Hepatic STAT3 inhibition amplifies the inflammatory response in obese mice during sepsis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 316, Issue 2, 2019, Pages E286-E292

  Williamson, Lauren ^a   Ayalon, Itay ^a   Shen, Hui ^a   Kaplan, Jennifer ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Inflammation; Liver; Obesity; Sepsis; STAT3

Indexed keywords

INTERLEUKIN 6; JANUS KINASE; LEPTIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; ALANINE AMINOTRANSFERASE; COMPLEMENTARY DNA; LIVER PROTEIN; MESSENGER RNA; MYELOPEROXIDASE; PROTEIN SH2; STAT3 PROTEIN, MOUSE; STATTIC; SULFOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT GAIN; C57BL 6 MOUSE; CONTROLLED STUDY; ECHO PLANAR IMAGING; ENDOCRINE FUNCTION; ENZYME ACTIVATION; FAT MASS; FEMALE; GENE AMPLIFICATION; GENE REPRESSION; GENOTYPE; HEPATITIS; INFLAMMATION; KNOCKOUT MOUSE; LIVER INJURY; MALE; METABOLIC ACTIVATION; MORTALITY RATE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SEPSIS; SIGNAL TRANSDUCTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; COMPARATIVE STUDY; DIET INDUCED OBESITY; ENZYME ACTIVITY; LIPID DIET; MRNA EXPRESSION LEVEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN FUNCTION; ANIMAL; CECUM; DRUG EFFECT; GENETICS; IMMUNOLOGY; INTESTINE PERFORATION; LIVER; METABOLISM; MORTALITY; RANDOMIZATION; SURGERY;

ANIMALS; BODY COMPOSITION; CECUM; CYCLIC S-OXIDES; DIET, HIGH-FAT; INFLAMMATION; INTESTINAL PERFORATION; LIVER; MICE; NEUTROPHIL INFILTRATION; OBESITY; RANDOM ALLOCATION; SEPSIS; STAT3 TRANSCRIPTION FACTOR;

EID: 85061128739     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00341.2018     Document Type: Article

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