메뉴 건너뛰기




Volumn 13, Issue 1, 2019, Pages 37-42

Prospects for repurposing CNS drugs for cancer treatment

Author keywords

Cancer; CNS drug; Repositioning; Repurposable drugs

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; IMIPRAMINE; PHENOTHIAZINE DERIVATIVE; PIMOZIDE; TRIFLUOPERAZINE; VALPROIC ACID;

EID: 85067838450     PISSN: 19705557     EISSN: 19705565     Source Type: Journal    
DOI: 10.4081/oncol.2019.411     Document Type: Review
Times cited : (25)

References (72)
  • 1
    • 85067859984 scopus 로고    scopus 로고
    • World Health Organization
    • World Health Organization. WHO | Cancer Factsheet. Who [Internet]. 2018; Available from: http://www.who.int/cancer/en/
    • (2018) WHO | Cancer Factsheet. Who [Internet]
  • 2
    • 84865165918 scopus 로고    scopus 로고
    • The price we pay for progress: A meta-analysis of harms of newly approved anticancer drugs
    • Niraula S, Seruga B, Ocana A, Shao T, Goldstein R, Tannock IF, et al. The price we pay for progress: A meta-analysis of harms of newly approved anticancer drugs. J Clin Oncol. 2012;30(24):3012-9.
    • (2012) J Clin Oncol , vol.30 , Issue.24 , pp. 3012-3019
    • Niraula, S.1    Seruga, B.2    Ocana, A.3    Shao, T.4    Goldstein, R.5    Tannock, I.F.6
  • 5
    • 4344566090 scopus 로고    scopus 로고
    • Peginterferon alfa-2a: A review of approved and investigational uses
    • Matthews SJ, McCoy C. Peginterferon alfa-2a: A review of approved and investigational uses. Clin Ther [Internet]. 2004;26(7):991-1025.
    • (2004) Clin Ther [Internet] , vol.26 , Issue.7 , pp. 991-1025
    • Matthews, S.J.1    McCoy, C.2
  • 13
    • 84883765692 scopus 로고    scopus 로고
    • Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial
    • Forget P, Berlière M, van Maanen A, Duhoux FP, Machiels JP, Coulie PG, et al. Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial. Med Hypotheses. 2013;81(4):707-12.
    • (2013) Med Hypotheses , vol.81 , Issue.4 , pp. 707-712
    • Forget, P.1    Berlière, M.2    Van Maanen, A.3    Duhoux, F.P.4    Machiels, J.P.5    Coulie, P.G.6
  • 15
    • 29144518618 scopus 로고    scopus 로고
    • Reduced cancer incidence among patients with schizophrenia
    • Dec. 15 [cited 2018 Apr 25]
    • Barak Y, Achiron A, Mandel M, Mirecki I, Aizenberg D. Reduced cancer incidence among patients with schizophrenia. Cancer [Internet]. 2005 Dec 15 [cited 2018 Apr 25];104(12):2817-21. Available from: http://doi.wiley.com/10.1002/cncr.21574
    • (2005) Cancer [Internet] , vol.104 , Issue.12 , pp. 2817-2821
    • Barak, Y.1    Achiron, A.2    Mandel, M.3    Mirecki, I.4    Aizenberg, D.5
  • 17
    • 85058605868 scopus 로고    scopus 로고
    • A brief history of antidepressant drug development: From tricyclics to beyond ketamine
    • Pereira VS, Hiroaki-Sato VA. A brief history of antidepressant drug development: from tricyclics to beyond ketamine. Acta Neuropsychiatr 2018;1-16.
    • (2018) Acta Neuropsychiatr , pp. 1-16
    • Pereira, V.S.1    Hiroaki-Sato, V.A.2
  • 18
    • 85048558766 scopus 로고    scopus 로고
    • Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma
    • Elmaci I, Altinoz MA. Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma. Crit Rev Oncol Hematol 2018;128:96-109.
    • (2018) Crit Rev Oncol Hematol , vol.128 , pp. 96-109
    • Elmaci, I.1    Altinoz, M.A.2
  • 19
    • 85044177237 scopus 로고    scopus 로고
    • Antipsychotic dopamine receptor antagonists, cancer, and cancer stem cells
    • Roney MSI, Park SK. Antipsychotic dopamine receptor antagonists, cancer, and cancer stem cells. Arch Pharm Res 2018;41(4):384-408.
    • (2018) Arch Pharm Res , vol.41 , Issue.4 , pp. 384-408
    • Roney, M.S.I.1    Park, S.K.2
  • 20
    • 35649016151 scopus 로고    scopus 로고
    • Fifty years chlorpromazine: A historical perspective
    • Ban TA. Fifty years chlorpromazine: A historical perspective. Neuropsychiatr Dis Treat. 2007;3(4):495-500.
    • (2007) Neuropsychiatr Dis Treat , vol.3 , Issue.4 , pp. 495-500
    • Ban, T.A.1
  • 21
    • 84928943235 scopus 로고    scopus 로고
    • The clinical discovery of imipramine
    • Brown WA, Rosdolsky M. The clinical discovery of imipramine. Am J Psychiatry. 2015;172(5):426-9.
    • (2015) Am J Psychiatry , vol.172 , Issue.5 , pp. 426-429
    • Brown, W.A.1    Rosdolsky, M.2
  • 23
    • 0036189180 scopus 로고    scopus 로고
    • Bromide, the first effective antiepileptic agent
    • Pearce JMS. Bromide, the first effective antiepileptic agent. J Neurol Neurosurg Psychiatry. 2002;72(3):412.
    • (2002) J Neurol Neurosurg Psychiatry , vol.72 , Issue.3 , pp. 412
    • Pearce, J.M.S.1
  • 24
    • 45249095946 scopus 로고    scopus 로고
    • The history of barbiturates a century after their clinical introduction
    • Dec
    • López-Muñoz F, Ucha-Udabe R, Alamo C. The history of barbiturates a century after their clinical introduction. Neuropsychiatr Dis Treat 2005 Dec;1(4):329-43.
    • (2005) Neuropsychiatr Dis Treat , vol.1 , Issue.4 , pp. 329-343
    • López-Muñoz, F.1    Ucha-Udabe, R.2    Alamo, C.3
  • 27
    • 77957258627 scopus 로고    scopus 로고
    • Antiepileptic drug discovery and development: What have we learned and where are we going?
    • Sep
    • Gerlach AC, Krajewski JL. Antiepileptic drug discovery and development: What have we learned and where are we going? Pharmaceuticals. 2010 Sep;3(9):2884-99.
    • (2010) Pharmaceuticals , vol.3 , Issue.9 , pp. 2884-2899
    • Gerlach, A.C.1    Krajewski, J.L.2
  • 28
    • 3242724333 scopus 로고    scopus 로고
    • The history of valproate in clinical neuroscience
    • Henry TR. The history of valproate in clinical neuroscience. Psychopharmacol Bull 2003;37 Suppl 2:5-16.
    • (2003) Psychopharmacol Bull , vol.37 , pp. 5-16
    • Henry, T.R.1
  • 29
    • 84859129495 scopus 로고    scopus 로고
    • Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma
    • Mar
    • Munson JM, Fried L, Rowson SA, Bonner MY, Karumbaiah L, Diaz B, et al. Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med. 2012 Mar;4(127):127ra36-127ra36.
    • (2012) Sci Transl Med , vol.4 , Issue.127 , pp. 127ra36-127ra37
    • Munson, J.M.1    Fried, L.2    Rowson, S.A.3    Bonner, M.Y.4    Karumbaiah, L.5    Diaz, B.6
  • 30
    • 84944030796 scopus 로고    scopus 로고
    • Dual targeting of the autophagic regulatory circuitry in gliomas with repurposed drugs elicits cell-lethal autophagy and therapeutic benefit
    • Shchors K, Massaras A, Hanahan D. Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit. Cancer Cell. 2015;28(4):456-71.
    • (2015) Cancer Cell , vol.28 , Issue.4 , pp. 456-471
    • Shchors, K.1    Massaras, A.2    Hanahan, D.3
  • 31
    • 84976297644 scopus 로고    scopus 로고
    • Inhibition of FoxM1-Mediated DNA repair by imipramine blue suppresses breast cancer growth and metastasis
    • Rajamanickam S, Panneerdoss S, Gorthi A, Timilsina S, Onyeagucha B, Kovalskyy D, et al. Inhibition of FoxM1-Mediated DNA repair by imipramine blue suppresses breast cancer growth and metastasis. Clin Cancer Res. 2016;22(14):3524-36.
    • (2016) Clin Cancer Res , vol.22 , Issue.14 , pp. 3524-3536
    • Rajamanickam, S.1    Panneerdoss, S.2    Gorthi, A.3    Timilsina, S.4    Onyeagucha, B.5    Kovalskyy, D.6
  • 32
    • 84938851963 scopus 로고    scopus 로고
    • Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation
    • Yang WH, Su YH, Hsu WH, Wang CC, Arbiser JL, Yang MH. Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation. Oncogene. 2016;35(18):2287-98.
    • (2016) Oncogene , vol.35 , Issue.18 , pp. 2287-2298
    • Yang, W.H.1    Su, Y.H.2    Hsu, W.H.3    Wang, C.C.4    Arbiser, J.L.5    Yang, M.H.6
  • 33
  • 34
    • 85021636928 scopus 로고    scopus 로고
    • Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
    • Metts J, Bradley HL, Wang Z, Shah NP, Kapur R, Arbiser JL, et al. Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. Sci Rep. 2017;7(1):4447.
    • (2017) Sci Rep , vol.7 , Issue.1 , pp. 4447
    • Metts, J.1    Bradley, H.L.2    Wang, Z.3    Shah, N.P.4    Kapur, R.5    Arbiser, J.L.6
  • 35
    • 84982279921 scopus 로고    scopus 로고
    • Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia
    • Laidlaw KME, Berhan S, Liu S, Silvestri G, Holyoake TL, Frank DA, et al. Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia. Oncotarget [Internet]. 2016;7(32):51651-64.
    • (2016) Oncotarget [Internet] , vol.7 , Issue.32 , pp. 51651-51664
    • Laidlaw, K.M.E.1    Berhan, S.2    Liu, S.3    Silvestri, G.4    Holyoake, T.L.5    Frank, D.A.6
  • 36
    • 85017559906 scopus 로고    scopus 로고
    • Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules
    • Ghorab MM, Alsaid MS, Samir N, Abdel-Latif GA, Soliman AM, Ragab FA, et al. Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules. Eur J Med Chem. 2017;134:304-15.
    • (2017) Eur J Med Chem , vol.134 , pp. 304-315
    • Ghorab, M.M.1    Alsaid, M.S.2    Samir, N.3    Abdel-Latif, G.A.4    Soliman, A.M.5    Ragab, F.A.6
  • 37
    • 84897441779 scopus 로고    scopus 로고
    • Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer
    • Zong D, Zielinska-Chomej K, Juntti T, Mörk B, Lewensohn R, Haag P, et al. Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer. Cell Death Dis. 2014;5(3):e1111-e1111.
    • (2014) Cell Death Dis , vol.5 , Issue.3 , pp. e1111
    • Zong, D.1    Zielinska-Chomej, K.2    Juntti, T.3    Mörk, B.4    Lewensohn, R.5    Haag, P.6
  • 38
    • 84974555439 scopus 로고    scopus 로고
    • Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy
    • Wu CH, Bai LY, Tsai MH, Chu PC, Chiu CF, Chen MY, et al. Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy. Sci Rep. 2016;6:27540.
    • (2016) Sci Rep , vol.6 , pp. 27540
    • Wu, C.H.1    Bai, L.Y.2    Tsai, M.H.3    Chu, P.C.4    Chiu, C.F.5    Chen, M.Y.6
  • 40
    • 85010029696 scopus 로고    scopus 로고
    • Trifluoperazine a well-known antipsychotic inhibits glioblastoma invasion by binding to calmodulin and disinhibiting calcium release channel IP 3 R
    • Kang S, Hong J, Lee JM, Moon HE, Jeon B, Choi J, et al. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP 3 R. Mol Cancer Ther [Internet]. 2017;16(1):217-27.
    • (2017) Mol Cancer Ther [Internet] , vol.16 , Issue.1 , pp. 217-227
    • Kang, S.1    Hong, J.2    Lee, J.M.3    Moon, H.E.4    Jeon, B.5    Choi, J.6
  • 41
    • 85040823119 scopus 로고    scopus 로고
    • Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells
    • Wen Y, Zhang Y, Li J, Luo F, Huang Z, Liu K. Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells. Sci Rep. 2018;8(1):1147.
    • (2018) Sci Rep , vol.8 , Issue.1 , pp. 1147
    • Wen, Y.1    Zhang, Y.2    Li, J.3    Luo, F.4    Huang, Z.5    Liu, K.6
  • 42
    • 84870421832 scopus 로고    scopus 로고
    • Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer
    • Yeh CT, Wu ATH, Chang PMH, Chen KY, Yang CN, Yang SC, et al. Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. Am J Respir Crit Care Med. 2012;186(11):1180-8.
    • (2012) Am J Respir Crit Care Med , vol.186 , Issue.11 , pp. 1180-1188
    • Yeh, C.T.1    Wu, A.T.H.2    Chang, P.M.H.3    Chen, K.Y.4    Yang, C.N.5    Yang, S.C.6
  • 43
    • 84922155662 scopus 로고    scopus 로고
    • Repurposing the antipsychotic trifluoperazine as an antimetastasis agent
    • Pulkoski-Gross A, Li J, Zheng C, Li Y, Ouyang N, Rigas B, et al. Repurposing the Antipsychotic Trifluoperazine as an Antimetastasis Agent. Mol Pharmacol 2015;87(3):501-12.
    • (2015) Mol Pharmacol , vol.87 , Issue.3 , pp. 501-512
    • Pulkoski-Gross, A.1    Li, J.2    Zheng, C.3    Li, Y.4    Ouyang, N.5    Rigas, B.6
  • 44
    • 75549086408 scopus 로고    scopus 로고
    • SuperCYP: A comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions
    • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, et al. SuperCYP: A comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2009;38:D237-43.
    • (2009) Nucleic Acids Res , vol.38 , pp. D237-D243
    • Preissner, S.1    Kroll, K.2    Dunkel, M.3    Senger, C.4    Goldsobel, G.5    Kuzman, D.6
  • 45
    • 0036073980 scopus 로고    scopus 로고
    • The Ca2+ channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms
    • Bertolesi GE. The Ca2+ Channel Antagonists Mibefradil and Pimozide Inhibit Cell Growth via Different Cytotoxic Mechanisms. Mol Pharmacol 2002;62(2):210-9.
    • (2002) Mol Pharmacol , vol.62 , Issue.2 , pp. 210-219
    • Bertolesi, G.E.1
  • 46
    • 85042424892 scopus 로고    scopus 로고
    • Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis
    • Mapes J, Anandan L, Li Q, Neff A, Clevenger C V., Bagchi IC, et al. Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis. J Biol Chem. 2018;293(8):2850-64.
    • (2018) J Biol Chem , vol.293 , Issue.8 , pp. 2850-2864
    • Mapes, J.1    Anandan, L.2    Li, Q.3    Neff, A.4    Clevenger, C.V.5    Bagchi, I.C.6
  • 47
    • 85015161744 scopus 로고    scopus 로고
    • The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma
    • Chen J-J, Cai N, Chen G-Z, Jia C-C, Qiu D-B, Du C, et al. The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma. Oncotarget 2017;8(11):17593-609.
    • (2017) Oncotarget , vol.8 , Issue.11 , pp. 17593-17609
    • Chen, J.-J.1    Cai, N.2    Chen, G.-Z.3    Jia, C.-C.4    Qiu, D.-B.5    Du, C.6
  • 48
    • 84875545724 scopus 로고    scopus 로고
    • The STAT5 inhibitor pimozide displays efficacy in models of acute myelogenous leukemia driven by FLT3 mutations
    • Nelson EA, Walker SR, Xiang M, Weisberg E, Bar-Natan M, Barrett R, et al. The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations. Genes and Cancer. 2012;3:503-11.
    • (2012) Genes and Cancer , vol.3 , pp. 503-511
    • Nelson, E.A.1    Walker, S.R.2    Xiang, M.3    Weisberg, E.4    Bar-Natan, M.5    Barrett, R.6
  • 49
    • 84899549061 scopus 로고    scopus 로고
    • Model steatogenic compounds (Amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices
    • Lobaccaro JMA, editor
    • Szalowska E, Van Der Burg B, Man HY, Hendriksen PJM, Peijnenburg AACM. Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices. Lobaccaro JMA, editor. PLoS One. 2014;9(1):e86795.
    • (2014) PLoS One , vol.9 , Issue.1
    • Szalowska, E.1    Van Der Burg, B.2    Man, H.Y.3    Hendriksen, P.J.M.4    Peijnenburg, A.A.C.M.5
  • 50
    • 84964227431 scopus 로고    scopus 로고
    • Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation
    • Ji MM, Wang L, Zhan Q, Xue W, Zhao Y, Zhao X, et al. Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation. Autophagy. 2015;11(12):160-2171.
    • (2015) Autophagy , vol.11 , Issue.12 , pp. 160-2171
    • Ji, M.M.1    Wang, L.2    Zhan, Q.3    Xue, W.4    Zhao, Y.5    Zhao, X.6
  • 52
    • 80053130009 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells
    • Chou YW, Chaturvedi NK, Ouyang S, Lin FF, Kaushik D, Wang J, et al. Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells. Cancer Lett. 2011;311(2):177-86.
    • (2011) Cancer Lett , vol.311 , Issue.2 , pp. 177-186
    • Chou, Y.W.1    Chaturvedi, N.K.2    Ouyang, S.3    Lin, F.F.4    Kaushik, D.5    Wang, J.6
  • 54
    • 85037704944 scopus 로고    scopus 로고
    • The combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer
    • molcanther.0074.2017
    • Tran LNK, Kichenadasse G, Butler LM, Centenera MM, Morel KL, Ormsby RJ, et al. The combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer. Mol Cancer Ther 2017;16(12):molcanther.0074.2017.
    • (2017) Mol Cancer Ther , vol.16 , Issue.12
    • Tran, L.N.K.1    Kichenadasse, G.2    Butler, L.M.3    Centenera, M.M.4    Morel, K.L.5    Ormsby, R.J.6
  • 55
    • 84856493335 scopus 로고    scopus 로고
    • Valproic acid: Growth inhibition of head and neck cancer by induction of terminal differentiation and senescence
    • Gan CP, Hamid S, Hor SY, Zain RB, Ismail SM, Wan Mustafa WM, et al. Valproic acid: Growth inhibition of head and neck cancer by induction of terminal differentiation and senescence. Head Neck [Internet]. 2012;34(3):344-53.
    • (2012) Head Neck [Internet] , vol.34 , Issue.3 , pp. 344-353
    • Gan, C.P.1    Hamid, S.2    Hor, S.Y.3    Zain, R.B.4    Ismail, S.M.5    Wan Mustafa, W.M.6
  • 56
    • 84997269759 scopus 로고    scopus 로고
    • Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial
    • Caponigro F, Di Gennaro E, Ionna F, Longo F, Aversa C, Pavone E, et al. Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial. BMC Cancer. 2016;16(1):918.
    • (2016) BMC Cancer , vol.16 , Issue.1 , pp. 918
    • Caponigro, F.1    Di Gennaro, E.2    Ionna, F.3    Longo, F.4    Aversa, C.5    Pavone, E.6
  • 58
    • 77954643043 scopus 로고    scopus 로고
    • Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines
    • Fu J, Shao CJ, Chen FR, Ng HK, Chen ZP. Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro Oncol. 2010;12(4):328-40.
    • (2010) Neuro Oncol , vol.12 , Issue.4 , pp. 328-340
    • Fu, J.1    Shao, C.J.2    Chen, F.R.3    Ng, H.K.4    Chen, Z.P.5
  • 61
    • 84859487538 scopus 로고    scopus 로고
    • Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically
    • Zapotocky M, Mejstrikova E, Smetana K, Stary J, Trka J, Starkova J. Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically. Cancer Lett. 2012;319(2):144-53.
    • (2012) Cancer Lett , vol.319 , Issue.2 , pp. 144-153
    • Zapotocky, M.1    Mejstrikova, E.2    Smetana, K.3    Stary, J.4    Trka, J.5    Starkova, J.6
  • 62
    • 85040365229 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid exerts a synergistic cytotoxicity with the DNA-damaging drug ellipticine in neuroblastoma cells
    • Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, et al. The histone deacetylase inhibitor valproic acid exerts a synergistic cytotoxicity with the DNA-damaging drug ellipticine in neuroblastoma cells. Int J Mol Sci. 2018;19(1): 164.
    • (2018) Int J Mol Sci , vol.19 , Issue.1 , pp. 164
    • Cerna, T.1    Hrabeta, J.2    Eckschlager, T.3    Frei, E.4    Schmeiser, H.H.5    Arlt, V.M.6
  • 64
    • 84894823553 scopus 로고    scopus 로고
    • The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
    • Fredly H, Ersvær E, Kittang AO, Tsykunova G, Gjertsen BT, Bruserud O. The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia. Clin Epigenetics. 2013;5(1):13.
    • (2013) Clin Epigenetics , vol.5 , Issue.1 , pp. 13
    • Fredly, H.1    Ersvær, E.2    Kittang, A.O.3    Tsykunova, G.4    Gjertsen, B.T.5    Bruserud, O.6
  • 67
    • 85018966048 scopus 로고    scopus 로고
    • Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells
    • Liu S, Liang B, Jia H, Jiao Y, Pang Z, Huang Y. Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells. FEBS Open Bio. 2017;7(6):798-810.
    • (2017) FEBS Open Bio , vol.7 , Issue.6 , pp. 798-810
    • Liu, S.1    Liang, B.2    Jia, H.3    Jiao, Y.4    Pang, Z.5    Huang, Y.6
  • 68
    • 85019241724 scopus 로고    scopus 로고
    • Valproic acid induces endocytosis-mediated doxorubicin internalization and shows synergistic cytotoxic effects in hepatocellular carcinoma cells
    • Saha SK, Yin Y, Kim K, Yang GM, Dayemv AA, Choi HY, et al. Valproic acid induces endocytosis-mediated doxorubicin internalization and shows synergistic cytotoxic effects in hepatocellular carcinoma cells. Int J Mol Sci. 2017;18(5):1048.
    • (2017) Int J Mol Sci , vol.18 , Issue.5 , pp. 1048
    • Saha, S.K.1    Yin, Y.2    Kim, K.3    Yang, G.M.4    Dayemv, A.A.5    Choi, H.Y.6
  • 69
    • 84958794231 scopus 로고    scopus 로고
    • Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression
    • Terranova-Barberio M, Roca MS, Zotti AI, Leone A, Bruzzese F, Vitagliano C, et al. Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression. Oncotarget 2016;7(7):7715-31.
    • (2016) Oncotarget , vol.7 , Issue.7 , pp. 7715-7731
    • Terranova-Barberio, M.1    Roca, M.S.2    Zotti, A.I.3    Leone, A.4    Bruzzese, F.5    Vitagliano, C.6
  • 71
    • 77951247066 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the Alzheimer amyloid precursor protein
    • Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli IY, Walter J, et al. Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem. 2010;285(14):10678-89.
    • (2010) J Biol Chem , vol.285 , Issue.14 , pp. 10678-10689
    • Venkataramani, V.1    Rossner, C.2    Iffland, L.3    Schweyer, S.4    Tamboli, I.Y.5    Walter, J.6
  • 72
    • 84884950651 scopus 로고    scopus 로고
    • Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas
    • Li J, Bonifati S, Hristov G, Marttila T, Valmary-Degano S, Stanzel S, et al. Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas. EMBO Mol Med. 2013;5(10):1537-55.
    • (2013) EMBO Mol Med , vol.5 , Issue.10 , pp. 1537-1555
    • Li, J.1    Bonifati, S.2    Hristov, G.3    Marttila, T.4    Valmary-Degano, S.5    Stanzel, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.