Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn’s disease is a risk factor for disease relapse in Japanese patients

Journal of Gastroenterology

Volumn 52, Issue 12, 2017, Pages 1230-1239

  Kakuta, Yoichi ^a   Kimura, Tomoya ^a   Negoro, Kenichi ^a   Kuroha, Masatake ^a   Shiga, Hisashi ^a   Endo, Katsuya ^a   Kinouchi, Yoshitaka ^b   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Allelic expression imbalance; Crohn s disease; IL12B

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; INTERLEUKIN 12P40; MESSENGER RNA; IL12B PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; IMMUNOPATHOGENESIS; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MONOCYTE; PRIORITY JOURNAL; RELAPSE; RNA TRANSCRIPTION; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS; ALLELE; GENETIC PREDISPOSITION; GENETICS; JAPAN; PATHOPHYSIOLOGY; PHENOTYPE; RECURRENT DISEASE; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; ALLELES; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-12 SUBUNIT P40; JAPAN; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; RISK FACTORS; RNA, MESSENGER; YOUNG ADULT;

EID: 85013466894     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-017-1322-5     Document Type: Article

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