메뉴 건너뛰기




Volumn 33, Issue 6, 2019, Pages 549-566

Medication-Induced Akathisia with Newly Approved Antipsychotics in Patients with a Severe Mental Illness: A Systematic Review and Meta-Analysis

Author keywords

[No Author keywords available]

Indexed keywords

ASENAPINE; BREXPIPRAZOLE; CARIPRAZINE; ILOPERIDONE; LURASIDONE; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE;

EID: 85065499411     PISSN: 11727047     EISSN: 11791934     Source Type: Journal    
DOI: 10.1007/s40263-019-00625-3     Document Type: Review
Times cited : (31)

References (172)
  • 2
    • 85025117054 scopus 로고    scopus 로고
    • Revisiting antipsychotic-induced akathisia: current issues and prospective challenges
    • Salem H, Nagpal C, Pigott T, Teixeira AL. Revisiting antipsychotic-induced akathisia: current issues and prospective challenges. Curr Neuropharmacol. 2017;15(5):789–98.
    • (2017) Curr Neuropharmacol , vol.15 , Issue.5 , pp. 789-798
    • Salem, H.1    Nagpal, C.2    Pigott, T.3    Teixeira, A.L.4
  • 3
    • 84958038519 scopus 로고    scopus 로고
    • Antipsychotic-induced akathisia in delirium: a systematic review
    • Forcen FE, Matsoukas K, Alici Y. Antipsychotic-induced akathisia in delirium: a systematic review. Palliat Support Care. 2016;14(1):77–84.
    • (2016) Palliat Support Care. , vol.14 , Issue.1 , pp. 77-84
    • Forcen, F.E.1    Matsoukas, K.2    Alici, Y.3
  • 5
    • 0346024155 scopus 로고    scopus 로고
    • The Barnes Akathisia Rating Scale–revisited
    • Barnes TR. The Barnes Akathisia Rating Scale–revisited. J Psychopharmacol. 2003;17(4):365–70.
    • (2003) J Psychopharmacol. , vol.17 , Issue.4 , pp. 365-370
    • Barnes, T.R.1
  • 7
    • 85018343961 scopus 로고    scopus 로고
    • Beyond anxiety and agitation: a clinical approach to akathisia
    • Tachere RO, Modirrousta M. Beyond anxiety and agitation: a clinical approach to akathisia. Aust Fam Phys. 2017;46(5):296–8.
    • (2017) Aust Fam Phys , vol.46 , Issue.5 , pp. 296-298
    • Tachere, R.O.1    Modirrousta, M.2
  • 8
    • 84991269945 scopus 로고    scopus 로고
    • Drug-induced extrapyramidal syndromes: implications for contemporary practice
    • Caroff SN, Campbell EC. Drug-induced extrapyramidal syndromes: implications for contemporary practice. Psychiatr Clin N Am. 2016;39(3):391–411.
    • (2016) Psychiatr Clin N Am , vol.39 , Issue.3 , pp. 391-411
    • Caroff, S.N.1    Campbell, E.C.2
  • 9
  • 10
    • 78650251837 scopus 로고    scopus 로고
    • Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial
    • (viii
    • Caroff SN, Hurford I, Lybrand J, Campbell EC. Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial. Neurol Clin. 2011;29(1):127–48 (viii).
    • (2011) Neurol Clin. , vol.29 , Issue.1 , pp. 127-148
    • Caroff, S.N.1    Hurford, I.2    Lybrand, J.3    Campbell, E.C.4
  • 11
    • 77951165069 scopus 로고    scopus 로고
    • Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
    • Kane JM, Barnes TR, Correll CU, et al. Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials. J Psychopharmacol. 2010;24(7):1019–29.
    • (2010) J Psychopharmacol. , vol.24 , Issue.7 , pp. 1019-1029
    • Kane, J.M.1    Barnes, T.R.2    Correll, C.U.3
  • 12
    • 14044274779 scopus 로고    scopus 로고
    • Neuroleptic-induced movement disorders: an overview
    • (x
    • Sachdev PS. Neuroleptic-induced movement disorders: an overview. Psychiatr Clin N Am. 2005;28(1):255–74 (x).
    • (2005) Psychiatr Clin N Am. , vol.28 , Issue.1 , pp. 255-274
    • Sachdev, P.S.1
  • 13
    • 85020091826 scopus 로고    scopus 로고
    • Incidence and risk factors of acute akathisia in 493 individuals with first episode non-affective psychosis: a 6-week randomised study of antipsychotic treatment
    • Juncal-Ruiz M, Ramirez-Bonilla M, Gomez-Arnau J, et al. Incidence and risk factors of acute akathisia in 493 individuals with first episode non-affective psychosis: a 6-week randomised study of antipsychotic treatment. Psychopharmacology. 2017;234(17):2563–70.
    • (2017) Psychopharmacology , vol.234 , Issue.17 , pp. 2563-2570
    • Juncal-Ruiz, M.1    Ramirez-Bonilla, M.2    Gomez-Arnau, J.3
  • 14
    • 20444376911 scopus 로고    scopus 로고
    • Manual for the extrapyramidal symptom rating scale (ESRS)
    • Chouinard G, Margolese HC. Manual for the extrapyramidal symptom rating scale (ESRS). Schizophr Res. 2005;76(2–3):247–65.
    • (2005) Schizophr Res , vol.76 , Issue.2-3 , pp. 247-265
    • Chouinard, G.1    Margolese, H.C.2
  • 15
    • 84977098572 scopus 로고    scopus 로고
    • A randomized trial of iloperidone for prevention of relapse in schizophrenia: the REPRIEVE study
    • Weiden PJ, Manning R, Wolfgang CD, et al. A randomized trial of iloperidone for prevention of relapse in schizophrenia: the REPRIEVE study. CNS Drugs. 2016;30(8):735–47.
    • (2016) CNS Drugs , vol.30 , Issue.8 , pp. 735-747
    • Weiden, P.J.1    Manning, R.2    Wolfgang, C.D.3
  • 16
    • 85003707591 scopus 로고    scopus 로고
    • Clarithromycin-induced akathisia: a class effect of macrolides
    • Gbinigie II, Lasserson D. Clarithromycin-induced akathisia: a class effect of macrolides. BMJ Case Rep. 2016. 10.1136/bcr-2016-217421.
    • (2016) BMJ Case Rep.
    • Gbinigie, I.I.1    Lasserson, D.2
  • 19
    • 84898896898 scopus 로고    scopus 로고
    • Tardive dystonic syndrome induced by the calcium-channel blocker amlodipine
    • Dressler D. Tardive dystonic syndrome induced by the calcium-channel blocker amlodipine. J Neural Transm (Vienna). 2014;121(4):367–9.
    • (2014) J Neural Transm (Vienna). , vol.121 , Issue.4 , pp. 367-369
    • Dressler, D.1
  • 20
    • 35948979310 scopus 로고    scopus 로고
    • Antiemetics, akathisia, and pregnancy
    • Wright MT. Antiemetics, akathisia, and pregnancy. Psychosomatics. 2007;48(6):461–6.
    • (2007) Psychosomatics. , vol.48 , Issue.6 , pp. 461-466
    • Wright, M.T.1
  • 21
    • 84866240639 scopus 로고    scopus 로고
    • Antipsychotic drugs and extrapyramidal side effects in first episode psychosis: a systematic review of head-head comparisons
    • Haddad PM, Das A, Keyhani S, Chaudhry IB. Antipsychotic drugs and extrapyramidal side effects in first episode psychosis: a systematic review of head-head comparisons. J Psychopharmacol. 2012;26(5 Suppl):15–26.
    • (2012) J Psychopharmacol , vol.26 , pp. 15-26
    • Haddad, P.M.1    Das, A.2    Keyhani, S.3    Chaudhry, I.B.4
  • 22
    • 85021659148 scopus 로고    scopus 로고
    • Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review
    • Solmi M, Murru A, Pacchiarotti I, Undurraga J, Veronese N, Fornaro M, et al. Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review. Ther Clin Risk Manag. 2017;13:757–77.
    • (2017) Ther Clin Risk Manag , vol.13 , pp. 757-777
    • Solmi, M.1    Murru, A.2    Pacchiarotti, I.3    Undurraga, J.4    Veronese, N.5    Fornaro, M.6
  • 23
    • 84953739974 scopus 로고    scopus 로고
    • Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset
    • Berna F, Misdrahi D, Boyer L, Aouizerate B, Brunel L, Capdevielle D, FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group, et al. Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset. Schizophr Res. 2015;169(1–3):255–61.
    • (2015) Schizophr Res. , vol.169 , Issue.1-3 , pp. 255-261
    • Berna, F.1    Misdrahi, D.2    Boyer, L.3    Aouizerate, B.4    Brunel, L.5    Capdevielle, D.6
  • 24
    • 84878877318 scopus 로고    scopus 로고
    • Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis
    • Zhang JP, Gallego JA, Robinson DG, Malhotra AK, Kane JM, Correll CU. Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis. Int J Neuropsychopharmacol. 2013;16(6):1205–18.
    • (2013) Int J Neuropsychopharmacol , vol.16 , Issue.6 , pp. 1205-1218
    • Zhang, J.P.1    Gallego, J.A.2    Robinson, D.G.3    Malhotra, A.K.4    Kane, J.M.5    Correll, C.U.6
  • 25
    • 85028065748 scopus 로고    scopus 로고
    • The safety and tolerability of cariprazine in long-term treatment of schizophrenia: a post hoc pooled analysis
    • Nasrallah HA, Earley W, Cutler AJ, Wang Y, Lu K, Laszlovszky I, et al. The safety and tolerability of cariprazine in long-term treatment of schizophrenia: a post hoc pooled analysis. BMC Psychiatry. 2017;17(1):305.
    • (2017) BMC Psychiatry , vol.17 , Issue.1 , pp. 305
    • Nasrallah, H.A.1    Earley, W.2    Cutler, A.J.3    Wang, Y.4    Lu, K.5    Laszlovszky, I.6
  • 26
    • 85047417424 scopus 로고    scopus 로고
    • Movement disorders associated with antipsychotic medication in people with schizophrenia: an overview of Cochrane reviews and meta-analysis
    • Martino D, Karnik V, Osland S, Barnes TRE, Pringsheim TM. Movement disorders associated with antipsychotic medication in people with schizophrenia: an overview of Cochrane reviews and meta-analysis. Can J Psychiatry. 2018;1:706743718777392.
    • (2018) Can J Psychiatry , vol.1
    • Martino, D.1    Karnik, V.2    Osland, S.3    Barnes, T.R.E.4    Pringsheim, T.M.5
  • 27
    • 0242332618 scopus 로고    scopus 로고
    • The causes of underdiagnosing akathisia
    • Hirose S. The causes of underdiagnosing akathisia. Schizophr Bull. 2003;29(3):547–58.
    • (2003) Schizophr Bull , vol.29 , Issue.3 , pp. 547-558
    • Hirose, S.1
  • 30
    • 80052477010 scopus 로고    scopus 로고
    • Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study
    • Meltzer HY, Cucchiaro J, Silva R, et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry. 2011;168(9):957–67.
    • (2011) Am J Psychiatry , vol.168 , Issue.9 , pp. 957-967
    • Meltzer, H.Y.1    Cucchiaro, J.2    Silva, R.3
  • 31
    • 84875270413 scopus 로고    scopus 로고
    • Lurasidone for the treatment of acutely psychotic patients with schizophrenia: a 6-week, randomized, placebo-controlled study
    • Nasrallah HA, Silva R, Phillips D, et al. Lurasidone for the treatment of acutely psychotic patients with schizophrenia: a 6-week, randomized, placebo-controlled study. J Psychiatr Res. 2013;47(5):670–7.
    • (2013) J Psychiatr Res , vol.47 , Issue.5 , pp. 670-677
    • Nasrallah, H.A.1    Silva, R.2    Phillips, D.3
  • 32
    • 84873710953 scopus 로고    scopus 로고
    • Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study
    • Ogasa M, Kimura T, Nakamura M, Guarino J. Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study. Psychopharmacology. 2013;225(3):519–30.
    • (2013) Psychopharmacology , vol.225 , Issue.3 , pp. 519-530
    • Ogasa, M.1    Kimura, T.2    Nakamura, M.3    Guarino, J.4
  • 33
    • 84998065445 scopus 로고    scopus 로고
    • A 6-week, double-blind, placebo- and haloperidol-controlled, phase II study of lurasidone in patients with acute schizophrenia
    • Potkin SG, Kimura T, Guarino J. A 6-week, double-blind, placebo- and haloperidol-controlled, phase II study of lurasidone in patients with acute schizophrenia. Ther Adv Psychopharmacol. 2015;5(6):322–31.
    • (2015) Ther Adv Psychopharmacol. , vol.5 , Issue.6 , pp. 322-331
    • Potkin, S.G.1    Kimura, T.2    Guarino, J.3
  • 34
    • 84945252861 scopus 로고    scopus 로고
    • Asenapine: efficacy and safety of 5 and 10 mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder
    • Landbloom RL, Mackle M, Wu X, et al. Asenapine: efficacy and safety of 5 and 10 mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder. J Affect Disord. 2016;190:103–10.
    • (2016) J Affect Disord , vol.190 , pp. 103-110
    • Landbloom, R.L.1    Mackle, M.2    Wu, X.3
  • 35
    • 40849114977 scopus 로고    scopus 로고
    • Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia
    • Kane JM, Lauriello J, Laska E, Di Marino M, Wolfgang CD. Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia. J Clin Psychopharmacol. 2008;28(2 Suppl 1):S29–35.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. S29-S35
    • Kane, J.M.1    Lauriello, J.2    Laska, E.3    Di Marino, M.4    Wolfgang, C.D.5
  • 36
    • 40849111788 scopus 로고    scopus 로고
    • Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia
    • Cutler AJ, Kalali AH, Weiden PJ, Hamilton J, Wolfgang CD. Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol. 2008;28(2 Suppl 1):S20–8.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. S20-S28
    • Cutler, A.J.1    Kalali, A.H.2    Weiden, P.J.3    Hamilton, J.4    Wolfgang, C.D.5
  • 37
    • 40849102838 scopus 로고    scopus 로고
    • Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials
    • Weiden PJ, Cutler AJ, Polymeropoulos MH, Wolfgang CD. Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol. 2008;28(2 Suppl 1):S12–9.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. S12-S19
    • Weiden, P.J.1    Cutler, A.J.2    Polymeropoulos, M.H.3    Wolfgang, C.D.4
  • 38
    • 40849089245 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies
    • Potkin SG, Litman RE, Torres R, Wolfgang CD. Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. J Clin Psychopharmacol. 2008;28(2 Suppl 1):S4–11.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. S4-S11
    • Potkin, S.G.1    Litman, R.E.2    Torres, R.3    Wolfgang, C.D.4
  • 39
    • 84856324879 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials
    • Citrome L, Meng X, Hochfeld M, Stahl SM. Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials. Hum Psychopharmacol. 2012;27(1):24–32.
    • (2012) Hum Psychopharmacol , vol.27 , Issue.1 , pp. 24-32
    • Citrome, L.1    Meng, X.2    Hochfeld, M.3    Stahl, S.M.4
  • 40
    • 84873087000 scopus 로고    scopus 로고
    • A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone
    • Potkin SG, Preskorn S, Hochfeld M, Meng X. A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone. J Clin Psychopharmacol. 2013;33(1):3–10.
    • (2013) J Clin Psychopharmacol , vol.33 , Issue.1 , pp. 3-10
    • Potkin, S.G.1    Preskorn, S.2    Hochfeld, M.3    Meng, X.4
  • 41
    • 70350540771 scopus 로고    scopus 로고
    • A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states
    • McIntyre RS, Cohen M, Zhao J, Alphs L, Macek TA, Panagides J. A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states. Bipolar Disord. 2009;11(7):673–86.
    • (2009) Bipolar Disord , vol.11 , Issue.7 , pp. 673-686
    • McIntyre, R.S.1    Cohen, M.2    Zhao, J.3    Alphs, L.4    Macek, T.A.5    Panagides, J.6
  • 43
    • 77957334940 scopus 로고    scopus 로고
    • Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study
    • McIntyre RS, Cohen M, Zhao J, Alphs L, Macek TA, Panagides J. Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study. J Affect Disord. 2010;126(3):358–65.
    • (2010) J Affect Disord , vol.126 , Issue.3 , pp. 358-365
    • McIntyre, R.S.1    Cohen, M.2    Zhao, J.3    Alphs, L.4    Macek, T.A.5    Panagides, J.6
  • 44
    • 77649340254 scopus 로고    scopus 로고
    • Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial
    • McIntyre RS, Cohen M, Zhao J, Alphs L, Macek TA, Panagides J. Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial. J Affect Disord. 2010;122(1–2):27–38.
    • (2010) J Affect Disord , vol.122 , Issue.1-2 , pp. 27-38
    • McIntyre, R.S.1    Cohen, M.2    Zhao, J.3    Alphs, L.4    Macek, T.A.5    Panagides, J.6
  • 45
    • 84855345812 scopus 로고    scopus 로고
    • Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension
    • Szegedi A, Calabrese JR, Stet L, Mackle M, Zhao J, Panagides J, Apollo Study Group. Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension. J Clin Psychopharmacol. 2012;32(1):46–55.
    • (2012) J Clin Psychopharmacol. , vol.32 , Issue.1 , pp. 46-55
    • Szegedi, A.1    Calabrese, J.R.2    Stet, L.3    Mackle, M.4    Zhao, J.5    Panagides, J.6
  • 46
    • 84872861182 scopus 로고    scopus 로고
    • Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses
    • Azorin JM, Sapin C, Weiller E. Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses. J Affect Disord. 2013;145(1):62–9.
    • (2013) J Affect Disord , vol.145 , Issue.1 , pp. 62-69
    • Azorin, J.M.1    Sapin, C.2    Weiller, E.3
  • 47
    • 77952154800 scopus 로고    scopus 로고
    • Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia
    • Kane JM, Cohen M, Zhao J, Alphs L, Panagides J. Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia. J Clin Psychopharmacol. 2010;30(2):106–15.
    • (2010) J Clin Psychopharmacol , vol.30 , Issue.2 , pp. 106-115
    • Kane, J.M.1    Cohen, M.2    Zhao, J.3    Alphs, L.4    Panagides, J.5
  • 48
    • 79953039210 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment
    • Kane JM, Mackle M, Snow-Adami L, Zhao J, Szegedi A, Panagides J. A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment. J Clin Psychiatry. 2011;72(3):349–55.
    • (2011) J Clin Psychiatry , vol.72 , Issue.3 , pp. 349-355
    • Kane, J.M.1    Mackle, M.2    Snow-Adami, L.3    Zhao, J.4    Szegedi, A.5    Panagides, J.6
  • 49
    • 77953885825 scopus 로고    scopus 로고
    • Long-term assessment of asenapine vs. olanzapine in patients with schizophrenia or schizoaffective disorder
    • Schoemaker J, Naber D, Vrijland P, Panagides J, Emsley R. Long-term assessment of asenapine vs. olanzapine in patients with schizophrenia or schizoaffective disorder. Pharmacopsychiatry. 2010;43(4):138–46.
    • (2010) Pharmacopsychiatry. , vol.43 , Issue.4 , pp. 138-146
    • Schoemaker, J.1    Naber, D.2    Vrijland, P.3    Panagides, J.4    Emsley, R.5
  • 50
    • 84863931968 scopus 로고    scopus 로고
    • Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study
    • Schoemaker J, Stet L, Vrijland P, Naber D, Panagides J, Emsley R. Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study. Pharmacopsychiatry. 2012;45(5):196–203.
    • (2012) Pharmacopsychiatry. , vol.45 , Issue.5 , pp. 196-203
    • Schoemaker, J.1    Stet, L.2    Vrijland, P.3    Naber, D.4    Panagides, J.5    Emsley, R.6
  • 51
    • 84855339931 scopus 로고    scopus 로고
    • Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia
    • Buchanan RW, Panagides J, Zhao J, et al. Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia. J Clin Psychopharmacol. 2012;32(1):36–45.
    • (2012) J Clin Psychopharmacol , vol.32 , Issue.1 , pp. 36-45
    • Buchanan, R.W.1    Panagides, J.2    Zhao, J.3
  • 52
    • 84932637973 scopus 로고    scopus 로고
    • Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis
    • Berk M, Tiller JW, Zhao J, Yatham LN, Malhi GS, Weiller E. Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis. J Clin Psychiatry. 2015;76(6):728–34.
    • (2015) J Clin Psychiatry , vol.76 , Issue.6 , pp. 728-734
    • Berk, M.1    Tiller, J.W.2    Zhao, J.3    Yatham, L.N.4    Malhi, G.S.5    Weiller, E.6
  • 53
    • 84976421815 scopus 로고    scopus 로고
    • Efficacy and safety of asenapine in Asian patients with an acute exacerbation of schizophrenia: a multicentre, randomized, double-blind, 6-week, placebo-controlled study
    • Kinoshita T, Bai YM, Kim JH, Miyake M, Oshima N. Efficacy and safety of asenapine in Asian patients with an acute exacerbation of schizophrenia: a multicentre, randomized, double-blind, 6-week, placebo-controlled study. Psychopharmacology. 2016;233(14):2663–74.
    • (2016) Psychopharmacology , vol.233 , Issue.14 , pp. 2663-2674
    • Kinoshita, T.1    Bai, Y.M.2    Kim, J.H.3    Miyake, M.4    Oshima, N.5
  • 54
    • 84994634491 scopus 로고    scopus 로고
    • Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control
    • Landbloom R, Mackle M, Wu X, Kelly L, Snow-Adami L, McIntyre RS, et al. Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control. CNS Spectr. 2017;22(4):333–41.
    • (2017) CNS Spectr , vol.22 , Issue.4 , pp. 333-341
    • Landbloom, R.1    Mackle, M.2    Wu, X.3    Kelly, L.4    Snow-Adami, L.5    McIntyre, R.S.6
  • 55
    • 85026806966 scopus 로고    scopus 로고
    • Exploring the long-term safety of asenapine in adults with schizophrenia in a double-blind, fixed-dose, extension study
    • Durgam S, Landbloom RP, Mackle M, Wu X, Mathews M, Nasrallah HA. Exploring the long-term safety of asenapine in adults with schizophrenia in a double-blind, fixed-dose, extension study. Neuropsychiatr Dis Treat. 2017;13:2021–35.
    • (2017) Neuropsychiatr Dis Treat. , vol.13 , pp. 2021-2035
    • Durgam, S.1    Landbloom, R.P.2    Mackle, M.3    Wu, X.4    Mathews, M.5    Nasrallah, H.A.6
  • 56
    • 85040318819 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of asenapine maintenance therapy in adults with an acute manic or mixed episode associated with bipolar i disorder
    • Szegedi A, Durgam S, Mackle M, Yu SY, Wu X, Mathews M, Landbloom RP. Randomized, double-blind, placebo-controlled trial of asenapine maintenance therapy in adults with an acute manic or mixed episode associated with bipolar i disorder. Am J Psychiatry. 2018;175(1):71–9.
    • (2018) Am J Psychiatry , vol.175 , Issue.1 , pp. 71-79
    • Szegedi, A.1    Durgam, S.2    Mackle, M.3    Yu, S.Y.4    Wu, X.5    Mathews, M.6    Landbloom, R.P.7
  • 57
    • 85011601251 scopus 로고    scopus 로고
    • Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial
    • Németh G, Laszlovszky I, Czobor P, Szalai E, Szatmári B, Harsányi J, et al. Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet. 2017;389(10074):1103–13.
    • (2017) Lancet , vol.389 , Issue.10074 , pp. 1103-1113
    • Németh, G.1    Laszlovszky, I.2    Czobor, P.3    Szalai, E.4    Szatmári, B.5    Harsányi, J.6
  • 58
    • 84963624901 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive cariprazine in inadequate responders to antidepressants: a randomized, double-blind, placebo-controlled study in adult patients with major depressive disorder
    • Durgam S, Earley W, Guo H, Li D, Németh G, Laszlovszky I, et al. Efficacy and safety of adjunctive cariprazine in inadequate responders to antidepressants: a randomized, double-blind, placebo-controlled study in adult patients with major depressive disorder. J Clin Psychiatry. 2016;77(3):371–8.
    • (2016) J Clin Psychiatry , vol.77 , Issue.3 , pp. 371-378
    • Durgam, S.1    Earley, W.2    Guo, H.3    Li, D.4    Németh, G.5    Laszlovszky, I.6
  • 59
    • 84921600142 scopus 로고    scopus 로고
    • The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial
    • Durgam S, Starace A, Li D, Migliore R, Ruth A, Németh G, Laszlovszky I. The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial. Bipolar Disord. 2015;17(1):63–75.
    • (2015) Bipolar Disord , vol.17 , Issue.1 , pp. 63-75
    • Durgam, S.1    Starace, A.2    Li, D.3    Migliore, R.4    Ruth, A.5    Németh, G.6    Laszlovszky, I.7
  • 60
    • 84954287364 scopus 로고    scopus 로고
    • Cariprazine in acute exacerbation of schizophrenia: a fixed-dose, phase 3, randomized, double-blind, placebo- and active-controlled trial
    • Durgam S, Cutler AJ, Lu K, Migliore R, Ruth A, Laszlovszky I, et al. Cariprazine in acute exacerbation of schizophrenia: a fixed-dose, phase 3, randomized, double-blind, placebo- and active-controlled trial. J Clin Psychiatry. 2015;76(12):e1574–82.
    • (2015) J Clin Psychiatry , vol.76 , Issue.12 , pp. e1574-e1582
    • Durgam, S.1    Cutler, A.J.2    Lu, K.3    Migliore, R.4    Ruth, A.5    Laszlovszky, I.6
  • 61
    • 84892852345 scopus 로고    scopus 로고
    • An evaluation of the safety and efficacy of cariprazine in patients with acute exacerbation of schizophrenia: a phase II, randomized clinical trial
    • Durgam S, Starace A, Li D, Migliore R, Ruth A, Németh G, et al. An evaluation of the safety and efficacy of cariprazine in patients with acute exacerbation of schizophrenia: a phase II, randomized clinical trial. Schizophr Res. 2014;152(2–3):450–7.
    • (2014) Schizophr Res , vol.152 , Issue.2-3 , pp. 450-457
    • Durgam, S.1    Starace, A.2    Li, D.3    Migliore, R.4    Ruth, A.5    Németh, G.6
  • 62
    • 84930532517 scopus 로고    scopus 로고
    • Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study
    • Calabrese JR, Keck PE Jr, Starace A, Lu K, Ruth A, Laszlovszky I, et al. Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study. J Clin Psychiatry. 2015;76(3):284–92.
    • (2015) J Clin Psychiatry , vol.76 , Issue.3 , pp. 284-292
    • Calabrese, J.R.1    Keck, P.E.2    Starace, A.3    Lu, K.4    Ruth, A.5    Laszlovszky, I.6
  • 63
    • 84936931469 scopus 로고    scopus 로고
    • Efficacy and safety of cariprazine in acute exacerbation of schizophrenia: results from an international, phase III clinical trial
    • Kane JM, Zukin S, Wang Y, Lu K, Ruth A, Nagy K, et al. Efficacy and safety of cariprazine in acute exacerbation of schizophrenia: results from an international, phase III clinical trial. J Clin Psychopharmacol. 2015;35(4):367–73.
    • (2015) J Clin Psychopharmacol , vol.35 , Issue.4 , pp. 367-373
    • Kane, J.M.1    Zukin, S.2    Wang, Y.3    Lu, K.4    Ruth, A.5    Nagy, K.6
  • 64
    • 84919622725 scopus 로고    scopus 로고
    • Cariprazine in the treatment of acute mania in bipolar I disorder: a double-blind, placebo-controlled, phase III trial
    • Sachs GS, Greenberg WM, Starace A, Lu K, Ruth A, Laszlovszky I, et al. Cariprazine in the treatment of acute mania in bipolar I disorder: a double-blind, placebo-controlled, phase III trial. J Affect Disord. 2015;174:296–302.
    • (2015) J Affect Disord , vol.174 , pp. 296-302
    • Sachs, G.S.1    Greenberg, W.M.2    Starace, A.3    Lu, K.4    Ruth, A.5    Laszlovszky, I.6
  • 65
    • 84959491677 scopus 로고    scopus 로고
    • An 8-week randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of cariprazine in patients with bipolar I depression
    • Durgam S, Earley W, Lipschitz A, Guo H, Laszlovszky I, Németh G, et al. An 8-week randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of cariprazine in patients with bipolar I depression. Am J Psychiatry. 2016;173(3):271–81.
    • (2016) Am J Psychiatry , vol.173 , Issue.3 , pp. 271-281
    • Durgam, S.1    Earley, W.2    Lipschitz, A.3    Guo, H.4    Laszlovszky, I.5    Németh, G.6
  • 66
    • 85022187263 scopus 로고    scopus 로고
    • Safety and tolerability of cariprazine in patients with acute exacerbation of schizophrenia: a pooled analysis of four phase II/III randomized, double-blind, placebo-controlled studies
    • Earley W, Durgam S, Lu K, Laszlovszky I, Debelle M, Kane JM. Safety and tolerability of cariprazine in patients with acute exacerbation of schizophrenia: a pooled analysis of four phase II/III randomized, double-blind, placebo-controlled studies. Int Clin Psychopharmacol. 2017;32(6):319–28.
    • (2017) Int Clin Psychopharmacol , vol.32 , Issue.6 , pp. 319-328
    • Earley, W.1    Durgam, S.2    Lu, K.3    Laszlovszky, I.4    Debelle, M.5    Kane, J.M.6
  • 67
    • 85016036459 scopus 로고    scopus 로고
    • Tolerability of cariprazine in the treatment of acute bipolar I mania: a pooled post hoc analysis of 3 phase II/III studies
    • Earley W, Durgam S, Lu K, Debelle M, Laszlovszky I, Vieta E, et al. Tolerability of cariprazine in the treatment of acute bipolar I mania: a pooled post hoc analysis of 3 phase II/III studies. J Affect Disord. 2017;215:205–12.
    • (2017) J Affect Disord , vol.215 , pp. 205-212
    • Earley, W.1    Durgam, S.2    Lu, K.3    Debelle, M.4    Laszlovszky, I.5    Vieta, E.6
  • 68
    • 84983527726 scopus 로고    scopus 로고
    • Tolerability and safety profile of cariprazine in treating psychotic disorders, bipolar disorder and major depressive disorder: a systematic review with meta-analysis of randomized controlled trials
    • Lao KS, He Y, Wong IC, Besag FM, Chan EW. Tolerability and safety profile of cariprazine in treating psychotic disorders, bipolar disorder and major depressive disorder: a systematic review with meta-analysis of randomized controlled trials. CNS Drugs. 2016;30(11):1043–54.
    • (2016) CNS Drugs , vol.30 , Issue.11 , pp. 1043-1054
    • Lao, K.S.1    He, Y.2    Wong, I.C.3    Besag, F.M.4    Chan, E.W.5
  • 69
    • 84978821878 scopus 로고    scopus 로고
    • Long-term cariprazine treatment for the prevention of relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial
    • Durgam S, Earley W, Li R, Li D, Lu K, Laszlovszky I, et al. Long-term cariprazine treatment for the prevention of relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. Schizophr Res. 2016;176(2–3):264–71.
    • (2016) Schizophr Res , vol.176 , Issue.2-3 , pp. 264-271
    • Durgam, S.1    Earley, W.2    Li, R.3    Li, D.4    Lu, K.5    Laszlovszky, I.6
  • 71
    • 85066423112 scopus 로고    scopus 로고
    • [ClinicalTrials.gov identifier NCT00852202]. National Institutes of Health, ClinicalTrials.gov, Accessed 26 Sep 2018
    • Forest Laboratories. Safety and efficacy of RGH-188 (cariprazine) in bipolar depression. 2010 [ClinicalTrials.gov identifier NCT00852202]. National Institutes of Health, ClinicalTrials.gov. https://clinicaltrials.gov. Accessed 26 Sep 2018
    • (2010) Safety and Efficacy of RGH-188 (Cariprazine) in Bipolar Depression
  • 72
    • 85050600677 scopus 로고    scopus 로고
    • Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: a 6-week, randomized, double-blind, placebo-controlled study
    • Ishigooka J, Iwashita S, Tadori Y. Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: a 6-week, randomized, double-blind, placebo-controlled study. Psychiatry Clin Neurosci. 2018;72(9):692–700.
    • (2018) Psychiatry Clin Neurosci , vol.72 , Issue.9 , pp. 692-700
    • Ishigooka, J.1    Iwashita, S.2    Tadori, Y.3
  • 73
    • 85052616010 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the efficacy and safety of fixed-dose brexpiprazole 2 mg/d as adjunctive treatment of adults with major depressive disorder
    • Hobart M, Skuban A, Zhang P, Augustine C, Brewer C, Hefting N, et al. A randomized, placebo-controlled study of the efficacy and safety of fixed-dose brexpiprazole 2 mg/d as adjunctive treatment of adults with major depressive disorder. J Clin Psychiatry. 2018;79(4):17m12058. 10.4088/JCP.17m12058.
    • (2018) J Clin Psychiatry , vol.79 , Issue.4 , pp. 17m12058
    • Hobart, M.1    Skuban, A.2    Zhang, P.3    Augustine, C.4    Brewer, C.5    Hefting, N.6
  • 74
    • 85041098950 scopus 로고    scopus 로고
    • Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study
    • Hobart M, Skuban A, Zhang P, Josiassen MK, Hefting N, Augustine C, et al. Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study. Curr Med Res Opin. 2018;34(4):633–42.
    • (2018) Curr Med Res Opin , vol.34 , Issue.4 , pp. 633-642
    • Hobart, M.1    Skuban, A.2    Zhang, P.3    Josiassen, M.K.4    Hefting, N.5    Augustine, C.6
  • 75
    • 85012306014 scopus 로고    scopus 로고
    • Efficacy and safety of brexpiprazole (opc-34712) as maintenance treatment in adults with schizophrenia: a randomized, double-blind, placebo-controlled study
    • Fleischhacker WW, Hobart M, Ouyang J, Forbes A, Pfister S, McQuade RD, et al. Efficacy and safety of brexpiprazole (opc-34712) as maintenance treatment in adults with schizophrenia: a randomized, double-blind, placebo-controlled study. Int J Neuropsychopharmacol. 2017;20(1):11–21.
    • (2017) Int J Neuropsychopharmacol , vol.20 , Issue.1 , pp. 11-21
    • Fleischhacker, W.W.1    Hobart, M.2    Ouyang, J.3    Forbes, A.4    Pfister, S.5    McQuade, R.D.6
  • 76
    • 84967261783 scopus 로고    scopus 로고
    • Overview of short- and long-term tolerability and safety of brexpiprazole in patients with schizophrenia
    • Kane JM, Skuban A, Hobart M, Ouyang J, Weiller E, Weiss C, et al. Overview of short- and long-term tolerability and safety of brexpiprazole in patients with schizophrenia. Schizophr Res. 2016;174(1–3):93–8.
    • (2016) Schizophr Res , vol.174 , Issue.1-3 , pp. 93-98
    • Kane, J.M.1    Skuban, A.2    Hobart, M.3    Ouyang, J.4    Weiller, E.5    Weiss, C.6
  • 77
    • 84964734763 scopus 로고    scopus 로고
    • Efficacy of brexpiprazole in patients with acute schizophrenia: review of three randomized, double-blind, placebo-controlled studies
    • Correll CU, Skuban A, Hobart M, Ouyang J, Weiller E, Weiss C, et al. Efficacy of brexpiprazole in patients with acute schizophrenia: review of three randomized, double-blind, placebo-controlled studies. Schizophr Res. 2016;174(1–3):82–92.
    • (2016) Schizophr Res , vol.174 , Issue.1-3 , pp. 82-92
    • Correll, C.U.1    Skuban, A.2    Hobart, M.3    Ouyang, J.4    Weiller, E.5    Weiss, C.6
  • 78
    • 84960344877 scopus 로고    scopus 로고
    • The effect of brexpiprazole (OPC-34712) and aripiprazole in adult patients with acute schizophrenia: results from a randomized, exploratory study
    • Citrome L, Ota A, Nagamizu K, Perry P, Weiller E, Baker RA. The effect of brexpiprazole (OPC-34712) and aripiprazole in adult patients with acute schizophrenia: results from a randomized, exploratory study. Int Clin Psychopharmacol. 2016;31(4):192–201.
    • (2016) Int Clin Psychopharmacol , vol.31 , Issue.4 , pp. 192-201
    • Citrome, L.1    Ota, A.2    Nagamizu, K.3    Perry, P.4    Weiller, E.5    Baker, R.A.6
  • 79
    • 84942502726 scopus 로고    scopus 로고
    • Adjunctive brexpiprazole 1 and 3 mg for patients with major depressive disorder following inadequate response to antidepressants: a phase 3, randomized, double-blind study
    • Thase ME, Youakim JM, Skuban A, Hobart M, Zhang P, McQuade RD, et al. Adjunctive brexpiprazole 1 and 3 mg for patients with major depressive disorder following inadequate response to antidepressants: a phase 3, randomized, double-blind study. J Clin Psychiatry. 2015;76(9):1232–40.
    • (2015) J Clin Psychiatry , vol.76 , Issue.9 , pp. 1232-1240
    • Thase, M.E.1    Youakim, J.M.2    Skuban, A.3    Hobart, M.4    Zhang, P.5    McQuade, R.D.6
  • 80
    • 84942502416 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants
    • Thase ME, Youakim JM, Skuban A, Hobart M, Augustine C, Zhang P, et al. Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants. J Clin Psychiatry. 2015;76(9):1224–31.
    • (2015) J Clin Psychiatry , vol.76 , Issue.9 , pp. 1224-1231
    • Thase, M.E.1    Youakim, J.M.2    Skuban, A.3    Hobart, M.4    Augustine, C.5    Zhang, P.6
  • 81
    • 84969217028 scopus 로고    scopus 로고
    • Brexpiprazole as adjunctive treatment of major depressive disorder with anxious distress: results from a post hoc analysis of two randomised controlled trials
    • McIntyre RS, Weiller E, Zhang P, Weiss C. Brexpiprazole as adjunctive treatment of major depressive disorder with anxious distress: results from a post hoc analysis of two randomised controlled trials. J Affect Disord. 2016;201:116–23.
    • (2016) J Affect Disord , vol.201 , pp. 116-123
    • McIntyre, R.S.1    Weiller, E.2    Zhang, P.3    Weiss, C.4
  • 82
    • 84995687172 scopus 로고    scopus 로고
    • Brexpiprazole in patients with schizophrenia: overview of short- and long-term phase 3 controlled studies
    • Marder SR, Hakala MJ, Josiassen MK, Zhang P, Ouyang J, Weiller E, et al. Brexpiprazole in patients with schizophrenia: overview of short- and long-term phase 3 controlled studies. Acta Neuropsychiatr. 2017;29(5):278–90.
    • (2017) Acta Neuropsychiatr , vol.29 , Issue.5 , pp. 278-290
    • Marder, S.R.1    Hakala, M.J.2    Josiassen, M.K.3    Zhang, P.4    Ouyang, J.5    Weiller, E.6
  • 83
    • 85031732767 scopus 로고    scopus 로고
    • Efficacy of adjunctive brexpiprazole on the core symptoms of major depressive disorder: a post hoc analysis of two pooled clinical studies
    • Nelson JC, Weiller E, Zhang P, Weiss C, Hobart M. Efficacy of adjunctive brexpiprazole on the core symptoms of major depressive disorder: a post hoc analysis of two pooled clinical studies. J Affect Disord. 2018;227:103–8.
    • (2018) J Affect Disord , vol.227 , pp. 103-108
    • Nelson, J.C.1    Weiller, E.2    Zhang, P.3    Weiss, C.4    Hobart, M.5
  • 84
    • 85006952481 scopus 로고    scopus 로고
    • Overview of short-term and long-term safety of brexpiprazole in patients with major depressive disorder and inadequate response to antidepressant treatment
    • Nelson JC, Zhang P, Skuban A, Hobart M, Weiss C, Weiller E, et al. Overview of short-term and long-term safety of brexpiprazole in patients with major depressive disorder and inadequate response to antidepressant treatment. Curr Psychiatry Rev. 2016;12:278–90.
    • (2016) Curr Psychiatry Rev , vol.12 , pp. 278-290
    • Nelson, J.C.1    Zhang, P.2    Skuban, A.3    Hobart, M.4    Weiss, C.5    Weiller, E.6
  • 85
    • 85004011508 scopus 로고    scopus 로고
    • Adjunctive brexpiprazole as a novel effective strategy for treating major depressive disorder: a systematic review and meta-analysis
    • Yoon S, Jeon SW, Ko YH, Patkar AA, Masand PS, Pae CU, et al. Adjunctive brexpiprazole as a novel effective strategy for treating major depressive disorder: a systematic review and meta-analysis. J Clin Psychopharmacol. 2017;37(1):46–53.
    • (2017) J Clin Psychopharmacol , vol.37 , Issue.1 , pp. 46-53
    • Yoon, S.1    Jeon, S.W.2    Ko, Y.H.3    Patkar, A.A.4    Masand, P.S.5    Pae, C.U.6
  • 86
    • 84928640856 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia
    • Kane JM, Skuban A, Ouyang J, Hobart M, Pfister S, McQuade RD, et al. A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia. Schizophr Res. 2015;164(1–3):127–35.
    • (2015) Schizophr Res , vol.164 , Issue.1-3 , pp. 127-135
    • Kane, J.M.1    Skuban, A.2    Ouyang, J.3    Hobart, M.4    Pfister, S.5    McQuade, R.D.6
  • 87
    • 84937234454 scopus 로고    scopus 로고
    • Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia: a 6-week randomized, double-blind, placebo-controlled trial
    • Correll CU, Skuban A, Ouyang J, Hobart M, Pfister S, McQuade RD, et al. Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia: a 6-week randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2015;172(9):870–80.
    • (2015) Am J Psychiatry , vol.172 , Issue.9 , pp. 870-880
    • Correll, C.U.1    Skuban, A.2    Ouyang, J.3    Hobart, M.4    Pfister, S.5    McQuade, R.D.6
  • 91
    • 84962921387 scopus 로고    scopus 로고
    • Lurasidone adjunctive with lithium or valproate for bipolar depression: a placebo-controlled trial utilizing prospective and retrospective enrolment cohorts
    • Suppes T, Kroger H, Pikalov A, Loebel A. Lurasidone adjunctive with lithium or valproate for bipolar depression: a placebo-controlled trial utilizing prospective and retrospective enrolment cohorts. J Psychiatr Res. 2016;78:86–93.
    • (2016) J Psychiatr Res , vol.78 , pp. 86-93
    • Suppes, T.1    Kroger, H.2    Pikalov, A.3    Loebel, A.4
  • 92
    • 84962342216 scopus 로고    scopus 로고
    • Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study
    • Suppes T, Silva R, Cucchiaro J, Mao Y, Targum S, Streicher C, et al. Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2016;173(4):400–7.
    • (2016) Am J Psychiatry , vol.173 , Issue.4 , pp. 400-407
    • Suppes, T.1    Silva, R.2    Cucchiaro, J.3    Mao, Y.4    Targum, S.5    Streicher, C.6
  • 93
    • 85007591469 scopus 로고    scopus 로고
    • Lurasidone dose escalation in early nonresponding patients with schizophrenia: a randomized, placebo-controlled study
    • Loebel A, Silva R, Goldman R, Watabe K, Cucchiaro J, Citrome L, et al. Lurasidone dose escalation in early nonresponding patients with schizophrenia: a randomized, placebo-controlled study. J Clin Psychiatry. 2016;77(12):1672–80.
    • (2016) J Clin Psychiatry , vol.77 , Issue.12 , pp. 1672-1680
    • Loebel, A.1    Silva, R.2    Goldman, R.3    Watabe, K.4    Cucchiaro, J.5    Citrome, L.6
  • 94
    • 84945901098 scopus 로고    scopus 로고
    • Treatment of early non-response in patients with schizophrenia: assessing the efficacy of antipsychotic dose escalation
    • Loebel A, Citrome L, Correll CU, Xu J, Cucchiaro J, Kane JM. Treatment of early non-response in patients with schizophrenia: assessing the efficacy of antipsychotic dose escalation. BMC Psychiatry. 2015;15:271.
    • (2015) BMC Psychiatry , vol.15 , pp. 271
    • Loebel, A.1    Citrome, L.2    Correll, C.U.3    Xu, J.4    Cucchiaro, J.5    Kane, J.M.6
  • 95
    • 84893636659 scopus 로고    scopus 로고
    • Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study
    • Loebel A, Cucchiaro J, Silva R, Kroger H, Hsu J, Sarma K, et al. Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2014;171(2):160–8.
    • (2014) Am J Psychiatry , vol.171 , Issue.2 , pp. 160-168
    • Loebel, A.1    Cucchiaro, J.2    Silva, R.3    Kroger, H.4    Hsu, J.5    Sarma, K.6
  • 96
    • 84893669193 scopus 로고    scopus 로고
    • Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study
    • Loebel A, Cucchiaro J, Silva R, Kroger H, Sarma K, Xu J, et al. Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2014;171(2):169–77.
    • (2014) Am J Psychiatry , vol.171 , Issue.2 , pp. 169-177
    • Loebel, A.1    Cucchiaro, J.2    Silva, R.3    Kroger, H.4    Sarma, K.5    Xu, J.6
  • 97
    • 84875255343 scopus 로고    scopus 로고
    • Efficacy and safety of lurasidone 80 mg/day and 160 mg/day in the treatment of schizophrenia: a randomized, double-blind, placebo- and active-controlled trial
    • Loebel A, Cucchiaro J, Sarma K, et al. Efficacy and safety of lurasidone 80 mg/day and 160 mg/day in the treatment of schizophrenia: a randomized, double-blind, placebo- and active-controlled trial. Schizophr Res. 2013;145(1–3):101–9.
    • (2013) Schizophr Res , vol.145 , Issue.1-3 , pp. 101-109
    • Loebel, A.1    Cucchiaro, J.2    Sarma, K.3
  • 98
    • 84877148423 scopus 로고    scopus 로고
    • Effectiveness of lurasidone vs. quetiapine XR for relapse prevention in schizophrenia: a 12-month, double-blind, noninferiority study
    • Loebel A, Cucchiaro J, Xu J, Sarma K, Pikalov A, Kane JM. Effectiveness of lurasidone vs. quetiapine XR for relapse prevention in schizophrenia: a 12-month, double-blind, noninferiority study. Schizophr Res. 2013;147(1):95–102.
    • (2013) Schizophr Res , vol.147 , Issue.1 , pp. 95-102
    • Loebel, A.1    Cucchiaro, J.2    Xu, J.3    Sarma, K.4    Pikalov, A.5    Kane, J.M.6
  • 99
    • 84859268864 scopus 로고    scopus 로고
    • Long-term safety and tolerability of lurasidone in schizophrenia: a 12-month, double-blind, active-controlled study
    • Citrome L, Cucchiaro J, Sarma K, Phillips D, Silva R, Tsuchiya S, et al. Long-term safety and tolerability of lurasidone in schizophrenia: a 12-month, double-blind, active-controlled study. Int Clin Psychopharmacol. 2012;27(3):165–76.
    • (2012) Int Clin Psychopharmacol , vol.27 , Issue.3 , pp. 165-176
    • Citrome, L.1    Cucchiaro, J.2    Sarma, K.3    Phillips, D.4    Silva, R.5    Tsuchiya, S.6
  • 100
    • 80054080823 scopus 로고    scopus 로고
    • Double-blind comparison of the safety and efficacy of lurasidone and ziprasidone in clinically stable outpatients with schizophrenia or schizoaffective disorder
    • Potkin SG, Ogasa M, Cucchiaro J, Loebel A. Double-blind comparison of the safety and efficacy of lurasidone and ziprasidone in clinically stable outpatients with schizophrenia or schizoaffective disorder. Schizophr Res. 2011;132(2–3):101–7.
    • (2011) Schizophr Res , vol.132 , Issue.2-3 , pp. 101-107
    • Potkin, S.G.1    Ogasa, M.2    Cucchiaro, J.3    Loebel, A.4
  • 101
    • 67649222011 scopus 로고    scopus 로고
    • Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial
    • Nakamura M, Ogasa M, Guarino J, et al. Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial. J Clin Psychiatry. 2009;70(6):829–36.
    • (2009) J Clin Psychiatry , vol.70 , Issue.6 , pp. 829-836
    • Nakamura, M.1    Ogasa, M.2    Guarino, J.3
  • 103
    • 85066418316 scopus 로고    scopus 로고
    • Sunovion, A 6-week, double-blind, randomized, fixed-dose, parallel-group study of the efficacy and safety of three dose levels of sm-13496 compared to placebo and haloperidol in patients with schizophrenia who are experiencing an acute exacerbation of symptoms, [ClinicalTrials.gov identifier NCT00044044]. National Institutes of Health, ClinicalTrials.gov, Accessed 26 Sep 2018
    • Sunovion, A 6-week, double-blind, randomized, fixed-dose, parallel-group study of the efficacy and safety of three dose levels of sm-13496 compared to placebo and haloperidol in patients with schizophrenia who are experiencing an acute exacerbation of symptoms. 2003 [ClinicalTrials.gov identifier NCT00044044]. National Institutes of Health, ClinicalTrials.gov. https://clinicaltrials.gov. Accessed 26 Sep 2018
    • (2003)
  • 104
    • 85011282367 scopus 로고    scopus 로고
    • Activating and sedating adverse effects of second-generation antipsychotics in the treatment of schizophrenia and major depressive disorder: absolute risk increase and number needed to harm
    • Citrome L. Activating and sedating adverse effects of second-generation antipsychotics in the treatment of schizophrenia and major depressive disorder: absolute risk increase and number needed to harm. J Clin Psychopharmacol. 2017;37(2):138–47.
    • (2017) J Clin Psychopharmacol , vol.37 , Issue.2 , pp. 138-147
    • Citrome, L.1
  • 105
    • 84946741626 scopus 로고    scopus 로고
    • The incidence of akathisia in the treatment of schizophrenia with aripiprazole, asenapine and lurasidone: a meta-analysis
    • Thomas JE, Caballero J, Harrington CA. The incidence of akathisia in the treatment of schizophrenia with aripiprazole, asenapine and lurasidone: a meta-analysis. Curr Neuropharmacol. 2015;13(5):681–91.
    • (2015) Curr Neuropharmacol , vol.13 , Issue.5 , pp. 681-691
    • Thomas, J.E.1    Caballero, J.2    Harrington, C.A.3
  • 106
    • 85015309830 scopus 로고    scopus 로고
    • Clinical role of brexpiprazole in depression and schizophrenia
    • Parikh NB, Robinson DM, Clayton AH. Clinical role of brexpiprazole in depression and schizophrenia. Ther Clin Risk Manag. 2017;13:299–306.
    • (2017) Ther Clin Risk Manag , vol.13 , pp. 299-306
    • Parikh, N.B.1    Robinson, D.M.2    Clayton, A.H.3
  • 107
    • 84555186903 scopus 로고    scopus 로고
    • Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons
    • Rummel-Kluge C, Komossa K, Schwarz S, Hunger H, Schmid F, Kissling W, et al. Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons. Schizophr Bull. 2012;38(1):167–77.
    • (2012) Schizophr Bull , vol.38 , Issue.1 , pp. 167-177
    • Rummel-Kluge, C.1    Komossa, K.2    Schwarz, S.3    Hunger, H.4    Schmid, F.5    Kissling, W.6
  • 108
    • 85041737870 scopus 로고    scopus 로고
    • Brexpiprazole: a new leaf on the partial dopamine agonist branch
    • Hope J, Castle D, Keks NA. Brexpiprazole: a new leaf on the partial dopamine agonist branch. Australas Psychiatry. 2018;26(1):92–4.
    • (2018) Australas Psychiatry , vol.26 , Issue.1 , pp. 92-94
    • Hope, J.1    Castle, D.2    Keks, N.A.3
  • 109
    • 85018387957 scopus 로고    scopus 로고
    • Evaluation of the long-term safety and tolerability of cariprazine in patients with schizophrenia: results from a 1-year open-label study
    • Cutler AJ, Durgam S, Wang Y, et al. Evaluation of the long-term safety and tolerability of cariprazine in patients with schizophrenia: results from a 1-year open-label study. CNS Spectr. 2018;23(1):39–50.
    • (2018) CNS Spectr , vol.23 , Issue.1 , pp. 39-50
    • Cutler, A.J.1    Durgam, S.2    Wang, Y.3
  • 110
    • 84891638911 scopus 로고    scopus 로고
    • Cariprazine in schizophrenia: clinical efficacy, tolerability, and place in therapy
    • Citrome L. Cariprazine in schizophrenia: clinical efficacy, tolerability, and place in therapy. Adv Ther. 2013;30(2):114–26.
    • (2013) Adv Ther , vol.30 , Issue.2 , pp. 114-126
    • Citrome, L.1
  • 111
    • 84872473680 scopus 로고    scopus 로고
    • Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability
    • Citrome L. Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013;9(2):193–206.
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , Issue.2 , pp. 193-206
    • Citrome, L.1
  • 112
    • 84887097223 scopus 로고    scopus 로고
    • A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach
    • Citrome L. A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach. CNS Drugs. 2013;27(11):879–911.
    • (2013) CNS Drugs , vol.27 , Issue.11 , pp. 879-911
    • Citrome, L.1
  • 114
    • 84994252975 scopus 로고    scopus 로고
    • Safety and tolerability of cariprazine in the long-term treatment of schizophrenia: results from a 48-week, single-arm, open-label extension study
    • Durgam S, Greenberg WM, Li D, Lu K, Laszlovszky I, Nemeth G, et al. Safety and tolerability of cariprazine in the long-term treatment of schizophrenia: results from a 48-week, single-arm, open-label extension study. Psychopharmacology. 2017;234(2):199–209.
    • (2017) Psychopharmacology , vol.234 , Issue.2 , pp. 199-209
    • Durgam, S.1    Greenberg, W.M.2    Li, D.3    Lu, K.4    Laszlovszky, I.5    Nemeth, G.6
  • 115
    • 85006337654 scopus 로고    scopus 로고
    • Cariprazine for schizophrenia and bipolar disorder
    • Scarff JR. Cariprazine for schizophrenia and bipolar disorder. Innov Clin Neurosci. 2016;13(9–10):49–52.
    • (2016) Innov Clin Neurosci , vol.13 , Issue.9-10 , pp. 49-52
    • Scarff, J.R.1
  • 116
    • 85066418957 scopus 로고    scopus 로고
    • Highlights of prescribing information. Revised 11, Accessed 28 Sep 2018
    • ® (cariprazine) capsules, for oral use. Highlights of prescribing information. Revised 11/2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204370s002s003lbl.pdf. Accessed 28 Sep 2018.
    • (2017) ® (Cariprazine) Capsules, for Oral Use
  • 117
    • 84881562922 scopus 로고    scopus 로고
    • A new generation of antipsychotics: pharmacology and clinical utility of cariprazine in schizophrenia
    • Caccia S, Invernizzi RW, Nobili A, Pasina L. A new generation of antipsychotics: pharmacology and clinical utility of cariprazine in schizophrenia. Ther Clin Risk Manag. 2013;9:319–28.
    • (2013) Ther Clin Risk Manag , vol.9 , pp. 319-328
    • Caccia, S.1    Invernizzi, R.W.2    Nobili, A.3    Pasina, L.4
  • 119
    • 85028015895 scopus 로고    scopus 로고
    • The safety and tolerability of cariprazine in patients with manic or mixed episodes associated with bipolar I disorder: a 16-week open-label study
    • Ketter TA, Sachs GS, Durgam S, Lu K, Starace A, Laszlovszky I, Németh G. The safety and tolerability of cariprazine in patients with manic or mixed episodes associated with bipolar I disorder: a 16-week open-label study. J Affect Disord. 2018;225:350–6.
    • (2018) J Affect Disord , vol.225 , pp. 350-356
    • Ketter, T.A.1    Sachs, G.S.2    Durgam, S.3    Lu, K.4    Starace, A.5    Laszlovszky, I.6    Németh, G.7
  • 120
    • 40949136198 scopus 로고    scopus 로고
    • Antipsychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia: a systematic review
    • Gao K, Kemp DE, Ganocy SJ, Gajwani P, Xia G, Calabrese JR. Antipsychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia: a systematic review. J Clin Psychopharmacol. 2008;28(2):203–9.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.2 , pp. 203-209
    • Gao, K.1    Kemp, D.E.2    Ganocy, S.J.3    Gajwani, P.4    Xia, G.5    Calabrese, J.R.6
  • 121
    • 85051995485 scopus 로고    scopus 로고
    • Revised 3/2018, Accessed 28 Sep
    • ® (Lurasidone HCl tablets). Highlights of prescribing information. Revised 3/2018. https://www.latuda.com/LatudaPrescribingInformation.pdf. Accessed 28 Sep 2018
    • (2018) Highlights of Prescribing Information
  • 123
    • 84995356823 scopus 로고    scopus 로고
    • Lurasidone for the treatment of depressive symptoms in schizophrenia: analysis of 4 pooled, 6-week, placebo-controlled studies
    • Nasrallah HA, Cucchiaro JB, Mao Y, Pikalov AA, Loebel AD. Lurasidone for the treatment of depressive symptoms in schizophrenia: analysis of 4 pooled, 6-week, placebo-controlled studies. CNS Spectr. 2015;20(2):140–7.
    • (2015) CNS Spectr , vol.20 , Issue.2 , pp. 140-147
    • Nasrallah, H.A.1    Cucchiaro, J.B.2    Mao, Y.3    Pikalov, A.A.4    Loebel, A.D.5
  • 124
    • 85048525540 scopus 로고    scopus 로고
    • Short-term efficacy and tolerability of lurasidone in the treatment of acute schizophrenia: a meta-analysis of randomized controlled trials
    • Zheng W, Cai DB, Yang XH, Li L, Zhang QE, Ng CH, et al. Short-term efficacy and tolerability of lurasidone in the treatment of acute schizophrenia: a meta-analysis of randomized controlled trials. J Psychiatr Res. 2018;103:244–51.
    • (2018) J Psychiatr Res , vol.103 , pp. 244-251
    • Zheng, W.1    Cai, D.B.2    Yang, X.H.3    Li, L.4    Zhang, Q.E.5    Ng, C.H.6
  • 125
    • 84964078725 scopus 로고    scopus 로고
    • Long-term safety and effectiveness of lurasidone in schizophrenia: a 22-month, open-label extension study
    • Correll CU, Cucchiaro J, Silva R, Hsu J, Pikalov A, Loebel A. Long-term safety and effectiveness of lurasidone in schizophrenia: a 22-month, open-label extension study. CNS Spectr. 2016;21(5):393–402.
    • (2016) CNS Spectr , vol.21 , Issue.5 , pp. 393-402
    • Correll, C.U.1    Cucchiaro, J.2    Silva, R.3    Hsu, J.4    Pikalov, A.5    Loebel, A.6
  • 126
    • 84878245007 scopus 로고    scopus 로고
    • Effectiveness of lurasidone for patients with schizophrenia following 6 weeks of acute treatment with lurasidone, olanzapine, or placebo: a 6-month, open-label, extension study
    • Stahl SM, Cucchiaro J, Simonelli D, Hsu J, Pikalov A, Loebel A. Effectiveness of lurasidone for patients with schizophrenia following 6 weeks of acute treatment with lurasidone, olanzapine, or placebo: a 6-month, open-label, extension study. J Clin Psychiatry. 2013;74(5):507–15.
    • (2013) J Clin Psychiatry , vol.74 , Issue.5 , pp. 507-515
    • Stahl, S.M.1    Cucchiaro, J.2    Simonelli, D.3    Hsu, J.4    Pikalov, A.5    Loebel, A.6
  • 127
    • 84874607585 scopus 로고    scopus 로고
    • Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study
    • McEvoy JP, Citrome L, Hernandez D, Cucchiaro J, Hsu J, Pikalov A, et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study. J Clin Psychiatry. 2013;74(2):170–9.
    • (2013) J Clin Psychiatry , vol.74 , Issue.2 , pp. 170-179
    • McEvoy, J.P.1    Citrome, L.2    Hernandez, D.3    Cucchiaro, J.4    Hsu, J.5    Pikalov, A.6
  • 128
    • 85019547479 scopus 로고    scopus 로고
    • Lurasidone in the treatment of bipolar depression: systematic review of systematic reviews
    • Fornaro M, De Berardis D, Perna G, Solmi M, Veronese N, Orsolini L, et al. Lurasidone in the treatment of bipolar depression: systematic review of systematic reviews. Biomed Res Int. 2017;2017:3084859.
    • (2017) Biomed Res Int , vol.2017 , pp. 3084859
    • Fornaro, M.1    De Berardis, D.2    Perna, G.3    Solmi, M.4    Veronese, N.5    Orsolini, L.6
  • 129
    • 84930480288 scopus 로고    scopus 로고
    • Management of bipolar I depression: clinical utility of lurasidone
    • Findlay LJ, El-Mallakh P, El-Mallakh RS. Management of bipolar I depression: clinical utility of lurasidone. Ther Clin Risk Manag. 2015;11:75–81.
    • (2015) Ther Clin Risk Manag , vol.11 , pp. 75-81
    • Findlay, L.J.1    El-Mallakh, P.2    El-Mallakh, R.S.3
  • 130
    • 84939955194 scopus 로고    scopus 로고
    • Lurasidone: a review of its use in adult patients with bipolar I depression
    • Sanford M, Dhillon S. Lurasidone: a review of its use in adult patients with bipolar I depression. CNS Drugs. 2015;29(3):253–63.
    • (2015) CNS Drugs , vol.29 , Issue.3 , pp. 253-263
    • Sanford, M.1    Dhillon, S.2
  • 131
    • 84938083174 scopus 로고    scopus 로고
    • Lurasidone: a new treatment option for bipolar depression-a review
    • Bawa R, Scarff JR. Lurasidone: a new treatment option for bipolar depression-a review. Innov Clin Neurosci. 2015;12(1–2):21–3.
    • (2015) Innov Clin Neurosci , vol.12 , Issue.1-2 , pp. 21-23
    • Bawa, R.1    Scarff, J.R.2
  • 132
    • 84891867256 scopus 로고    scopus 로고
    • Clinical assessment of lurasidone benefit and risk in the treatment of bipolar I depression using number needed to treat, number needed to harm, and likelihood to be helped or harmed
    • Citrome L, Ketter TA, Cucchiaro J, Loebel A. Clinical assessment of lurasidone benefit and risk in the treatment of bipolar I depression using number needed to treat, number needed to harm, and likelihood to be helped or harmed. J Affect Disord. 2014;155:20–7.
    • (2014) J Affect Disord , vol.155 , pp. 20-27
    • Citrome, L.1    Ketter, T.A.2    Cucchiaro, J.3    Loebel, A.4
  • 133
    • 84890612272 scopus 로고    scopus 로고
    • A review of FDA-approved treatment options in bipolar depression
    • McIntyre RS, Cha DS, Kim RD, Mansur RB. A review of FDA-approved treatment options in bipolar depression. CNS Spectr. 2013;18(Suppl 1):4–20.
    • (2013) CNS Spectr , vol.18 , pp. 4-20
    • McIntyre, R.S.1    Cha, D.S.2    Kim, R.D.3    Mansur, R.B.4
  • 134
    • 84885467441 scopus 로고    scopus 로고
    • Lurasidone as a potential therapy for bipolar disorder
    • Woo YS, Wang HR, Bahk WM. Lurasidone as a potential therapy for bipolar disorder. Neuropsychiatr Dis Treat. 2013;9:1521–9.
    • (2013) Neuropsychiatr Dis Treat , vol.9 , pp. 1521-1529
    • Woo, Y.S.1    Wang, H.R.2    Bahk, W.M.3
  • 136
    • 84932155059 scopus 로고    scopus 로고
    • Lurasidone in the treatment of bipolar depression with mixed (subsyndromal hypomanic) features: post hoc analysis of a randomized placebo-controlled trial
    • McIntyre RS, Cucchiaro J, Pikalov A, Kroger H, Loebel A. Lurasidone in the treatment of bipolar depression with mixed (subsyndromal hypomanic) features: post hoc analysis of a randomized placebo-controlled trial. J Clin Psychiatry. 2015;76(4):398–405.
    • (2015) J Clin Psychiatry , vol.76 , Issue.4 , pp. 398-405
    • McIntyre, R.S.1    Cucchiaro, J.2    Pikalov, A.3    Kroger, H.4    Loebel, A.5
  • 137
    • 84895787295 scopus 로고    scopus 로고
    • A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to iloperidone in patients with schizophrenia
    • Weiden PJ, Citrome L, Alva G, Brams M, Glick ID, Jackson R, et al. A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to iloperidone in patients with schizophrenia. Schizophr Res. 2014;153(1–3):160–8.
    • (2014) Schizophr Res , vol.153 , Issue.1-3 , pp. 160-168
    • Weiden, P.J.1    Citrome, L.2    Alva, G.3    Brams, M.4    Glick, I.D.5    Jackson, R.6
  • 138
    • 85015625406 scopus 로고    scopus 로고
    • Iloperidone in the treatment of schizophrenia: an evidence-based review of its place in therapy
    • Tonin FS, Wiens A, Fernandez-Llimos F, Pontarolo R. Iloperidone in the treatment of schizophrenia: an evidence-based review of its place in therapy. Core Evid. 2016;11:49–61.
    • (2016) Core Evid , vol.11 , pp. 49-61
    • Tonin, F.S.1    Wiens, A.2    Fernandez-Llimos, F.3    Pontarolo, R.4
  • 139
    • 84879020098 scopus 로고    scopus 로고
    • Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial
    • Cutler AJ, Kalali AH, Mattingly GW, Kunovac J, Meng X. Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial. CNS Spectr. 2013;18(1):43–54.
    • (2013) CNS Spectr , vol.18 , Issue.1 , pp. 43-54
    • Cutler, A.J.1    Kalali, A.H.2    Mattingly, G.W.3    Kunovac, J.4    Meng, X.5
  • 140
    • 84859715500 scopus 로고    scopus 로고
    • Iloperidone for the treatment of schizophrenia: an updated clinical review
    • Weiden PJ. Iloperidone for the treatment of schizophrenia: an updated clinical review. Clin Schizophr Relat Psychoses. 2012;6(1):34–44.
    • (2012) Clin Schizophr Relat Psychoses , vol.6 , Issue.1 , pp. 34-44
    • Weiden, P.J.1
  • 141
    • 84555218388 scopus 로고    scopus 로고
    • Iloperidone: a clinical overview
    • Citrome L. Iloperidone: a clinical overview. J Clin Psychiatry. 2011;72(Suppl 1):19–23.
    • (2011) J Clin Psychiatry , vol.72 , pp. 19-23
    • Citrome, L.1
  • 142
    • 85051995485 scopus 로고    scopus 로고
    • Revised 2/2017, Accessed 28 Sep
    • ® (Iloperidone). Highlights of prescribing information. Revised 2/2017. https://www.fanapt.com/product/pi/pdf/fanapt.pdf. Accessed 28 Sep 2018.
    • (2018) Highlights of Prescribing Information
  • 143
    • 79959978210 scopus 로고    scopus 로고
    • Asenapine: a review of acute and extension phase data in bipolar disorder
    • McIntyre RS. Asenapine: a review of acute and extension phase data in bipolar disorder. CNS Neurosci Ther. 2011;17(6):645–8.
    • (2011) CNS Neurosci Ther , vol.17 , Issue.6 , pp. 645-648
    • McIntyre, R.S.1
  • 144
    • 84976339024 scopus 로고    scopus 로고
    • Asenapine: a review in schizophrenia
    • Plosker GL, Deeks ED. Asenapine: a review in schizophrenia. CNS Drugs. 2016;30(7):655–66.
    • (2016) CNS Drugs , vol.30 , Issue.7 , pp. 655-666
    • Plosker, G.L.1    Deeks, E.D.2
  • 146
    • 85065492721 scopus 로고    scopus 로고
    • Efficacy and safety of asenapine 5 mg bid and 10 mg bid in adults with a manic or mixed episode associated with bipolar I disorder
    • McIntyre R, Landbloom R, Mackle M, Wu X, Kelly L, Snow-Adami L, et al. Efficacy and safety of asenapine 5 mg bid and 10 mg bid in adults with a manic or mixed episode associated with bipolar I disorder. Bipolar Disord. 2015;17(Suppl 1):92.
    • (2015) Bipolar Disord , vol.17 , pp. 92
    • McIntyre, R.1    Landbloom, R.2    Mackle, M.3    Wu, X.4    Kelly, L.5    Snow-Adami, L.6
  • 147
    • 85066420867 scopus 로고    scopus 로고
    • SAPHRIS (Asenapine) sublingual tablets
    • Revised 02, Accessed 28 Sep 2018
    • SAPHRIS (asenapine) sublingual tablets. Highlights of prescribing information. Revised 02/2017. https://www.allergan.com/assets/pdf/saphris_pi. Accessed 28 Sep 2018.
    • (2017) Highlights of Prescribing Information
  • 149
    • 84930485789 scopus 로고    scopus 로고
    • Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia
    • Cazorla P, Mackle M, Zhao J, Ha X, Szegedi A. Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia. Neuropsychiatr Dis Treat. 2012;8:247–57.
    • (2012) Neuropsychiatr Dis Treat , vol.8 , pp. 247-257
    • Cazorla, P.1    Mackle, M.2    Zhao, J.3    Ha, X.4    Szegedi, A.5
  • 150
    • 85066416112 scopus 로고    scopus 로고
    • ® (Brexpiprazole tablets). Highlights of prescribing information. Revised 2/2018, Accessed 28 Sep 2018
    • ® (Brexpiprazole tablets). Highlights of prescribing information. Revised 2/2018. https://www.otsuka-us.com/media/static/Rexulti-PI.pdf. Accessed 28 Sep 2018.
  • 151
    • 84988947518 scopus 로고    scopus 로고
    • Brexpiprazole: a new treatment option for schizophrenia
    • Scarff JR. Brexpiprazole: a new treatment option for schizophrenia. Innov Clin Neurosci. 2016;13(7–8):26–9.
    • (2016) Innov Clin Neurosci , vol.13 , Issue.7-8 , pp. 26-29
    • Scarff, J.R.1
  • 152
    • 85032044525 scopus 로고    scopus 로고
    • Efficacy and safety of brexpiprazole (OPC-34712) in acute schizophrenia: a pooled analysis of two pivotal studies
    • Correll CU, Skuban A, Ouyang J, Weiss C, Weiller E, Kane JM. Efficacy and safety of brexpiprazole (OPC-34712) in acute schizophrenia: a pooled analysis of two pivotal studies. Eur Neuropsychopharmacol. 2015;25(Suppl 2):S522–3.
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. S522-S523
    • Correll, C.U.1    Skuban, A.2    Ouyang, J.3    Weiss, C.4    Weiller, E.5    Kane, J.M.6
  • 153
    • 85047249287 scopus 로고    scopus 로고
    • A long-term, open-label study to evaluate the safety and tolerability of brexpiprazole as maintenance treatment in adults with schizophrenia
    • Forbes A, Hobart M, Ouyang J, Shi L, Pfister S, Hakala M. A long-term, open-label study to evaluate the safety and tolerability of brexpiprazole as maintenance treatment in adults with schizophrenia. Int J Neuropsychopharmacol. 2018;21(5):433–41.
    • (2018) Int J Neuropsychopharmacol , vol.21 , Issue.5 , pp. 433-441
    • Forbes, A.1    Hobart, M.2    Ouyang, J.3    Shi, L.4    Pfister, S.5    Hakala, M.6
  • 154
    • 85046026627 scopus 로고    scopus 로고
    • Long-term safety and effectiveness of brexpiprazole in Japanese patients with schizophrenia: a 52-week, open-label study
    • Ishigooka J, Iwashita S, Tadori Y. Long-term safety and effectiveness of brexpiprazole in Japanese patients with schizophrenia: a 52-week, open-label study. Psychiatry Clin Neurosci. 2018;72(6):445–53.
    • (2018) Psychiatry Clin Neurosci , vol.72 , Issue.6 , pp. 445-453
    • Ishigooka, J.1    Iwashita, S.2    Tadori, Y.3
  • 157
    • 77956626923 scopus 로고    scopus 로고
    • Adjunctive aripiprazole, olanzapine, or quetiapine for major depressive disorder: an analysis of number needed to treat, number needed to harm, and likelihood to be helped or harmed
    • Citrome L. Adjunctive aripiprazole, olanzapine, or quetiapine for major depressive disorder: an analysis of number needed to treat, number needed to harm, and likelihood to be helped or harmed. Postgrad Med. 2010;122(4):39–48.
    • (2010) Postgrad Med , vol.122 , Issue.4 , pp. 39-48
    • Citrome, L.1
  • 158
    • 38349106715 scopus 로고    scopus 로고
    • Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies
    • Thase ME, Jonas A, Khan A, Bowden CL, Wu X, McQuade RD, et al. Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies. J Clin Psychopharmacol. 2008;28(1):13–20.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.1 , pp. 13-20
    • Thase, M.E.1    Jonas, A.2    Khan, A.3    Bowden, C.L.4    Wu, X.5    McQuade, R.D.6
  • 159
    • 85028352040 scopus 로고    scopus 로고
    • Rapid vs. slow antipsychotic initiation in schizophrenia: a systematic review and meta-analysis
    • Takeuchi H, Thiyanavadivel S, Agid O, Remington G. Rapid vs. slow antipsychotic initiation in schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2018;193:29–36.
    • (2018) Schizophr Res. , vol.193 , pp. 29-36
    • Takeuchi, H.1    Thiyanavadivel, S.2    Agid, O.3    Remington, G.4
  • 160
    • 85041845010 scopus 로고    scopus 로고
    • Tardive dyskinesia associated with atypical antipsychotics: prevalence, mechanisms and management strategies
    • Stegmayer K, Walther S, van Harten P. Tardive dyskinesia associated with atypical antipsychotics: prevalence, mechanisms and management strategies. CNS Drugs. 2018;32(2):135–47.
    • (2018) CNS Drugs , vol.32 , Issue.2 , pp. 135-147
    • Stegmayer, K.1    Walther, S.2    van Harten, P.3
  • 161
    • 45549107737 scopus 로고    scopus 로고
    • Ethnic differences in the risks of adverse reactions to drugs used in the treatment of psychoses and depression: a systematic review and meta-analysis
    • Ormerod S, McDowell SE, Coleman JJ, Ferner RE. Ethnic differences in the risks of adverse reactions to drugs used in the treatment of psychoses and depression: a systematic review and meta-analysis. Drug Saf. 2008;31(7):597–607.
    • (2008) Drug Saf , vol.31 , Issue.7 , pp. 597-607
    • Ormerod, S.1    McDowell, S.E.2    Coleman, J.J.3    Ferner, R.E.4
  • 163
    • 0034945152 scopus 로고    scopus 로고
    • D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
    • Hurd YL, Suzuki M, Sedvall GC. D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. J Chem Neuroanat. 2001;22(1–2):127–37.
    • (2001) J Chem Neuroanat , vol.22 , Issue.1-2 , pp. 127-137
    • Hurd, Y.L.1    Suzuki, M.2    Sedvall, G.C.3
  • 165
    • 84890033510 scopus 로고    scopus 로고
    • Role of α1 adrenergic antagonism in the mechanism of action of iloperidone: reducing extrapyramidal symptoms
    • Stahl SM. Role of α1 adrenergic antagonism in the mechanism of action of iloperidone: reducing extrapyramidal symptoms. CNS Spectr. 2013;18(6):285–8.
    • (2013) CNS Spectr , vol.18 , Issue.6 , pp. 285-288
    • Stahl, S.M.1
  • 166
    • 79953006319 scopus 로고    scopus 로고
    • The mechanism of drug-induced akathisia
    • Stahl SM, Lonnen AJ. The mechanism of drug-induced akathisia. CNS Spectr. 2011;16(1):7–10.
    • (2011) CNS Spectr. , vol.16 , Issue.1 , pp. 7-10
    • Stahl, S.M.1    Lonnen, A.J.2
  • 167
    • 84857448446 scopus 로고    scopus 로고
    • The role of striatal dopamine D2 receptors in the occurrence of extrapyramidal side effects: iodine-123-iodobenzamide single photon emission computed tomography study
    • Corripio I, Ferreira A, Portella MJ, Pérez V, Escartí MJ, Del Valle Camacho M, et al. The role of striatal dopamine D2 receptors in the occurrence of extrapyramidal side effects: iodine-123-iodobenzamide single photon emission computed tomography study. Psychiatry Res. 2012;201(1):73–7.
    • (2012) Psychiatry Res , vol.201 , Issue.1 , pp. 73-77
    • Corripio, I.1    Ferreira, A.2    Portella, M.J.3    Pérez, V.4    Escartí, M.J.5    Del Valle, C.M.6
  • 169
    • 85051547283 scopus 로고    scopus 로고
    • Long-term effects of iloperidone on cerebral serotonin and adrenoceptor subtypes
    • Choi YK, Tarazi FI. Long-term effects of iloperidone on cerebral serotonin and adrenoceptor subtypes. J Mol Neurosci. 2018;66(1):59–67.
    • (2018) J Mol Neurosci , vol.66 , Issue.1 , pp. 59-67
    • Choi, Y.K.1    Tarazi, F.I.2
  • 170
    • 85051521869 scopus 로고    scopus 로고
    • Long-term effects of iloperidone on cerebral dopamine receptor subtypes
    • (Epub 2018 Jun 23
    • Kee Choi Y, Tarazi FI. Long-term effects of iloperidone on cerebral dopamine receptor subtypes. Synapse. 2018. 10.1002/syn.22039 (Epub 2018 Jun 23).
    • (2018) Synapse
    • Kee Choi, Y.1    Tarazi, F.I.2
  • 171
    • 85055401763 scopus 로고    scopus 로고
    • Graphic representation of pharmacology: development of an alternative model
    • Saklad SR. Graphic representation of pharmacology: development of an alternative model. Ment Health Clin. 2018;7(5):201–6.
    • (2018) Ment Health Clin. , vol.7 , Issue.5 , pp. 201-206
    • Saklad, S.R.1
  • 172
    • 77957857398 scopus 로고    scopus 로고
    • New antipsychotic drugs: how do their receptor-binding profiles compare?
    • Richelson E. New antipsychotic drugs: how do their receptor-binding profiles compare? J Clin Psychiatry. 2010;71(9):1243–4.
    • (2010) J Clin Psychiatry , vol.71 , Issue.9 , pp. 1243-1244
    • Richelson, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.