Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

Acta Pharmaceutica Sinica B

Volumn 9, Issue 2, 2019, Pages 433-442

  Cao, Zhiqin ^a   Li, Shaoyang ^a   Lv, Jianming ^a   Gao, Hao ^a   Chen, Guodong ^a   Awakawa, Takayoshi ^b   Abe, Ikuro ^b   Yao, Xinsheng ^a   Hu, Dan ^a  

^a JINAN UNIVERSITY   (China)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Biosynthesis; Fungi; Fusidane type antibiotics; Fusidic acid; SDR

Indexed keywords

FUSIDIC ACID; SHORT CHAIN DEHYDROGENASE/REDUCTASE; SHORT CHAIN DEHYDROGENASE/REDUCTASE FUSC1; SHORT CHAIN DEHYDROGENASE/REDUCTASE FUSC2; UNCLASSIFIED DRUG;

ACREMONIUM; ACREMONIUM FUSIDIOIDES; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; FUNGAL GENOME; GENE CLUSTER; GENE SEQUENCE; GENOME ANALYSIS; HETEROLOGOUS EXPRESSION; NONHUMAN; STEREOSELECTIVITY;

EID: 85061093065     PISSN: 22113835     EISSN: 22113843     Source Type: Journal    
DOI: 10.1016/j.apsb.2018.10.007     Document Type: Article

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