Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

American Journal of Human Genetics

Volumn 100, Issue 4, 2017, Pages 635-649

  Martin, Alicia R ^a,b,c   Gignoux, Christopher R ^c   Walters, Raymond K ^a,b   Wojcik, Genevieve L ^c   Neale, Benjamin M ^a,b   Gravel, Simon ^d   Daly, Mark J ^a,b   Bustamante, Carlos D ^c   Kenny, Eimear E ^e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c STANFORD UNIVERSITY   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

1000 Genomes Project; admixed populations; complex trait genetics; GWAS; local ancestry; polygenic risk scores; population genetics; statistical genetics; summary statistics

Indexed keywords

AFRICAN AMERICAN; AMERICAN INDIAN; ARTICLE; ASTHMA; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; DEMOGRAPHY; EAST ASIAN; FOUNDER EFFECT; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPE; HERITABILITY; HETEROZYGOSITY; HISPANIC; HUMAN; HUMAN GENOME; NIGERIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; POLYGENIC RISK; PREDICTION; PRIORITY JOURNAL; PYGMY; QUANTITATIVE ANALYSIS; SAMPLE; SCHIZOPHRENIA; SOUTHERN EUROPEAN; WESTERN HEMISPHERE; ANCESTRY GROUP; GENETIC PREDISPOSITION; GENETICS; HUMAN GENOME PROJECT; MEDICAL GENETICS; MULTIFACTORIAL INHERITANCE; POPULATION GENETICS;

AMERICAS; CONTINENTAL POPULATION GROUPS; GENETIC PREDISPOSITION TO DISEASE; GENETICS, MEDICAL; GENETICS, POPULATION; HAPLOTYPES; HUMAN GENOME PROJECT; HUMANS; MULTIFACTORIAL INHERITANCE;

EID: 85016462296     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.03.004     Document Type: Article

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