Effect of COMT val158met genotype on cognition and personality

European Psychiatry

Volumn 23, Issue 6, 2008, Pages 385-389

  Sheldrick, A J ^a   Krug, A ^a   Markov, V ^a   Leube, D ^a   Michel, T M ^a   Zerres, K ^a   Eggermann, T ^a   Kircher, T ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cognition; COMT; Personality; Schizophrenia

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ALLELE; ARTICLE; CASE REPORT; COGNITION; DISORIENTATION; DNA POLYMORPHISM; EDUCATION; FEMALE; FUNCTION TEST; GENOTYPE; HUMAN; MALE; NORMAL HUMAN; PERFORMANCE; PERSONALITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; CHARACTER; GENE FREQUENCY; GENETICS; HETEROZYGOTE DETECTION; INDIVIDUALITY; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PERSONALITY TEST; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; SCHIZOTYPAL PERSONALITY DISORDER; SHORT TERM MEMORY; SINGLE NUCLEOTIDE POLYMORPHISM; STUDENT;

ADULT; ALLELES; CATECHOL O-METHYLTRANSFERASE; CHARACTER; DOPAMINE; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; INDIVIDUALITY; MALE; MEMORY, SHORT-TERM; METHIONINE; NEUROPSYCHOLOGICAL TESTS; PERSONALITY INVENTORY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; SCHIZOTYPAL PERSONALITY DISORDER; STUDENTS; VALINE; YOUNG ADULT;

EID: 51249102126     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2008.05.002     Document Type: Article

References (44)

1. Aquilera M., Barrantes-Vidal N., Arias B., Moya J., Villa H., Ibáñez M.I., et al. Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population. Am J Med Genet B Neuropsychiatr Genet (2008)
2. Badner J.A., and Gershon E.S. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7 (2002) 405-411
3. Barnett J.H., Jones P.B., Robbins T.W., and Müller U. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 12 (2007) 502-509
4. Bertocci B., Miggiano V., Da Prada M., Dembic Z., Lahm H.W., and Herbe P. Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. Neurobiology 88 (1991) 1416-1420
5. Bilder R.M., Volavka J., Lachman H.M., and Grace A.A. The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 29 (2004) 1943-1961
6. Bilder R.M., Volavka J., Czobor P., Malhotra A.K., Kennedy J.L., Ni X., et al. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52 (2002) 701-707
7. Breier A., Kestler L., Adler C., Elman I., Wiesenfeld N., Malhotra A., et al. Dopamine D2 receptor density and personal detachment in healthy subjects. Am J Psychiatry 155 (1998) 1440-1442
8. Brickenkamp R. Der Aufmerksamkeits-Belastungstest d2 (2002), Hogrefe, Göttingen
9. Bruder G.E., Keilp J.G., Xu H., Shikhman M., Schori E., Gorman J.M., et al. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58 (2005) 901-907
10. Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem S., et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects of mRNA, protein and enzyme activity in postmortem human brain. Am J Hum Genet 75 (2004) 807-821
11. Costa P.T., and McCrae R.R. Revised NEO personality inventory (NEO PI-R) and NEO Five Factor Inventory. Professional Manual (1992), Psychological Assessement Resources, Odessa, Fl.
12. Daum I., Graber S., Schugens M.M., and Mayes A.R. Memory dysfunction of the frontal type in normal ageing. Neuroreport 7 (1996) 2625-2628
13. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., et al. Effect of COMT Val(108/158) Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98 (2001) 6917-6922
14. Ehlis A.C., Reif A., Herrmann M.J., Lesch K.P., and Fallgatter A.J. Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders. Neuropsychopharmacology 32 (2007) 162-170
15. Ettinger U., Kumari V., Collier D.A., Powell J., Luzi S., Michel T.M., et al. Catechol-O-methyltransferase (COMT) Val158Met genotype is associated with BOLD response as a function of task characteristic. Neuropsychopharmacology (2008) Advance online publication
16. Gold J.M., Carpenter C., Randolph C., Goldberg T.E., and Weinberger D.R. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 54 (1997) 159-165
17. Goldberg T.E., Egan M.F., Gscheidle T., Coppola R., Weickert T., Kolachana B.S., et al. Executive subprocesses in working memory: relationship of catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60 (2003) 889-896
18. Härting C., Markowitsch H.J., Neufeld H., Calabrese P., and Deisinger K. Wechlser Gedächtnis Test - Revidierte Fassung (2002), Hogrefe, Göttingen
19. Ho B.-C., Wassink T.H., O'Leary D.S., Sheffield V.C., and Andreasen N.C. Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Mol Psychiatry 10 (2005) 287-298
20. Joober R., Rouleau G.A., Lal S., Dixon M., ÓDriscoll G., Palmour R., et al. Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteers. Schizophr Res 53 (2002) 229-238
21. Laakso A., Vilkman H., Kajander J., Bergman J., Paranta M., Solin O., et al. Prediction of detached personality in healthy subjects by low dopamine transporter binding. Am J Psychiatry 157 (2000) 290-292
22. Laakso A., Wallius E., Kajander J., Bergman J., Eskola O., Solin O., et al. Personality traits and striatal dopamine synthesis capacity in healthy subjects. Am J Psychiatry 160 (2003) 904-910
23. Lachman H.M., Papolos D.F., Saito T., Yu Y.M., Szumlanski C.L., and Weinshilboum R.M. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychological disorders. Pharmacogenetics 6 (1996) 243-250
24. Lehrl S. Der Mehrfachwahl-Wortschatz-Intelligenztest (2005), Hogrefe
25. Lotta T., Vidgren J., Tilgmann C., Ulmanen I., Melén K., Julkunen I., et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34 (1995) 4202-4210
26. Ma X., Sun J., Yao J., Wang Q., Hu X., Deng W., et al. A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population. Psychiatry Res 153 (2007) 7-15
27. Malhotra A.K., Kestler L.J., Mazzanti C., Bates J.A., Goldberg T., and Goldman D.A. Functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 59 (1992) 652-654
28. Minzenberg M.J., Xu K., Mitropoulou V., Harvey P.D., Finch T., Flory J.D., et al. Catechol-O-methyltransferase VaI(158)Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. Psychiatr Genet 16 (2006) 117-124
29. Morón J.A., Brockington A., Wise R., Rocha B.A., and Hope B.T. Dopamine uptake through the Norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 22 (2001) 389-395
30. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9 (1971) 97-113
31. Palmatier M.A., Kang M., and Kidd K.K. Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol Psychiatry 46 (1999) 567
32. Pooley E.C., Fineberg N., and Harrison P.J. The met158 allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Mol Psychiatry 12 (2007) 556-561
33. Raine A. The SPQ: a scale for the assessment of schizotypical personality based on DSM-III-R criteria. Schizophr Bull 17 (1991) 556-564
34. Reitan R.M., and Wolfson D. The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation (1985), Neuropsychology Press, Tucson
35. Rosa A., Peralta V., Cuesta M.J., Zarzuela A., Serrano F., Martínez-Larrea A., et al. New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. Am J Psychiatry 161 (2004) 1110-1112
36. Schneier F.R., Liebowitz M.R., Abi-Dargham A., Zea-Ponce Y., Lin S.-H., and Laruelle M. Low dopamine D2 receptor binding potential in social phobia. Am J Psychiatry 157 (2000) 457-459
37. Schürhoff F., Szöke A., Chevalier F., Roy I., Méary A., Bellivier F., et al. Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele. Am J Med Genet B Neuropsychiatr Genet 144B (2007) 64-68
38. Stefanis N.C., Van Os J., Avramopoulos D., Smyrnis N., Evdokimidis I., Hantoumi I., et al. Variation in catechol-O-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biol Psychiatry 56 (2004) 510-515
39. Stefanis N.C., Van Os J., Avramopoulos D., Smyrnis N., Evdokimidis I., and Stefanis C.N. Effect of COMT Val158Met polymorphism on the continuous performance test, identical pairs version: tuning rather than improving performance. Am J Psychiatry 162 (2005) 1752-1754
40. Suhara T., Yasuno F., Sudo Y., Yamamoto M., Inoue M., Okubo Y., et al. Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking. Neuroimage 13 (2001) 891-895
41. Tan H.Y., Chen Q., Goldberg T.E., Mattay V.S., Meyer-Lindenberg A., Weinberger D.R., et al. Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J Neurosci 27 (2007) 13393-13401
42. Wechsler D. Wechsler memory scale: administration and scoring manual. 3rd ed. (1997), The Psychological Corporation: Harcourt Brace & Co, San Antonio
43. Weinshilboum R.M., Otterness D.M., and Szumlanski C.L. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol 39 (1999) 19-52
44. World Health Organization. The ICD-10 classification of mental and behavioural disorders. Diagnostic criteria for research (1993), WHO, Geneva