Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Journal of Medicinal Chemistry

Volumn 63, Issue 6, 2020, Pages 2789-2801

  Liu, Bin ^a   Trout, Robert E Lee ^a   Chu, Guo Hua ^a   Mcgarry, Daniel ^a   Jackson, Randy W ^a   Hamrick, Jodie C ^a   Daigle, Denis M ^a   Cusick, Susan M ^a   Pozzi, Cecilia ^b   De Luca, Filomena ^b   Benvenuti, Manuela ^b   Mangani, Stefano ^b   Docquier, Jean Denis ^b   Weiss, William J ^c   Pevear, Daniel C ^a   Xerri, Luigi ^a   Burns, Christopher J ^a  

^a VenatoRx Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 {TRANS 4 [(2 AMINOETHYL)AMINO]CYCLOHEXYL}ACETAMIDO) 2 HYDROXY 3,4 DIHYDRO 2H 1,2 BENZOXABORININE 8 CARBOXYLIC ACID; ANTIBIOTIC AGENT; AVIBACTAM; CARBAPENEM; CEFEPIME; CEPHALOSPORIN; CLAVULANIC ACID; MEROPENEM; TANIBORBACTAM; TAZOBACTAM; UNCLASSIFIED DRUG; VABORBACTAM; ANTIINFECTIVE AGENT; BETA LACTAMASE INHIBITOR; BORINIC ACID DERIVATIVE; CARBAPENEM DERIVATIVE; CARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CARBAPENEM RESISTANT PSEUDOMONAS AERUGINOSA; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; COMBINATION DRUG THERAPY; CONTROLLED STUDY; DRUG DESIGN; ENZYME INHIBITION; HYDROPHILICITY; HYDROPHOBICITY; IC50; IN VITRO STUDY; IN VIVO STUDY; LUNG INFECTION; MOUSE; NONHUMAN; STEREOSELECTIVITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; BACTERIUM; BETA-LACTAM RESISTANCE; CHEMISTRY; DRUG EFFECT; HUMAN; MOLECULAR MODEL; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; BETA-LACTAM RESISTANCE; BETA-LACTAMASE INHIBITORS; BORINIC ACIDS; CARBAPENEMS; CARBOXYLIC ACIDS; HUMANS; MICE; MODELS, MOLECULAR;

EID: 85077130672     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.9b01518     Document Type: Article

References (44)

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