The human gut bacterial genotoxin colibactin alkylates DNA

Science

Volumn 363, Issue 6428, 2019, Pages

  Wilson, Matthew R ^a,g   Jiang, Yindi ^a   Villalta, Peter W ^b   Stornetta, Alessia ^b   Boudreau, Paul D ^a   Carrá, Andrea ^b   Brennan, Caitlin A ^c   Chun, Eunyoung ^c   Ngo, Lizzie ^d   Samson, Leona D ^d   Engelward, Bevin P ^d   Garrett, Wendy S ^c,e,f   Balbo, Silvia ^b   Balskus, Emily P ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d Massachusetts Institute of Technology   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYPYRROLIDIN 2 ONE; BACTERIAL TOXIN; COLIBACTIN; CYCLOPROPANE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; ALKYLATING AGENT; CYCLOPROPANE DERIVATIVE; MUTAGENIC AGENT; PEPTIDE; POLYKETIDE;

CANCER; CELL; CHEMICAL ANALYSIS; COLIFORM BACTERIUM; DIGESTIVE SYSTEM; DNA; GENOTOXICITY; MOLECULAR ANALYSIS; PATHOGENICITY; TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL LOAD; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; DNA CROSS LINKING; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; G2 PHASE CELL CYCLE CHECKPOINT; GENOMIC INSTABILITY; GENOTOXICITY; HELA CELL LINE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RING OPENING; ALKYLATION; ANIMAL; C57BL MOUSE; CHEMISTRY; COLORECTAL TUMOR; ESCHERICHIA COLI; GENETICS; GERMFREE ANIMAL; HT-29 CELL LINE; METABOLISM; MICROBIOLOGY; PATHOGENICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MUS;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; CARCINOGENESIS; COLORECTAL NEOPLASMS; CYCLOPROPANES; DNA ADDUCTS; DNA DAMAGE; ESCHERICHIA COLI; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; HELA CELLS; HT29 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MUTAGENS; PEPTIDES; POLYKETIDES;

EID: 85061611431     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aar7785     Document Type: Article

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