GA I2 signaling regulates inflammasome priming and cytokine production by biasing macrophage phenotype determination

Journal of Immunology

Volumn 202, Issue 5, 2019, Pages 1510-1520

  Vural, Ali ^c,d   Nabar, Neel R ^a,d   Hwang, Il Young ^d   Sohn, Silke ^a   Park, Chung ^d   Karlsson, Mikael C I ^a   Blumer, Joe B ^b   Kehrl, John H ^d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CRYOPYRIN; G PROTEIN COUPLED RECEPTOR KINASE 2; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN AIM2; PROTEIN NLRC4; STAT3 PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;

AKT SIGNALING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL CULTURE; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; IMMUNOBLOTTING; MACROPHAGE; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; IMMUNOLOGY; KNOCKOUT MOUSE;

ANIMALS; CELLS, CULTURED; CYTOKINES; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; INFLAMMASOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 85061845387     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1801145     Document Type: Article

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