A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia

Molecular Psychiatry

Volumn 24, Issue 3, 2019, Pages 328-337

  Legge, Sophie E ^a   Pardiñas, Antonio F ^a   Helthuis, Marinka ^b   Jansen, John A ^b   Jollie, Karel ^b   Knapper, Steven ^a   MacCabe, James H ^c   Rujescu, Dan ^d   Collier, David A ^e   O’Donovan, Michael C ^a   Owen, Michael J ^a   Walters, James T R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b Leyden Delta   (Netherlands)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; ACKR1 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; NEUROLEPTIC AGENT;

ACKR1 GENE; ALLELE; ARTICLE; BLACK PERSON; DISEASE PREDISPOSITION; DUFFY NULL GENOTYPE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HOMOZYGOTE; HUMAN; NEUTROPENIA; NEUTROPHIL COUNT; PHARMACOGENETICS; PRIORITY JOURNAL; TREATMENT-RESISTANT SCHIZOPHRENIA; BLOOD; BLOOD GROUP DUFFY SYSTEM; DRUG EFFECT; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; NEUTROPHIL; PATHOLOGY; PROCEDURES; RISK FACTOR; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ANTIPSYCHOTIC AGENTS; CLOZAPINE; DUFFY BLOOD-GROUP SYSTEM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; NEUTROPENIA; NEUTROPHILS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; RISK FACTORS; SCHIZOPHRENIA;

EID: 85060132069     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/s41380-018-0335-7     Document Type: Article

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