-
1
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff LA, Sethupathy P, Junkins H a, Ramos EM, Mehta JP, et al. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362–9367. doi: 10.1073/pnas.0903103106 19474294
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.3
Ramos, E.M.4
Mehta, J.P.5
-
2
-
-
80052322958
-
Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA
-
Fehrmann RSN, Jansen RC, Veldink JH, Westra H-J, Arends D, et al. (2011) Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA. PLoS Genet 7: 14.
-
(2011)
PLoS Genet
, vol.7
, pp. 14
-
-
Fehrmann, R.S.N.1
Jansen, R.C.2
Veldink, J.H.3
Westra, H.-J.4
Arends, D.5
-
3
-
-
84884611024
-
Integrative Modeling of eQTLs and Cis-Regulatory Elements Suggests Mechanisms Underlying Cell Type Specificity of eQTLs
-
Brown CD, Mangravite LM, Engelhardt BE, (2013) Integrative Modeling of eQTLs and Cis-Regulatory Elements Suggests Mechanisms Underlying Cell Type Specificity of eQTLs. PLoS Genet 9: e1003649. doi: 10.1371/journal.pgen.1003649 23935528
-
(2013)
PLoS Genet
, vol.9
, pp. e1003649
-
-
Brown, C.D.1
Mangravite, L.M.2
Engelhardt, B.E.3
-
4
-
-
84860317030
-
Genetics of gene expression in primary immune cells identifies cell-specific master regulators and roles of HLA alleles
-
Fairfax BPB, Makino S, Radhakrishnan J, Plant K, Leslie S, et al. (2012) Genetics of gene expression in primary immune cells identifies cell-specific master regulators and roles of HLA alleles. Nat Genet 44: 502–510. doi: 10.1038/ng.2205.GENETICS 22446964
-
(2012)
Nat Genet
, vol.44
, pp. 502-510
-
-
Fairfax, B.P.B.1
Makino, S.2
Radhakrishnan, J.3
Plant, K.4
Leslie, S.5
-
5
-
-
84857487802
-
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
-
Fu J, Wolfs MGM, Deelen P, Westra H-J, Fehrmann RSN, et al. (2012) Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet 8: e1002431. doi: 10.1371/journal.pgen.1002431 22275870
-
(2012)
PLoS Genet
, vol.8
, pp. e1002431
-
-
Fu, J.1
Wolfs, M.G.M.2
Deelen, P.3
Westra, H.-J.4
Fehrmann, R.S.N.5
-
6
-
-
84860637797
-
DNA methylation arrays as surrogate measures of cell mixture distribution
-
Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, et al. (2012) DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 13: 86. doi: 10.1186/1471-2105-13-86 22568884
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 86
-
-
Houseman, E.A.1
Accomando, W.P.2
Koestler, D.C.3
Christensen, B.C.4
Marsit, C.J.5
-
7
-
-
84900824657
-
Reference-free cell mixture adjustments in analysis of DNA methylation data
-
Houseman EA, Molitor J, Marsit CJ (2014) Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics.
-
(2014)
-
-
Houseman, E.A.1
Molitor, J.2
Marsit, C.J.3
-
8
-
-
84899115256
-
Quantitative reconstruction of leukocyte subsets using DNA methylation
-
Accomando WP, Wiencke JK, Houseman EA, Nelson HH, Kelsey KT, (2014) Quantitative reconstruction of leukocyte subsets using DNA methylation. Genome Biol 15: R50. doi: 10.1186/gb-2014-15-3-r50 24598480
-
(2014)
Genome Biol
, vol.15
, pp. R50
-
-
Accomando, W.P.1
Wiencke, J.K.2
Houseman, E.A.3
Nelson, H.H.4
Kelsey, K.T.5
-
9
-
-
84893192328
-
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
-
Jaffe AE, Irizarry RA, (2014) Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol 15: R31. doi: 10.1186/gb-2014-15-2-r31 24495553
-
(2014)
Genome Biol
, vol.15
, pp. R31
-
-
Jaffe, A.E.1
Irizarry, R.A.2
-
10
-
-
34848914038
-
Capturing heterogeneity in gene expression studies by surrogate variable analysis
-
Leek JT, Storey JD, (2007) Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet 3: 1724–1735. 17907809
-
(2007)
PLoS Genet
, vol.3
, pp. 1724-1735
-
-
Leek, J.T.1
Storey, J.D.2
-
11
-
-
77951634577
-
Cell type-specific gene expression differences in complex tissues
-
Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler F, et al. (2010) Cell type-specific gene expression differences in complex tissues. Nat Methods 7: 287–289. doi: 10.1038/nmeth.1439 20208531
-
(2010)
Nat Methods
, vol.7
, pp. 287-289
-
-
Shen-Orr, S.S.1
Tibshirani, R.2
Khatri, P.3
Bodian, D.L.4
Staedtler, F.5
-
12
-
-
9644260645
-
The Estonian Genome Project
-
Metspalu A, (2004) The Estonian Genome Project. Drug Dev Res 62: 97–101. doi: 10.1002/ddr.10371
-
(2004)
Drug Dev Res
, vol.62
, pp. 97-101
-
-
Metspalu, A.1
-
13
-
-
59249096217
-
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
-
Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet 5: e1000338. doi: 10.1371/journal.pgen.1000338 19148276
-
(2009)
PLoS Genet
, vol.5
, pp. e1000338
-
-
Tanaka, T.1
Shen, J.2
Abecasis, G.R.3
Kisialiou, A.4
Ordovas, J.M.5
-
14
-
-
84890555012
-
The Rotterdam Study: 2014 objectives and design update
-
Hofman A, Darwish Murad S, van Duijn CM, Franco OH, Goedegebure A, et al. (2013) The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol 28: 889–926. doi: 10.1007/s10654-013-9866-z 24258680
-
(2013)
Eur J Epidemiol
, vol.28
, pp. 889-926
-
-
Hofman, A.1
Darwish, M.S.2
van Duijn, C.M.3
Franco, O.H.4
Goedegebure, A.5
-
15
-
-
79953680469
-
Cohort profile: the study of health in Pomerania
-
Völzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, et al. (2011) Cohort profile: the study of health in Pomerania. Int J Epidemiol 40: 294–307. doi: 10.1093/ije/dyp394 20167617
-
(2011)
Int J Epidemiol
, vol.40
, pp. 294-307
-
-
Völzke, H.1
Alte, D.2
Schmidt, C.O.3
Radke, D.4
Lorbeer, R.5
-
16
-
-
84871207895
-
Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
-
Mehta D, Heim K, Herder C, Carstensen M, Eckstein G, et al. (2013) Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood. Eur J Hum Genet 21: 48–54. doi: 10.1038/ejhg.2012.106 22692066
-
(2013)
Eur J Hum Genet
, vol.21
, pp. 48-54
-
-
Mehta, D.1
Heim, K.2
Herder, C.3
Carstensen, M.4
Eckstein, G.5
-
17
-
-
78049420683
-
An immune response network associated with blood lipid levels
-
Inouye M, Silander K, Hamalainen E, Salomaa V, Harald K, et al. (2010) An immune response network associated with blood lipid levels. PLoS Genet 6: e1001113. doi: 10.1371/journal.pgen.1001113 20844574
-
(2010)
PLoS Genet
, vol.6
, pp. e1001113
-
-
Inouye, M.1
Silander, K.2
Hamalainen, E.3
Salomaa, V.4
Harald, K.5
-
18
-
-
79959824142
-
Multiple loci are associated with white blood cell phenotypes
-
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, et al. (2011) Multiple loci are associated with white blood cell phenotypes. PLoS Genet 7: e1002113. doi: 10.1371/journal.pgen.1002113 21738480
-
(2011)
PLoS Genet
, vol.7
, pp. e1002113
-
-
Nalls, M.A.1
Couper, D.J.2
Tanaka, T.3
van Rooij, F.J.A.4
Chen, M.-H.5
-
19
-
-
84860874813
-
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
-
Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, et al. (2012) Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet 131: 639–652. doi: 10.1007/s00439-011-1103-9 22037903
-
(2012)
Hum Genet
, vol.131
, pp. 639-652
-
-
Crosslin, D.R.1
McDavid, A.2
Weston, N.3
Nelson, S.C.4
Zheng, X.5
-
20
-
-
0022353293
-
A comparative study of neutrophil purification and function
-
Grisham MB, Engerson TD, McCord JM, Jones HP, (1985) A comparative study of neutrophil purification and function. J Immunol Methods 82: 315–320. 2995497
-
(1985)
J Immunol Methods
, vol.82
, pp. 315-320
-
-
Grisham, M.B.1
Engerson, T.D.2
McCord, J.M.3
Jones, H.P.4
-
21
-
-
84930789916
-
-
Blueprint DCC Portal (n.d.). Available: http://dcc.blueprint-epigenome.eu/#/home. Accessed 25 November 2014.
-
-
-
-
22
-
-
84885018609
-
-
Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, et al. (2013) Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. doi: 10.1038/ng.2756
-
-
-
-
23
-
-
84887421132
-
Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease
-
Uhlig HH, (2013) Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease. Gut 62: 1795–1805. doi: 10.1136/gutjnl-2012-303956 24203055
-
(2013)
Gut
, vol.62
, pp. 1795-1805
-
-
Uhlig, H.H.1
-
24
-
-
19444363154
-
Sargramostim for active Crohn’s disease
-
Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert MJ, (2005) Sargramostim for active Crohn’s disease. N Engl J Med 352: 2193–2201. 15917384
-
(2005)
N Engl J Med
, vol.352
, pp. 2193-2201
-
-
Korzenik, J.R.1
Dieckgraefe, B.K.2
Valentine, J.F.3
Hausman, D.F.4
Gilbert, M.J.5
-
25
-
-
0037413468
-
Natalizumab for active Crohn’s disease
-
Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, et al. (2003) Natalizumab for active Crohn’s disease. N Engl J Med 348: 24–32. 12510039
-
(2003)
N Engl J Med
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
Goldin, E.2
Gordon, F.H.3
Malchow, H.A.4
Rask-Madsen, J.5
-
26
-
-
0141989856
-
Sex-Specific Risks for Pediatric Onset Among Patients With Crohn’s Disease
-
Montgomery SM, Wakefield AJ, Ekbom A, (2003) Sex-Specific Risks for Pediatric Onset Among Patients With Crohn’s Disease. Clin Gastroenterol Hepatol 1: 303–309. doi: 10.1016/S1542-3565(03)00135-6 15017672
-
(2003)
Clin Gastroenterol Hepatol
, vol.1
, pp. 303-309
-
-
Montgomery, S.M.1
Wakefield, A.J.2
Ekbom, A.3
-
27
-
-
84906348279
-
Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis
-
Goodman WA, Garg RR, Reuter BK, Mattioli B, Rissman EF, et al. (2014) Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis. Mucosal Immunol 7: 1255–1265. doi: 10.1038/mi.2014.15 24621993
-
(2014)
Mucosal Immunol
, vol.7
, pp. 1255-1265
-
-
Goodman, W.A.1
Garg, R.R.2
Reuter, B.K.3
Mattioli, B.4
Rissman, E.F.5
-
28
-
-
84875985398
-
Blood-informative transcripts define nine common axes of peripheral blood gene expression
-
Preininger M, Arafat D, Kim J, Nath AP, Idaghdour Y, et al. (2013) Blood-informative transcripts define nine common axes of peripheral blood gene expression. PLoS Genet 9: e1003362. doi: 10.1371/journal.pgen.1003362 23516379
-
(2013)
PLoS Genet
, vol.9
, pp. e1003362
-
-
Preininger, M.1
Arafat, D.2
Kim, J.3
Nath, A.P.4
Idaghdour, Y.5
-
29
-
-
84964308876
-
Gene expression analysis identifies global gene dosage sensitivity in cancer
-
Fehrmann RSN, Karjalainen JM, Krajewska M, Westra H-J, Maloney D, et al. (2015) Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet 47: 115–125. doi: 10.1038/ng.3173 25581432
-
(2015)
Nat Genet
, vol.47
, pp. 115-125
-
-
Fehrmann, R.S.N.1
Karjalainen, J.M.2
Krajewska, M.3
Westra, H.-J.4
Maloney, D.5
-
30
-
-
84885645853
-
Transcriptome and genome sequencing uncovers functional variation in humans
-
Lappalainen T, Sammeth M, Friedländer MR, ‘t Hoen PAC, Monlong J, et al. (2013) Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501: 506–511. doi: 10.1038/nature12531 24037378
-
(2013)
Nature
, vol.501
, pp. 506-511
-
-
Lappalainen, T.1
Sammeth, M.2
Friedländer, M.R.3
‘t Hoen, P.A.C.4
Monlong, J.5
-
31
-
-
84879674031
-
DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts
-
Zhernakova D V, de Klerk E, Westra H-J, Mastrokolias A, Amini S, et al. (2013) DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. PLoS Genet 9: e1003594. doi: 10.1371/journal.pgen.1003594 23818875
-
(2013)
PLoS Genet
, vol.9
, pp. e1003594
-
-
Zhernakova, D.V.1
de Klerk, E.2
Westra, H.-J.3
Mastrokolias, A.4
Amini, S.5
-
32
-
-
33746331248
-
-
The International HapMap Consortium (2003) The International HapMap Project. 426: 789–796. 14685227
-
(2003)
The International HapMap Project
, vol.426
, pp. 789-796
-
-
-
33
-
-
79960426031
-
MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects
-
Westra H-J, Jansen RC, Fehrmann RSN, te Meerman GJ, van Heel D, et al. (2011) MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. Bioinformatics 27: 2104–2111. doi: 10.1093/bioinformatics/btr323 21653519
-
(2011)
Bioinformatics
, vol.27
, pp. 2104-2111
-
-
Westra, H.-J.1
Jansen, R.C.2
Fehrmann, R.S.N.3
te Meerman, G.J.4
van Heel, D.5
-
34
-
-
77950243833
-
Multiple common variants for celiac disease influencing immune gene expression
-
Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, et al. (2010) Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 42: 295–302. doi: 10.1038/ng.543 20190752
-
(2010)
Nat Genet
, vol.42
, pp. 295-302
-
-
Dubois, P.C.A.1
Trynka, G.2
Franke, L.3
Hunt, K.A.4
Romanos, J.5
-
35
-
-
28444493739
-
Combining probability from independent tests: the weighted Z-method is superior to Fisher’s approach
-
Whitlock MC, (2005) Combining probability from independent tests: the weighted Z-method is superior to Fisher’s approach. J Evol Biol 18: 1368–1373. doi: 10.1111/j.1420-9101.2005.00917.x 16135132
-
(2005)
J Evol Biol
, vol.18
, pp. 1368-1373
-
-
Whitlock, M.C.1
|