Efficacy of a synbiotic supplementation in the prevention of common winter diseases in children: A randomized, double-blind, placebo-controlled pilot study

Therapeutic Advances in Respiratory Disease

Volumn 4, Issue 5, 2010, Pages 271-278

  Cazzola, Mario ^a   Pham Thi, Nhân ^b   Kerihuel, Jean Charles ^c   Durand, Henri ^d   Bohbot, Serge ^e  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Vertical   (France)

^d LALLEMAND SAS   (France)

^e Laboratoires URGO   (France)

Author keywords

Bifidobacterium; Lactobacillus; prebiotics; probiotics; respiratory tract and gastrointestinal infections; synbiotic

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; PLACEBO; PROBIOKID; SYNBIOTIC AGENT; UNCLASSIFIED DRUG;

ABSENTEEISM; ADENOIDECTOMY; ALLERGY; ANKLE EDEMA; ANKLE SPRAIN; ARTICLE; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM LONGUM INFANTIS; CHICKENPOX; CHILD; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DYSURIA; EAR NOSE THROAT DISEASE; ECZEMA; FEMALE; FLU LIKE SYNDROME; GASTROINTESTINAL DISEASE; HUMAN; LACTOBACILLUS HELVETICUS; LARYNGITIS; LEG PAIN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUCLEOTIDE SEQUENCE; OTITIS; OUTCOME ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; RISK REDUCTION; SORE THROAT; TREATMENT DURATION; WINTER;

BIFIDOBACTERIUM; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL DISEASES; HUMANS; LACTOBACILLUS HELVETICUS; MALE; PILOT PROJECTS; RESPIRATORY TRACT INFECTIONS; SEASONS; SYNBIOTICS; TREATMENT OUTCOME;

EID: 77957944262     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465810379010     Document Type: Article

References (23)

1. Autret, E., Dutertre, J.P., Barbier, P., Jonville, A.P., Pierre, F. and Berger, C. ( 1993) Parental opinions about biomedical research in children in Tours, France. Dev Pharmacol Ther 20: 64-71.
2. Boyle, R.J. and Tang, M.L. ( 2006) The role of probiotics in the management of allergic disease. Clin Exp Allergy 36: 568-576.
3. de Vrese, M. and Schrezenmeir, J. (2002) Probiotics and non-intestinal infectious conditions. Br J Nutr 88: 59-66.
4. de Vrese, M. and Schrezenmeir, J. ( 2008) Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 111: 1-66.
5. de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C. et al. (2006) Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. Vaccine 24: 6670-6674.
6. FAO/WHO ( 2002) Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. London, Ontario, Canada.
7. Forestier, C., Guelon, D., Cluytens, V., Gillart, T., Sirot, J. and De Champs, C. ( 2008) Oral probiotic and prevention of Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study in intensive care unit patients. Crit Care 12: R69.
8. Goldin, B.R. and Gorbach, S.L. ( 2008) Clinical indications for probiotics: an overview. Clin Infect Dis 46(Suppl 2): S96-S100.
9. Hatakka, K., Savilahti, E., Pönkå, A., Meurman, J.H., Poussa, T., Nåse, L. et al. (2001) Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322: 1327.
10. Kukkonen, K., Savilahti, E., Haahtela, T., Juntunen-Backman, K., Korpela, R., Poussa, T. et al. (2008) Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 122: 8-12.
11. Leyer, G.J., Li, S., Mubasher, M.E., Reifer, C. and Ouwehand, A.C. (2009) Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics 124: e172-e179.
12. Loscalzo, J. ( 2009) Pilot trials in clinical research: of ne what value are they? Circulation 119: 1694-1696.
13. Minocha, A. ( 2009) Probiotics for preventive health. Nutr Clin Pract 24: 227-241.
14. Naser, S.M., Hagen, K.E., Vancanneyt, M., Cleenwerck, I., Swings, J. and Tompkins, T.A. ( 2005) Lactobacillus suntoryeus Cachat and Priest 2005 is a later synonym of Lactobacillus helveticus (Orla-Jensen 1919) Bergey et al. 1925 (Approved Lists 1980). Int J Syst Evol Microbiol 56: 355-360.
15. Ng, S.C., Hart, A.L., Kamm, M.A., Stagg, A.J. and Knight, S.C. (2009) Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis 15: 300-310.
16. Pregliasco, F., Anselmi, G., Fonte, L., Giussani, F., Schieppati, S. and Soletti, L. ( 2008) A new chance of preventing winter diseases by the administration of synbiotic formulations. J Clin Gastroenterol 42(Suppl 3): S224-S233.
17. Roberfroid, M. ( 2007) Prebiotics: the concept revisited. J Nutr 137(3 Suppl 2): 830S-837S.
18. Schultz, M. and Sartor, R.B. ( 2000) Probiotics and inflammatory bowel diseases. Am J Gastroenterol 95(1 Suppl.): S19-S21.
19. Siempos, I.I., Ntaidou, T.K. and Falagas, M.E. (2010) Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med 38: 954-962.
20. Szajewska, H. and Mrukowicz, J.Z. ( 2001) Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr 33(Suppl 2): S17-S25.
21. Turchet, P., Laurenzano, M., Auboiron, S. and Antoine, J.M. ( 2003) Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J Nutr Health Aging 7: 75-77.
22. Van Niel, C.W. ( 2005) Probiotics: not just for treatment anymore. Pediatrics 115: 174-177.
23. Vouloumanou, E.K., Makris, G.C., Karageorgopoulos, D.E. and Falagas, M.E. (2009) Probiotics for the prevention of respiratory tract infections: a systematic review. Int J Antimicrob Agents 34: 197, e1-e10.