Probiotics and health: An evidence-based review

Pharmacological Research

Volumn 63, Issue 5, 2011, Pages 366-376

  Aureli, Paolo ^a   Capurso, Lucio ^b   Castellazzi, Anna Maria ^c   Clerici, Mario ^d   Giovannini, Marcello ^e   Morelli, Lorenzo ^f   Poli, Andrea ^g   Pregliasco, Fabrizio ^d   Salvini, Filippo ^d   Zuccotti, Gian Vincenzo ^h  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAN FILIPPO NERI HOSPITAL   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e Italian Society for Pediatric Nutrition   (Italy)

^f UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

^g Nutrition Foundation of Italy   (Italy)

^h UNIVERSITY OF MILAN   (Italy)

Author keywords

Immune system; Microbiota; Probiotics

Indexed keywords

PLACEBO; PROBIOTIC AGENT;

ALLERGIC RHINITIS; ANTIBIOTIC ASSOCIATED DIARRHEA; ANTIBODY RESPONSE; ATOPIC DERMATITIS; BACTERIAL FLORA; BACTERIAL STRAIN; BLOATING; CELLULAR IMMUNITY; CHILD HEALTH; CONSTIPATION; DIARRHEA; DIGESTIVE SYSTEM; EVIDENCE BASED MEDICINE; FLU LIKE SYNDROME; GASTROENTERITIS; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTIOUS DIARRHEA; INFLUENZA VACCINATION; MILK; NECROTIZING ENTEROCOLITIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; RISK FACTOR; UPPER RESPIRATORY TRACT INFECTION; VIRAL GASTROENTERITIS;

ANIMALS; HEALTH; HUMANS; IMMUNE SYSTEM; INTESTINES; PROBIOTICS;

EID: 79955483907     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.02.006     Document Type: Review

References (129)

1. E.M. Quigley Prebiotics and probiotics; modifying and mining the microbiota Pharmacol Res 61 2010 213 218
2. J.M. Laparra, and Y. Sanz Interactions of gut microbiota with functional food components and nutraceuticals Pharmacol Res 61 2010 219 225
3. B.V. Jones, and J.R. Marchesi Accessing the mobile metagenome of the human gut microbiota Mol Biosyst 3 2007 749 758 (Pubitemid 47587184)
4. R.E. Ley, M. Hamady, C. Lozupone, P.J. Turnbaugh, R.R. Ramey, and J.S. Bircher Evolution of mammals and their gut microbes Science 320 2008 1647 1651 (Pubitemid 351931256)
5. J. Qin, R. Li, J. Raes, M. Arumugam, K.S. Burgdorf, and C. Manichanh A human gut microbial gene catalogue established by metagenomic sequencing Nature 464 2010 59 65
6. B.V. Jones, F. Sun, and J.R. Marchesi Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome BMC Genomics 11 2010 46
7. K. Kurokawa, T. Itoh, T. Kuwahara, K. Oshima, H. Toh, and A. Toyoda Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes DNA Res 14 2007 169 181
8. S.R. Gill, M. Pop, R.T. Deboy, P.B. Eckburg, P.J. Turnbaugh, and B.S. Samuel Metagenomic analysis of the human distal gut microbiome Science 312 2006 1355 1359 (Pubitemid 43839542)
9. L.V. Hooper, and J.I. Gordon Commensal host-bacterial relationships in the gut Science 292 2001 1115 1118 (Pubitemid 32440925)
10. F. Backhed, R.E. Ley, J.L. Sonnenburg, D.A. Peterson, and J.I. Gordon Host-bacterial mutualism in the human intestine Science 307 2005 1915 1920 (Pubitemid 40404694)
11. R.E. Ley, D.A. Peterson, and J.I. Gordon Ecological and evolutionary forces shaping microbial diversity in the human intestine Cell 124 2006 837 848 (Pubitemid 43261456)
12. P.D. Cani, and N.M. Delzenne The role of the gut microbiota in energy metabolism and metabolic disease Curr Pharm Des 15 2009 1546 1558
13. Metahit. Metagenomics of the Human Intestinal Tract; 2009. http://www.metahit.eu/fileadmin/Content/Management-Files/Periodic-Report/ First-periodic-MetaHIT-report-extended-summary pdf.
14. S. Nissle Ueber die Grundlagen einer neuen ursaechlichen Bekaempfung der pathologischen Darmflora Dtsch Med Woch 42 1916 1181 1184
15. J.H. Cummings, and G.T. Macfarlane Role of intestinal bacteria in nutrient metabolism JPEN J Parenter Enteral Nutr 21 1997 357 365
16. S.C. Resta Effects of probiotics and commensals on intestinal epithelial physiology: implications for nutrient handling J Physiol 587 2009 4169 4174
17. D.K. Lanning, K.J. Rhee, and K.L. Knight Intestinal bacteria and development of the B-lymphocyte repertoire Trends Immunol 26 2005 419 425 (Pubitemid 41008078)
18. M. Tsuji, K. Suzuki, K. Kinoshita, and S. Fagarasan Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis Semin Immunol 20 2008 59 66
19. P.J. Turnbaugh, M. Hamady, T. Yatsunenko, B.L. Cantarel, A. Duncan, and R.E. Ley A core gut microbiome in obese and lean twins Nature 457 2009 480 484
20. R.E. Ley Obesity and the human microbiome Curr Opin Gastroenterol 26 2010 5 11
21. P.G. Falk, L.V. Hooper, T. Midtvedt, and J.I. Gordon Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology Microbiol Mol Biol Rev 62 1998 1157 1170 (Pubitemid 28558295)
22. C. Caballero-Franco, K. Keller, C. De Simone, and K. Chadee The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells Am J Physiol Gastrointest Liver Physiol 292 2007 G315 G322
23. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria; 2001. www.fao.org.
24. Ministero della Salute Italiano. Linee guida probiotici e prebiotici; 2005.
25. Guidelines for the evaluation of probiotics in food; 2002. www.fao.org.
26. C.M. Thomas, and J. Versalovic Probiotics-host communication: modulation of signaling pathways in the intestine Gut Microbes 1 2010 1 16
27. AFFSA. Effets des probiotiques et prébiotiques sur la flore et l'immunité de l'homme adulte; 2005.
28. EFSA. EFSA Scientific Colloquium Summary Report. QPS: qualified presumption of safety of microorganisms in food and feed; 2004.
29. S. Barlow, A. Chesson, J.D. Collins, E. Dybing, A. Flynn, and C. FruijtierPölloth Introduction of a qualified presumption of safety (QPS) approach for assessment of selected microorganisms referred to EFSA. Opinion of the Scientific Committee EFSA J 587 2007 1 16
30. W.T. Jansen, J.T. van der Bruggen, J. Verhoef, and A.C. Fluit Bacterial resistance: a sensitive issue complexity of the challenge and containment strategy in Europe Drug Resist Updat 9 2006 123 133 (Pubitemid 44279521)
31. F. Yan, and D.B. Polk Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells J Biol Chem 277 2002 50959 50965 (Pubitemid 36042264)
32. M.T. Tien, S.E. Girardin, B. Regnault, L. Le Bourhis, M.A. Dillies, and J.Y. Coppee Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells J Immunol 176 2006 1228 1237 (Pubitemid 43099727)
33. K. Takeda, T. Suzuki, S.I. Shimada, K. Shida, M. Nanno, and K. Okumura Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota Clin Exp Immunol 146 2006 109 115 (Pubitemid 44393845)
34. K. Takeda, and K. Okumura Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity J Nutr 137 2007 S791 S793
35. L.E. Niers, M.O. Hoekstra, H.M. Timmerman, N.O. van Uden, P.M. de Graaf, and H.H. Smits Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells Clin Exp Immunol 149 2007 344 352 (Pubitemid 47063056)
36. H.H. Smits, A. Engering, K.D. van der, E.C. de Jong, K. Schipper, and T.M. van Capel Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin J Allergy Clin Immunol 115 2005 1260 1267 (Pubitemid 40824599)
37. I.D. Iliev, H. Kitazawa, T. Shimosato, S. Katoh, H. Morita, and F. He Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern Cell Microbiol 7 2005 403 414 (Pubitemid 40277920)
38. I.D. Iliev, M. Tohno, D. Kurosaki, T. Shimosato, F. He, and M. Hosoda Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice Scand J Immunol 67 2008 370 376 (Pubitemid 351392928)
39. I.P. Kaur, K. Chopra, and A. Saini Probiotics: potential pharmaceutical applications Eur J Pharm Sci 15 2002 1 9 (Pubitemid 34136963)
40. M.L. Marco, S. Pavan, and M. Kleerebezem Towards understanding molecular modes of probiotic action Curr Opin Biotechnol 17 2006 204 210
41. G. Perdigon, S. Alvarez, M. Medina, E. Vintini, and E. Roux Influence of the oral administration of lactic acid bacteria on iga producing cells associated to bronchus Int J Immunopathol Pharmacol 12 1999 97 102 (Pubitemid 29366729)
42. K. Morimoto, T. Takeshita, M. Nanno, S. Tokudome, and K. Nakayama Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers Prev Med 40 2005 589 594 (Pubitemid 40320727)
43. K. Hatakka, E. Savilahti, A. Ponka, J.H. Meurman, T. Poussa, and L. Nase Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial BMJ 322 2001 1327
44. J.S. Lin, Y.H. Chiu, N.T. Lin, C.H. Chu, K.C. Huang, and K.W. Liao Different effects of probiotic species/strains on infections in preschool children: a double-blind, randomized, controlled study Vaccine 27 2009 1073 1079
45. G.L. Marseglia, M. Tosca, I. Cirillo, A. Licari, M. Leone, and A. Marseglia Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study Ther Clin Risk Manag 3 2007 13 17 (Pubitemid 46671819)
46. L. Lu, and W.A. Walker Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium Am J Clin Nutr 73 2001 S1124 S1130
47. S. Santosa, E. Farnworth, and P.J. Jones Probiotics and their potential health claims Nutr Rev 64 2006 265 274 (Pubitemid 43953291)
48. G.V. Zuccotti, F. Meneghin, C. Raimondi, D. Dilillo, C. Agostoni, and E. Riva Probiotics in clinical practice: an overview J Int Med Res 36 Suppl. 1 2008 1A 53A (Pubitemid 351255962)
49. G.P. Davidson, and R.N. Butler Probiotics in pediatric gastrointestinal disorders Curr Opin Pediatr 12 2000 477 481
50. H. Szajewska, M. Setty, J. Mrukowicz, and S. Guandalini Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy J Pediatr Gastroenterol Nutr 42 2006 454 475 (Pubitemid 43804722)
51. S. Michail, F. Sylvester, G. Fuchs, and R. Issenman Clinical efficacy of probiotics: review of the evidence with focus on children J Pediatr Gastroenterol Nutr 43 2006 550 557 (Pubitemid 44569023)
52. S. Guandalini Probiotics for children: use in diarrhea J Clin Gastroenterol 40 2006 244 248 (Pubitemid 44309561)
53. C.W. Van Niel, C. Feudtner, M.M. Garrison, and D.A. Christakis Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis Pediatrics 109 2002 678 684 (Pubitemid 34286304)
54. H. Szajewska, M. Kotowska, J.Z. Mrukowicz, M. Armanska, and W. Mikolajczyk Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants J Pediatr 138 2001 361 365 (Pubitemid 32207138)
55. S. Guandalini, L. Pensabene, M.A. Zikri, J.A. Dias, L.G. Casali, and H. Hoekstra Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial J Pediatr Gastroenterol Nutr 30 2000 54 60 (Pubitemid 30349946)
56. M. Kaila, E. Isolauri, E. Soppi, E. Virtanen, S. Laine, and H. Arvilommi Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain Pediatr Res 32 1992 141 144
57. H. Szymanski, J. Pejcz, M. Jawien, A. Chmielarczyk, M. Strus, and P.B. Heczko Treatment of acute infectious diarrhoea in infants and children with a mixture of three Lactobacillus rhamnosus strains - a randomized, double-blind, placebo-controlled trial Aliment Pharmacol Ther 23 2006 247 253 (Pubitemid 43382034)
58. R.A. Oberhelman, R.H. Gilman, P. Sheen, D.N. Taylor, R.E. Black, and L. Cabrera A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children J Pediatr 134 1999 15 20 (Pubitemid 29048673)
59. E. Mastretta, P. Longo, A. Laccisaglia, L. Balbo, R. Russo, and A. Mazzaccara Effect of Lactobacillus GG and breast-feeding in the prevention of rotavirus nosocomial infection J Pediatr Gastroenterol Nutr 35 2002 527 531 (Pubitemid 35191072)
60. H. Costa-Ribeiro, T.C. Ribeiro, A.P. Mattos, S.S. Valois, D.A. Neri, and P. Almeida Limitations of probiotic therapy in acute, severe dehydrating diarrhea J Pediatr Gastroenterol Nutr 36 2003 112 115 (Pubitemid 41672629)
61. E. Salazar-Lindo, P. Miranda-Langschwager, M. Campos-Sanchez, E. Chea-Woo, and R.B. Sack Lactobacillus casei strain GG in the treatment of infants with acute watery diarrhea: a randomized, double-blind, placebo controlled clinical trial [ISRCTN67363048] BMC Pediatr 4 2004 18
62. D.R. Mack, S. Michail, S. Wei, L. McDougall, and M.A. Hollingsworth Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression Am J Physiol 276 1999 G941 G950
63. S.A. Sarker, S. Sultana, G.J. Fuchs, N.H. Alam, T. Azim, and H. Brussow Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh Pediatrics 116 2005 e221 e228
64. A. Guarino, V.A. Lo, and R.B. Canani Probiotics as prevention and treatment for diarrhea Curr Opin Gastroenterol 25 2009 18 23
65. H. Szajewska, M. Ruszczynski, and A. Radzikowski Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials J Pediatr 149 2006 367 372
66. F. Cremonini, S. Di Caro, E.C. Nista, F. Bartolozzi, G. Capelli, and G. Gasbarrini Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea Aliment Pharmacol Ther 16 2002 1461 1467 (Pubitemid 34953587)
67. A.L. D'Souza, C. Rajkumar, J. Cooke, and C.J. Bulpitt Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis BMJ 324 2002 1361
68. T. Arvola, K. Laiho, S. Torkkeli, H. Mykkanen, S. Salminen, and L. Maunula Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study Pediatrics 104 1999 e64
69. S.J. Lewis, L.F. Potts, and R.E. Barry The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients J Infect 36 1998 171 174 (Pubitemid 28165587)
70. I. Castagliuolo, M.F. Riegler, L. Valenick, J.T. LaMont, and C. Pothoulakis Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa Infect Immun 67 1999 302 307 (Pubitemid 29021663)
71. L.V. McFarland Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections Anaerobe 15 2009 274 280
72. E.C. Claud, and W.A. Walker Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis FASEB J 15 2001 1398 1403 (Pubitemid 32531817)
73. G. Deshpande, S. Rao, S. Patole, and M. Bulsara Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates Pediatrics 125 2010 921 930
74. B. Bjorksten, P. Naaber, E. Sepp, and M. Mikelsaar The intestinal microflora in allergic Estonian and Swedish 2-year-old children Clin Exp Allergy 29 1999 342 346 (Pubitemid 29145134)
75. S. Watanabe, Y. Narisawa, S. Arase, H. Okamatsu, T. Ikenaga, and Y. Tajiri Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects J Allergy Clin Immunol 111 2003 587 591 (Pubitemid 36337881)
76. M. Giovannini, C. Agostoni, E. Riva, F. Salvini, A. Ruscitto, and G.V. Zuccotti A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis Pediatr Res 62 2007 215 220 (Pubitemid 47205726)
77. T.R. Abrahamsson, T. Jakobsson, M.F. Bottcher, M. Fredrikson, M.C. Jenmalm, and B. Bjorksten Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial J Allergy Clin Immunol 119 2007 1174 1180 (Pubitemid 46654165)
78. A.L. Taylor, J.A. Dunstan, and S.L. Prescott Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial J Allergy Clin Immunol 119 2007 184 191 (Pubitemid 46037800)
79. K. Kukkonen, E. Savilahti, T. Haahtela, K. Juntunen-Backman, R. Korpela, and T. Poussa Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial J Allergy Clin Immunol 119 2007 192 198 (Pubitemid 46037805)
80. C. Valsecchi, A. Marseglia, A. Ricci, L. Montagna, M. Leone, and G.L. Marseglia Probiotics and children: is an integration useful in allergic diseases? Pediatr Med Chir 30 2008 197 203
81. H. Johannsen, and S.L. Prescott Practical prebiotics, probiotics and synbiotics for allergists: how useful are they? Clin Exp Allergy 39 2009 1801 1814
82. T.C. Yao, C.J. Chang, Y.H. Hsu, and J.L. Huang Probiotics for allergic diseases: realities and myths Pediatr Allergy Immunol 21 2010 900 919
83. R.J. Boyle, F.J. Bath-Hextall, J. Leonardi-Bee, D.F. Murrell, and M.L. Tang Probiotics for the treatment of eczema: a systematic review Clin Exp Allergy 39 2009 1117 1127
84. L.B. van der Aa, H.S. Heymans, W.M. van Aalderen, and A.B. Sprikkelman Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence Pediatr Allergy Immunol 21 2010 e355 e367
85. J.I. Santos Nutrition, infection, and immunocompetence Infect Dis Clin North Am 8 1994 243 267 (Pubitemid 24114825)
86. O.A. Levander Nutrition and newly emerging viral diseases: an overview J Nutr 127 1997 S948 S950
87. M.A. Beck Antioxidants and viral infections: host immune response and viral pathogenicity J Am Coll Nutr 20 2001 S384 S388
88. K. Goodwin, C. Viboud, and L. Simonsen Antibody response to influenza vaccination in the elderly: a quantitative review Vaccine 24 2006 1159 1169 (Pubitemid 43202262)
89. A.M. Iorio, B. Camilloni, M. Basileo, M. Neri, E. Lepri, and M. Spighi Effects of repeated annual influenza vaccination on antibody responses against unchanged vaccine antigens in elderly frail institutionalized volunteers Gerontology 53 2007 411 418 (Pubitemid 351664667)
90. S. Rautava, S. Salminen, and E. Isolauri Specific probiotics in reducing the risk of acute infections in infancy - a randomised, double-blind, placebo-controlled study Br J Nutr 101 2009 1722 1726
91. G.J. Leyer, S. Li, M.E. Mubasher, C. Reifer, and A.C. Ouwehand Probiotic effects on cold and influenza-like symptom incidence and duration in children Pediatrics 124 2009 e172 e179
92. M. de Vrese, P. Winkler, P. Rautenberg, T. Harder, C. Noah, and C. Laue Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial Clin Nutr 24 2005 481 491 (Pubitemid 41051901)
93. M. de Vrese, P. Winkler, P. Rautenberg, T. Harder, C. Noah, and C. Laue Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial Vaccine 24 2006 6670 6674 (Pubitemid 46107165)
94. F. Pregliasco, G. Anselmi, L. Fonte, F. Giussani, S. Schieppati, and L. Soletti A new chance of preventing winter diseases by the administration of synbiotic formulations J Clin Gastroenterol 42 Suppl. 3, Part 2 2008 S224 S233
95. E.K. Vouloumanou, G.C. Makris, D.E. Karageorgopoulos, and M.E. Falagas Probiotics for the prevention of respiratory tract infections: a systematic review Int J Antimicrob Agents 34 2009 197 210
96. T. Boge, M. Remigy, S. Vaudaine, J. Tanguy, R. Bourdet-Sicard, and W.S. van der A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials Vaccine 27 2009 5677 5684
97. E. Guillemard, F. Tondu, F. Lacoin, and J. Schrezenmeir Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial Br J Nutr 103 2010 58 68
98. A. Chmielewska, and H. Szajewska Systematic review of randomised controlled trials: probiotics for functional constipation World J Gastroenterol 16 2010 69 75
99. P. Coccorullo, C. Strisciuglio, M. Martinelli, E. Miele, L. Greco, and A. Staiano Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study J Pediatr 157 2010 598 602
100. M.C. Lee, L.H. Lin, K.L. Hung, and H.Y. Wu Oral bacterial therapy promotes recovery from acute diarrhea in children Acta Paediatr Taiwan 42 2001 301 305
101. M. Medina, E. Izquierdo, S. Ennahar, and Y. Sanz Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications Clin Exp Immunol 150 2007 531 538 (Pubitemid 350098744)
102. C.N. Jacobsen, V. Rosenfeldt Nielsen, A.E. Hayford, P.L. Moller, K.F. Michaelsen, and A. Paerregaard Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans Appl Environ Microbiol 65 1999 4949 4956
103. C. Cesena, L. Morelli, M. Alander, T. Siljander, E. Tuomola, and S. Salminen Lactobacillus crispatus and its nonaggregating mutant in human colonization trials J Dairy Sci 84 2001 1001 1010 (Pubitemid 33609687)
104. S.J. Allen, B. Okoko, E. Martinez, G. Gregorio, and L.F. Dans Probiotics for treating infectious diarrhoea Cochrane Database Syst Rev 2004 CD003048
105. S. Sazawal, G. Hiremath, U. Dhingra, P. Malik, S. Deb, and R.E. Black Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials Lancet Infect Dis 6 2006 374 382 (Pubitemid 43737276)
106. M. Hickson, A.L. D'Souza, N. Muthu, T.R. Rogers, S. Want, and C. Rajkumar Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial BMJ 335 2007 80
107. E.C. Nista, M. Candelli, F. Cremonini, I.A. Cazzato, M.A. Zocco, and F. Franceschi Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial Aliment Pharmacol Ther 20 2004 1181 1188 (Pubitemid 39657952)
108. M. Beausoleil, N. Fortier, S. Guenette, A. L'ecuyer, M. Savoie, and M. Franco Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial Can J Gastroenterol 21 2007 732 736 (Pubitemid 351166126)
109. J.L. Tong, Z.H. Ran, J. Shen, C.X. Zhang, and S.D. Xiao Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy Aliment Pharmacol Ther 25 2007 155 168 (Pubitemid 46046372)
110. J. Sykora, K. Valeckova, J. Amlerova, K. Siala, P. Dedek, and S. Watkins Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study J Clin Gastroenterol 39 2005 692 698 (Pubitemid 41177089)
111. M. Montalto, V. Curigliano, L. Santoro, M. Vastola, G. Cammarota, and R. Manna Management and treatment of lactose malabsorption World J Gastroenterol 12 2006 187 191 (Pubitemid 43336915)
112. A. Gawronska, P. Dziechciarz, A. Horvath, and H. Szajewska A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children Aliment Pharmacol Ther 25 2007 177 184 (Pubitemid 46046374)
113. H.J. Kim, M.I. Vazquez Roque, M. Camilleri, D. Stephens, D.D. Burton, and K. Baxter A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating Neurogastroenterol Motil 17 2005 687 696 (Pubitemid 41400717)
114. K. Kajander, K. Hatakka, T. Poussa, M. Farkkila, and R. Korpela A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention Aliment Pharmacol Ther 22 2005 387 394 (Pubitemid 41248105)
115. D. Guyonnet, O. Chassany, P. Ducrotte, C. Picard, M. Mouret, and C.H. Mercier Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial Aliment Pharmacol Ther 26 2007 475 486 (Pubitemid 47063138)
116. W. Kruis, P. Fric, J. Pokrotnieks, M. Lukas, B. Fixa, and M. Kascak Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine Gut 53 2004 1617 1623 (Pubitemid 39434105)
117. P. Gionchetti, K.M. Lammers, F. Rizzello, and M. Campieri VSL#3: an analysis of basic and clinical contributions in probiotic therapeutics Gastroenterol Clin North Am 34 2005 499 513 (Pubitemid 41097280)
118. G. Deshpande, S. Rao, and S. Patole Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials Lancet 369 2007 1614 1620 (Pubitemid 46710124)
119. Y. Tao, K.A. Drabik, T.S. Waypa, M.W. Musch, J.C. Alverdy, and O. Schneewind Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells Am J Physiol Cell Physiol 290 2006 C1018 C1030
120. E.O. Petrof, K. Kojima, M.J. Ropeleski, M.W. Musch, Y. Tao, and C. De Simone Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition Gastroenterology 127 2004 1474 1487 (Pubitemid 39457773)
121. A.S. Neish, A.T. Gewirtz, H. Zeng, A.N. Young, M.E. Hobert, and V. Karmali Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination Science 289 2000 1560 1563
122. P.A. Ruiz, M. Hoffmann, S. Szcesny, M. Blaut, and D. Haller Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats Immunology 115 2005 441 450 (Pubitemid 41032432)
123. E.O. Petrof, E.C. Claud, J. Sun, T. Abramova, Y. Guo, and T.S. Waypa Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function Inflamm Bowel Dis 15 2009 1537 1547
124. L. Dubuquoy, E.A. Jansson, S. Deeb, S. Rakotobe, M. Karoui, and J.F. Colombel Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis Gastroenterology 124 2003 1265 1276 (Pubitemid 36531802)
125. S. Voltan, D. Martines, M. Elli, P. Brun, S. Longo, and A. Porzionato Lactobacillus crispatus M247-derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-gamma in the intestinal mucosa Gastroenterology 135 2008 1216 1227
126. D. Kelly, J.I. Campbell, T.P. King, G. Grant, E.A. Jansson, and A.G. Coutts Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA Nat Immunol 5 2004 104 112 (Pubitemid 38081475)
127. A. Are, L. Aronsson, S. Wang, G. Greicius, Y.K. Lee, and J.A. Gustafsson Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells Proc Natl Acad Sci USA 105 2008 1943 1948 (Pubitemid 351439444)
128. F. Yan, H. Cao, T.L. Cover, R. Whitehead, M.K. Washington, and D.B. Polk Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth Gastroenterology 132 2007 562 575 (Pubitemid 46274659)
129. D. Czerucka, S. Dahan, B. Mograbi, B. Rossi, and P. Rampal Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells Infect Immun 68 2000 5998 6004