Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases

Biotechnology for Biofuels

Volumn 10, Issue 1, 2017, Pages

  Hull, Claire M ^a   Warrilow, Andrew G S ^a   Rolley, Nicola J ^a   Price, Claire L ^a   Donnison, Iain S ^b   Kelly, Diane E ^a   Kelly, Steven L ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

11 Hydroxyprogesterone; Bioconversion; Bioethanol; Biorefinery; Ryegrass; Yeast

Indexed keywords

BIOCONVERSION; BIOETHANOL; ENZYMES; ETHANOL; GENE EXPRESSION; GENES; GLUCOSE; REFINING; YEAST;

ASPERGILLUS OCHRACEUS; BIO-ETHANOL PRODUCTION; BIOREFINERIES; CONSTITUTIVE EXPRESSIONS; FUNGAL BIOTRANSFORMATION; MONOOXYGENASE ENZYMES; RYEGRASS; VALUE ADDED PRODUCTS;

MANUFACTURE;

ENZYME; ETHANOL; FUNGUS; GENOME; GRASS; YEAST;

ASPERGILLUS OCHRACEUS; FUNGI; LOLIUM; LOLIUM PERENNE; RHIZOPUS ORYZAE; SACCHAROMYCES CEREVISIAE;

EID: 85030234447     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-017-0904-z     Document Type: Article

References (41)

1. Murray HC, Peterson DH. Oxygenation of steroids by Mucorales fungi. U.S. Patent 2602769. 1952.
2. Goodman JJ, Smith LL. 16α-Hydroxy steroids. XI. 2β-and 16α-hydroxylation of 9α-fluorohydrocortisone by strains of Streptomyces roseochromogenes. Appl Microbiol. 1961;9:372-5.
3. Donova MV. Transformation of steroids by actinobacteria: a review. Appl Biochem Microbiol. 2007;43:1-14.
4. Restaino OF, Marseglia M, De Castro C, Diana P, Forni P, Parrilli M, et al. Biotechnological transformation of hydrocortisone to 16α-hydroxy hydrocortisone by Streptomyces roseochromogenes. Appl Microbiol Biotechnol. 2014;98:1291-9.
5. Restaino OF, Marseglia M, Diana P, Borzacchiello MG, Finamore R, Vitiello M, et al. Advances in 16α-hydroxy transformation of hydrocortisone by Streptomyces roseochromogenes. Process Biochem. 2016;51:1-8.
6. Zhang W, Cui L, Wu M, Zhang R, Xie L, Wang H. Transformation of prednisolone to a 20β-hydroxy prednisolone compound by Streptomyces roseochromogenes TS79. Appl Microbiol Biotechnol. 2011;92:727-35.
7. Breskvar K, Hudnik-Plevnik T. Inducibility of Cytochrome P-450 and of NADPH-cytochrome C reductase in progesterone treated filamentous fungi Rhizopus nigricans and Rhizopus arrhizus. J Steroid Biochem. 1981;14:395-9.
8. Samanta TB, Ghosh DK. Characterization of progesterone 11α-hydroxylase of Aspergillus ochraceus TS: a cytochrome P-450 linked monooxygenase. J Steroid Biochem. 1987;28:327-32.
9. Smith KE, Ahmed F, Williams RAD, Kelly SL. Microbial transformations of steroids - VIII. Transformation of progesterone by whole cells and microsomes of Aspergillus fumigatus. J Steroid Biochem Mol Biol. 1994;49:93-100.
10. Donova MV, Egorova OV. Microbial steroid transformations: current state and prospects. Appl Microbiol Biotechnol. 2012;94:1423-47.
11. Sambamurthy K, Kar A. Biotransformation process and its improvements with special reference to steroids. In: Sambamurthy K, Kar A, editors. Pharm Biotechnology. New Delhi: New Age International Ltd.; 2006. p. 295-304.
12. Kristan K, Rižner TL. Steroid-transforming enzymes in fungi. J Steroid Biochem Mol Biol. 2012;129:79-91.
13. Fernandes P, Cruz A, Angelova B, Pinheiro H, Cabral JM. Microbial conversion of steroid compounds: recent developments. Enzym Microb Technol. 2003;32:688-705.
14. Bolten SL, Clayton RA, Easton AM, Engel LC, Messing DM, Ng JS, et al. Aspergillus ochraceus 11 α hydroxylase and oxidoreductase. U.S. Patent 7033807 B2. 2007.
15. Petrič Š, Hakki T, Bernhardt R, Žigon D, Črešnar B. Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application. J Biotechnol. 2010;150:428-37.
16. Kelly SL, Kelly DE. Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Philos Trans R Soc Lond B Biol Sci. 2013;368:20120476.
17. Mukherjee A, Banerjee S, Mahato SB. Metabolism of progesterone by Aspergillus fumigatus. J Steroid Biochem. 1982;17:443-6.
18. Dragan C, Zearo S, Hannemann F, Bernhardt R, Bureik M. Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe. FEMS Yeast Res. 2005;5:621-5.
19. Mehmood Z, Kelly DE, Kelly SL. Metabolism of the herbicide chlortoluron by human cytochrome P450 3A4. Chemosphere. 1995;31:4515-29.
20. Kelly D, Kelly S. Rewiring yeast for drug synthesis. Nat Biotechnol. 2003;21:133-4.
21. Nielsen J, Larsson C, van Maris A, Pronk J. Metabolic engineering of yeast for production of fuels and chemicals. Curr Opin Biotechnol. 2013;24:398-404.
22. Martinez CA, Rupashinghe SG. Cytochrome P450 bioreactors in the pharmaceutical industry: challenges and opportunities. Curr Top Med Chem. 2013;13:1470-90.
23. Clark JH, Luque R, Matharu AS. Green chemistry, biofuels, and biorefinery. Annu Rev Chem Biomol Eng. 2012;3:183-207.
24. Martel CM, Warrilow AGS, Jackson CJ, Mullins JGL, Togawa RC, Parker JE, et al. Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresour Technol. 2010;101:4395-402.
25. Pajič T, Vitas M, Žigon D, Pavko A, Kelly SL, Komel R. Biotransformation of steroids by the fission yeast Schizosaccharomyces pombe. Yeast. 1999;15:639-45.
26. Martel CM, Parker JE, Jackson CJ, Warrilow AGS, Rolley N, Greig C, et al. Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresour Technol. 2011;102:1503-8.
27. Morris SM, Jackson CJ, Gallagher JA, Kelly RO, Donnison IS. High-sugar perennial ryegrass as a bioethanol feedstock. An alternative use for forage grasses. In: Proceedings 16th Europe Biomass Conference Exhibition ETA-Florence Renewable Energies. ETA-Florence Renewable Energies; 2008. p. 60-6. http://cadair.aber.ac.uk/dspace/handle/2160/13953.
28. Charlton A, Elias R, Fish S, Fowler P, Gallagher J. The biorefining opportunities in Wales: understanding the scope for building a sustainable, biorenewable economy using plant biomass. Chem Eng Res Des. 2009;87:1147-61.
29. Farrar K, Bryant DN, Turner L, Gallagher JA, Thomas A, Farrell M, et al. Breeding for bio-ethanol production in Lolium perenne L.: association of allelic variation with high water-soluble carbohydrate content. Bioenergy Res. 2012;5:149-57.
30. Bureik M, Bernhardt R. Steroid hydroxylation: microbial steroid biotransformations using cytochrome P450 enzymes. In: Schmid RD, Urlacher VB, editors. Modern biooxidation enzymes reactions applications. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA; 2007. p. 155-76.
31. Saini JK, Saini R, Tewari L. Lignocellulosic agriculture wastes as biomass feedstocks for second-generation bioethanol production: concepts and recent developments. 3 Biotech. 2015;5:337-53.
32. Žnidaršič P, Komel R, Pavko A. Studies of a pelleted growth form of Rhizopus nigricans as a biocatalyst for progesterone 11α-hydroxylation. J Biotechnol. 1998;60:207-16.
33. Nguyen KT, Virus C, Günnewich N, Hannemann F, Bernhardt R. Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone. ChemBioChem. 2012;13:1161-6.
34. Cvelbar D, Žist V, Kobal K, Žigon D, Žakelj-Mavrič M. Steroid toxicity and detoxification in Ascomycetous fungi. Chem Biol Interact. 2013;202:243-58.
35. Črešnar B, Žakelj-Mavrič M. Aspects of the steroid response in fungi. Chem Biol Interact. 2009;178:303-9.
36. Znidarsic-Plazl P, Plazl I. Steroid extraction in a microchannel system-mathematical modelling and experiments. Lab Chip. 2007;7:883-9.
37. Zhang T, Chi Z, Chi Z, Parrou J-L, Gong F. Expression of the inulinase gene from the marine-derived Pichia guilliermondii in Saccharomyces sp. W0 and ethanol production from inulin. Microb Biotechnol. 2010;3:576-82.
38. Choi G-W, Kang H-W, Moon S-K. Repeated-batch fermentation using flocculent hybrid, Saccharomyces cerevisiae CHFY0321 for efficient production of bioethanol. Appl Microbiol Biotechnol. 2009;84:261-9.
39. Thiry M, Cingolani D. Optimizing scale-up fermentation processes. Trends Biotechnol. 2002;20:103-5.
40. Mumberg D, Müller R, Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene. 1995;156:119-22.
41. Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AGS, et al. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob Agents Chemother. 2010;54:3578-83.