Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways

Journal of Experimental and Clinical Cancer Research

Volumn 38, Issue 1, 2019, Pages

  Ma, Liwei ^a   Wei, Jianwei ^a   Wan, Junhu ^a   Wang, Weiwei ^a   Wang, Li ^a   Yuan, Yongjie ^a   Yang, Zijun ^a,b   Liu, Xianzhi ^a   Ming, Liang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b Henan Medical College   (China)

Author keywords

ASK1; ER stress; Metformin; Mitochondrial damage; Ovarian cancer

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; GLUCOSE; METFORMIN; NQDI 1; PROTEIN NOXA; PROTEIN SERINE THREONINE KINASE INHIBITOR; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MAP3K5 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRION; MOUSE; MTT ASSAY; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; DRUG SCREENING; METABOLISM; NUDE MOUSE; OVARY TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CULTURE MEDIA; ENDOPLASMIC RETICULUM STRESS; FEMALE; GLUCOSE; HUMANS; MAP KINASE KINASE KINASE 5; METFORMIN; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; OVARIAN NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85061531096     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-019-1090-6     Document Type: Article

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