Negative selection in humans and fruit flies involves synergistic epistasis

Science

Volumn 356, Issue 6337, 2017, Pages 539-542

  Sohail, Mashaal ^a,b   Vakhrusheva, Olga A ^c   Sul, Jae Hoon ^d   Pulit, Sara L ^e   Francioli, Laurent C ^e   Van Den Berg, Leonard H ^e   Veldink, Jan H ^e   De Bakker, Paul I W ^e   Bazykin, Georgii A ^c,f   Kondrashov, Alexey S ^g,h   Sunyaev, Shamil R ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c INSTITUTE FOR INFORMATION TRANSMISSION PROBLEMS   (Russian Federation)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^g MOSCOW STATE UNIVERSITY   (Russian Federation)

^h UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPISTASIS; FLY; GENE EXPRESSION; GENOME; HUMAN EVOLUTION; INTRAPOPULATION VARIATION; MUTATION; NATURAL SELECTION; PROTEIN;

ALLELE; ARTICLE; DROSOPHILA MELANOGASTER; EPISTASIS; GENOMICS; HUMAN; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PURIFYING SELECTION; ANIMAL; GENE LINKAGE DISEQUILIBRIUM; GENETIC SELECTION; GENETICS; HUMAN GENOME; INSECT GENOME; REPRODUCTIVE FITNESS;

ALLELES; ANIMALS; DROSOPHILA MELANOGASTER; EPISTASIS, GENETIC; GENETIC FITNESS; GENOME, HUMAN; GENOME, INSECT; HUMANS; LINKAGE DISEQUILIBRIUM; MUTATION RATE; MUTATION, MISSENSE; SELECTION, GENETIC;

EID: 85018792261     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah5238     Document Type: Article

References (26)

1. H. J. Muller, Am.J.Hum.Genet.2, 111-176 (1950).
2. E. E. Shnol, A. S. Kondrashov, Genetics 134, 995-996 (1993).
3. M. Kimura, T. Maruyama, Genetics 54, 1337-1351 (1966).
4. J. F. Crow, M. Kimura, Proc. Natl. Acad. Sci. U.S.A. 76, 396-399 (1979).
5. A. S. Kondrashov, Nature 336, 435-440 (1988).
6. J. A. G. M. de Visser, S. F. Elena, Nat. Rev. Genet. 8, 139-149 (2007).
7. H.-C. Chiu, C. J. Marx, D. Segrè, Proc. Biol. Sci. 279, 4156-4164 (2012).
8. C. Bank, R. T. Hietpas, J. D. Jensen, D. N. A. Bolon, Mol. Biol. Evol. 32, 229-238 (2015).
9. O. Puchta et al., Science 352, 840-844 (2016).
10. M. Bulmer, The Mathematical Theory of Quantitative Genetics (Clarendon, 1980).
11. A. S. Kondrashov, Genet. Res. 65, 113-121 (1995).
12. B. Charlesworth, Genet. Res. 55, 199-221 (1990).
13. M. G. Bulmer, Genet. Res. 28, 101-117 (1976).
14. L. C. Francioli et al., Nat. Genet. 46, 818-825 (2014).
15. J. B. Lack et al., Genetics 199, 1229-1241 (2015).
16. R. C. Yang, Genetics 155, 1449-1458 (2000).
17. G. R. Abecasis et al., Nature 491, 56-65 (2012).
18. T. F. C. Mackay et al., Nature 482, 173-178 (2012).
19. B. Charlesworth, Evolution. 67, 3354-3361 (2013).
20. J. Felsenstein, Genetics 78, 737-756 (1974).
21. N. H. Barton, S. P. Otto, Genetics 169, 2353-2370 (2005).
22. S. Besenbacher et al., Nat. Commun. 6, 5969 (2015).
23. C. M. Rands, S. Meader, C. P. Ponting, G. Lunter, PLOS Genet. 10, e1004525 (2014).
24. Y. Lesecque, P. D. Keightley, A. Eyre-Walker, Genetics 191, 1321-1330 (2012).
25. S. C. Stearns, S. G. Byars, D. R. Govindaraju, D. Ewbank, Nat. Rev. Genet. 11, 611-622 (2010).
26. E. C. Larsen, O. B. Christiansen, A. M. Kolte, N. Macklon, BMC Med. 11, 154(2013).