An origin of the immunogenicity of in vitro transcribed RNA

Nucleic Acids Research

Volumn 46, Issue 10, 2018, Pages 5239-5249

  Mu, Xin ^a,b   Greenwald, Emily ^b   Ahmad, Sadeem ^a,b   Hur, Sun ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; DOUBLE STRANDED RNA; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; MAGNESIUM ION; RNA POLYMERASE; BACTERIOPHAGE T7 RNA POLYMERASE; BETA INTERFERON; DDX58 PROTEIN, HUMAN; DNA DIRECTED RNA POLYMERASE; IFIH1 PROTEIN, HUMAN; MAGNESIUM; NUCLEOTIDE; RETINOIC ACID INDUCIBLE PROTEIN I; VIRAL PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DNA TRANSCRIPTION; GENE ACTIVITY; HUMAN; IMMUNOGENICITY; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INNATE IMMUNITY; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSCRIPTION; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

DEAD BOX PROTEIN 58; DNA-DIRECTED RNA POLYMERASES; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; INTERFERON-INDUCED HELICASE, IFIH1; MAGNESIUM; NUCLEOTIDES; PROMOTER REGIONS, GENETIC; RNA, DOUBLE-STRANDED; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 85061132711     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gky177     Document Type: Article

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