Increasing prevalence of carbapenem-resistant Enterobacteriaceae and strategies to avert a looming crisis

Expert Review of Anti-Infective Therapy

Volumn 11, Issue 6, 2013, Pages 543-545

  Watkins, Richard R ^a,b   Bonomo, Robert A ^c  

^a AKRON GENERAL MEDICAL CENTER   (United States)

^b Northeastern Ohio Medical University   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

antibiotic resistance; antibiotic stewardship; carbapenemases; Klebsiella pneumoniae

Indexed keywords

AMINOGLYCOSIDE; AVIBACTAM; BAL 30072; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CARBAPENEMASE; CEPHALOSPORIN; COLISTIN; DORIPENEM; ERTAPENEM; FOSFOMYCIN; IMIPENEM; MALEIC ACID DERIVATIVE; ME 1071; MEROPENEM; METALLO BETA LACTAMASE; METHYLIDENE PENEM; MK 7655; NAB 7061; NAB 739; OXACILLINASE 48; PLAZOMICIN; POLYMYXIN; POLYMYXIN DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTIFICIAL VENTILATION; BACTERIAL GENE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CYSTITIS; DRUG EXPOSURE; DRUG USE; ENTEROBACTERIACEAE; GRAM NEGATIVE INFECTION; HEALTH CARE COST; HEALTHCARE ASSOCIATED INFECTION; HOSPITALIZATION; HUMAN; INFECTION; INTEGRON; INTESTINE FLORA; KLEBSIELLA PNEUMONIAE; LENGTH OF STAY; MECHANICAL VENTILATOR; NONHUMAN; PLASMID; PRESCRIPTION; PREVALENCE; PUBLIC HEALTH; REVIEW; RISK FACTOR; STEM CELL TRANSPLANTATION; TRANSPOSON;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; CARBAPENEMS; EARLY DIAGNOSIS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS;

EID: 84878850292     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.13.46     Document Type: Review

References (20)

1. Leverstein-van Hall MA, M Blok HE, T Donders AR, Paauw A, Fluit AC, Verhoef J. Multidrug resistance among Enterobacteriaceae is strongly associated with the presence of integrons and is independent of species or isolate origin. J. Infect. Dis. 187(2), 251-259 (2003).
2. Prabaker K, Weinstein RA. Trends in antimicrobial resistance in intensive care units in the United States. Curr. Opin. Crit. Care 17(5), 472-479 (2011).
3. Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin. Infect. Dis. 53(1), 60-67 (2011).
4. Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. Outcomes of carbapenemresistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control Hosp. Epidemiol. 29(12), 1099-1106 (2008).
5. Yigit H, Queenan AM, Anderson GJ et al. Novel carbapenem-hydrolyzing ?-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45(4), 1151-1161 (2001).
6. Centers for Disease Control and Prevention (CDC). Vital signs: carbapenem-resistant Enterobacteriaceae. MMWR Morb. Mortal Wkly. Rep. 62(9), 165-170 (2013).
7. van Duijn PJ, Dautzenberg MJ, Oostdijk EA. Recent trends in antibiotic resistance in European ICUs. Curr. Opin. Crit. Care 17(6), 658-665 (2011).
8. Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. Outcomes of carbapenemresistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control Hosp. Epidemiol. 29(12), 1099-1106 (2008).
9. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerging Infect. Dis. 17(10), 1791-1798 (2011).
10. van Duin D, Kaye KS, Neuner EA, Bonomo RA. Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn. Microbiol. Infect. Dis. 75(2), 115-120 (2013).
11. Patel G, Bonomo RA. 'Stormy waters ahead': global emergence of carbapenemases. Front. Microbiol. 4, 48 (2013).
12. Kochar S, Sheard T, Sharma R et al. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol. 30(5), 447-452 (2009).
13. Chitnis AS, Caruthers PS, Rao AK et al. Outbreak of carbapenem-resistant Enterobacteriaceae at a long-term acute care hospital: sustained reductions in transmission through active surveillance and targeted interventions. Infect. Control Hosp. Epidemiol. 33(10), 984-992 (2012).
14. Schwaber MJ, Lev B, Israeli A et al.; Israel Carbapenem-Resistant Enterobacteriaceae Working Group. Containment of a countrywide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin. Infect. Dis. 52(7), 848-855 (2011).
15. Girlich D, Poirel L, Nordmann P. Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J. Clin. Microbiol. 50(2), 477-479 (2012).
16. Mosca A, Miragliotta L, Del Prete R et al. Rapid and sensitive detection of blaKPC gene in clinical isolates of Klebsiella pneumoniae by a molecular real-time assay. Springerplus 2(1), 31 (2013).
17. Nordmann P, Poirel L, Dortet L. Rapid detection of carbapenemase- producing Enterobacteriaceae. Emerging Infect. Dis. 18(9), 1503-1507 (2012).
18. Endimiani A, Hujer AM, Hujer KM et al. Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type ?-lactamase genes in Gram-negative isolates. J. Clin. Microbiol. 48(7), 2618-2622 (2010).
19. Endimiani A, Hujer KM, Hujer AM, Sampath R, Ecker DJ, Bonomo RA. Rapid identification of blaKPC-possessing Enterobacteriaceae by PCR/electrospray ionization-mass spectrometry. J. Antimicrob. Chemother. 65(8), 1833-1834 (2010).
20. Baquero F, Coque TM, de la Cruz F. Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance. Antimicrob. Agents Chemother. 55(8), 3649-3660 (2011).