Enzyme promiscuity shapes adaptation to novel growth substrates

Molecular Systems Biology

Volumn 15, Issue 4, 2019, Pages

  Guzmán, Gabriela I ^a   Sandberg, Troy E ^a   LaCroix, Ryan A ^a   Nyerges, Ákos ^b   Papp, Henrietta ^c   de Raad, Markus ^d   King, Zachary A ^a   Hefner, Ying ^a   Northen, Trent R ^d   Notebaart, Richard A ^e   Pál, Csaba ^b   Palsson, Bernhard O ^a,f,g   Papp, Balázs ^b   Feist, Adam M ^a,f  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF PÉCS   (Hungary)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e WAGENINGEN UNIVERSITY   (Netherlands)

^f Chalmers University of Technology   (Denmark)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

adaptive evolution; enzyme promiscuity; genome scale modeling; systems biology

Indexed keywords

2 DEOXYRIBOSE; ARABINOSE; SUCCINIC ACID METHYL ESTER; TARTARIC ACID; DEOXYRIBOSE; ENZYME; ESCHERICHIA COLI PROTEIN; SUCCINIC ACID DERIVATIVE; TARTARIC ACID DERIVATIVE;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL STRAIN; CARBON SOURCE; CELL DIVISION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE; ESCHERICHIA COLI K 12; EVOLUTIONARY ADAPTATION; GENE LIBRARY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; TURNOVER RATE; WHOLE GENOME SEQUENCING; ADAPTATION; CHEMISTRY; COMPUTER SIMULATION; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI K-12; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR EVOLUTION; MUTATION;

ADAPTATION, PHYSIOLOGICAL; ARABINOSE; COMPUTER SIMULATION; DEOXYRIBOSE; ENZYMES; ESCHERICHIA COLI K12; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; MUTATION; SUBSTRATE SPECIFICITY; SUCCINATES; TARTRATES;

EID: 85064552294     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.15252/msb.20188462     Document Type: Article

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