Dopaminergic foundations of schizotypy as measured by the german version of the oxford-liverpool inventory of feelings and experiences (O-LIFE) -a suitable endophenotype of schizophrenia

Frontiers in Human Neuroscience

Volumn , Issue JAN, 2013, Pages

  Grant, Phillip ^a   Kuepper, Yvonne ^a   Mueller, Eva ^a   Wielpuetz, Catrin ^a   Mason, Oliver ^b   Hennig, Juergen ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Dopamine; Endophenotype; Genetic associations; O life; Psychosis; Schizophrenia; Schizotypy

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ASSESSMENT TOOL; COMT GENE; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRD2 GENE; ENDOPHENOTYPE; ETHNIC GROUP; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GERMAN; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; OXFORD LIVERPOOL INVENTORY OF FEELINGS AND EXPERIENCES; PHENOTYPIC VARIATION; PSYCHOMETRY; SCHIZOPHRENIA; SLC6A3 GENE; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 85087583261     PISSN: None     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00001     Document Type: Article

References (60)

1. Addington, J., Brooks, B.L., and Addington, D. (2003). Cognitive functioning in first episode psychosis: initial presentation. Schizophrenia Research 62, 59-64.
2. Allen, N.C., Bagade, S., Mcqueen, M.B., Ioannidis, J.P.A., Kavvoura, F.K., Khoury, M.J., Tanzi, R.E., and Bertram, L. (2008). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics 40, 827-834.
3. Armbruster, D., Mueller, A., Strobel, A., Lesch, K.-P., Kirschbaum, C., and Brocke, B. Variation in genes involved in dopamine clearance influence the startle response in older adults. Journal of Neural Transmission 118, 1281-1292.
4. Avramopoulos, D., Stefanis, N.C., Hantoumi, I., Smyrnis, N., Evdokimidis, I., and Stefanis, C.N. (2002). Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Molecular Psychiatry 7, 706-711.
5. Batey, M., and Furnham, A. (2008). The relationship between measures of creativity and schizotypy. Personality and Individual Differences 45, 816-821.
6. Bortolato, M., Chen, K., Godar, S.C., Chen, G., Wu, W.H., Rebrin, I., Farrell, M.R., Scott, A.L., Wellman, C.L., and Shih, J.C. Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice. Neuropsychopharmacology 36, 2674-2688.
7. Caspi, A., Mcclay, J., Moffitt, T.E., Mill, J., Martin, J., Craig, I.W., Taylor, A., and Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science 297, 851-854.
8. Claridge, G. (1997). Theoretical background and issues, in Schizotypy: Implications for Illness and Health, ed. G. Claridge (Oxford, United Kingdom: Oxford University Press), 3-18.
9. Comings, D.E., and Macmurray, J.P. (2000). Molecular heterosis: A review. Molecular Genetics and Metabolism 71, 19-31.
10. Deckert, J., Catalano, M., Syagailo, Y.V., Bosi, M., Okladnova, O., Di Bella, D., Nothen, M.M., Maffei, P., Franke, P., Fritze, J., Maier, W., Propping, P., Beckmann, H., Bellodi, L., and Lesch, K.P. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics 8, 621-624.
11. Ettinger, U., Joober, R., De Guzman, R., and O'driscoll, G.A. (2006). Schizotypy, attention deficit hyperactivity disorder, and dopamine genes. Psychiatry and Clinical Neurosciences 60, 764-767.
12. Gottesman, I.I., and Gould, T.D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry 160, 636-645.
13. Graham, D.G. (1978). Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 14, 633-643.
14. Graham, D.G., Tiffany, S.M., Bell, W.R., Jr., and Gutknecht, W.F. (1978). Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol Pharmacol 14, 644-653.
15. Grant, P. (2011). Dopamine neurotoxicity, oxidative stress and schizophrenia -in vitro and in vivo studies of peroxisomal reactions to increased dopamine. Giessen, Univ., Diss., 2011. URN: urn:nbn:de:hebis:26-opus-84954.
16. Hamidovic, A., Dlugos, A., Skol, A., Palmer, A.A., and De Wit, H. (2009). Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants. Experimental and clinical psychopharmacology 17, 374-383.
17. Hauser, J., Kapelski, P., Czerski, P.M., Godlewski, S., Dmitrzak-Weglarz, M., Twardowska, K., and Rybakowski, J.K. (2002). [Lack of association between VNTR polymorphism of DAT gene and schizophrenia]. Psychiatria polska 36, 403-412.
18. Howes, O.D., and Kapur, S. (2009). The Dopamine Hypothesis of Schizophrenia: Version III -The Final Common Pathway. Schizophrenia Bulletin 35, 549-562.
19. Javali S.B., Gudaganavar, N.V. &J, S.M., (2011). Effect Of Varying Sample Size In Estimation Of Reliability Coefficients Of Internal Consistency. WebmedCentral BIOSTATISTICS 2011;2(2):WMC001572
20. Karoum, F., Chrapusta, S.J., and Egan, M.F. (1994). 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal-cortex-Reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontalcortex, nucelaus-accumbens, and striatum by a simple 2-pool model. Journal of Neurochemistry 63, 972-979.
21. Kirsch, P., Reuter, M., Mier, D., Lonsdorf, T., Stark, R., Gallhofer, B., Vaitl, D., and Hennig, J. (2006). Imaging gene-substance interactions: The effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward. Neuroscience Letters 405, 196-201.
22. Klein, T.A., Neumann, J., Reuter, M., Hennig, J., Von Cramon, D.Y., and Ullsperger, M. (2007). Genetically determined differences in learning from errors. Science 318, 1642-1645.
23. Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y.M., Szumlanski, C.L., and Weinshilboum, R.M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6, 243-250.
24. Lamb, B.C. (2010). The Queen's English and how to use it. Michael O'Mara Books Ltd.
25. Large, M.M., and Nielssen, O. (2011). Violence in first-episode psychosis: A systematic review and meta-analysis. Schizophrenia Research 125, 209-220.
26. Linney, Y.M., Murray, R.M., Peters, E.R., Macdonald, A.M., Rijsdijk, F., and Sham, P.C. (2003). A quantitative genetic analysis of schizotypal personality traits. Psychological Medicine 33, 803-816.
27. Lui, S., Deng, W., Huang, X.Q., Jiang, L.J., Ma, X.H., Chen, H.F., Zhang, T.J., Li, X.L., Li, D.M., Zou, L., Tang, H.H., Zhou, X.H.J., Mechelli, A., Collier, D.A., Sweeney, J.A., Li, T., and Gong, Q.Y. (2009). Association of Cerebral Deficits With Clinical Symptoms in Antipsychotic-Naive First-Episode Schizophrenia: An Optimized Voxel-Based Morphometry and Resting State Functional Connectivity Study. American Journal of Psychiatry 166, 196-205.
28. Ma, X., Sun, J., Yao, J., Wang, Q., Hu, X., Deng, W., Sun, X., Liu, X., Murray, R.M., Collier, D.A., and Li, T. (2007). A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population. Psychiatry Research 153, 7-15.
29. Maker, H.S., Weiss, C., Silides, D.J., and Cohen, G. (1981). Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates. J Neurochem 36, 589-593.
30. Mason, O., and Claridge, G. (2006). The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE): Further description and extended norms. Schizophrenia Research 82, 203-211.
31. Mason, O., Claridge, G., and Jackson, M. (1995). NEW SCALES FOR THE ASSESSMENT OF SCHIZOTYPY. Personality and Individual Differences 18, 7-13.
32. Mason, O., Linney, Y., and Claridge, G. (2005). Short scales for measuring schizotypy. Schizophrenia Research 78, 293-296.
33. Meehl, P.E. (1962). Schizotaxia, Schizotypy, Schizophrenia. American Psychologist 17, 827-838.
34. Mueser, K.T., and Mcgurk, S.R. (2004). Schizophrenia. Lancet 363, 2063-2072.
35. Nettle, D. (2006). Schizotypy and mental health amongst poets, visual artists, and mathematicians. Journal of Research in Personality 40, 876-890.
36. Nieoullon, A. (2002). Dopamine and the regulation of cognition and attention. Progress in Neurobiology 67, 53-83.
37. Pohjalainen, T., Rinne, J.O., Nagren, K., Lehikoinen, P., Anttila, K., Syvalahti, E.K.G., and Hietale J. (1998). The A1 allele of the human D-2 dopamine receptor gene predicts low D-2 receptor availability in healthy volunteers. Molecular Psychiatry 3, 256-260.
38. Prata, D.P., Mechelli, A., Fu, C.H.Y., Picchioni, M., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R.M., Colliera, D.A., and Mcguire, P. (2009). Epistasis between the DAT 3 ' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 106, 13600-13605.
39. Rado, S. (1953). Dynamics and classification of disordered behavior. American Journal of Psychiatry 110, 406-416.
40. Raine, A. (1991). The SPQ -A Scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555-564.
41. Reuter, M., and Hennig, J. (2005). Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. Neuroreport 16, 1135-1138.
42. Rust, J. (1988). The Rust Inventory of Schizotypal Cognitions (RISC). Schizophrenia Bulletin 14, 317-322.
43. Sabol, S.Z., Hu, S., and Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics 103, 273-279.
44. Schurhoff, F., Szoke, A., Chevalier, F., Roy, I., Meary, A., Bellivier, F., Giros, B., and Leboyer, M. (2007). Schizotypal dimensions: An intermediate phenotype associated with the COMT high activity allele. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 144B, 64-68.
45. Sheldrick, A.J., Krug, A., Markov, V., Leube, D., Michel, T.M., Zerres, K., Eggermann, T., and Kircher, T. (2008). Effect of COMT val(158)met genotype on cognition and personality. European Psychiatry 23, 385-389.
46. Shippey, T. (2000). J.R.R. Tolkien -Author of the Century. New York: Houghton Mifflin Company.
47. Shippey, T. (2003). The Road to Middle-Earth -How J.R.R. Tolkien created a new mythology. New York: Houghton Mifflin Company.
48. Smyrnis, N., Avramopoulos, D., Evdokimidis, I., Stefanis, C.N., Tsekou, H., and Stefanis, N.C. (2007). Effect of schizotypy on cognitive performance and its tuning by COMT val(158) met genotype variations in a large population of young men. Biological Psychiatry 61, 845-853.
49. Smythies, J.R. (1997). Oxidative reactions and schizophrenia: A review-discussion. Schizophrenia Research 24, 357-364.
50. Smythies, J.R. (1999). The Neurotoxicity of Glutamate, Dopamine, Iron and Reactive Oxygen Species: Functional Interrelationships in Health and Disease: A Review -Discussion. Neurotoxicity Research 1, 27-39.
51. Suzuki, M., Zhou, S.Y., Hagino, H., Niu, L., Takahashi, T., Kawasaki, Y., Matsui, M., Seto, H., Ono, T., and Kurachi, M. (2005). Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia: a MRI study. Psychological Medicine 35, 549-560.
52. Ustun, T.B. (1999). The global burden of mental disorders. American Journal of Public Health 89, 1315-1318.
53. Van Os, J., and Kapur, S. (2009). Schizophrenia. Lancet 374, 635-645.
54. Van Os, J., Kenis, G., and Rutten, B.P. (2010). The environment and schizophrenia. Nature 468, 203-212.
55. Vandenbergh, D.J., Persico, A.M., Hawkins, A.L., Griffin, C.A., Li, X., Jabs, E.W., and Uhl, G.R. (1992). Human dopamine transporter gene (DAT1) maps to chromosome-5p15.3 and displays a VNTR. Genomics 14, 1104-1106.
56. Vinogradov, S. (2003). Book Review on Sharma, T. & Harvey, P. (Eds.) (2000). Cognition in Schizophrenia -Impairments, Importance, and Treatment Strategies. Am J Psychiatry, 160 (2): 404-405.
57. Who (2008). "The Global Burden of Disease -2004 Update".
58. Woodberry, K.A., Giuliano, A.J., and Seidman, L.J. (2008). Premorbid IQ in schizophrenia: a meta-analytic review. Am J Psychiatry 165, 579-587.
59. Yang, J.W., Lee, S.H., Ryu, S.H., Lee, B.C., Kim, S.H., Joe, S.H., Jung, I.K., Choi, I.G., and Ham, B.J. (2007). Association between monoamine oxidase a Polymorphisms and anger-related personality traits in Korean women. Neuropsychobiology 56, 19-23.
60. Yu, Q. (2012). Developmental Monoamine Signaling Impacts Adult Affective and Aggressive behaviors. Doctoral Thesis: Columbia University.