How we evaluate and treat neutropenia in adults

Blood

Volumn 124, Issue 8, 2014, Pages 1251-1258

  Gibson, Christopher ^a   Berliner, Nancy ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYCLOPHOSPHAMIDE; HEMOGLOBIN; METHOTREXATE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE DISEASE; ADULT; ADULT DISEASE; AGED; AGRANULOCYTOSIS; ARTICLE; BLOOD CELL COUNT; BONE MARROW BIOPSY; CASE REPORT; CHRONIC IDIOPATHIC NEUTROPENIA; CYANOCOBALAMIN DEFICIENCY; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLIC ACID DEFICIENCY; GENERAL PRACTITIONER; HUMAN; LARGE GRANULAR LYMPHOCYTE; MALE; MIDDLE AGED; NEUTROPENIA; NEUTROPHIL COUNT; PATHOPHYSIOLOGY; PHARYNGITIS; PRIORITY JOURNAL; SEVERE CONGENITAL NEUTROPENIA; SKIN DEFECT; VERY ELDERLY;

ADULT; AGED, 80 AND OVER; AMBULATORY CARE; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUTROPENIA;

EID: 84907350793     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-02-482612     Document Type: Article

References (59)

1. Djaldetti M, Joshua H, Kalderon M. Familial leukopenia-neutropenia in Yemenite Jews. Observations on eleven families. Bull Res Counc Isr Sect E Exp Med. 1961;9E:24-28.
2. Shaper AG, Lewis P. Genetic neutropenia in people of African origin. Lancet. 1971;2(7732):1021-1023.
3. Reich D, Nalls MA, Kao WH, et al. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet. 2009;5(1):e1000360.
4. Jacobs P. Familial benign chronic neutropenia. South Afr Med J. 1975;49(17):692.
5. Berliner N. Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis. Blood. 2008;111(12):5427-5432.
6. Dale DC, Cottle TE, Fier CJ, et al. Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. Am J Hematol. 2003;72(2):82-93. (Pubitemid 36164341)
7. Freedman MH, Alter BP. Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. Semin Hematol. 2002;39(2):128-133. (Pubitemid 34298837)
8. Rosenberg PS, Alter BP, Bolyard AA, et al; Severe Chronic Neutropenia International Registry. The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. Blood. 2006;107(12):4628-4635. (Pubitemid 43882607)
9. Dong F, Brynes RK, Tidow N, Welte K, Löwenberg B, Touw IP. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med. 1995;333(8):487-493.
10. Hunter MG, Avalos BR. Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. Blood. 2000;95(6):2132-2137. (Pubitemid 30151656)
11. Beekman R, Valkhof MG, Sanders MA, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood. 2012;119(22):5071-5077.
12. Beekman R, Touw IP. G-CSF and its receptor in myeloid malignancy. Blood. 2010;115(25):5131-5136.
13. Carlsson G, Aprikyan AA, Tehranchi R, et al. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood. 2004;103(9):3355-3361. (Pubitemid 38525664)
14. Grenda DS, Murakami M, Ghatak J, et al. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood. 2007;110(13):4179-4187. (Pubitemid 351377781)
15. Köllner I, Sodeik B, Schreek S, et al. Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response. Blood. 2006;108(2):493-500. (Pubitemid 44061347)
16. Klein C, Grudzien M, Appaswamy G, et al. HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet. 2007;39(1):86-92. (Pubitemid 46026506)
17. Klein C. Genetic defects in severe congenital neutropenia: emerging insights into life and death of human neutrophil granulocytes. Annu Rev Immunol. 2011;29:399-413.
18. Boztug K, Klein C. Genetics and pathophysiology of severe congenital neutropenia syndromes unrelated to neutrophil elastase. Hematol Oncol Clin North Am. 2013;27(1):43-60, vii. [vii.]
19. Horwitz MS, Corey SJ, Grimes HL, Tidwell T. ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology. Hematol Oncol Clin North Am. 2013;27(1):19-41, vii.
20. Lange RD. Cyclic hematopoiesis: human cyclic neutropenia. Exp Hematol. 1983;11(6):435-451. (Pubitemid 13035095)
21. Morley AA, Carew JP, Baikie AG. Familial cyclical neutropenia. Br J Haematol. 1967;13(5):719-738.
22. Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet. 1999;23(4):433-436.
23. Newburger PE, Pindyck TN, Zhu Z, et al. Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes. Pediatr Blood Cancer. 2010;55(2):314-317.
24. Shwachman H, Diamond LK, Oski FA, Khaw KT. The syndrome of pancreatic insufficiency and bone marrow dysfunction. J Pediatr. 1964;65:645-663.
25. Kutler DI, Singh B, Satagopan J, et al. A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood. 2003;101(4):1249-1256. (Pubitemid 36182492)
26. Trowbridge AA, Sirinavin C, Linman JW. Dyskeratosis congenita: hematologic evaluation of a sibship and review of the literature. Am J Hematol. 1977;3:143-152. (Pubitemid 8261713)
27. Armanios MY, Chen JJ, Cogan JD, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356(13):1317-1326. (Pubitemid 46513297)
28. Blume RS, Bennett JM, Yankee RA, Wolff SM. Defective granulocyte regulation in the Chediak-Higashi syndrome. N Engl J Med. 1968;279(19):1009- 1015.
29. Zuelzer WW. "Myelokathexis" - a new form of chronic granulocytopenia. Report of a case. N Engl J Med. 1964;270:699-704.
30. Aprikyan AA, Liles WC, Park JR, Jonas M, Chi EY, Dale DC. Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors. Blood. 2000;95(1):320-327. (Pubitemid 30017259)
31. Ménasché G, Pastural E, Feldmann J, et al. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat Genet. 2000;25(2):173-176. (Pubitemid 30394987)
32. Lux SE, Johnston RB Jr, August CS, et al. Chronic neutropenia and abnormal cellular immunity in cartilage-hair hypoplasia. N Engl J Med. 1970;282(5):231-236.
33. Schooley RT, Densen P, Harmon D, et al. Antineutrophil antibodies in infectious mononucleosis. Am J Med. 1984;76(1):85-90. (Pubitemid 14216364)
34. Zon LI, Groopman JE. Hematologic manifestations of the human immune deficiency virus (HIV). Semin Hematol. 1988;25(3):208-218.
35. Christensen RD, Rothstein G. Exhaustion of mature marrow neutrophils in neonates with sepsis. J Pediatr. 1980;96(2):316-318. (Pubitemid 10129430)
36. Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005;165(8):869-874. (Pubitemid 40563233)
37. van der Klauw MM, Goudsmit R, Halie MR, et al. A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999;159(4):369-374. (Pubitemid 29091625)
38. Pereira A, Dean B. Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis. Biochem Pharmacol. 2006;72(6):783-793. (Pubitemid 44233548)
39. Pisciotta AV. Immune and toxic mechanisms in drug-induced agranulocytosis. Semin Hematol. 1973;10(4):279-310.
40. Neftel KA, Hauser SP, Müller MR. Inhibition of granulopoiesis in vivo and in vitro by betalactam antibiotics. J Infect Dis. 1985;152(1):90-98. (Pubitemid 15038839)
41. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146(9):657-665. (Pubitemid 351650522)
42. Bux J, Kissel K, Nowak K, Spengel U, Mueller-Eckhardt C. Autoimmune neutropenia: clinical and laboratory studies in 143 patients. Ann Hematol. 1991;63(5):249-252.
43. Lalezari P, Jiang AF, Yegen L, Santorineou M. Chronic autoimmune neutropenia due to anti-NA2 antibody. N Engl J Med. 1975;293(15):744-747.
44. Bruin MC, von dem Borne AE, Tamminga RY, Kleijer M, Buddelmeijer L, de Haas M. Neutrophil antibody specificity in different types of childhood autoimmune neutropenia. Blood. 1999;94(5):1797-1802. (Pubitemid 29411331)
45. Lalezari P, Nussbaum M, Gelman S, Spaet TH. Neonatal neutropenia due to maternal isoimmunization. Blood. 1960;15:236-243.
46. Bux J, Behrens G, Jaeger G, Welte K. Diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases. Blood. 1998;91(1):181-186. (Pubitemid 28018743)
47. Bruin M, Dassen A, Pajkrt D, Buddelmeyer L, Kuijpers T, de Haas M. Primary autoimmune neutropenia in children: a study of neutrophil antibodies and clinical course. Vox Sang. 2005;88(1):52-59.
48. Starkebaum G. Chronic neutropenia associated with autoimmune disease. Semin Hematol. 2002;39(2):121-127. (Pubitemid 34298836)
49. Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore). 1990;69(2):69-80. (Pubitemid 20138872)
50. Narváez J, Domingo-Domenech E, Gómez-Vaquero C, et al. Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 2012;41(5):658-668.
51. Choi MF, Mant MJ, Turner AR, Akabutu JJ, Aaron SL. Successful reversal of neutropenia in Felty's syndrome with recombinant granulocyte colony stimulating factor. Br J Haematol. 1994;86(3):663-664. (Pubitemid 24199062)
52. Saway PA, Prasthofer EF, Barton JC. Prevalence of granular lymphocyte proliferation in patients with rheumatoid arthritis and neutropenia. Am J Med. 1989;86(3):303-307. (Pubitemid 19081472)
53. Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Curr Hematol Malig Rep. 2007;2(4):278-282.
54. Lamy T, Loughran TP Jr. How I treat LGL leukemia. Blood. 2011;117(10):2764-2774.
55. Papadaki HA, Coulocheri S, Eliopoulos GD. Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. Am J Hematol. 2000;65(4):271-277.
56. Papadaki HA, Eliopoulos AG, Kosteas T, et al. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood. 2003;101(7):2591-2600. (Pubitemid 36857618)
57. Loughran TP Jr, Kidd PG, Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood. 1994;84(7):2164- 2170. (Pubitemid 24296373)
58. Moignet A, Hasanali Z, Zambello R, et al. Cyclophosphamide as a first-line therapy in LGL leukemia. Leukemia. 2014;28(5):1134-1136.
59. Cornec D, Devauchelle-Pensec V, Jousse-Joulin S, et al. Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. Blood. 2013;122(9):1583-1586.