Probiotics and prebiotics in preventing episodes of acute otitis media in high-risk children: A randomized, double-blind, placebo-controlled study

Pediatric Infectious Disease Journal

Volumn 32, Issue 8, 2013, Pages 810-814

  Cohen, Robert ^a,b   Martin, Elvira ^a   De La Rocque, France ^a   Thollot, Franck ^c   Pecquet, Sophie ^d   Werner, Andreas ^c   Boucherat, Michel ^a,b   Varon, Emmanuelle ^e   Bingen, Edouard ^c   Levy, Corinne ^a,b  

^a ACTIV Association Clinique et Therapeutique Infantile du Val de Marne   (France)

^b CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

^e HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

acute otitis media; children; prebiotics; probiotics

Indexed keywords

PLACEBO; PNEUMOCOCCUS VACCINE; PREBIOTIC AGENT; PROBIOTIC AGENT;

ABDOMINAL PAIN; ACUTE OTITIS MEDIA; ANOREXIA; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD DISEASE; CHRONIC DIARRHEA; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRY SKIN; FOLLOW UP; FRANCE; GASTROINTESTINAL DISEASE; HIGH RISK POPULATION; HUMAN; INCIDENCE; INFANT; LACTOBACILLUS RHAMNOSUS; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PEDIATRICIAN; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STREPTOCOCCUS SALIVARIUS; STREPTOCOCCUS THERMOPHILUS;

ACUTE DISEASE; BACTERIA; BACTERIAL INFECTIONS; CARRIER STATE; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; HUMANS; INCIDENCE; INFANT; NASOPHARYNX; OTITIS MEDIA; PNEUMOCOCCAL VACCINES; PREBIOTICS; PROBIOTICS; TREATMENT OUTCOME; VACCINES, CONJUGATE;

EID: 84880643709     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e31828df4f3     Document Type: Article

References (30)

1. Goossens H. Guillemot D, Ferech M, et al. National campaigns to improve antibiotic use. Eur J Clin Pharmacol. 2006;62:373-379.
2. Cohen R, Bingen E, Grimprel E, et al. Resistance to antibiotics: a new turning point not to be missed. Arch Pediatr. 2011;18:359-361.
3. Cohen R, Bingen E, Levy C, et al. Antibiotic resistance of pneumococci and H. influenzae isolated from the nasopharyngeal flora of children with acute otitis media between 2006 and 2010. Arch Pediatr. 2011;18:926-931.
4. Levy C, Thollot F, Corrard F, et al. Acute otitis media in ambulatory practice: epidemiological and clinical characteristics after 7 valent pneumococcal conjugate vaccine (PCV7) implementation. Arch Pediatr. 2011;18: 712-718.
5. Vergison A, Dagan R, Arguedas A, et al. Otitis media and its consequences: beyond the earache. Lancet Infect Dis. 2010;10:195-203.
6. Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2010;29:304-309.
7. Couloigner V, Levy C, François M, et al. Pathogens implicated in acute otitis media failures after 7-valent pneumococcal conjugate vaccine implementation in France: distribution, serotypes, and resistance levels. Pediatr Infect Dis J. 2012;31:154-158.
8. Arslanoglu S, Moro GE, Boehm G. Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J Nutr. 2007;137:2420-2424.
9. Hao Q, Lu Z, Dong BR, et al. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev. 2011;CD006895.
10. Hatakka K, Blomgren K, Pohjavuori S, et al. Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. Clin Nutr. 2007;26:314-321.
11. Hatakka K, Savilahti E, Pönkä A, et al. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ. 2001;322:1327.
12. Kumpu M, Kekkonen RA, Kautiainen H, et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2012;66:1020-1023.
13. Rautava S, Salminen S, Isolauri E. Specific probiotics in reducing the risk of acute infections in infancy-a randomised, double-blind, placebo-controlled study. Br J Nutr. 2009;101:1722-1726.
14. Sazawal S, Dhingra U, Hiremath G, et al. Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial. PLoS ONE. 2010;5:e12164.
15. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005;115:5-9.
16. Weichert S, Schroten H, Adam R. The role of prebiotics and probiotics in prevention and treatment of childhood infectious diseases. Pediatr Infect Dis J. 2012;31:856-862.
17. Shane AL, Cabana MD, Vidry S, et al. Guide to designing, conducting, publishing and communicating results of clinical studies involving probiotic applications in human participants. Gut Microbes. 2010;1:243-253.
18. Cohen R, Bingen E, Levy C, et al. Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France. BMC Infect Dis. 2012;12:52.
19. Cohen R, Levy C, Bingen E, et al. Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media. Pediatr Infect Dis J. 2012;31:297-301.
20. Cohen R, Levy C, Bonnet E, et al. Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France. Vaccine. 2010;28:6114-6121.
21. Cohen R, Levy C, Hentgen V, et al. Relationship between clinical signs and symptoms and nasopharyngeal flora in acute otitis media. Clin Microbiol Infect. 2006;12:679-682.
22. Cohen R, Levy C, de La Rocque F, et al. Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media. Pediatr Infect Dis J. 2006;25:1001-1007.
23. Paradise JL. On classifying otitis media as suppurative or nonsuppurative, with a suggested clinical schema. J Pediatr. 1987;111(6 Pt 1):948-951.
24. Greenberg D, Hoffman S, Leibovitz E, et al. Acute otitis media in children: association with day care centers-antibacterial resistance, treatment, and prevention. Paediatr Drugs. 2008;10:75-83.
25. Cohen R, Levy C, Boucherat M, et al. Five vs. ten days of antibiotic therapy for acute otitis media in young children. Pediatr Infect Dis J. 2000;19:458-463.
26. Varon E. Janoir C, Gutmann L. Centre National de Référence des Pneumocoques. Rapport d'activité 2009: Epidémiologie 2008. Available at: http://www.invs.sante.fr/content/download/4787/31587/version/1/ file/rapport-cnrp-2009.pdf. Accessed April 18, 2013.
27. Taipale T, Pienihakkinen K, Isolauri E, et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr. 2011;105:409-416.
28. Kukkonen K, Savilahti E, Haahtela T, et al. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics. 2008;122:8-12.
29. Eskola J, Kilpi T, Palmu A, et al.; Finnish Otitis Media Study Group. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med. 2001;344:403-409.
30. Maldonado J, Canabate F, Sempere L, et al. Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants. J Pediatr Gastroenterol Nutr. 2012;54:55-61.