 28 Ministério da Saúde 2007. Available online: http://portal.anvisa.gov.br/wps/wcm/connect/47c169804eb542de862b868a610f4177/Informe+T%C3%A9 cnico+sobre+CLA.pdf?MOD=AJPERES (accessed on 22 Februray 2016).
10. Bassaganya-Riera, J.; Hontecillas, R. Dietary CLA and n-3 PUFA in inflammatory bowel disease. Curr. Opin. Clin. Nutr. Metab. Care 2010, 13, 569–573. [CrossRef] [PubMed]
11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to conjugated linoleic acid (CLA) isomers and contribution to the maintenance or achievement of a normal body weight (ID 686, 726, 1516, 1518, 2892, 3165), increase in lean body mass (ID 498, 731), increase in insulin sensitivity (ID 1517), protection of DNA, proteins and lipids from oxidative damage (ID 564, 1937), and contribution to immune defences by stimulation of production of protective antibodies in response to vaccination (ID 687, 1519) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J. 2010, 8, 1794.
12. Fitzpatrick, K.C. Regulatory issues related to functional foods and natural health products in Canada: Possible implications for manufacturers of conjugated linoleic acid. Am. J. Clin. Nutr. 2004, 79, 1217–1220.
13. Thuillier, P.; Pande, N.T.; Ghena, A.; Song, S.; Lawrence, Y.; Shridhar, V.; Akkari, Y.; Pejovic, T.; Olson, S. Dietary conjugated linoleic acids arrest cell cycle progression and prevent ovarian cancer xenografts growth suggesting a trans-10 cis-12 isoform specific activity. J. Cancer Ther. 2013, 4, 33–42. [CrossRef]
14. Malinska, H.; Hüttl, M.; Oliyarnyk, O.; Bratova, M.; Kazdova, L. Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriglyceridemia. Nutrition 2015, 31, 1045–1051. [CrossRef] [PubMed]
15. Stachowska, E.; Siennicka, A.; Baśkiewcz-Hałasa, M.; Bober, J.; Machalinski, B.; Chlubek, D. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. Int. J. Food Sci. Nutr. 2012, 63, 30–35. [CrossRef] [PubMed]
16. DeGuire, J.R.; Makarem, N.; Vanstone, C.A.; Morin, S.; Duque, G.; Weiler, H.A. Conjugated linoleic acid is related to bone mineral density but does not affect parathyroid hormone in men. Nutr. Res. 2012, 32, 911–920. [CrossRef] [PubMed]
17. Chen, S.C.; Lin, Y.H.; Huang, H.P.; Hsu, W.L.; Houng, J.Y.; Huang, C.K. Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition 2012, 28, 559–565. [CrossRef] [PubMed]
18. Bassaganya-Riera, J.; Hontecillas, R.; Horne, W.T.; Sandridge, M.; Herfarth, H.H.; Bloomfeld, R.; Isaacs, K.L. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn’s disease. Clin. Nutr. 2012, 31, 721–727.
19. Block, J.M.; Barrera-Arellano, D. Temas Selectos en Aceites y Grasas: Procesamiento; Blucher: São Paulo, Brazil, 2009.
20. Bomfim, M.A.D.; Queiroga, R.C.E.; Aguila, M.B.; Medeiros, M.D.C.; Fisberg, M.; Rodrigues, M.T.; Lanna, D.P.D. Abordagem multidisciplinar de P, D & I para o desenvolvimento de produto lácteo caprino com alto teor de CLA e alegação de propriedade funcional. R. Bras. Zootec. 2011, 40, 98–106.
21. Jiang, J.; Björck, L.; Fonden, R. Production of conjugated linoleic acid by dairy starter cultures. J. Appl. Microbiol. 1998, 85, 95–102. [CrossRef] [PubMed]
22. Lin, T.Y.; Lin, C.W.; Lee, C.H. Conjugated linoleic acid concentration as affected by lactic cultures and added linoleic acid. Food Chem. 1999, 67, 1–5. [CrossRef]
23. Kim, Y.J.; Liu, R.H. Increase of conjugated linoleic acid content in milk by fermentation with lactic acid bacteria. J. Food Sci. 2002, 67, 1731–1737. [CrossRef]
24. Van Nieuwenhove, C.P.; Oliszewski, R.; González, S.N.; Perez Chaia, A.B. Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. Lett. Appl. Microbiol. 2007, 44, 467–474. [CrossRef] [PubMed]
25. Khosravi-Darani, K.; Reihani, F.S.; Feili, R. Bioproduction of conjugated linoleic acid in yogurt by probiotic bacteria. Int. J. Biotechnol. Wellness Ind. 2014, 3, 62–68. [CrossRef]
26. Khosravi, A.; Safari, M.; Khodaiyan, F.; Gharibzahedi, S.M.T. Bioconversion enhancement of conjugated linoleic acid by Lactobacillus plantarum using the culture media manipulation and numerical optimization. J. Food Sci. Technol. 2015, 52, 5781–5789. [CrossRef] [PubMed]
27. Gorissen, L.; Leroy, F.; de Vuyst, L.; de Smet, S.; Raes, K. Bacterial production of conjugated linoleic and linolenic acid in foods: A technological challenge. Crit. Rev. Food Sci. Nutr. 2015, 55, 1561–1574. [CrossRef] [PubMed]
28. Damodaran, S.; Parkin, K.; Fennema, O. R. Química de Alimentos de Fennema, 4th ed.; Artmed: Porto Alegre, Brazil, 2010.
29. Motard-Bélanger, A.; Charest, A.; Grenier, G.; Paquin, P.; Chouinard, Y.; Lemieux, S.; Couture, P.; Lamarche, B. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factor for cardiovascular disease. Am. J. Clin. Nutr. 2008, 87, 593–599. [PubMed]
30. Pinho, D.M.M.; Suarez, P.A.Z. A hidrogenação de óleos e gorduras e suas aplicações industriais. Rev. Virtual Quim. 2013, 5, 47–62.
31. Akoh, C.C.; Min, D.B. Food Lipids: Chemistry, Nutrition, and Biotechnology, 3rd ed.; Marcel Dekker, Inc: New York, NY, USA, 2008.
32. Tvrzicka, E.; Kremmyda, L.S.; Stankova, B.; Zak, A. Fatty acids as biocompounds: Their role in human metabolism, health and disease—A review. Part 1: Classification, dietary sources and biological functions. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech. Repub. 2011, 155, 117–130. [CrossRef] [PubMed]
33. Lin, H.; Boylston, T.D.; Chang, M.J.; Luedecke, L.O.; Shultz, T.D. Survey of the conjugated linoleic acid contents of dairy products. J. Dairy Sci. 1995, 78, 2358–2365. [CrossRef]
34. Kepler, C.R.; Hirons, K.P.; McNeill, J.J.; Tove, S.B. Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens. J. Biol. Chem. 1966, 241, 1350–1354. [PubMed]
35. De Holanda, M.A.C.; de Holanda, M.C.R.; Mendonça, A., Jr. Suplementação dietética de lipídios na concentração de ácido linoleico conjugado na gordura do leite. Acta Vet. Bras. 2012, 5, 221–229.
36. Jenkins, T.C.; Wallace, R.J.; Moate, P.J.; Mosley, E.E. Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystem. J. Anim. Sci. 2008, 86, 397–412. [CrossRef] [PubMed]
37. Parodi, P.W. Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat. J. Dairy Sci. 1999, 82, 1339–1349. [CrossRef]
38. Lucatto, J.N.; de Mendonça, S.N.T.G.; Drunkler, D.A. Ácido linoleico conjugado: estrutura química, efeitos sobre a saúde humana e análise em lácteos. Rev. Inst. Latic. Cândido Tostes 2014, 69, 199–211. [CrossRef]
39. Kishino, S.; Ogawa, J.; Omura, Y.; Matsumura, K.; Shimizu, S. Conjugated linoleic acid production from linoleic acid by lactic acid bacteria. J. Am. Oil Chem. Soc. 2002, 79, 159–163. [CrossRef]
40. Terán, V.; Pizarro, P.L.; Zacarías, M.F.; Vinderola, G.; Medina, R.; van Nieuwenhove, C. Production of conjugated dienoic and trienoic fatty acids by lactic acid bacteria and bifidobacteria. J. Funct. Foods 2015, 19, 417–425.
41. Xu, S.; Boylston, T.D.; Glatz, B.A. Effect of lipid source on probiotic bacteria and conjugated linoleic acid formation in milk model systems. J. Am. Oil Chem. Soc. 2004, 81, 589–595. [CrossRef]
42. Pandit, A.; Anand, S.; Kalscheur, K.; Hassan, A. Production of conjugated linoleic acid by lactic acid bacteria in milk without any additional substrate. Int. J. Dairy Technol. 2012, 65, 603–608. [CrossRef]
43. Xu, S.; Boylston, T.D.; Glatz, B.A. Conjugated linoleic acid content and organoleptic attributes of fermented milk products produced with probiotic bacteria. J. Agric. Food Chem. 2005, 53, 9064–9072. [CrossRef] [PubMed]
44. Serafeimidou, A.; Zlatanos, S.; Kritikos, G.; Tourianis, A. Change of fatty acid profile, including conjugated linoleic acid (CLA) content, during refrigerated storage of yogurt made of cow and sheep milk. J. Food Compost. Anal. 2013, 31, 24–30. [CrossRef]
45. Ritzenthaler, K.L.; McGuire, M.K.; Falen, R.; Shultz, T.D.; Dasgupta, N.; McGuire, M.A. Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. J. Nutr. 2001, 131, 1548–1554. [PubMed]
46. Herbel, B.K.; McGuire, M.K.; McGuire, M.A.; Shultz, T.D. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am. J. Clin. Nutr. 1998, 67, 332–337. [PubMed]
47. Park, Y.; McGuire, M.K.; Behr, R.; McGuire, M.A.; Evans, M.A.; Shultz, T.D. High-fat dairy product consumption increases ∆9c’11t-18:2 (rumenic acid) and total lipid concentrations of human milk. Lipids 1999, 34, 543–549. [CrossRef] [PubMed]
48. Nunes, J.C.; Torres, A.G. Fatty acid and CLA composition of Brazilian dairy products, and contribution to daily intake of CLA. J. Food Compost. Anal. 2010, 23, 782–789. [CrossRef]
49. Watkins, B.A.; Li, Y.; Sébédio, J.L.; Christie, W.W.; Adlof, R. CLA in functional food: Enrichment of animal products. Adv. Conjug. Linoleic Acid Res. 2003, 2, 174–188.
50. Ip, C.; Chin, S.F.; Scimeca, J.A.; Pariza, M.W. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res. 1991, 51, 6118–6124. [PubMed]
51. Ip, C.; Singh, M.; Thompson, H.J.; Scimeca, J.A. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res. 1994, 54, 1212–1215.
52. Ip, M.M.; Masso-Welch, P.A.; Shoemaker, S.F.; Shea-Eaton, W.K.; Ip, C. Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary cells in primary culture. Exp. Cell Res. 1999, 250, 22–34. [CrossRef] [PubMed]
53. Ochoa, J.J.; Farquharson, A.J.; Grant, I.; Moffat, L.E.; Heys, S.D.; Wahle, W.J. Conjugated linoleics acids (CLAs) decrease prostate cancer cell proliferation: Different molecular mechanisms for cis-9, trans-11 and cis-10, trans-12 isomers. Carcinogenesis 2004, 25, 1185–1191. [CrossRef] [PubMed]
54. Blankson, H.; Stakkestad, J.A.; Fagertun, H.; Thom, E.; Wadstein, J.; Gudmundsen, O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J. Nutr. 2000, 130, 2943–2948. [PubMed]
55. Gaullier, J.M.; Halse, J.; Høye, K.; Kristiansen, K.; Fagertun, H.; Vik, H.; Gudmundsen, O. Conjugated linoleic acid supplementation for 1 year reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 2004, 79, 1118–1125. [PubMed]
56. Laso, N.; Brugué, E.; Vidal, J.; Ros, E.; Arnaiz, J.A.; Carné, X.; Vidal, S.; Mas, S.; Deulofeu, R.; Lafuente, A. Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome. Br. J. Nutr. 2007, 98, 860–867. [CrossRef] [PubMed]
57. Whigham, L.D.; Watras, A.C.; Schoeller, D.A. Efficacy of conjugated linoleic acid for reducing fat mass: A meta-analysis in humans. Am. J. Clin. Nutr. 2007, 85, 1203–1211. [PubMed]
58. Riserus, U.; Berglund, L.; Vessby, B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of metabolic syndrome: A randomized controlled trial. Int. J. Obes. 2001, 25, 1129–1135. [CrossRef] [PubMed]
59. Belury, M.A. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action 1. Annu. Rev. Nutr. 2002, 22, 505–531. [CrossRef] [PubMed]
60. Pariza, M.W.; Park, Y.; Cook, M.E. The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res. 2001, 40, 283–298. [CrossRef]
61. Gaullier, J.M.; Halse, J.; Høivik, H.O.; Høye, K.; Syvertsen, C.; Nurminiemi, M.; Hassfeld, C.; Einerhand, A.; O’Shea, M.; Gudmundsen, O. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br. J. Nutr. 2006, 97, 550–560. [CrossRef] [PubMed]
62. Barbosa, N.R.; Gama, M.A.S.; Lopes, F.C.F.; Defillipo, P.P.; Mury, F.B.; Trevisani, R.; Oliveira, D.E.; Gattaz, W.F. Activity of phospholipase A2 (PLA2) subtypes in rat brain is altered by feeding conjugated linoleic acid (CLA) and linseed oil. Alzheimers Dement. 2009, 5, 326. [CrossRef]
63. Gama, M.A.S.; Raposo, N.R.B.; Mury, F.B.; Lopes, F.C.F.; Dias-Neto, E.; Talib, L.L.; Gattaz, W.F. Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipase A2 encoding-genes in rat brain tissue. J. Neural Transm. 2015, 122, 1371–1380. [CrossRef] [PubMed]
64. Smit, L.A.; Katan, M.B.; Wanders, A.J.; Basu, S.; Brouwer, I.A. A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. J. Nutr. 2011, 141, 1673–1678. [CrossRef] [PubMed]
65. Wang, Y.W.; Jones, P.J.H. Conjugated linoleic acid and obesity control: Efficacy and mechanisms. Int. J. Obes. 2004, 28, 941–955. [CrossRef] [PubMed]
66. Bhattacharya, A.; Banu, J.; Rahman, M.; Causey, J.; Fernandes, G. Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 2006, 17, 789–810. [CrossRef] [PubMed]