Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells

Scientific Reports

Volumn 8, Issue 1, 2018, Pages

  Wen, Yulin ^a,b   Zhang, Yong ^c   Li, Jinbang ^a,b   Luo, Feng ^a,b   Huang, Zhongxi ^d   Liu, Kunping ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Jinan University   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CALCIUM; CYCLINE; KI 67 ANTIGEN; MKI67 PROTEIN, MOUSE; TRIFLUOPERAZINE; TUMOR MARKER;

ANIMAL; APOPTOSIS; BRAIN TUMOR; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; COMPLICATION; DEPRESSION; DRUG EFFECT; GENETICS; GLIA; GLIOMA; HUMAN; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR VOLUME; XENOGRAFT;

ANIMALS; ANTIDEPRESSIVE AGENTS; APOPTOSIS; BIOMARKERS, TUMOR; BRAIN NEOPLASMS; CALCIUM; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DEPRESSION; GLIOMA; HETEROGRAFTS; HUMANS; KI-67 ANTIGEN; MALE; MICE; MICE, NUDE; NEUROGLIA; PROLIFERATING CELL NUCLEAR ANTIGEN; TRIFLUOPERAZINE; TUMOR BURDEN;

EID: 85040823119     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-018-19413-y     Document Type: Article

References (34)

1. Dolecek, T. A., Propp, J. M., Stroup, N. E. & Kruchko, C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 14(Suppl 5), v1-49 (2012).
2. Torre, L. A. et al. Global cancer statistics, 2012. CA Cancer J Clin 65, 87-108 (2015).
3. Lacroix, M. et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95, 190-198 (2001).
4. Sai, K., Yang, Q. Y., Shen, D. & Chen, Z. P. Chemotherapy for gliomas in mainland China: An overview. Oncol Lett 5, 1448-1452 (2013).
5. Sarkaria, J. N. et al. Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin Cancer Res 14, 2900-2908 (2008).
6. Ho, V. K. et al. Changing incidence and improved survival of gliomas. Eur J Cancer 50, 2309-2318 (2014).
7. Kang, M. K. & Kang, S. K. Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem Cells Dev 16, 837-847 (2007).
8. Johnson, B. E. et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343, 189-193 (2014).
9. Hirst, T. C. et al. Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted? Br J Cancer 108, 64-71 (2013).
10. Gatti, L., Cassinelli, G., Zaffaroni, N., Lanzi, C. & Perego, P. New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants. Drug Resist Updat 20, 1-11 (2015).
11. Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006).
12. Lamb, J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 7, 54-60 (2007).
13. Yu, X. M. The Role of Intracellular Sodium in the Regulation of NMDA-Receptor-Mediated Channel Activity and Toxicity. Mol Neurobiol 33, 63-80 (2006).
14. Wang, H. G. et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284, 339-343 (1999).
15. Zhang, X. Z. et al. Analyzing gene expression profile in K562 cells exposed to sodium valproate using microarray combined with the connectivity map database. J Biomed Biotechnol 2012, 654291 (2012).
16. Yeh, C. T. et al. Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. Am J Respir Crit Care Med 186, 1180-1188 (2012).
17. Bielecka, A. M. & Obuchowicz, E. Antidepressant drugs can modify cytotoxic action of temozolomide. Eur J Cancer Care (Engl) (2016).
18. Brandes, L. J. et al. Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses. Cancer Res 52, 3796-3800 (1992).
19. Xu, Y. et al. MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways. Cancer Lett 371, 171-181 (2016).
20. Martins-Neves, S. R. et al. Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/beta-catenin signaling. Cancer Lett 370, 286-295 (2016).
21. Mao, M., Yu, T., Hu, J. & Hu, L. Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa. J Obstet Gynaecol Res 41, 1240-1245 (2015).
22. Yin, T. et al. Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model. Mol Med Rep 12, 4103-4108 (2015).
23. Sachlos, E. et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. CELL 149, 1284-1297 (2012).
24. Lu, M. et al. Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis. Onco Targets Ther 8, 1543-1552 (2015).
25. Wen, Q. et al. Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies. BMC Syst Biol 9(Suppl 5), S4 (2015).
26. Chien, J. M. et al. The mechanism of sertraline-induced [Ca2+]i rise in human OC2 oral cancer cells. Hum Exp Toxicol 30, 1635-1643 (2011).
27. Kang, S. et al. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R. Mol Cancer Ther 16, 217-227 (2017).
28. Liu, S., Han, Y., Zhang, T. & Yang, Z. Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells. Brain Res Bull 84, 183-188 (2011).
29. Yuan, K. et al. Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. Oncotarget 6, 25308-25319 (2015).
30. Bowie, M. et al. Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer. World J Clin Oncol 6, 299-311 (2015).
31. Souza, D. S. P., Saraiva, D. F., Ferraz, D. C. D., Scofano, H. M. & de Carvalho-Alves, P. C. Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging. Exp Brain Res 177, 347-357 (2007).
32. Situ, R. et al. Establishement of human brain malignant glioma cell line (SWO-38) and observation of its biologic properties. Chin J Cancer 6, 235-238 (1987).
33. Zhong, X. Y., Chen, Y. X. & Ye, S. F. Establishment of two cell sublines from SWO-38 glioma cells: an immunohisto-chemical and ultrastructural Study. Int J Modern Cancer Therapy 3, 34-37 (2000).
34. Lin, C., Liang, Y., Zhu, H., Zhang, J. & Zhong, X. R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3beta/PTEN pathway. Neurosci Lett 529, 60-65 (2012).