Schizotypal dimensions: An intermediate phenotype associated with the COMT high activity allele

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 144, Issue 1, 2007, Pages 64-68

  Schürhoff, Franck ^a,b,c   Szöke, Andrei ^a,b   Chevalier, Fabien ^b   Roy, Isabelle ^a,b   Méary, Alexandre ^a,b   Bellivier, Frank ^a,b   Giros, Bruno ^b   Leboyer, Marion ^a,b  

^a HENRI MONDOR HOSPITAL   (France)

^b INSERM   (France)

^c Hopital Albert Chenevier   (France)

Author keywords

Association study; COMT; Dimensions; Schizotypal

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER;

ADULT; ALLELES; BASE SEQUENCE; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; DNA; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PERSONALITY INVENTORY; PHENOTYPE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER;

EID: 33846326875     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30395     Document Type: Article

References (58)

1. Akil M, Kolachana S, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE. 2003. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23:2008-2013.
2. Andreasen NC. 1995. Symptoms of schizophrenia. Methods, meanings and mechanisms. Arch Gen Psychiatry 52:352-360.
3. Arndt S, Alliger RJ, Andreasen NC. 1991. The distinction of positive and negative symptoms. The failure of a two-dimensional model. Br J Psychiatry 158:317-322.
4. Avramopoulos D, Stefanis NC, Hantoumi I, Smyrnis N, Evdokimidis I, Stefanis CN. 2002. Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Mol Psychiatry 7:706-711.
5. Battaglia M, Cavallini MC, Macciardi F, Bellodi L. 1997. The structure of the DSM-III-R schizotypal personality disorder diagnosed by direct interviews. Schizophr Bull 23:83-92.
6. Bech P, Rafaelsen OJ, Kramp P, Bolwig TG. 1978. The Mania Rating Scale: scale construction and inter-observer agreement. Neuropharmacology 17:430-431.
7. Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X, Goldman RS, Hoptman MJ, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, Kunz M, Chakos M, Cooper TB, Lieberman JA. 2002. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52:701-707.
8. Bruder GE, Keilp JG, Xu H, Shikhman M, Schori E, German JM, Gilliam TC. 2005. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58:901-907.
9. Cadenhead KS, Braff DL. 2002. Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum. Schizophr Res 54: 869-871.
10. Carter CS, Perlstein W, Ganguli R, Brar J, Mintum M, Cohen JD. 1998. Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 155:1285-1287.
11. Coon H, Jensen S, Holik J, Hoff M, Myles-Worsley M, Reimherr F, Wender P, Waldo M, Freedman R, Leppert M. 1994. Genomic scan for genes predisposing to schizophrenia. Am J Med Genet (Neuropsychiatr Genet) 54:59-71.
12. Dumas P, Bouafia S, Gutknecht C, Saoud M, Dalery J, d'Amato T. 2000. Validation of the French version of the Raine Schizotypal Personality Disorder Questionnaire-categorical and dimensional approach to schizotypal personality traits in a normal student population. Encephale 26:42-46.
13. Dunham I, Collins J, Wadey R, Scambler P. 1992. Possible role for COMT in psychosis associated with velo-cardio-facial syndrome. Lancet 340: 1361-1362.
14. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad sci USA 49:129-143.
15. Fanous AH, Kendler KS. 2004. The genetic relationship of personality to major depression and schizophrenia. Neurotox Res 6:43-50.
16. Fanous AH, Kendler KS. 2005. Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. Mol Psychiatry 10:6-13.
17. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. 1998. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 95:9991-9996.
18. Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, Kwon H, Jin S, Jo B, Antonarakis SE, Morris MA, Reiss AL. 2005. COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nature Neurosci 8:1500-1502.
19. Gruzelier JH. 1996. The factorial structure of schizotypy, part I: affinities with syndromes of schizophrenia. Schizophr Bull 22:611-620.
20. Huatori M, Santha M, Lucas LR, Karayiorgou M, Gogos JA, Mannisto PT. 2002a Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther 303:1309-1316.
21. Huotari M, Gogos JA, Karayiorgou M, Koponen O, Forsberg M, Raasmaja A, Hyttinen J, Mannisto PT. 2002b Brain catecholamine metabolism in catechol-O-methyltransferase COMT)-deficient mice. Eur J Neurosci 15:246-256.
22. Joober R, Gauthier J, Lal S, Bloom D, Lalonde P, Rouleau G, Benkelfat C, Labelle A. 2002. Catechol-O-methyltransferase Val-108/158 Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry 59:662-663.
23. Kety SS, Wender PH, Jacobsen B, Ingraham LJ, Jansson L, Faber B, Kinney DK. 1994. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Arch Gen Psychiatry 51:442-455.
24. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. 1996. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243-250.
25. Lachman HM, Nolan KA, Mohr P, Saito T, Volavka J. 1998. Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 155:835-837.
26. T, Vallada H, Curtis D, Arranz M, Xu K, Cai G, Deng H, Liu J, Murray R, Liu X, Collier DA. 1997. Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder. Pharmacogenetics 7:349-353.
27. YH, Wirth T, Huotari M, Laitinen K, MacDonald E, Mannisto PT. 1998. No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats. Eur J Pharmacol 356:127-137.
28. Liddle PF. 1987. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry 151:145-151.
29. Liddle PF, Barnes TR. 1990. Syndromes of chronic schizophrenia. Br J Psychiatry 157:558-561.
30. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschorn JN. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182.
31. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J. 1995. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34:4202-4210.
32. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D. 2002. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159:652-654.
33. Maxwell ME. 1992. Family interview for genetic studies. Clinical Neurogenetic Branch, Intramural Research Program, NIMH, USA.
34. Meyer-Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF. 2002. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci 5:267-271.
35. Montgomery SA, Åsberg M. 1979. A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382-389.
36. Murphy BM, Burke JG, Bray JC, Walsh D, Kendler KS. 1994. An analysis of the clinical features of familial schizophrenia. Acta Psychiatr Scand 89:421-427.
37. Murphy KC, Jones LA, Owen MJ. 1999. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 56:940-945.
38. Mynett-Johnson LA, Murphy VE, Claffey E, Shields DC, McKeon P. 1998. Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene. Psychiatr Genet 8:221-225.
39. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T. 1994. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51:849-859.
40. Preisig M, Fenton BT, Matthey ML, Berney A, Ferrero F. 2000. Diagnostic interview for genetic studies DIGS): inter-rater and test-retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 249:174-179.
41. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonorakis S, Housman D, Kazazian HH, Meyers D. 1994a. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22Q12-q13.1. Am J Med Genet (Neuropsychiatr Genet) 54:36-43.
42. Pulver AE, Nestadt G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyniec PS, Morrow B, Karayiorgou M, Antonarakis SE, Housman D. 1994b. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 182:476-478.
43. Raine A. 1991. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 17:555-564.
44. Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D. 1994. Cognitive-perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophr Bull 20:191-201.
45. Reynolds CA, Raine A, Mellingen K, Venables PH, Mednick SA. 2000. Three-factor model of schizotypal personality: invariance across culture, gender, religious affiliation, family adversity, and psychopathology. Schizophr Bull 26:603-618.
46. Rosa A, Peralta V, Cuesta JV, Zarzuela A, Serrano F, Martinez-Larrea A, Fananas L. 2004. New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. Am J Psychiatry 161:1110-1112.
47. Schürhoff F, Laguerre A, Szöke A, Méary A, Leboyer M. 2005. Schizotypal dimensions: continuity between schizophrenia and bipolar disorders. Schizophr Res 80:235-242.
48. Schwab SG, Wildenauer DB. 1999. Chromosome 22 workshop report. Am J Med Genet (Neuropsychiatr Genet) 88:276-278.
49. Shaw SH, Kelly M, Smith AB, Shields G, Hopkins PJ, Loftus J, Laval SH, Vita A, DeHert M, Cardon LR, Crow TJ, Sherrington R, DeLisi LE. 1998. A genome-wide search for schizophrenia susceptibility genes. Am J Med Genet (Neuropsychiatr Genet) 81:364-376.
50. Squires-Wheeler E, Skodol AE, Bassett A, Erlenmeyer-Kimling L. 1989. DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents. J Psychiatr Res 23:229-239.
51. Stefanis NC, Hanssen M, Smyrnis NK, Avramopoulos DA, Evdokimidis IK, Stefanis CN, Verdoux H, Van Os J. 2002. Evidence that the three dimensions of psychosis have a distribution in the general population. Psychol Med 32:347-358.
52. 158Met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biol Psychiatry 56:510-515.
53. Strous RD, Nolan KA, Lapidus R, Diaz L, Saito T, Lachman HM. 2003. Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study. Am J Med Genet Part B 120B:29-34.
54. Sugama S, Namihira T, Matsuoka R, Taira N, Eto Y, Maekawa K. 1999. Psychiatric inpatients and chromosome deletions within 22q11.2. J Neurol Neurosurg Psychiatry 67:803-806.
55. Vollema MG, Hoijtink H. 2000. The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional rasch models. Schizophr Bull 26:565-575.
56. Webb CT, Levinson DF. 1993. Schizotypal and paranoid personality disorder in the relatives of patients with schizophrenia and affective disorders: a review. Schizophr Res 11:81-92.
57. Weinberger DR, Berman KF, Zee RF. 1986. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. Regional blood flow evidence. Arch Gen Psychiatry 43:114-124.
58. Weinberger DR, Berman KF, Illowsky BP. 1988. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Arch Gen Psychiatry 45: 609-615.