Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

eLife

Volumn 8, Issue , 2019, Pages

  Sohail, Mashaal ^a,b,l   Maier, Robert M ^b,c   Ganna, Andrea ^b,c,d,e   Bloemendal, Alex ^b,c   Martin, Alicia R ^b,c   Turchin, Michael C ^f,g   Chiang, Charleston W K ^h   Hirschhorn, Joel ^a,b,i   Daly, Mark J ^b,c,e   Patterson, Nick ^a,b   Neale, Benjamin ^b,c   Mathieson, Iain ^j   Reich, David ^a,b,k   Sunyaev, Shamil R ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF HELSINKI   (Finland)

^f BROWN UNIVERSITY   (United States)

^g BROWN UNIVERSITY   (United States)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ BOSTON CHILDREN S HOSPITAL   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^l Langebio   (Mexico)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOBANK; EDITOR; EFFECT SIZE; EXCITEMENT; GENOME-WIDE ASSOCIATION STUDY; HEIGHT; HUMAN; META ANALYSIS; PEER REVIEW; STRATIFICATION; ADAPTATION; BIOLOGY; BIOSTATISTICS; BODY HEIGHT; FACTUAL DATABASE; MULTIFACTORIAL INHERITANCE; PHYLOGENY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

ADAPTATION, BIOLOGICAL; BIOSTATISTICS; BODY HEIGHT; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MULTIFACTORIAL INHERITANCE; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; UNITED KINGDOM;

EID: 85063639643     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.39702     Document Type: Article

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