Modified chitosan hydrogels as drug delivery and tissue engineering systems: Present status and applications

Acta Pharmaceutica Sinica B

Volumn 2, Issue 5, 2012, Pages 439-449

  Giri, Tapan Kumar ^a   Thakur, Amrita ^a   Alexander, Amit ^a   Ajazuddin, ^a   Badwaik, Hemant ^a   Tripathi, Dulal Krishna ^a  

^a RUNGTA COLLEGE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

Author keywords

Drug delivery; Hydrogels; Modified chitosan; Oral delivery of protein; Tissue engineering

Indexed keywords

ACICLOVIR; AMOXICILLIN; BERBERINE; CARBOXYMETHYLCELLULOSE; CHITIN; CHITOSAN; CHLORHEXIDINE; CLARITHROMYCIN; CURCUMIN; DICLOFENAC; EUDRAGIT; GENIPIN; GLIPIZIDE; GLUCOSAMINE; INSULIN; LIDOCAINE; METRONIDAZOLE; N ACETYLGLUCOSAMINE; N,N' METHYLENEBISACRYLAMIDE; NANOPARTICLE; NIFEDIPINE; OFLOXACIN; OXYTETRACYCLINE; PACLITAXEL; POLYELECTROLYTE; SATRANIDAZOLE; TETRACYCLINE; THEOPHYLLINE; TIMOLOL MALEATE; UNINDEXED DRUG;

ANGIOGENESIS; CANDIDIASIS; CARBOHYDRATE ANALYSIS; CELL MOTILITY; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL BOND; CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HELICOBACTER INFECTION; HUMAN; HYDROGEL; IONIC STRENGTH; IONIZATION; LIVER FAILURE; NONHUMAN; PH; POLYMERIZATION; REACTION TIME; REVIEW; SKIN LEISHMANIASIS; TEMPERATURE SENSITIVITY; TISSUE ENGINEERING; TISSUE REGENERATION; UNSPECIFIED SIDE EFFECT;

EID: 85076867225     PISSN: 22113835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apsb.2012.07.004     Document Type: Review

References (76)

1. Han X, Liu HC, Wang D, Su F, E LL, Wu X Effects of injectable chitosan thermosensitive hydrogel on dog bone marrow stromal cells in vitro. Shanghai J Stomatol 2011, 20:113-118.
2. Tan YL, Liu CG Preparation and characterization of self-assembles nanoparticles based on folic acid modified carboxymethyl chitosan. J Mater Sci Mater Med 2011, 22:1213-1220.
3. Zhao L, Zhu L, Liu F, Liu C, Shan-Dan, Wang Q, et al. pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel. Int J Pharm 2011, 410:83-91.
4. Ranjha NM, Ayub G, Naseem S, Ansari MT Preparation and characterization of hybrid pH-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil. J Mater Sci Mater Med 2011, 21:2805-2816.
5. Crini G, Badot PM Application of chitosan, a natural aminopolysaccharide, for dye removal from aqueous solutions by adsorption processes using batch studies: a review of recent literature. Prog Polym Sci 2008, 33:399-447.
6. Sun P, Li P, Li YM, Wei Q, Tian LH pH-sensitive chitosan-tripolyphosphate hydrogel beads for controlled glipizide delivery. J Biomed Mater Res B Appl Biomater 2011, 97:175-183.
7. Sajeesh S, Bouchemal K, Marsaud V, Vauthier C, Sharma CP Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin. J Control Release 2010, 147:377-384.
8. 2+ recovery. Anal Chem Acta 2011, 687:193-200.
9. Kato Y, Onishi H, Machida M Application of chitin and chitosan derivatives in the pharmaceutical field. Curr Pharm Biotechnol 2003, 4:303-309.
10. Molinaro G, Leroux JC, Damans J, Adams A Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials. Biomaterials 2002, 23:2717-2722.
11. Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 2000, 21:2155-2161.
12. Sugimoto M, Morimoto M, Sashiwa H, Saimoto H, Shigemasa Y Preparation and characterization of water-soluble chitin and chitosan derivatives. Carbohydr Polym 1998, 36:49-59.
13. Jayakumar R, Prabaharan M, Reis RL, Mano JF Graft copolymerized chitosan-present status and application. Carbohydr Polym 2005, 62:142-158.
14. Krishna Rao KSV, Naidu BVK, Subha MCS, Sairam M, Aminabahvi TM Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohydr Polym 2006, 66:333-344.
15. Rokhade AP, Shelke NB, Patil SA, Aminabhavi TM Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil. J Microencapsul 2007, 24:274-288.
16. Lin Y, Chen Q, Luo H Preparation and characterization of N-(2-carboxybenzyl) chitosan as a potential pH-sensitive hydrogel for drug delivery. Carbohydr Res 2007, 342:87-95.
17. Mi FL, Sung HW, Shyu SS Drug release from chitosan-alginate complex beads reinforced by a naturally occurring crosslinking agent. Carbohydr Polym 2002, 48:61-72.
18. Silva SS, Motta A, Rodrigues MT, Pinheiro AF, Gomes ME, Mano MF, et al. Novel genipin-crosslinked chitosan/silk fibroin sponges for cartilage engineering strategies. Biomacromolecules 2008, 9:2764-2774.
19. Guo BL, Gao QY Preparation and properties of a pH/temperature-responsive carboxymethyl chitosan/poly(N-isopropylacrylamide) semi-IPN hydrogel for oral delivery of drugs. Carbohydr Res 2007, 342:2416-2422.
20. Risbud MV, Bhonde RR Polyacrylamide-chitosan hydrogels: in vitro biocompatibility and sustained antibiotic release studies. Drug Deliv 2000, 7:69-75.
21. Sajeesh S, Sharma CP Mucoadhesive hydrogel microparticles based on poly (methacrylic acid-vinyl pyrrolidone)-chitosan for oral drug delivery. Drug Deliv 2011, 18:227-235.
22. Buranachai T, Praphairaksit N, Muangsin N Chitosan/polyethylene glycol beads crosslinked with tripolyphosphate and gluteraldehyde for gastrointestinal drug delivery. AAPS PharmSciTech 2010, 11:1128-1137.
23. Lin YC, Yu DG, Yang MC pH-sensitive polyelectrolyte complex gel microspheres composed of chitosan/sodium tripolyphosphate/dextran sulfate: swelling kinetics and drug delivery properties. Colloids Surf B Biointerface 2005, 44:143-151.
24. Zhang H, Mardyani S, Chain WC, Kumacheva E Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules 2006, 7:1568-1572.
25. Pourjavadi A, Mahdavinia GR Superabsorbency, pH sensitivity and swelling kinetics of partially hydrolyzed chitosan-g-poly(acrylamide). Turk J Chem 2006, 30:595-608.
26. Chen Y, Tan H Crosslinked carboxymethylchitosan-g-poly(acrylic acid) copolymer as a novel superabsorbent polymer. Carbohydr Res 2006, 341:887-896.
27. You I, Hu FQ, Du YZ, Yuan H Polymeric micelles with glycolipid-like structure and multiple hydrophobic domains for mediating molecular target delivery of paclitaxel. Biomacromolecules 2007, 8:2450-2456.
28. Marcasuzaa P, Reynaud S, Ehrenfeld F, Khoukh A, Desbrieres J Chitosan-graft-polyanilline-based hydrogels: elaboration and properties. Biomacromolecules 2010, 11:1684-1691.
29. El-Sherbiny IM Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: preparation and in-vitro assessment. Carbohydr Polym 2010, 80:1125-1136.
30. Cai H, Zhang ZP, Sun PC, He BL, Zhu XX Synthesis and characterization of thermo- and pH-sensitive hydrogel based on chitosan-grafted N-isopropolyacrylamide via γ radiation. Radiat Phys Chem 2005, 74:26-30.
31. El-Sherbiny IM, Smyth HD Poly(ethylene glycol)-carboxymethyl chitosan-based pH-responsive hydrogels, photo-induced synthesis, characterization, swelling and in vitro evaluation as potential drug carrier. Carbohydr Res 2010, 345:2004-2012.
32. Hamman JH Chitosan based polyelectrolyte complex as a potential carrier material in drug delivery system. Mar Drugs 2010, 8:1305-1322.
33. Zarate J, Virdis L, Orive G, Igartua M, Hernandez RM, Pedraz JL Design and characterization of calcium alginate microparticles coated with polycations as protein delivery system. J Microencapsul 2011, 28:614-620.
34. Czubenko JO, Druzynska MG Effect of ionic crosslinking on the water state in hydrogel chitosan membranes. Carbohydr Polym 2009, 77:590-598.
35. Kaihara S, Suzuki Y, Fujimoto K In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan. Colloids Surf B Biointerfaces 2011, 85:343-348.
36. Giunchedi P, Juliano C, Gavini E, Cossu M, Sorrenti M Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur J Pharm Biopharm 2002, 53:233-239.
37. Ji OX, Deng J, Yu XB, Xu QC, Xu XY An in vitro evaluation of the antibacterial activity of chitosan based thermosensitive hydrogel against periodontal pathogens. Shanghai J Stomatol 2009, 18:397-400.
38. Chang CH, Lin YH, Yeh CL, Chen YC, Chou SE, Hsu YM, et al. Nanoparticles incorporated in pH-sensitive hydrogels as amoxicillin delivery for eradication of Helicobacter pylori. Biomacromolecules 2010, 11:133-142.
39. Gisbert J, Torrado G, Torrado S, Olivares D, Pajares JM Clinical trial evaluating amoxicillin and clarithromycin hydrogel (chitosan-polyacrylic acid polyionic complexes) for H. pylori eradiction. J Biomed Mater Res A 2006, 40:618-622.
40. Wang Q, Zhang J, Wang A Preparation and characterization of a novel pH-sensitive chitosan-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium. Carbohydr Polym 2009, 78:731-737.
41. Dai YN, Li P, Zhang JP, Wang AQ, Wei Q A novel pH-sensitive N-succinyl chitosan/alginate hydrogel bead for nifedipine delivery. Biopharm Drug Dispos 2008, 29:173-184.
42. Yin L, Ding J, Zhang J, He C, Tang C, Yin C Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin. Biomaterials 2010, 31:3347-3356.
43. Yin L, Ding J, Fei L, He M, Cui F, Tang C, et al. Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. Int J Pharm 2008, 35:220-229.
44. Sokker HH, Abdel Ghaffar AM, Gad YH, Aly AS Synthesis and characterization of hydrogels based on grafted chitosan for the controlled drug release. Carbohydr Polym 2009, 75:222-229.
45. Chen SC, Wu YC, Mi FL, Lin YH, Lin CY, Hsing WS A novel pH sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate crosslinked by genipine for protein drug delivery. J Control Release 2008, 96:245-252.
46. Xu Y, Zhan C, Fan L, Wang L, Zheng H Preparation of dual crosslinked alginate-chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system. Int J Pharm 2007, 336:329-337.
47. Jain SK, Jain A, Gupta Y, Ahirwar M Design and development of hydrogel beads for targeted drug delivery to the colon. AAPS PharmSciTech 2007, 8:E34-E41.
48. Viyoch J, Sudedmark T, Srema W, Suwonkrua W Development of hydrogel patch for controlled release of alpha-hydroxy acid contained in tamarind fruit pulp extract. Int J Cosmet Sci 2005, 27:89-99.
49. He ZX, Wang ZH, Zhang HH, Pan X, Su WR, Liang D, et al. Doxycycline and hydroxypropyl-Β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery. Acta Pharm Sin B 2011, 1:254-260.
50. Srikanth MV, Rao NS, Sunil SA, Ram BJ, Kolapalli VR Statistical design and evaluation of a propranolol HCl gastric floating tablet. Acta Pharm Sin B 2012, 1:60-69.
51. Boriwanwattanarak P, Ingkaninan K, Khorana N, Viyoch J Development of curcuminoids hydrogel patch using chitosan from various sources as controlled release matrix. Ind J Cosmet Sci 2008, 30:205-218.
52. Tsai CJ, Hsu LR, Fang JY, Lin HH Chitosan hydrogel as a base for transdermal delivery of berberine and its evaluation in rat skin. Biol Pharm Bull 1999, 22:397-401.
53. Thein-Han WW, Stevens WF Transdermal delivery controlled by a chitosan membrane. Drug Dev Ind Pharm 2004, 30:397-404.
54. Honsy KM Preparation and evaluation of thermosensitive liposomal hydrogel for enhanced transcorneal permeation of ofloxacin. AAPS PharmaSciTech 2009, 10:1336-1342.
55. Cao Y, Zhang C, Shen W, Cheng Z, Yu LL, Ping Q Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery. J Control Release 2007, 120:186-194.
56. Genta I, Conti B, Perugini P, Pavanetto F, Spadaro A, Puglisi G Bioadhesive microspheres for ophthalmic administration of acyclovir. J Pharm Pharmacol 1997, 49:737-742.
57. Nazar H, Fatouros DG, Merwe SM, Bouropoulos N, Avgouropoulos G, Tisbouklis J, et al. Thermosensitive hydrogels for nasal drug delivery: the formulation and characterization of system based on N-trimethyl chitosan chloride. Eur J Pharm Biopharm 2011, 77:225-232.
58. Agarwal AK, Gupta PN, Khanna A, Sharma RK, Chandrawansh HK, Gupta N, et al. Development and characterization of in situ gel system for nasal delivery. Pharmazie 2010, 65:188-193.
59. Alsarra IA, Hamed AY, Mahrous GM, EI Maghrabhy GM, Ai-Robayan AA, Alanazi FK Mucoadhesive polymeric hydrogels for nasal delivery of acyclovir. Drug Dev Ind Pharm 2009, 35:352-362.
60. Wu J, Wei W, Wang LY, Su ZG, Ma GH A thermosensitive hydrogel based on quaternized chitosan and polyethylene glycol for nasal delivery system. Biomaterials 2007, 28:2220-2232.
61. Gavini E, Rassu G, Muzzarelli C, Cossu M, Giunchedi P Spray-dried microspheres based on methylpyrrolidinone chitosan as new carrier for nasal administration of metoclopramide. Eur J Biopharm Pharm 2008, 68:245-252.
62. EI-Leithy ES, Shaker DS, Ghorab MK, Abdel-Rashid RS Evaluation of mucoadhesive hydrogels loaded with diclofenac sodium-chitosan microspheres for rectal administration. AAPS PharmSciTech 2010, 11:1695-1702.
63. Ladet SG, Tahiri K, Montembault AS, Domard AJ, Corvol MT Multi-membrane chitosan hydrogels as chondrocytic cell bioreactors. Biomaterials 2011, 32:5354-5364.
64. Tan H, Rubin JP, Marra KG Injectable in situ forming biodegradable chitosan hyaluronic acid based hydrogels for adipose tissue regeneration. Organogenesis 2010, 6:173-180.
65. Tran NQ, Joung YK, Lih E, Park KD In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing. Biomacromolecules 2011, 12:2872-2880.
66. Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydr Polym 2010, 82:1297-1305.
67. Hong Y, Gong Y, Gao C, Shen J Collagen-coated polylactide microcarriers/chitosan hydrogel composite: injectable scaffold for cartilage regeneration. J Biomed Mater Res A 2006, 10:628-637.
68. Park KM, Lee SY, Joung YK, Na JS, Lee MC, Park KD Thermosensitive chitosan-pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration. Acta Biomater 2009, 5:1956-1965.
69. Luca L, Rougemant AL, Waloph BH, Gurny R, Jordan O The effect of carrier natural and pH on rhBMP-2-induced ectopic bone formation. J Control Release 2010, 147:38-44.
70. Qi B, Yu A, Zhu S, Chen B, Li Y The preparation and cytocompatibility of injectable thermosensitive chitosan/poly (vinyl alcohol) hydrogel. J Huazhong Univ Sci Technol Med Sci 2010, 30:89-93.
71. Tang Y, Wang X, Li Y, Lei M, Du Y, Kennedy JF, et al. Production and characterization of novel injectable chitosan/methylcellulose/salt blend hydrogels with potential application as tissue engineering scaffolds. Carbohydr Polym 2010, 82:833-841.
72. Ma G, Yang D, Li Q, Wang K, Chen B, Kennedy JF, et al. Injectable hydrogels based on chitosan derivative/polyethylene glycol dimethacrylate/N,N-dimethylacrlamide as bone tissue engineering matrix. Carbohydr Polym 2010, 79:620-627.
73. Yang J, Cung TW, Nagaoka M, Goto M, Cho CS, Akaike T Hepatocyte-specific porous polymer-scaffolds of alginate/galactosylated chitosan sponge for liver-tissue engineering. Biotechnol Lett 2001, 23:1385-1389.
74. Crompton KE, Goud JD, Bellamkonda RV, Gengenbach TR, Finkelstein DI, Horne MK, et al. Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. Biomaterials 2007, 28:441-449.
75. Rickett TA, Amoozgar Z, Tuchek AC, Park J, Yeo Y, Shi R Rapidly photo cross linkable chitosan hydrogel for peripheral neurosurgeries. Biomacromolecules 2011, 12:57-65.
76. Mathews DT, Birney A, Cahil YA, McGuinness GB Vascular cell viability on polyvinyl alcohol hydrogels modified with water-soluble and insoluble chitosan. J Biomed Mater Res B Appl Biol 2006, 10:531-540.