Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations

Journal of Biological Chemistry

Volumn 294, Issue 39, 2019, Pages 14185-14200

  Zhao, Wenchao ^a   Bohleber, Simon ^a   Schmidt, Henrik ^a   Seeher, Sandra ^a   Howard, Michael T ^b   Braun, Doreen ^a   Arndt, Simone ^a   Reuter, Uschi ^a   Wende, Hagen ^c   Birchmeier, Carmen ^c   Fradejas Villar, Noelia ^a   Schweizer, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF UTAH   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS;

INDIVIDUAL CELLS; INSERTION SEQUENCES; PATHOGENIC MUTATION; PROTEIN STABILITY; RESIDUAL ACTIVITY; RNA BINDING DOMAINS; SELENOPROTEIN EXPRESSION; THERMALLY UNSTABLE;

TRANSCRIPTION;

SELENOPROTEIN; PROTEIN BINDING; RNA BINDING PROTEIN; SECIS-BINDING PROTEIN 2, MOUSE; SELENOCYSTEINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; C696R GENE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE INSERTION; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LIVER TISSUE; MALE; MISSENSE MUTATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STABILITY; R543Q GENE; RIBOSOME; RNA TRANSLATION; RNA-BINDING DOMAIN; SECISBP2 GENE; ANIMAL; BINDING SITE; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CHEMISTRY; GENETICS; INBORN ERROR OF METABOLISM; LIVER; METABOLISM; PROTEIN DEGRADATION;

ANIMALS; BINDING SITES; BRAIN; LIVER; METABOLISM, INBORN ERRORS; MICE; MICE, INBRED C57BL; MUTATION, MISSENSE; PHENOTYPE; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; RIBOSOMES; RNA-BINDING PROTEINS; SELENOCYSTEINE; SELENOPROTEINS;

EID: 85072717135     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.RA119.009369     Document Type: Article

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