-
1
-
-
85019072998
-
Sodium-glucose co-transporters and their inhibition: Clinical physiology
-
Ferrannini E. Sodium-glucose co-transporters and their inhibition: clinical physiology. Cell Metab 2017;26:27–38
-
(2017)
Cell Metab
, vol.26
, pp. 27-38
-
-
Ferrannini, E.1
-
2
-
-
85003855318
-
Renal, metabolic and cardiovascular considerations of SGLT2 inhibition
-
DeFronzo RA, Norton L, Abdul-Ghani M. Renal, metabolic and cardiovascular considerations of SGLT2 inhibition. Nat Rev Nephrol 2017;13: 11–26
-
(2017)
Nat Rev Nephrol
, vol.13
, pp. 11-26
-
-
DeFronzo, R.A.1
Norton, L.2
Abdul-Ghani, M.3
-
3
-
-
84961794343
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman B, Lachin JM, Inzucchi SE. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2016;374: 1094
-
(2016)
N Engl J Med
, vol.374
, pp. 1094
-
-
Zinman, B.1
Lachin, J.M.2
Inzucchi, S.E.3
-
4
-
-
85034766786
-
Canagliflozin and cardiovascular and renal events in type 2 diabetes
-
Neal B, Perkovic V, Mahaffey KW, et al.; CANVAS Program Collaborative Group. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 2017;377:644–657
-
(2017)
N Engl J Med
, vol.377
, pp. 644-657
-
-
Neal, B.1
Perkovic, V.2
Mahaffey, K.W.3
-
5
-
-
85060042753
-
Dapagliflozin and cardiovascular outcomes in type 2 diabetes
-
Wiviott SD, Raz I, Bonaca MP, et al.; DECLARE–TIMI 58 Investigators. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2019;380:347–357
-
(2019)
N Engl J Med
, vol.380
, pp. 347-357
-
-
Wiviott, S.D.1
Raz, I.2
Bonaca, M.P.3
-
6
-
-
85066483412
-
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
-
Perkovic V, Jardine MJ, Neal B, et al.; CREDENCE Trial Investigators. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 2019;380:2295–2306
-
(2019)
N Engl J Med
, vol.380
, pp. 2295-2306
-
-
Perkovic, V.1
Jardine, M.J.2
Neal, B.3
-
7
-
-
85009211714
-
The cardiovascular benefits of empagliflozin: SGLT2-dependent and -independent effects
-
Vettor R, Inzucchi SE, Fioretto P. The cardiovascular benefits of empagliflozin: SGLT2-dependent and -independent effects. Diabetologia 2017;60:395–398
-
(2017)
Diabetologia
, vol.60
, pp. 395-398
-
-
Vettor, R.1
Inzucchi, S.E.2
Fioretto, P.3
-
8
-
-
84975840750
-
Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
-
Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care 2016;39: 1115–1122
-
(2016)
Diabetes Care
, vol.39
, pp. 1115-1122
-
-
Mudaliar, S.1
Alloju, S.2
Henry, R.R.3
-
9
-
-
85041180129
-
How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial
-
Inzucchi SE, Zinman B, Fitchett D, et al. How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial. Diabetes Care 2018; 41:356–363
-
(2018)
Diabetes Care
, vol.41
, pp. 356-363
-
-
Inzucchi, S.E.1
Zinman, B.2
Fitchett, D.3
-
11
-
-
85059820907
-
An evolutionary perspective on immunometabolism
-
Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science 2019;363:363
-
(2019)
Science
, vol.363
, pp. 363
-
-
Wang, A.1
Luan, H.H.2
Medzhitov, R.3
-
12
-
-
85041099511
-
An integrated view of immunometabolism
-
Lee YS, Wollam J, Olefsky JM. An integrated view of immunometabolism. Cell 2018;172:22–40
-
(2018)
Cell
, vol.172
, pp. 22-40
-
-
Lee, Y.S.1
Wollam, J.2
Olefsky, J.M.3
-
13
-
-
20744440824
-
Size at birth as a predictor of mortality in adulthood: A follow-up of 350 000 person-years
-
Kajantie E, Osmond C, Barker DJ, Forsén T, Phillips DI, Eriksson JG. Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years. Int J Epidemiol 2005;34:655–663
-
(2005)
Int J Epidemiol
, vol.34
, pp. 655-663
-
-
Kajantie, E.1
Osmond, C.2
Barker, D.J.3
Forsén, T.4
Phillips, D.I.5
Eriksson, J.G.6
-
14
-
-
35948943083
-
Body size at birth predicts hypothalamic-pituitaryadrenal axis response to psychosocial stress at age 60 to 70 years
-
Kajantie E, Feldt K, Räikkönen K, et al. Body size at birth predicts hypothalamic-pituitaryadrenal axis response to psychosocial stress at age 60 to 70 years. J Clin Endocrinol Metab 2007; 92:4094–4100
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 4094-4100
-
-
Kajantie, E.1
Feldt, K.2
Räikkönen, K.3
-
15
-
-
0031732846
-
Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?
-
Phillips DI, Barker DJ, Fall CH, et al. Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab 1998;83: 757–760
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 757-760
-
-
Phillips, D.I.1
Barker, D.J.2
Fall, C.H.3
-
16
-
-
85064400399
-
Stress related disorders and risk of cardiovascular disease: Population based, sibling controlled cohort study
-
Song H, Fang F, Arnberg FK, et al. Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study. BMJ 2019;365:l1255
-
(2019)
BMJ
, vol.365
, pp. l1255
-
-
Song, H.1
Fang, F.2
Arnberg, F.K.3
-
17
-
-
84904023285
-
Chronic variable stress activates hematopoietic stem cells
-
Heidt T, Sager HB, Courties G, et al. Chronic variable stress activates hematopoietic stem cells. Nat Med 2014;20:754–758
-
(2014)
Nat Med
, vol.20
, pp. 754-758
-
-
Heidt, T.1
Sager, H.B.2
Courties, G.3
-
18
-
-
84975794191
-
Stress and A1c among people with diabetes across the lifespan
-
Hilliard ME, Yi-Frazier JP, Hessler D, Butler AM, Anderson BJ, Jaser S. Stress and A1c among people with diabetes across the lifespan. Curr Diab Rep 2016;16:67
-
(2016)
Curr Diab Rep
, vol.16
, pp. 67
-
-
Hilliard, M.E.1
Yi-Frazier, J.P.2
Hessler, D.3
Butler, A.M.4
Anderson, B.J.5
Jaser, S.6
-
19
-
-
84920509071
-
Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010
-
Livingstone SJ, Levin D, Looker HC, et al.; Scottish Diabetes Research Network epidemiology group; Scottish Renal Registry. Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010. JAMA 2015;313:37–44
-
(2015)
JAMA
, vol.313
, pp. 37-44
-
-
Livingstone, S.J.1
Levin, D.2
Looker, H.C.3
-
20
-
-
84921434054
-
Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: A modelling study
-
Grover SA, Kaouache M, Rempel P, et al. Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol 2015;3:114–122
-
(2015)
Lancet Diabetes Endocrinol
, vol.3
, pp. 114-122
-
-
Grover, S.A.1
Kaouache, M.2
Rempel, P.3
-
21
-
-
84926662295
-
Fertility is reduced in women and in men with type1 diabetes: Results from the Type1 Diabetes Genetics Consortium (T1DGC)
-
Wiebe JC, Santana A, Medina-Rodríguez N, et al.; T1DGC. Fertility is reduced in women and in men with type1 diabetes: Results from the Type1 Diabetes Genetics Consortium (T1DGC). Diabetologia 2014;57:2501–2504
-
(2014)
Diabetologia
, vol.57
, pp. 2501-2504
-
-
Wiebe, J.C.1
Santana, A.2
Medina-Rodríguez, N.3
-
22
-
-
15544377794
-
Molecular and evolutionary basis of the cellular stress response
-
Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 2005;67:225–257
-
(2005)
Annu Rev Physiol
, vol.67
, pp. 225-257
-
-
Kültz, D.1
-
23
-
-
84890923262
-
Differential white cell count and incident type 2 diabetes: The insulin resistance atherosclerosis study
-
Lorenzo C, Hanley AJ, Haffner SM. Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetologia 2014;57:83–92
-
(2014)
Diabetologia
, vol.57
, pp. 83-92
-
-
Lorenzo, C.1
Hanley, A.J.2
Haffner, S.M.3
-
24
-
-
84875224846
-
Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population
-
Fadini GP, Marcuzzo G, Marescotti MC, de Kreutzenberg SV, Avogaro A. Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population. Acta Diabetol 2012;49:445–451
-
(2012)
Acta Diabetol
, vol.49
, pp. 445-451
-
-
Fadini, G.P.1
Marcuzzo, G.2
Marescotti, M.C.3
De Kreutzenberg, S.V.4
Avogaro, A.5
-
25
-
-
0037145886
-
Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: A TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis in Myocardial Infarction 18 trial) substudy
-
Sabatine MS, Morrow DA, Cannon CP, et al. Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis in Myocardial Infarction 18 trial) substudy. J Am Coll Cardiol 2002;40:1761–1768
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 1761-1768
-
-
Sabatine, M.S.1
Morrow, D.A.2
Cannon, C.P.3
-
26
-
-
84865485915
-
Inflammation in atherosclerosis
-
Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 2012;32:2045–2051
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 2045-2051
-
-
Libby, P.1
-
27
-
-
85029568219
-
Antiinflammatory therapy with canakinumab for atherosclerotic disease
-
Ridker PM, Everett BM, Thuren T, et al.; CANTOS Trial Group. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 2017;377:1119–1131
-
(2017)
N Engl J Med
, vol.377
, pp. 1119-1131
-
-
Ridker, P.M.1
Everett, B.M.2
Thuren, T.3
-
28
-
-
56749106312
-
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
-
Ridker PM, Danielson E, Fonseca FA, et al.; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008;359:2195–2207
-
(2008)
N Engl J Med
, vol.359
, pp. 2195-2207
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.3
-
29
-
-
84863903383
-
Myocardial infarction accelerates atherosclerosis
-
Dutta P, Courties G, Wei Y, et al. Myocardial infarction accelerates atherosclerosis. Nature 2012;487:325–329
-
(2012)
Nature
, vol.487
, pp. 325-329
-
-
Dutta, P.1
Courties, G.2
Wei, Y.3
-
30
-
-
34247184208
-
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
-
Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell 2007; 18:1437–1446
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1437-1446
-
-
Wieman, H.L.1
Wofford, J.A.2
Rathmell, J.C.3
-
31
-
-
27744519400
-
Fuel feeds function: Energy metabolism and the T-cell response
-
Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 2005;5:844–852
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
32
-
-
84933039838
-
HIF-1a and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages
-
Tawakol A, Singh P, Mojena M, et al. HIF-1a and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages. Arterioscler Thromb Vasc Biol 2015;35:1463–1471
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 1463-1471
-
-
Tawakol, A.1
Singh, P.2
Mojena, M.3
-
33
-
-
85028940591
-
Macrophage metabolism in atherosclerosis
-
Bories GFP, Leitinger N. Macrophage metabolism in atherosclerosis. FEBS Lett 2017;591: 3042–3060
-
(2017)
FEBS Lett
, vol.591
, pp. 3042-3060
-
-
Bories, G.F.P.1
Leitinger, N.2
-
34
-
-
33644834463
-
Dormancy and the cell cycle
-
Campbell MA. Dormancy and the cell cycle. Genet Eng (N Y) 2006;27:21–33
-
(2006)
Genet Eng (N Y)
, vol.27
, pp. 21-33
-
-
Campbell, M.A.1
-
36
-
-
85006001577
-
The role of the p53 tumor suppressor in metabolism and diabetes
-
Kung CP, Murphy ME. The role of the p53 tumor suppressor in metabolism and diabetes. J Endocrinol 2016;231:R61–R75
-
(2016)
J Endocrinol
, vol.231
, pp. R61-R75
-
-
Kung, C.P.1
Murphy, M.E.2
-
38
-
-
0032475922
-
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
-
Chinetti G, Griglio S, Antonucci M, et al. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 1998;273:25573–25580
-
(1998)
J Biol Chem
, vol.273
, pp. 25573-25580
-
-
Chinetti, G.1
Griglio, S.2
Antonucci, M.3
-
39
-
-
85008190862
-
The role of fibroblast growth factor 21 in atherosclerosis
-
Kokkinos J, Tang S, Rye KA, Ong KL. The role of fibroblast growth factor 21 in atherosclerosis. Atherosclerosis 2017;257:259–265
-
(2017)
Atherosclerosis
, vol.257
, pp. 259-265
-
-
Kokkinos, J.1
Tang, S.2
Rye, K.A.3
Ong, K.L.4
-
40
-
-
85028940810
-
Fibroblast growth factor 21: A regulator of metabolic disease and health span
-
Xie T, Leung PS. Fibroblast growth factor 21: A regulator of metabolic disease and health span.Am J Physiol Endocrinol Metab 2017;313:E292–E302
-
(2017)
Am J Physiol Endocrinol Metab
, vol.313
, pp. E292-E302
-
-
Xie, T.1
Leung, P.S.2
-
41
-
-
85042340937
-
Fibroblast growth factor 21-metabolic role in mice and men
-
Staiger H, Keuper M, Berti L, Hrabe de Angelis M, Häring HU. Fibroblast growth factor 21-metabolic role in mice and men. Endocr Rev 2017;38:468–488
-
(2017)
Endocr Rev
, vol.38
, pp. 468-488
-
-
Staiger, H.1
Keuper, M.2
Berti, L.3
Hrabe De Angelis, M.4
Häring, H.U.5
-
42
-
-
85049567851
-
Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: A double-blind randomised placebo-controlled study
-
Eriksson JW, Lundkvist P, Jansson PA, et al. Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study. Diabetologia 2018;61: 1923–1934
-
(2018)
Diabetologia
, vol.61
, pp. 1923-1934
-
-
Eriksson, J.W.1
Lundkvist, P.2
Jansson, P.A.3
-
43
-
-
85020077721
-
SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice
-
Xu L, Nagata N, Nagashimada M, et al. SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice. EBioMedicine 2017;20:137–149
-
(2017)
EBioMedicine
, vol.20
, pp. 137-149
-
-
Xu, L.1
Nagata, N.2
Nagashimada, M.3
-
44
-
-
85062630085
-
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
-
Osataphan S, Macchi C, Singhal G, et al. SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. JCI Insight 2019;4:4
-
(2019)
JCI Insight
, vol.4
, pp. 4
-
-
Osataphan, S.1
Macchi, C.2
Singhal, G.3
-
45
-
-
85071711907
-
Effects of sodium-glucose cotransporter 2 inhibitor (dapagliflozin) on food intake and plasma fibroblast growth factor 21 levels in type 2 diabetes patients
-
Kosugi R, Nakatani E, Okamoto K, Aoshima S, Arai H, Inoue T. Effects of sodium-glucose cotransporter 2 inhibitor (dapagliflozin) on food intake and plasma fibroblast growth factor 21 levels in type 2 diabetes patients. Endocr J 2019;66:677–682
-
(2019)
Endocr J
, vol.66
, pp. 677-682
-
-
Kosugi, R.1
Nakatani, E.2
Okamoto, K.3
Aoshima, S.4
Arai, H.5
Inoue, T.6
-
46
-
-
0022137603
-
Ketone body metabolism in a ground squirrel during hibernation and fasting
-
Krilowicz BL. Ketone body metabolism in a ground squirrel during hibernation and fasting. Am J Physiol 1985;249:R462–R470
-
(1985)
Am J Physiol
, vol.249
, pp. R462-R470
-
-
Krilowicz, B.L.1
-
47
-
-
84977079490
-
Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes
-
Apostolopoulou M, Strassburger K, Herder C, et al.; GDS group. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes. Diabetologia 2016;59: 2203–2207
-
(2016)
Diabetologia
, vol.59
, pp. 2203-2207
-
-
Apostolopoulou, M.1
Strassburger, K.2
Herder, C.3
-
48
-
-
85044723157
-
Mechanisms in endocrinology: SGLT2 inhibitors: Clinical benefits by restoration of normal diurnal metabolism?
-
Esterline RL, Vaag A, Oscarsson J, Vora J. MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism? Eur J Endocrinol 2018;178: R113–R125
-
(2018)
Eur J Endocrinol
, vol.178
, pp. R113-R125
-
-
Esterline, R.L.1
Vaag, A.2
Oscarsson, J.3
Vora, J.4
-
49
-
-
85064242710
-
Metabolic regulation of cell growth and proliferation
-
Zhu J, Thompson CB. Metabolic regulation of cell growth and proliferation. Nat Rev Mol Cell Biol 2019;20:436–450
-
(2019)
Nat Rev Mol Cell Biol
, vol.20
, pp. 436-450
-
-
Zhu, J.1
Thompson, C.B.2
-
50
-
-
85019419837
-
MenTORing immunity: MTOR signaling in the development and function of tissue-resident immune cells
-
Jones RG, Pearce EJ. MenTORing immunity: mTOR signaling in the development and function of tissue-resident immune cells. Immunity 2017; 46:730–742
-
(2017)
Immunity
, vol.46
, pp. 730-742
-
-
Jones, R.G.1
Pearce, E.J.2
-
51
-
-
85060661231
-
Regulation of dendritic cell immune function and metabolism by cellular nutrient sensor mammalian target of rapamycin (mTOR)
-
Snyder JP, Amiel E. Regulation of dendritic cell immune function and metabolism by cellular nutrient sensor mammalian target of rapamycin (mTOR). Front Immunol 2019;9:3145
-
(2019)
Front Immunol
, vol.9
, pp. 3145
-
-
Snyder, J.P.1
Amiel, E.2
-
52
-
-
0036727448
-
The role of PPARs in atherosclerosis
-
Duval C, Chinetti G, Trottein F, Fruchart JC, Staels B. The role of PPARs in atherosclerosis. Trends Mol Med 2002;8:422–430
-
(2002)
Trends Mol Med
, vol.8
, pp. 422-430
-
-
Duval, C.1
Chinetti, G.2
Trottein, F.3
Fruchart, J.C.4
Staels, B.5
-
53
-
-
85069780185
-
Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice
-
Inoue MK, Matsunaga Y, Nakatsu Y, et al. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice. Diabetol Metab Syndr 2019;11:57
-
(2019)
Diabetol Metab Syndr
, vol.11
, pp. 57
-
-
Inoue, M.K.1
Matsunaga, Y.2
Nakatsu, Y.3
-
54
-
-
85064442920
-
Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic Male rats and enhances endothelium-dependent vasorelaxation
-
Sayour AA, Korkmaz-Icöz S, Loganathan S, et al. Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation. J Transl Med 2019;17:127
-
(2019)
J Transl Med
, vol.17
, pp. 127
-
-
Sayour, A.A.1
Korkmaz-Icöz, S.2
Loganathan, S.3
-
56
-
-
85072351470
-
Empagliflozin attenuates diabetic tubulopathy by improving mitochondrial fragmentation and autophagy
-
Lee YH, Kim SH, Kang JM, et al. Empagliflozin attenuates diabetic tubulopathy by improving mitochondrial fragmentation and autophagy. Am J Physiol Renal Physiol 2019;317:F767–F780
-
(2019)
Am J Physiol Renal Physiol
, vol.317
, pp. F767-F780
-
-
Lee, Y.H.1
Kim, S.H.2
Kang, J.M.3
-
57
-
-
84885476895
-
Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
-
Tahara A, Kurosaki E, Yokono M, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol 2013;715: 246–255
-
(2013)
Eur J Pharmacol
, vol.715
, pp. 246-255
-
-
Tahara, A.1
Kurosaki, E.2
Yokono, M.3
-
59
-
-
85045051294
-
Combined SGLT2 and DPP4 inhibition reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic nephropathy in mice with type 2 diabetes
-
Birnbaum Y, Bajaj M, Yang HC, Ye Y. Combined SGLT2 and DPP4 inhibition reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic nephropathy in mice with type 2 diabetes. Cardiovasc Drugs Ther 2018;32:135–145
-
(2018)
Cardiovasc Drugs Ther
, vol.32
, pp. 135-145
-
-
Birnbaum, Y.1
Bajaj, M.2
Yang, H.C.3
Ye, Y.4
-
60
-
-
84937635957
-
Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
-
Scheen AJ, Esser N, Paquot N. Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control. Diabetes Metab 2015;41: 183–194
-
(2015)
Diabetes Metab
, vol.41
, pp. 183-194
-
-
Scheen, A.J.1
Esser, N.2
Paquot, N.3
-
61
-
-
85052947600
-
Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?
-
Prattichizzo F, De Nigris V, Micheloni S, La Sala L, Ceriello A. Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component? Diabetes Obes Metab 2018;20:2515–2522
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 2515-2522
-
-
Prattichizzo, F.1
De Nigris, V.2
Micheloni, S.3
La Sala, L.4
Ceriello, A.5
-
62
-
-
85041840805
-
The sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents renal and liver disease in Western diet induced obesity mice
-
Wang D, Luo Y, Wang X, et al. The sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents renal and liver disease in Western diet induced obesity mice. Int J Mol Sci 2018;19:137
-
(2018)
Int J Mol Sci
, vol.19
, pp. 137
-
-
Wang, D.1
Luo, Y.2
Wang, X.3
-
63
-
-
85064608731
-
Canagliflozin reduces inflammation and fibrosis biomarkers: A potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease
-
Heerspink HJL, Perco P, Mulder S, et al. Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease. Diabetologia 2019;62: 1154–1166
-
(2019)
Diabetologia
, vol.62
, pp. 1154-1166
-
-
Heerspink, H.J.L.1
Perco, P.2
Mulder, S.3
-
64
-
-
85031924469
-
Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: A pilot study
-
Solini A, Giannini L, Seghieri M, et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol 2017;16:138
-
(2017)
Cardiovasc Diabetol
, vol.16
, pp. 138
-
-
Solini, A.1
Giannini, L.2
Seghieri, M.3
-
65
-
-
85046115890
-
SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut micro-biota in type 2 diabetic mice
-
Lee DM, Battson ML, Jarrell DK, et al. SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut micro-biota in type 2 diabetic mice. Cardiovasc Diabetol 2018;17:62
-
(2018)
Cardiovasc Diabetol
, vol.17
, pp. 62
-
-
Lee, D.M.1
Battson, M.L.2
Jarrell, D.K.3
-
66
-
-
85021710250
-
Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DE-FENCE study
-
Shigiyama F, Kumashiro N, Miyagi M, et al. Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DE-FENCE study. Cardiovasc Diabetol 2017;16:84
-
(2017)
Cardiovasc Diabetol
, vol.16
, pp. 84
-
-
Shigiyama, F.1
Kumashiro, N.2
Miyagi, M.3
-
67
-
-
85039943841
-
Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
-
Zhou H, Wang S, Zhu P, Hu S, Chen Y, Ren J. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission. Redox Biol 2018;15:335–346
-
(2018)
Redox Biol
, vol.15
, pp. 335-346
-
-
Zhou, H.1
Wang, S.2
Zhu, P.3
Hu, S.4
Chen, Y.5
Ren, J.6
-
68
-
-
85054466162
-
Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: The potential contribution to diabetes complications and cardiovascular disease
-
Bonnet F, Scheen AJ. Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease. Diabetes Metab 2018;44:457–464
-
(2018)
Diabetes Metab
, vol.44
, pp. 457-464
-
-
Bonnet, F.1
Scheen, A.J.2
-
69
-
-
85055821036
-
A reduced M1-like/M2-like ratio of macrophages in healthy a dipose tissue expansion during SGLT2 inhibition
-
Miyachi Y, Tsuchiya K, Shiba K, et al. A reduced M1-like/M2-like ratio of macrophages in healthy a dipose tissue expansion during SGLT2 inhibition. Sci Rep 2018;8:16113
-
(2018)
Sci Rep
, vol.8
, pp. 16113
-
-
Miyachi, Y.1
Tsuchiya, K.2
Shiba, K.3
-
70
-
-
77957881978
-
Blood cell dynamics during hibernation in the European Ground Squirrel
-
Bouma HR, Strijkstra AM, Boerema AS, et al. Blood cell dynamics during hibernation in the European Ground Squirrel. Vet Immunol Immunopathol 2010;136:319–323
-
(2010)
Vet Immunol Immunopathol
, vol.136
, pp. 319-323
-
-
Bouma, H.R.1
Strijkstra, A.M.2
Boerema, A.S.3
-
72
-
-
84988912446
-
Dapagliflozin as additional treatment to liraglutide and insulin in patients with type 1 diabetes
-
Kuhadiya ND, Ghanim H, Mehta A, et al. Dapagliflozin as additional treatment to liraglutide and insulin in patients with type 1 diabetes. J Clin Endocrinol Metab 2016;101:3506–3515
-
(2016)
J Clin Endocrinol Metab
, vol.101
, pp. 3506-3515
-
-
Kuhadiya, N.D.1
Ghanim, H.2
Mehta, A.3
-
73
-
-
84858076944
-
The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress
-
McPherson PA, McEneny J. The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress. J Physiol Biochem 2012;68:141–151
-
(2012)
J Physiol Biochem
, vol.68
, pp. 141-151
-
-
McPherson, P.A.1
McEneny, J.2
-
74
-
-
85029584029
-
Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry
-
Sawada Y, Izumida Y, Takeuchi Y, et al. Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. Biochem Bio-phys Res Commun 2017;493:40–45
-
(2017)
Biochem Bio-Phys Res Commun
, vol.493
, pp. 40-45
-
-
Sawada, Y.1
Izumida, Y.2
Takeuchi, Y.3
-
75
-
-
1042299789
-
The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
-
Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 2004;70:309–319
-
(2004)
Prostaglandins Leukot Essent Fatty Acids
, vol.70
, pp. 309-319
-
-
Veech, R.L.1
-
76
-
-
84969920622
-
Integrating physiology, behavior, and energetics: Biologging in a free-living arctic hibernator
-
Williams CT, Barnes BM, Buck CL. Integrating physiology, behavior, and energetics: biologging in a free-living arctic hibernator. Comp Biochem Physiol A Mol Integr Physiol 2016;202:53–62
-
(2016)
Comp Biochem Physiol A Mol Integr Physiol
, vol.202
, pp. 53-62
-
-
Williams, C.T.1
Barnes, B.M.2
Buck, C.L.3
-
77
-
-
84924356420
-
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
-
Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 2015;21:263–269
-
(2015)
Nat Med
, vol.21
, pp. 263-269
-
-
Youm, Y.H.1
Nguyen, K.Y.2
Grant, R.W.3
-
78
-
-
84862613541
-
GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy
-
Gambhir D, Ananth S, Veeranan-Karmegam R, et al. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 2012;53:2208–2217
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 2208-2217
-
-
Gambhir, D.1
Ananth, S.2
Veeranan-Karmegam, R.3
-
79
-
-
84960517126
-
Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in Male mice
-
Obata A, Kubota N, Kubota T, et al. Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in male mice. Endocrinology 2016;157:1029–1042
-
(2016)
Endocrinology
, vol.157
, pp. 1029-1042
-
-
Obata, A.1
Kubota, N.2
Kubota, T.3
-
80
-
-
0034724687
-
Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species
-
Cominacini L, Pasini AF, Garbin U, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 2000;275:12633–12638
-
(2000)
J Biol Chem
, vol.275
, pp. 12633-12638
-
-
Cominacini, L.1
Pasini, A.F.2
Garbin, U.3
-
81
-
-
2542460047
-
The oxidation hypothesis of atherogenesis: The role of oxidized phospholipids and HDL
-
Navab M, Ananthramaiah GM, Reddy ST, et al. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res 2004;45:993–1007
-
(2004)
J Lipid Res
, vol.45
, pp. 993-1007
-
-
Navab, M.1
Ananthramaiah, G.M.2
Reddy, S.T.3
-
82
-
-
0344874199
-
Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome
-
Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun JF. Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome. Diabetes Metab 2003;29:509–518
-
(2003)
Diabetes Metab
, vol.29
, pp. 509-518
-
-
Dumortier, M.1
Brandou, F.2
Perez-Martin, A.3
Fedou, C.4
Mercier, J.5
Brun, J.F.6
-
83
-
-
49649115590
-
Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
-
Trenell MI, Hollingsworth KG, Lim EL, Taylor R. Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes. Diabetes Care 2008;31:1644–1649
-
(2008)
Diabetes Care
, vol.31
, pp. 1644-1649
-
-
Trenell, M.I.1
Hollingsworth, K.G.2
Lim, E.L.3
Taylor, R.4
-
84
-
-
0033924298
-
Lipid metabolism in the elderly
-
Toth MJ, Tchernof A. Lipid metabolism in the elderly. Eur J Clin Nutr 2000;54(Suppl. 3):S121–S125
-
(2000)
Eur J Clin Nutr
, vol.54
, pp. S121-S125
-
-
Toth, M.J.1
Tchernof, A.2
-
85
-
-
84906319549
-
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
-
Huang SC, Everts B, Ivanova Y, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol 2014;15:846–855
-
(2014)
Nat Immunol
, vol.15
, pp. 846-855
-
-
Huang, S.C.1
Everts, B.2
Ivanova, Y.3
-
86
-
-
84929682990
-
Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation
-
Malandrino MI, Fucho R, Weber M, et al. Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation. Am J Physiol Endocrinol Metab 2015;308:E756–E769
-
(2015)
Am J Physiol Endocrinol Metab
, vol.308
, pp. E756-E769
-
-
Malandrino, M.I.1
Fucho, R.2
Weber, M.3
-
87
-
-
0023102937
-
Pancreatic hormones in the nonhibernating and hibernating golden mantled ground squirrel
-
Bauman WA, Meryn S, Florant GL. Pancreatic hormones in the nonhibernating and hibernating golden mantled ground squirrel. Comp Biochem Physiol A Comp Physiol 1987;86:241–244
-
(1987)
Comp Biochem Physiol A Comp Physiol
, vol.86
, pp. 241-244
-
-
Bauman, W.A.1
Meryn, S.2
Florant, G.L.3
-
88
-
-
0025371756
-
Seasonal changes in pancreatic insulin and glucagon in the little brown bat (Myotis lucifugus)
-
Bauman WA. Seasonal changes in pancreatic insulin and glucagon in the little brown bat (Myotis lucifugus). Pancreas 1990;5:342–346
-
(1990)
Pancreas
, vol.5
, pp. 342-346
-
-
Bauman, W.A.1
-
89
-
-
84997354438
-
Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus and skeletal muscle of mice
-
Naznin F, Sakoda H, Okada T, et al. Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus and skeletal muscle of mice. Eur J Pharmacol 2017;794:37–44
-
(2017)
Eur J Pharmacol
, vol.794
, pp. 37-44
-
-
Naznin, F.1
Sakoda, H.2
Okada, T.3
-
90
-
-
50949132040
-
Hypothalamic protein kinase C regulates glucose production
-
Ross R, Wang PY, Chari M, et al. Hypothalamic protein kinase C regulates glucose production. Diabetes 2008;57:2061–2065
-
(2008)
Diabetes
, vol.57
, pp. 2061-2065
-
-
Ross, R.1
Wang, P.Y.2
Chari, M.3
-
91
-
-
84960156656
-
Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction
-
Forreider B, Pozivilko D, Kawaji Q, Geng X, Ding Y. Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction. Prog Neurobiol 2017;157:174–187
-
(2017)
Prog Neurobiol
, vol.157
, pp. 174-187
-
-
Forreider, B.1
Pozivilko, D.2
Kawaji, Q.3
Geng, X.4
Ding, Y.5
-
92
-
-
0032772890
-
The kidney during hibernation and arousal from hibernation. A natural model of organ preservation during cold ischaemia and reperfusion
-
Zancanaro C, Malatesta M, Mannello F, Vogel P, Fakan S. The kidney during hibernation and arousal from hibernation. A natural model of organ preservation during cold ischaemia and reperfusion. Nephrol Dial Transplant 1999;14: 1982–1990
-
(1999)
Nephrol Dial Transplant
, vol.14
, pp. 1982-1990
-
-
Zancanaro, C.1
Malatesta, M.2
Mannello, F.3
Vogel, P.4
Fakan, S.5
-
93
-
-
84903461650
-
Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells
-
Suh HN, Lee YJ, Kim MO, Ryu JM, Han HJ. Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells. J Cell Physiol 2014;229:1557–1568
-
(2014)
J Cell Physiol
, vol.229
, pp. 1557-1568
-
-
Suh, H.N.1
Lee, Y.J.2
Kim, M.O.3
Ryu, J.M.4
Han, H.J.5
-
94
-
-
84884513093
-
Effects of short-term nutritional interventions on right ventricular function in healthy men
-
Widya RL, Hammer S, Boon MR, et al. Effects of short-term nutritional interventions on right ventricular function in healthy men. PLoS One 2013;8:e76406
-
(2013)
PLoS One
, vol.8
-
-
Widya, R.L.1
Hammer, S.2
Boon, M.R.3
-
95
-
-
84925302301
-
Soluble receptor for advanced glycation end products as a potential biomarker to predict weight loss and improvement of insulin sensitivity by a very low calorie diet of obese human subjects
-
Hagen I, Schulte DM, Müller N, et al. Soluble receptor for advanced glycation end products as a potential biomarker to predict weight loss and improvement of insulin sensitivity by a very low calorie diet of obese human subjects. Cytokine 2015;73:265–269
-
(2015)
Cytokine
, vol.73
, pp. 265-269
-
-
Hagen, I.1
Schulte, D.M.2
Müller, N.3
-
96
-
-
85070547149
-
Dietary intake regulates the circulating inflammatory monocyte pool
-
e17
-
Jordan S, Tung N, Casanova-Acebes M, et al. Dietary intake regulates the circulating inflammatory monocyte pool. Cell 2019;178:1102–1114.e17
-
(2019)
Cell
, vol.178
, pp. 1102-1114
-
-
Jordan, S.1
Tung, N.2
Casanova-Acebes, M.3
-
97
-
-
85055564428
-
Nutritional modulation of AMPK-impact upon metabolic-inflammation
-
Lyons CL, Roche HM. Nutritional modulation of AMPK-impact upon metabolic-inflammation. Int J Mol Sci 2018;19:3092
-
(2018)
Int J Mol Sci
, vol.19
, pp. 3092
-
-
Lyons, C.L.1
Roche, H.M.2
|