Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: A systematic review and meta-analyses of randomized trials

Nutrition Reviews

Volumn 77, Issue 6, 2019, Pages 430-450

  Suzumura, Erica A ^a,c   Bersch Ferreira, Ângela C ^c   Torreglosa, Camila R ^c   Da Silva, Jacqueline T ^c   Coqueiro, Audrey Y ^a   Kuntz, Marilyn G F ^b   Chrispim, Pedro P ^c   Weber, Bernardete ^c   Cavalcanti, Alexandre B ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Instituto Dona Helena de Ensino e Pesquisa   (Brazil)

^c Hospital Do Coração de São Paulo HCor   (Brazil)

Author keywords

Dietary supplements; Meta analyses; Obesity; Probiotics; Systematic review

Indexed keywords

PROBIOTIC AGENT; SYNBIOTIC AGENT;

ADULT; AGED; BODY MASS; BODY WEIGHT; FEMALE; HUMAN; MALE; META ANALYSIS; MIDDLE AGED; OBESITY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); VERY ELDERLY; WAIST CIRCUMFERENCE; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; BODY WEIGHT; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PROBIOTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SYNBIOTICS; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 85067702987     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nuz001     Document Type: Review

References (63)

1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 1289 million children, adolescents, and adults. Lancet. 2017;390:2627–2642. doi: 10.1016/S0140-6736(17)32129-3
2. McAllister EJ, Dhurandhar NV, Keith SW, et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009;49:868–913.
3. Romieu I, Dossus L, Barquera S, et al. Energy balance and obesity: what are the main drivers? Cancer Causes Control. 2017;28:247–258.
4. Musso G, Gambino R, Cassader M. Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care. 2010;33:2277–2284.
5. Torres-Fuentes C, Schellekens H, Dinan TG, et al. The microbiota–gut–brain axis in obesity. Lancet Gastroenterol Hepatol. 2017;2:747–756.
6. van de Wouw M, Schellekens H, Dinan TG, et al. Microbiota–gut–brain axis: modulator of host metabolism and appetite. J Nutr. 2017;147:727–745.
7. Saez-Lara MJ, Robles-Sanchez C, Ruiz-Ojeda FJ, et al. Effects of probiotics and synbiotics on obesity, insulin resistance syndrome, type 2 diabetes and non-alcoholic fatty liver disease: a review of human clinical trials. Int J Mol Sci. 2016;17:928. doi:10.3390/ijms17060928
8. Hill C, Guarner F, Reid G, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514.
9. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14:491–502.
10. Kolida S, Gibson GR. Synbiotics in health and disease. Annu Rev Food Sci Technol. 2011;2:373–393.
11. Martinez RCR, Bedani R, Saad SMI. Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges. Br J Nutr. 2015;114:1993–2015.
12. Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1. doi:10.1186/2046-4053-4-1
13. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
14. Higgins J, Altman D. Assessing risk of bias in included studies. In: Higgins J, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration; 2011. http://handbook.cochrane.org. Accessed December 15, 2017.
15. Higgins J, Deeks J, Altman D. Special topics in statistics. In: Higgins J, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration; 2011. http://handbook.cochrane.org. Accessed June 10, 2018.
16. Deeks J, Higgins J, Altman D. Analysing data and undertaking meta-analyses. In: Higgins J, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration; 2011. www.cochranehandbook.org. Accessed December 15, 2017.
17. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560.
18. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 7. Rating the quality of evidence—inconsistency. J Clin Epidemiol. 2011;64:1294–1302.
19. Egger M, Smith GD. Bias in location and selection of studies. BMJ. 1998;316:61–66.
20. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323:101–105.
21. Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias). J Clin Epidemiol. 2011;64:407–415.
22. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines 6. Rating the quality of evidence—imprecision. J Clin Epidemiol. 2011;64:1283–1293.
23. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 8. Rating the quality of evidence—indirectness. J Clin Epidemiol. 2011;64:1303–1310.
24. Guyatt GH, Oxman AD, Montori V, et al. GRADE guidelines: 5. Rating the quality of evidence—publication bias. J Clin Epidemiol. 2011;64:1277–1282.
25. Agerholm-Larsen L, Raben A, Haulrik N, et al. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr. 2000;54:288–297.
26. Chung HJ, Yu JG, Lee IA, et al. Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity. FEBS Open Bio. 2016;6:64–76.
27. Fathi Y, Ghodrati N, Zibaeenezhad MJ, et al. Kefir drink causes a significant yet similar improvement in serum lipid profile, compared with low-fat milk, in a dairy-rich diet in overweight or obese premenopausal women: a randomized controlled trial. J Clin Lipidol. 2017;11:136–146.
28. Fathi Y, Faghih S, Zibaeenezhad MJ, et al. Kefir drink leads to a similar weight loss, compared with milk, in a dairy-rich non-energy-restricted diet in overweight or obese premenopausal women: a randomized controlled trial. Eur J Nutr. 2016;55:295–304.
29. Gomes AC, Sousa RGM, Botelho PB, et al. The additional effects of a probiotic mix on abdominal adiposity and antioxidant status: a double-blind, randomized trial. Obesity. 2017;25:30–38.
30. Gomes AC, Sousa RGM, Botelho PB, et al. Probiotic mix associated with dietetic intervention was more effective to reduce abdominal adiposity than an isolated dietary intervention. Obes Rev. 2016;17(suppl S2):169. Abstract T6:36:32. doi:10.1111/obr.12403
31. Higashikawa F, Noda M, Awaya T, et al. Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial. Eur J Clin Nutr. 2016;70:582–587.
32. Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010;64:636–643.
33. Kim M, Kang M, Yoo HJ, et al. Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals. Food Funct. 2017;8:250–261.
34. Jung S, Lee YJ, Kim M, et al. Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects. J Funct Foods. 2015;19:744–752.
35. Lee SJ, Bose S, Seo JG, et al. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: a randomized double-blind controlled clinical trial. Clin Nutr. 2014;33:973–981.
36. Lee SJ, Song MY, Park JH, et al. The effects of co-administration of probiotics with herbal medicine on weight, blood lipid metabolism, intestinal permeability and gut micobiota in obese Korean women: a randomized double-blind controlled clinical trial [abstract]. Obes Facts. 2013;6(suppl 1):63. https://www.karger.com/Article/Pdf/170983
37. Madjd A, Taylor MA, Mousavi N, et al. Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial. Am J Clin Nutr. 2016;103:323–329.
38. Minami JI, Kondo S, Yanagisawa N, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. J Nutr Sci. 2015;4:e17. doi: 10.1017/jns.2015.5
39. Mobini R, Tremaroli V, Ståhlman M, et al. Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab. 2017;19:579–589.
40. Nabavi S, Rafraf M, Somi MH, et al. Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease. J Dairy Sci. 2014;97:7386–7393.
41. Rafraf M, Nabavi S, Somi MH, et al. The effect of probiotic and conventional yogurt consumptions on anthropometric parameters in individuals with non alcoholic fatty liver disease. J Babol Univ Med Sci. 2014;16:55–62. doi:10.18869/acadpub.jbums.16.9.55
42. Rabiei S, Shakerhosseini R, Saadat N. The effects of symbiotic therapy on anthropometric measures, body composition and blood pressure in patient with metabolic syndrome: a triple blind RCT. Med J Islam Repub Iran. 2015;29:213.
43. Sanchez M, Darimont C, Panahi S, et al. Effects of a diet-based weight-reducing program with probiotic supplementation on satiety efficiency, eating behaviour traits, and psychosocial behaviours in obese individuals. Nutrients. 2017;9:284. doi:10.3390/nu9030284
44. Sanchez M, Darimont C, Drapeau V, et al. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br J Nutr. 2014;111:1507–1519.
45. Sanchez M, Darimont C, Drapeau V, et al. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Can J Diabetes. 2013;37:S269.
46. Sharafedtinov KK, Plotnikova OA, Alexeeva RI, et al. Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients—a randomized double-blind placebo-controlled pilot study. Nutr J. 2013;12:138. doi:10.1186/1475-2891-12-138
47. Sharafetdinov KK, Plotnikova OA, Alekseeva RI, et al. Influence of a low-calorie diet with inclusion of probiotic product containing bacterias Lactobacillus plantarum Tensia DSM 21380 on clinical and metabolic characteristics in patients with obesity and arterial hypertension [in Russian]. Vopr Pitan. 2012;81:80–85.
48. Stenman LK, Lehtinen MJ, Meland N, et al. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults—randomized controlled trial. EBioMedicine. 2016;13:190–200.
49. Tajabadi-Ebrahimi M, Sharifi N, Farrokhian A, et al. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Exp Clin Endocrinol Diabetes. 2017;125:21–27.
50. Tovar J, Nilsson A, Johansson M, et al. A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects. Nutr Metab (Lond). 2012;9:29.
51. Zarrati M, Salehi E, Nourijelyani K, et al. Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononu-clear cells in overweight and obese people with or without weight-loss diet. J Am Coll Nutr. 2014;33:417–425.
52. Zarrati M, Shidfar F, Nourijelyani K, et al. Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 modulate gene expression of subset specific transcription factors and cytokines in peripheral blood mononu-clear cells of obese and overweight people. Biofactors. 2013;39:633–643.
53. Zhang Q, Wu Y, Fei X. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials. Int J Food Sci Nutr. 2015;67:571–580.
54. Borgeraas H, Johnson LK, Skattebu J, et al. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2018;19:219–232.
55. John GK, Wang L, Nanavati J, et al. Dietary alteration of the gut microbiome and its impact on weight and fat mass: a systematic review and meta-analysis. Genes (Basel). 2018;9.
56. Asemi Z, Samimi M, Tabassi Z, et al. Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial. Eur J Clin Nutr. 2013;67:71–74.
57. Javadi L, Ghavami M, Khoshbaten M, et al. The potential role of probiotics or/and prebiotic on serum lipid profile and insulin resistance in alcoholic fatty liver disease: a double blind randomized clinical trial. Crescent J Med Biol Sci. 2017;4:131–138.
58. Kadooka Y, Sato M, Ogawa A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr. 2013;110:1696–1703.
59. Leber B, Tripolt NJ, Blattl D, et al. The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study. Eur J Clin Nutr. 2012;66:1110–1115.
60. Aureli P, Capurso L, Castellazzi AM, et al. Probiotics and health: an evidence-based review. Pharmacol Res. 2011;63:366–376.
61. Smith GD. Is there a role for probiotics in older people? Br J Community Nurs. 2016;21:501–503.
62. Guo Z, Liu XM, Zhang QX, et al. Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis. 2011;21:844–850.
63. Million M, Angelakis E, Paul M, et al. Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb Pathog. 2012;53:100–108.